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Kim J. E., Won C. H., Bak H., Kositratna G., Manstein D., Dotto G. P., Chang S. E. (2013), Gene profiling analysis of the early effects of ablative fractional carbon dioxide laser treatment on human skin, in Dermatol Surg
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Dotto G. P. (2012), p63 and FGFR: when development meets proliferation, in EMBO Mol Med
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Epithelial-mesenchymal interactions play a determining function in organ morphogenesis, tissue homeostasis and carcinogenesis. Notch signaling is an important form of cell-cell communication with a key role in control of cell fate commitment. The role of this pathway in the epithelial cell compartments of organs like the skin is by now well established. In our most recent work funded by the SNF over the last three years, we have demonstrated that it plays an equally important function in the skin mesenchymal compartment. In particular, we have found that down-modulation of the Notch1 gene plays an equally important tumor suppressing function in both keratinocytes and fibroblasts. As a continuation of our work, we are now planning to dissect the molecular mechanisms involved in transcriptional control of the Notch1 gene, and test the hypothesis that restoration of normal mechanisms of Notch regulation in cancer cells and/or surrounding stroma will have substantial effects in promoting commitment to differentiation and suppressing tumor development.