Hustedt Nicole, Seeber Andrew, Sack Ragna, Tsai-Pflugfelder Monika, Bhullar Bhupinder, Vlaming Hanneke, van Leeuwen Fred, Guénolé Aude, van Attikum Haico, Srivas Rohith, Ideker Trey, Shimada Kenji, Gasser Susan M (2015), Yeast PP4 Interacts with ATR Homolog Ddc2-Mec1 and Regulates Checkpoint Signaling., in Molecular cell
, 57(2), 273-89.
Gerhold Christian B., Gasser Susan M. (2014), INO80 and SWR complexes: relating structure to function in chromatin remodeling, in TRENDS IN CELL BIOLOGY
, 24(11), 619-631.
Gerhold Christian-Benedikt, Hauer Michael H, Gasser Susan M (2014), INO80-C and SWR-C: Guardians of the Genome., in Journal of molecular biology
, pii: S002.
Seeber Andrew, Dion Vincent, Gasser Susan M. (2014), Remodelers move chromatin in response to DNA damage, in CELL CYCLE
, 13(6), 877-878.
Seeber Andrew, Dion Vincent, Gasser Susan M (2014), Remodelers move chromatin in response to DNA damage., in Cell cycle (Georgetown, Tex.)
, 13(6), 877-8.
Horigome Chihiro, Oma Yukako, Konishi Tatsunori, Schmid Roger, Marcomini Isabella, Hauer Michael H., Dion Vincent, Harata Masahiko, Gasser Susan M. (2014), SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice, in MOLECULAR CELL
, 55(4), 626-639.
Weisman Ronit, Cohen Adiel, Gasser Susan M. (2014), TORC2-a new player in genome stability, in EMBO MOLECULAR MEDICINE
, 6(8), 995-1002.
Nielsen Ida, Bentsen Iben Bach, Andersen Anni H., Gasser Susan M., Bjergbaek Lotte (2013), A Rad53 Independent Function of Rad9 Becomes Crucial for Genome Maintenance in the Absence of the RecQ Helicase Sgs1, in PLOS ONE
, 8(11), e810.
Seeber Andrew, Dion Vincent, Gasser Susan M (2013), Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage., in Genes & development
, 27(18), 1999-2008.
Dion V, Gasser SM (2013), Chromatin movement in the maintenance of genome stability, in Cell
, 152, 1255-1364.
Dion Vincent, Kalck Véronique, Seeber Andrew, Schleker Thomas, Gasser Susan M (2013), Cohesin and the nucleolus constrain the mobility of spontaneous repair foci., in EMBO reports
, 14(11), 984-91.
Oppikofer Mariano, Kueng Stephanie, Keusch Jeremy J, Hassler Markus, Ladurner Andreas G, Gut Heinz, Gasser Susan M (2013), Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation., in The EMBO journal
, 32(3), 437-49.
Grunstein Michael, Gasser Susan M (2013), Epigenetics in Saccharomyces cerevisiae., in Cold Spring Harbor perspectives in biology
, 5(7), pii: a0174.
Towbin Benjamin D., Gonzalez-Sandoval Adriana, Gasser Susan M. (2013), Mechanisms of heterochromatin subnuclear localization, in TRENDS IN BIOCHEMICAL SCIENCES
, 38(7), 356-363.
Seeber Andrew, Hauer Michael, Gasser Susan M (2013), Nucleosome remodelers in double-strand break repair., in Current opinion in genetics & development
, 23(2), 174-84.
Gasser Susan M (2013), Open questions: epigenetics and the role of heterochromatin in development., in BMC biology
, 11, 21-21.
Rohner Sabine, Kalck Veronique, Wang Xuefei, Ikegami Kohta, Lieb Jason D, Gasser Susan M, Meister Peter (2013), Promoter- and RNA polymerase II-dependent hsp-16 gene association with nuclear pores in Caenorhabditis elegans., in The Journal of cell biology
, 200(5), 589-604.
