Respiratory virus; Paramyxovirus; Virus particle morphogenesis; Virus protein structure function analysis; Vaccine vector
Essaidi-Laziosi M Shevtsova A Gerlier D Roux L. (2014), . Minimal features of efficient incorporation of the hemagglutinin-neuraminidase protein into sendai virus particles., in J Virol
, 88(1), 303-313.
Bampi C Rasga L Roux L. (2013), Antagonism to human BST-2/tetherin by Sendai virus glycoproteins., in J Gen Vir
, 94(6), 1211-1219.
Essaidi-Laziosi M Shevtsova A Gerlier D Roux L (2013), Mutation of the TYTLE Motif in the Cytoplasmic Tail of the Sendai Virus Fusion Protein Deeply Affects Viral Assembly and Particle Production., in PlosOne
, 8(12), e78074.
Bampi C Grenet AS Caignard G Vidalain PO Roux L. (2013), The cellular protein TIP47 restricts Respirovirus multiplication leading to decreased virus particle production., in Virrus Research
, 173, 354-363.
Miazza V Mottet-Osman G Startchick S Chaponnier C Roux L. (2011), Sendai virus induced cytoplasmic actin remodeling correlates with efficient virus particle production., in Virology
, 410(1), 7-16.
The general objective of the project is to detail the molecular mechanisms of Sendai virus assembly. This includes the interactions required between the viral constituents as well as the protein motifs involved. The relevance of these motifs will have to be evaluated. The understanding of the mechanisms involved should eventually allow directed pseudotyping of SeV with selected glycoproteins. The experimental approach is base on an original "integrated suppression complementation system" (ISCS).