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Structural Plasticity in the Hippocampus

English title Structural Plasticity in the Hippocampus
Applicant Caroni Pico
Number 138471
Funding scheme Project funding (Div. I-III)
Research institution Friedrich Miescher Institute for Biomedical Research
Institution of higher education Institute Friedrich Miescher - FMI
Main discipline Neurophysiology and Brain Research
Start/End 01.09.2012 - 31.08.2015
Approved amount 565'446.00
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All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Cellular Biology, Cytology

Keywords (3)

learning and memory; synaptic plasticity; mental health

Lay Summary (English)

Lead
Lay summary

Structural plasticity modifies the connectivity of brain circuits by disassembling existing synapses and assembling new synaptic connections in response to experience. In spite of its major potential importance for learning, memory and resilience to dysfunction, this dramatic long-term form of plasticity has remained poorly understood. Structural plasticity may be particularly important in systems with prominent roles in learning and memory such as the hippocampus. The aim of our studies is to elucidate principles and mechanisms underlying structural plasticity of hippocampal circuits in the adult, and how that plasticity provides insights into hippocampal function. 

In addition to their immediate implications to undertand learning and memory, these projects have important potential implications to investigate how dysfunction in hippocampal circuits impacts on disease. Specifically, potential avenues for exploration include stress and schizophrenia.

Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Early- and Late-Born Parvalbumin Basket Cell Subpopulations Exhibiting Distinct Regulation and Roles in Learning
Donato Flavio, Chowdhury Ananya, Lahr Maria, Caroni Pico (2015), Early- and Late-Born Parvalbumin Basket Cell Subpopulations Exhibiting Distinct Regulation and Roles in Learning, in NEURON, 85(4), 770-786.
Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning
Donato Flavio, Rompani Santiago Belluco, Caroni Pico (2013), Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning, in NATURE, 504(7479), 272-272.
Synapse rearrangements upon learning: From divergent-sparse connectivity to dedicated sub-circuits
Caroni Pico, Chowdhury Ananya, Lahr Maria (2013), Synapse rearrangements upon learning: From divergent-sparse connectivity to dedicated sub-circuits, in Trends in Neurosciences, 37(10), 604-614.
Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning
Ruediger Sarah, Spirig Dominique, Donato Flavio, Caroni Pico (2012), Goal-oriented searching mediated by ventral hippocampus early in trial-and-error learning, in NATURE NEUROSCIENCE, 15(11), 1563-1571.
Structural plasticity upon learning: Regulation and functions
Caroni Pico, Donato Flavio, Muller Dominique (2012), Structural plasticity upon learning: Regulation and functions, in Nature Reviews Neuroscience, 13(7), 478-490.

Collaboration

Group / person Country
Types of collaboration
NCCR Synapsy Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Jan Pielage Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Silvia Arber Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Peer Wulff Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
PF7 Plasticize Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Edvard Moser Norway (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Botond Roska Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Cortical Interneuron Conference Talk given at a conference Roles of PV basket cell subpopulations in learning 06.06.2015 Mallorca, Spain Caroni Pico;
Memory Consolidation Conference Talk given at a conference Adjusting brain circuits for learning and memory 07.05.2015 Montpellier, France Caroni Pico;
LIN Learning and Memory Conference Talk given at a conference Adjusting brain circuits for learning and memory 12.03.2015 Magdeburg, Germany Caroni Pico;
Annual Meeting Finland Soc. of Neuroscience, Plenary lecture Talk given at a conference Adjusting brain circuits for learning and memory 15.12.2014 Helsinki, Finland Caroni Pico;
Univ. of Innsbruck, Seminars in Neuroscience Individual talk Adjusting brain circuits for learning and memory 05.12.2014 Innsbruck, Austria Caroni Pico;
MPI Frankfurt Seminars Individual talk Adjusting brain circuits for learning and memory 05.10.2014 Frankfurt, Germany Caroni Pico;
Calcium in Cell Signaling Talk given at a conference Regulation of PV basket cell plasticity 05.09.2014 Aix-en-Provence, France Caroni Pico;
FENS Forum, Plenary Lecture Talk given at a conference Adjusting brain circuits for learning and memory 05.07.2014 Milano, Italy Lahr Maria; Caroni Pico;
Role of ECM in plasticity Talk given at a conference Adjusting brain circuits for learning and memory 02.07.2014 Volterra, Italy Caroni Pico;
Neuroscience Seminars at KCL Individual talk Adjusting brain circuits for learning and memory 05.04.2014 London, Great Britain and Northern Ireland Caroni Pico;
Neuroscience Seminars, Univ, of Freiburg Individual talk Plasticity of PV basket cells upon learning 04.03.2014 Freiburg, Germany Caroni Pico;
SFB Conference on Memory Talk given at a conference Adjusting brain circuits for learning and memory 28.11.2013 Hamburg, Germany Caroni Pico;
Society for Neuroscience Annual Meeting, Plenary Lecture Talk given at a conference Adjusting brain circuits for learning and memory 25.10.2013 San Diego, United States of America Caroni Pico;
Theodor-Ott Awards Symposium Talk given at a conference Adjusting brain circuits for learning and memory 04.07.2013 Montreux, Switzerland Caroni Pico;
Kavli Distinguished Lecture Individual talk Adjusting brain circuits for learning and memory 26.06.2013 Trondheim, Norway Caroni Pico;
Golgi Science Days Talk given at a conference Adjusting brain circuits for learning and memory 08.06.2013 Roma, Italy Caroni Pico;
The future of axon guidance Talk given at a conference Adjusting brain circuits for learning and memory 04.06.2013 Les Treilles, France Caroni Pico;
BNA Bi-annual meeting Talk given at a conference Adjusting brain circuits for learning and memory 03.04.2013 London, Great Britain and Northern Ireland Caroni Pico;
Neuroscience Seminars at Columbia University Individual talk Adjusting brain circuits for learning and memory 05.03.2013 New York City, United States of America Caroni Pico;
VIB Seminars Individual talk Adjusting brain circuits for learning and memory 16.02.2013 Leuven, Belgium Caroni Pico;
Swiss Society for Neuroscience Annual Meeting Talk given at a conference Adjusting brain circuits for learning and memory 04.02.2013 Geneva, Switzerland Caroni Pico; Donato Flavio;
50th Anniversary of HiFo Zurich Talk given at a conference Adjusting brain circuits for learning and memory 15.12.2012 Zurich, Switzerland Caroni Pico;
Helsinki University Neuroscience Series Individual talk Adjusting brain circuits for learning and memory 05.12.2012 Helsinki, Finland Caroni Pico;
VIMM Annual Meeting Talk given at a conference Adjusting brain circuits for learning 06.11.2012 Marostica, Italy Caroni Pico;
- GABAergic interneuron development Talk given at a conference Plasticity of PV basket cells in learning 03.10.2012 St Raphael, France Caroni Pico;