Hustedt Nicole, Gasser Susan M, Shimada Kenji (2013), Replication checkpoint: tuning and coordination of replication forks in s phase., in Genes
, 4(3), 388-434.
Kueng Stephanie, Oppikofer Mariano, Gasser Susan M (2013), SIR proteins and the assembly of silent chromatin in budding yeast., in Annual review of genetics
, 47, 275-306.
Oppikofer Mariano, Kueng Stephanie, Gasser Susan M. (2013), SIR-nucleosome interactions: Structure-function relationships in yeast silent chromatin, in GENE
, 527(1), 10-25.
Gonzalez-Sandoval Adriana, Towbin Benjamin D., Gasser Susan M. (2013), The formation and sequestration of heterochromatin during development Delivered on 7 September 2012 at the 37th FEBS Congress in Sevilla, Spain, in FEBS JOURNAL
, 280(14), 3212-3219.
Ferreira Helder C, Towbin Benjamin D, Jegou Thibaud, Gasser Susan M (2013), The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery., in The Journal of cell biology
, 203(5), 727-35.
Shimada Kenji, Filipuzzi Ireos, Stahl Michael, Helliwell Stephen B, Studer Christian, Hoepfner Dominic, Seeber Andrew, Loewith Robbie, Movva N Rao, Gasser Susan M (2013), TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks., in Molecular cell
, 51(6), 829-39.
Hegnauer Anna Maria, Hustedt Nicole, Shimada Kenji, Pike Brietta L., Vogel Markus, Amsler Philipp, Rubin Seth M., van Leeuwen Fred, Guenole Aude, van Attikum Haico, Thomae Nicolas H., Gasser Susan M. (2012), An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks, in EMBO JOURNAL
, 31(18), 3768-3783.
Dion V, Kalck V, Horigome C, Towbin B, Gasser S.M (2012), Increased dynamics at double strand breaks requires Mec1, Rad9 and the homologous recombination machinery, in Nature Cell Biol
, 14(5), 502-509.
Neumann F.R, Dion V, Gehlen L., Taddei A, Tsai-Pflugfelder M., Gasser S.M. (2012), Nucleosome remodeler-induced chromatin dynamics enhance repair by homologous recombination, in Genes & Development
, 26(4), 369-383.
Kueng S, Tsai-Pflugfelder M, Oppikofer M., Sack R, Ferreira. H.C, Gasser S.M (2012), Regulating Repression: Roles for the Sir4 N-Terminus in Linker DNA Protection and Stabilization of Epigenetic States, in PLOS Genetics
, 8 (5), e1002727.
Towbin Benjamin D, González-Aguilera Cristina, Sack Ragna, Gaidatzis Dimos, Kalck Véronique, Meister Peter, Askjaer Peter, Gasser Susan M (2012), Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery., in Cell
, 150(5), 934-47.
Taddei Angela, Gasser Susan M. (2012), Structure and Function in the Budding Yeast Nucleus, in GENETICS
, 192(1), 107-129.
Taddei Angela, Gasser Susan M (2012), Structure and function in the budding yeast nucleus., in Genetics
, 192(1), 107-29.
Nuclear organization is known to influence transcription, but has only recently been shown to be relevant for DNA repair. We hypothesize that nuclear subcompartments influence repair efficiency as well as repair pathway choice. We propose to test this with a combined imaging and genetic approach that examines chromatin movement during the repair process. We will examine the role of factors that regulate both movement and DNA repair in vivo, namely chromatin remodelers and SUMO modification. Work in yeast allows us to perform detailed functional studies describing the core mechanisms of damage relocalization. We then expand our studies to C. elegans, where we will examine how this is regulated by heterochromatin context and differentiation. We will analyse whether chromatin context, such as developmentally or repeat-induced heterochromatin, alters either the rate or outcome of repair, and whether the importance of chromatin remodeling or damage relocation increases when damage occurs in a heterochromatic context. The use of model organisms allows us to screen for novel chromatin remodeling / modulatory factors important for double strand break repair.