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BASEL IX - Basel Syncope Evaluation Study

English title BASEL IX - Basel Syncope Evaluation Study
Applicant Mueller Christian
Number 138403
Funding scheme Project funding (Div. I-III)
Research institution Abteilung für Allgemeine Innere Medizin Medizinische Universitätsklinik A Universitätsspital Basel
Institution of higher education University of Basel - BS
Main discipline Clinical Cardiovascular Research
Start/End 01.01.2012 - 31.12.2014
Approved amount 491'000.00
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All Disciplines (2)

Discipline
Clinical Cardiovascular Research
Internal Medicine

Keywords (4)

syncope; diagnosis; arrhythmia; cost

Lay Summary (English)

Lead
Lay summary

Background: Syncope is a transient loss of consciousness and usually leads to a fall. It may have very different causes. Some of these are acute life-threatening, others are completely bengin. Initially it can be very difficult to identify the cause responsible for syncope in the individual patient. Therefore, the management of patients presenting with syncope is a serious challenge.

Aim: The aim of the study is to evaluate the diagnostic value of patient’s history, clinical judgement and novel cardiac biomarkers (proteins that can be measured in blood), alone or in combination, in the diagnosis and risk stratification of patients with syncope.

The aim of the study is to evaluate the diagnostic value of patient’s history, clinical judgement and novel cardiac biomarkers (proteins that can be measured in blood), alone or in combination, in the diagnosis and risk stratification of patients with syncope.

Methodology: This is a prospective, multicenter study, designed and coordinated by the University Hospital Basel. This study is designed to enroll 720 patients > 40 years presenting to the emergency department with a recent (<12h) episode of syncope. Patient history will be standardized using a predefined form. Treating physicians will be asked to quantify their clinical judgment regarding the cause of the syncope, using a visual analogue scale. Blood samples will be drawn for the measurement of novel biomarkers. Patients will be contacted at 6, 12 and 24 months to determine which patients had a benign course (no events) and which suffered adverse events like e.g. another syncope.

This is a prospective, multicenter study, designed and coordinated by the University Hospital Basel. This study is designed to enroll 720 patients > 40 years presenting to the emergency department with a recent (<12h) episode of syncope. Patient history will be standardized using a predefined form. Treating physicians will be asked to quantify their clinical judgment regarding the cause of the syncope, using a visual analogue scale. Blood samples will be drawn for the measurement of novel biomarkers. Patients will be contacted at 6, 12 and 24 months to determine which patients had a benign course (no events) and which suffered adverse events like e.g. another syncope.

Potential significance: A more accurate and more rapid diagnosis of cardiac syncope, the most dangerous form of syncope, can help identify patients at high risk of adverse events and initiate cost effective prevention strategies at the right time. Overall, we expect this study to provide novel insights, holding important scientific, clinical and economic implications.

A more accurate and more rapid diagnosis of cardiac syncope, the most dangerous form of syncope, can help identify patients at high risk of adverse events and initiate cost effective prevention strategies at the right time. Overall, we expect this study to provide novel insights, holding important scientific, clinical and economic implications.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Pulmonary Embolism in Patients Hospitalized for Syncope
Badertscher Patrick Du Fay de Lavallaz Jeanne Mueller Christian (2017), Pulmonary Embolism in Patients Hospitalized for Syncope, in New England Journal of Medicine, 494-497.
Diagnostic and prognostic value of cTnT high-sensitive in patients with syncope
Christ M et al. (2015), Diagnostic and prognostic value of cTnT high-sensitive in patients with syncope, in Am J Med , 128, 161-170.
Prävalenz und prognostische Bedeutung von Beinahe-Synkope und Synkope
Greve Y et al. (2014), Prävalenz und prognostische Bedeutung von Beinahe-Synkope und Synkope, in Dtsch Arztebl Int, 111(12), 197-204.
High-sensitivity cardiac troponin in acute conditions.
Gualandro DM et al. (2014), High-sensitivity cardiac troponin in acute conditions., in Current Opinion in Critical Care, 20, 472-477.
What Cardiologists Should Know About Copeptin?
Rubini Gimenez M et al. (2014), What Cardiologists Should Know About Copeptin?, in Rev Esp Cardiol (Engl Ed). , 67(7), 519-521.
Happy Birthday BNP
Mueller C (2012), Happy Birthday BNP, in Eur Heart J Acute Cardiovasc Care, 1(2), 109-110.
How to use high-sensitivity cardiac troponins in acute cardiac care.
Thygesen K et al. (2012), How to use high-sensitivity cardiac troponins in acute cardiac care., in Eur Heart J 2012, 33(18), 2252-2257.
Recommendations for the use of natriuretic peptides in acute cardiac care.
Thygesen K et al. (2012), Recommendations for the use of natriuretic peptides in acute cardiac care., in Eur Heart J, 33(16), 2001-2006.