Self-organised

Title Date Place
The Assembly and Function of Neuronal Circuits 28.09.2013 Ascona, Monte Verità, Switzerland

Awards

Title Year
Theodor-Ott Award Career award of Swiss Academy of Medical Sciences (awarded all 5 years) 2013

Associated projects

Number Title Start Funding scheme
160311 Circuit mechanisms of learning and memory 01.09.2015 Project funding (Div. I-III)
160311 Circuit mechanisms of learning and memory 01.09.2015 Project funding (Div. I-III)

Abstract

Structural plasticity modifies the connectivity of brain circuits by disassembling existing synapses and assembling new synaptic connections in response to experience. In spite of its major potential importance for learning, memory and resilience to dysfunction, this dramatic long-term form of plasticity has remained poorly understood. Structural plasticity may be particularly important in systems with prominent roles in learning and memory such as the hippocampus. The aim of our studies is to elucidate principles and mechanisms underlying structural plasticity of hippocampal circuits in the adult, and how that plasticity provides insights into hippocampal function. The projects are based on recent published findings from our lab, and address novel or unresolved issues of hippocampal function at the mechanistic level. They involve a broad spectrum of experimental approaches, but all rely on the analysis of identified neurons and synaptic structures, and aim at establishing causal relationships between modifications at those specific circuit elements, hippocampal function and mouse behavior.The following experimental approaches will represent the major effort of our laboratory over the next several years and are described in detail in this research plan:(1) Microcircuits of hippocampal principal neuron subpopulations: In these projects we will address the implications of our recent discovery of parallel principal neuron microcircuits with different structural plasticity properties in the hippocampus. We will investigate (1) the functional properties of the principal neuron subpopulations, (2) the mechanisms underlying their selective connectivity, and (3) their roles for information processing and learning in the hippocampus. (2) Circuit-specific control of developmental and adult plasticity in the hippocampus: In these projects we will investigate the mechanisms underlying parvalbumin (PV+) interneuron maturation in the hippocampus, a major target of control to regulate long-term plasticity in the juvenile and adult brain. We will investigate (1) circuit mechanisms underlying PV+ interneuron maturation in the hippocampus, (2) the role of temporal and spatial PV+ maturation patterns for hippocampal circuit assembly in juveniles, and (3) the possibility that similar mechanisms involving mossy fibers and PV+ neuron phenotypes may orchestrate plasticity in the adult.(3) Mechanisms regulating filopodial synapse numbers onto PV neurons in CA3: These projects build upon our discovery of filopodial synapses formation onto PV+ interneurons upon learning to investigate synaptogenesis mechanisms upon plasticity in the adult. We will investigate (1) the possible induction of filopodial synapses by ACh in vivo and in slice cultures, (2) the cellular regulation of LMT filopodial growth and synaptogenesis in slice cultures, and (3) the roles of feedforward inhibition connectivity levels for hippocampal learning and memory. (4) Hippocampal network plasticity in hippocampus-dependent learning: These projects exploit filopodial synapse increase upon learning in hippocampal CA3 as a sensitive readout for learning-related plasticity. The experiments aim at determining when and how the hippocampal network undergoes long-term plasticity related to learning, and at contrasting the roles of the hippocampus in memory, learning, and memory retrieval to support behavior. We will investigate (1) the roles of dorsal and ventral hippocampus in learning, and (2) the involvement of brain systems connected to the hippocampus in controlling hippocampal plasticity and learning.
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