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Physiological mechanisms of parasite resistance, local adaptation and host preference by vectors in a natural population of great tits infected with two main lineages of avian malaria

Titel Englisch Physiological mechanisms of parasite resistance, local adaptation and host preference by vectors in a natural population of great tits infected with two main lineages of avian malaria
Gesuchsteller/in Christe Philippe
Nummer 138187
Förderungsinstrument Projektförderung (Abt. I-III)
Forschungseinrichtung Département d'Ecologie et d'Evolution Faculté de Biologie et de Médecine Université de Lausanne
Hochschule Universität Lausanne - LA
Hauptdisziplin Oekologie
Beginn/Ende 01.01.2012 - 31.03.2015
Bewilligter Betrag 443'507.00
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Keywords (5)

oxidative stress; local adaptation; host selection; life-history traits; virulence

Lay Summary (Englisch)

Lead
Lay summary

Several ill-understood evolutionary processes have been elucidated through the study of host-parasite interactions. A central concept is that there is a cost to parasite resistance, which generates trade-offs between the various mechanisms of defence and fitness related traits. Oxidative stress has gained considerable interest as potential mediator of life history trade-offs and the current challenge is to understand these trade-offs. Although avian malaria is a very common and widely distributed parasite, the complex interactions between the different actors of this bird-mosquito-Plasmodium system remain largely unknown. In a previous study, we found a strong segregated spatial distribution of two main Plasmodium lineages infecting great tits (Parus major) in two natural populations of great tits. The present research program focuses on different aspects of interactions between parasites and hosts (physiological mechanisms, local adaptation, virulence) and between parasites and vectors, mainly the mosquito Culex pipiens (host choice, life-history traits).

Overall, we expect that the results obtained from a series of field and lab experiments will not only reveal little known connections between infection status and host preference, but also uncover part of the complex interactions and constraints affecting the relationship between hosts, vectors and parasites in a natural avian malaria model. 


Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Publikationen

Publikation
Exposure of the mosquito vector Culex pipiens to the malaria parasite Plasmodium relictum: effect of infected blood intake on immune and antioxidant defences, fecundity and survival.
Delhaye Jessica, Aletti Consolée, Glaizot Olivier, Christe Philippe (2016), Exposure of the mosquito vector Culex pipiens to the malaria parasite Plasmodium relictum: effect of infected blood intake on immune and antioxidant defences, fecundity and survival., in Parasites & vectors, 9(1), 616-616.
Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds
Delhaye J. Salamin N. Roulin A. Criscuolo F. Bize P. Christe P. (2016), Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds, in Age, 38(5), 433-443.
Plasmodium infection and oxidative status in breeding great tits, Parus major
Delhaye Jessica Jenkins Tania Christe Philippe (2016), Plasmodium infection and oxidative status in breeding great tits, Parus major, in Malaria Journal, 15, 531.
Plasmodium infection and oxidative status in breeding great tits, Parus major.
Delhaye Jessica, Jenkins Tania, Christe Philippe (2016), Plasmodium infection and oxidative status in breeding great tits, Parus major., in Malaria journal, 15(1), 531-531.
Bringing together phylogeny and behavioural ecology in host-parasite interactions
Jenkins Tania, Christe Philippe (2015), Bringing together phylogeny and behavioural ecology in host-parasite interactions, in Morand Serge (ed.), Cambridge University Press, Cambridge, 434-449.
How a haemosporidian parasite of bats gets around: the genetic structure of a parasite, vector and host compared
Witsenburg Fardo, Clément Laura, Lopez-Baucells Adria, Palmeirim Jorge, Pavlinic Igor, Scaravelli Dino, Sevcik Martin, Dutoit Ludovic, Salamin Nicolas, Goudet Jérôme, Christe Philippe (2015), How a haemosporidian parasite of bats gets around: the genetic structure of a parasite, vector and host compared, in Molecular Ecology, 24, 926-940.
Signs of a vector’s adaptive choice: on the evasion of infectious hosts and parasite-induced mortality
Witsenburg Fardo, Schneider Franziska, Christe Philippe (2015), Signs of a vector’s adaptive choice: on the evasion of infectious hosts and parasite-induced mortality, in Oikos, 124, 668-676.
Epidemiological traits of the malaria-like parasite Polychromophilus murinus in the Daubenton's bat Myotis daubentonii.
Witsenburg Fardo, Schneider Franziska, Christe Philippe (2014), Epidemiological traits of the malaria-like parasite Polychromophilus murinus in the Daubenton's bat Myotis daubentonii., in Parasites & Vectors, 7(1), 566.
Natural malaria infection reduces starvation resistance of nutritionally stressed mosquitoes.
Lalubin Fabrice, Delédevant Aline, Glaizot Olivier, Christe Philippe (2014), Natural malaria infection reduces starvation resistance of nutritionally stressed mosquitoes., in Journal of Animal Ecology, 83, 850-857.
North-African house martins endure greater haemosporidian infection than their European counterparts
van Rooyen Juan, Jenkins Tania, Lahlah Naouel, Christe Philippe (2014), North-African house martins endure greater haemosporidian infection than their European counterparts, in Journal of Avian Biology, 45(5), 450-456.
Senescence in cell oxidative status in two bird species with contrasting life expectancy.
Bize Pierre, Cotting Sophie, Devevey Godefroy, van Rooyen Juan, Lalubin Fabrice, Glaizot Olivier, Christe Philippe (2014), Senescence in cell oxidative status in two bird species with contrasting life expectancy., in Oecologia, 174(4), 1097-105.
Altitudinal variation in haemosporidian parasite distribution in great tit populations.
Rooyen Juan van, Lalubin Fabrice, Glaizot Olivier, Christe Philippe (2013), Altitudinal variation in haemosporidian parasite distribution in great tit populations., in Parasites & vectors, 6, 139-139.
Avian haemosporidian persistence and co-infection in great tits at the individual level.
van Rooyen Juan, Lalubin Fabrice, Glaizot Olivier, Christe Philippe (2013), Avian haemosporidian persistence and co-infection in great tits at the individual level., in Malaria Journal, 12(40), 40.
Temporal changes in mosquito abundance (Culex pipiens), avian malaria prevalence and lineage composition
Lalubin Fabrice, Deledevant Aline, Glaizot Olivier, Christe Philippe (2013), Temporal changes in mosquito abundance (Culex pipiens), avian malaria prevalence and lineage composition, in PARASITES & VECTORS, 6, 307.
High Prevalence and Lineage Diversity of Avian Malaria in Wild Populations of Great Tits (Parus major) and Mosquitoes (Culex pipiens)
Glaizot Olivier, Fumagalli Luca, Iritano Katia, Lalubin Fabrice, Van Rooyen Juan, Christe Philippe (2012), High Prevalence and Lineage Diversity of Avian Malaria in Wild Populations of Great Tits (Parus major) and Mosquitoes (Culex pipiens), in PLOS ONE, 7(4), e34964-e34964.
Potential evidence of parasite avoidance in an avian malarial vector
Lalubin Fabrice, Bize Pierre, van Rooyen Juan, Christe Philippe, Glaizot Olivier (2012), Potential evidence of parasite avoidance in an avian malarial vector, in ANIMAL BEHAVIOUR, 84(3), 539-545.
The evolutionary host switches of Polychromophilus: a multi-gene phylogeny of the bat malaria genus suggests a second invasion of mammals by a haemosporidian parasite
Witsenburg Fardo, Salamin Nicolas, Christe Philippe (2012), The evolutionary host switches of Polychromophilus: a multi-gene phylogeny of the bat malaria genus suggests a second invasion of mammals by a haemosporidian parasite, in Malaria Journal, 11, 53.

Zusammenarbeit

Gruppe / Person Land
Formen der Zusammenarbeit
Dr Olivier Glaizot, Musée cantonal de Zoologie, Lausanne Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
- Austausch von Mitarbeitern
Luca Fumagalli, Dpt Ecology and Evolution, UNIL Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
- Austausch von Mitarbeitern