Collaboration

Group / person Country
Types of collaboration
Royal brisbane and Women's Hospital, Professor L. Cullen Australia (Oceania)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Christchurch University Hospital, Professor M. Than New Zealand (Oceania)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Royal infirmary of Edinburgh, United Kingdom: Prof. Matthew Reed Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Kantonsspital Liestal, Dr. Geigy Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Exchange of personnel
Universitätsspital Zürich, Prof. D. Keller Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Baylor College of Medicine Houston, Professor F. Peacock United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
General Hospital, Zabrze, Dr. Beate Morawiec, Dr. Damian Kawecki Poland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Geneva University Hospital, Switzerland: Prof. Francois Pierre Sarasin Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Sant'Andrea Hospital, Rome, Professor DiSomma Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
- Exchange of personnel
Barcelona, Hospital del Mar, Professor J. Gea Spain (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
BRAHMS Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Industry/business/other use-inspired collaboration
Barcelona, Hospital Clinic, Professor O. Miro Spain (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Spital Lachen Zürich, Switzerland: Dr. Imke Poepping Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Klinikum Nürnberg, Felicitas Geier Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events



Self-organised

Title Date Place
International GREAT Meeting 01.09.2016 Rome, Italy
International GREAT Meeting 03.09.2015 Rom, Italy
International GREAT Meeting 26.06.2014 Helsinki, Finland
International GREAt Meeting 27.06.2013 Prag, Czech Republic
International GREAT Meeting 05.06.2012 Barcelona, Spain

Awards

Title Year
Otto Hess Research Award 2014

Associated projects

Number Title Start Funding scheme
135434 Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study 01.04.2011 Project funding (Div. I-III)
175604 BASEL IX (BAsel Syncope EvaLuation Study): Validation 01.10.2017 Project funding (Div. I-III)

Abstract

Background: Management of patients with syncope is a serious problem concerning 1-2% of emergency department visits. In 6-20% of these, syncope will be due to a cardiac origin. The rapid and accurate identification of these patients is an important unmet clinical need.Aim: The aim of the study is to evaluate the diagnostic value of patient’s history, clinical judgement and novel cardiac biomarkers, alone or in combination, in the diagnosis and risk stratification of patients with syncope.Methodology: This is a prospective, multicenter study, designed and coordinated by the University Hospital Basel. This study is designed to enroll 720 patients > 40 years presenting to the ED with recent (<12h) episode of syncope. Patient history will be standardized using a predefined form. Treating physicians will be asked to quantify their clinical judgment regarding the cause of the syncope, using a visual analogue scale. Blood samples will be drawn for the measurement of novel biomarkers (including copeptin, proendothelin-1, pro-adrenomedulin, natriuretic peptides and high-sensitive cardiac troponins). Patients will be contacted at 6, 12 and 24 months to determine adverse events (death, resuscitation, recurrence of syncope, hospitalization for syncope) and further investigations. The primary endpoint is to assess the performance of a standardised form of patient’s history, clinical judgment and biomarkers, alone and in combination, in the diagnosic of a cardiac syncope, as adjudicated by two independent experts. Secondary endpoints include the accuracy of the above cited items in prognostic stratification and the determination of the cost-effectiveness of the best approach.Potential significance: A more accurate and more rapid diagnosis of cardiac syncope can help identify patients at high risk of adverse events and initiate cost effective prevention strategies at right time. Overall, we expect this study to provide novel insights, holding important scientific, clinical and economic implications.
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