The synthesis of modified vitamin B12 derivatives for medical applications has recently gained considerable attention. Since rapidly proliferating cells demand high amounts of B12, the development of inhibitors of B12 dependent enzymes, so called anti-vitamins seems to be very attractive and has not been explored sufficiently enough. The project aims towards the development of a new class of these compounds that develop cytostatic or cytotoxic activity in vivo.
In a second part of the project, we study biomimetic B12 complexes to gain insights into the mechanism of B12 dependent enzymes. The third objective is to apply these derivatives for improved cyanide detection.