Wissenschaftliche Veranstaltungen

Aktiver Beitrag

Titel Art des Beitrags Titel des Artikels oder Beitrages Datum Ort Beteiligte Personen
Biology 15 Vortrag im Rahmen einer Tagung Local adaptation between malaria and its great tit hosts: an experimental approach 12.02.2015 Dübendorf (EAWAG), Schweiz Jenkins Antoinette; Delhaye Jessica;
Biology 15 Poster Infection dynamics of two Plasmodium species and oxidative stress in a canary model 12.02.2015 Dübendorf (Eawag), Schweiz Delhaye Jessica; Jenkins Antoinette;
Joint 2014 Annual Meeting British Ecological Society and Société Française d’Ecologie Vortrag im Rahmen einer Tagung Local adaptation between malaria and its great tit hosts: an experimental approach 09.12.2014 Lille, Frankreich Jenkins Antoinette;
Société  Entomologique Suisse  +  Swiss Vector  Entomology Group Vortrag im Rahmen einer Tagung Exposure of the mosquito vector Culex pipiens to Plasmodium parasite and potential cost of resistance 07.03.2014 Berne, Schweiz Delhaye Jessica; Lalubin Fabrice;
XIV Congress of the European Society for Evolutionary Biology (ESEB) Poster A progression of evolution 19.08.2013 Lisbon, Portugal Jenkins Antoinette; Delhaye Jessica;
XIV Congress of the European Society for Evolutionary Biology (ESEB) Poster Oxidative stress in breeding Great tit, Parus major, naturally infected by Plasmodium spp. 19.08.2013 Lisbonne, Portugal Delhaye Jessica; Jenkins Antoinette;
16th International Bat Research Conference, San José, Costa Rica Vortrag im Rahmen einer Tagung How Malaria Gets Around: the Genetic Structure of a Parasite, Vector, and Host Compared 11.08.2013 San José, Costa Rica Christe Philippe;
International conference on malaria and related Haemosporidian parasites of wildlife Poster Oxidative stress in breeding Great tit, Parus major, naturally infected by Plasmodium spp. 07.08.2013 Vilnius, Litauen Delhaye Jessica; Jenkins Antoinette;
Second Annual International Workshop on Malaria and Related Haemosporidian Parasites of Wildlife Vortrag im Rahmen einer Tagung Signatures of coevolution among Leucocytozoa of birds 06.08.2012 Shepherdstown, Vereinigte Staaten von Amerika Jenkins Antoinette;


Verbundene Projekte

Nummer Titel Start Förderungsinstrument
159600 Evolution of host preferences and mechanisms of parasite resistance in birds and mosquitoes infected with avian malaria 01.04.2015 Projektförderung (Abt. I-III)
120479 Virulence, host preferences and life-history traits in a natural population of great tits infected with malaria 01.09.2008 Projektförderung (Abt. I-III)
179378 Dynamic of haemosporidian parasites: from individual to communities 01.11.2018 Projektförderung (Abt. I-III)

Abstract

Several ill-understood evolutionary processes have been elucidated through the study of host-parasite interactions, which remains one of the most promising fields of research in evolutionary biology and behavioural ecology. A central concept is that there is a cost to parasite resistance, which generates trade-offs between the various mechanisms of defense and fitness related traits. The current challenge is to understand these trade-offs. Oxidative stress has gained considerable interest as potential mediator of these life history trade-offs. Although avian malaria is a very common and widely distributed parasite, the complex interactions between the different actors of this bird-mosquito-Plasmodium system remain largely unknown. In a current research project funded by the SNF, we have found a very high prevalence (about 90%) of different Plasmodium lineages infecting natural populations of great tits (Parus major). The two main Plasmodium lineages occurring in our study populations showed a strong segregated spatial distribution. Multiple infections from divergent parasite lineages could result in the evolution of increased virulence because of intense competition for a limited number of hosts. The mosquito Culex pipiens appears to be the main vector for Plasmodium in these populations, with a rather high prevalence of about 7%. C. pipiens were able to discriminate between infected and uninfected birds and were more likely to choose the uninfected ones, according to their body odor differences. The present application is a continuation of that research program and focuses on avian malaria in the great tit and Culex pipiens, looking at different aspects of interactions between parasites and hosts (physiological mechanisms, local adaptation, virulence) and between parasites and vectors (host choice, life-history traits). Specifically, we will first perform a series of field and lab experiments in order to:a) Test experimentally the interaction between parasitaemia, ability to mount an immune response and oxidative stress level.b) Test if local adaptation takes place in this host-parasite system in a series of cross-infection experiments. c) Investigate in laboratory conditions if there is competition between two Plasmodium species (P. relictum, lineage SGS1) and P. polare (lineage SW2) within single bird host.Secondly, we will focus on different aspects of interactions between Plasmodium and mosquitoes. With a series of lab and field experiments we will:d) Investigate the costs imposed by Plasmodium on mosquitoes by comparing life history parameters between infected and non-infected individuals in different environmental conditions.e) Test if host selection, based on uropygial gland secretions, is affected by the status (parasitized or not) of the vector.f) Determine the association between several species/lineages of Plasmodium and their natural vector species.Overall, we expect that these experiments will not only reveal little known connections between infection status and host preference, but also uncover part of the complex interactions and constraints affecting the relationship between hosts, vectors and parasites in a natural avian malaria model.
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