Emotion; Imaging; Prematurity; Cognition ; Brain; Music; Prematurity
Fischi-Gomez Elda (2016), Brain network characterization of high-risk preterm-born school-age children, in Neuroimage Clin
, 6(11), 195-209.
Išgum Ivana, Benders Manon J N L, Avants Brian, Cardoso M Jorge, Counsell Serena J, Gomez Elda Fischi, Gui Laura, Hűppi Petra S, Kersbergen Karina J, Makropoulos Antonios, Melbourne Andrew, Moeskops Pim, Mol Christian P, Kuklisova-Murgasova Maria, Rueckert Daniel, Schnabel Julia A, Srhoj-Egekher Vedran, Wu Jue, Wang Siying, de Vries Linda S, Viergever Max A (2015), Evaluation of automatic neonatal brain segmentation algorithms: the NeoBrainS12 challenge., in Medical image analysis
, 20(1), 135-51.
Réveillon Morgane, Borradori Tolsa Cristina, Monnier Maryline, Hüppi Petra S, Barisnikov Koviljka (2015), Response inhibition difficulties in preterm children aged 9-12 years: Relations with emotion and behavior., in Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
Monnier M, Jaunin L, Bickle Graz M, Borradori Tolsa C, Hüppi P, Sancho Rossignol A, Barisnikov K, Forcada Guex M (2014), [Detection of executive function disorders with a standard neurodevelopmental follow-up of premature children]., in Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
, 21(9), 944-52.
Borradori Tolsa C, Barisnikov K, Lejeune F, Hüppi P (2014), [Executive functions in preterm-born children]., in Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
, 21(9), 1035-40.
Witt Arnaud, Theurel Anne, Tolsa Cristina Borradori, Lejeune Fleur, Fernandes Lisa, de Jonge Laurence van Hanswijck, Monnier Maryline, Bickle Graz Myriam, Barisnikov Koviljka, Gentaz Edouard, Hüppi Petra S (2014), Emotional and effortful control abilities in 42-month-old very preterm and full-term children., in Early human development
, 90(10), 565-9.
Fischi-Gómez Elda, Vasung Lana, Meskaldji Djalel-Eddine, Lazeyras Fançois, Borradori-Tolsa Cristina, Hagmann Patric, Barisnikov Koviljka, Thiran Jean-Philippe, Hüppi Petra S (2014), Structural Brain Connectivity in School-Age Preterm Infants Provides Evidence for Impaired Networks Relevant for Higher Order Cognitive Skills and Social Cognition., in Cerebral cortex (New York, N.Y. : 1991)
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Langerock, van Hanswijck de Jonge Laurence, Bickle Graz Myriam, Hüppi Pétra Susan, Borradori Tolsa Cristina, Barisnikov Koviljka (2013), Emotional reactivity at 12 months in very preterm infants born at <29 weeks of gestation, in Infant Behavior and Development
, 36(3), 289-297.
Réveillon, Urben Sébastien, Barisnikov Koviljka, Borradori Tolsa Cristina, Hüppi Pétra Susan, Lazeyras François Oois (2013), Functional neuroimaging study of performances on a Go/No-go task in 6- to 7-year-old preterm children: Impact of intrauterine growth restriction, in NeuroImage: Clinical
, 3, 429-437.
Réveillon Morgane, Urben Sébastien, Barisnikov Koviljka, Borradori Tolsa Cristina, Hüppi Petra S, Lazeyras François (2013), Functional neuroimaging study of performances on a Go/No-go task in 6- to 7-year-old preterm children: Impact of intrauterine growth restriction., in NeuroImage. Clinical
, 3, 429-37.
Barisnikov K. Lejeune F. (2012), Développement des prématurés: Prédicteurs et prévention, in Psychoscope
, 30(5), 12-15.
Barisnikov K Van Hanswijck de Jonge L Reveillon M Urben S Lazeyras F Borradori Tolsa C Hüpp, Development of executive functions in children born prematurely: cognitive, neuronal and behavioural aspects, in K. Barishnikov and Y. Zinchenko (ed.), Lomonosov Moscow State University: Publ.House, Moscow, 229-253.
Borradori Tolsa C. Xavier T. Langerock N. bachmann A. Hüppi P. & Barisnikov K., Emotion regulation and attention abilities in preterm born children at 12 months., in K. Barisnikov and Y. Zinchenko (ed.), Lomonosov Moscow State University: Publ. House, Moscow, 283-300.
Brain development takes place both intrauterine as well as postnatally and many factors influence structural and functional brain development. Poor intrauterine environment leading to growth restriction and premature birth are conditions shown to be associated with considerable effects on cognitive development. Cognition is characterized by executive processes that develop during childhood and characterize both intellectual as well as behavioural development, but behaviour is defined not only by cognitive capacities but also by emotional processing and regulation. The development of affective cognition is fundamental to human behaviour. Cognitive tasks such as decision making are taking place in an emotional context, but conversely cognitive capacities modulate emotional responses. Therefore one can argue that the emotional development (feelings) is as important than the cognitive development (logical thought) in understanding the development of human behaviour. As outlined in the results from our prior project emotional regulation is indeed affected in infants born premature and with poor intrauterine growth, but to what extent the development of emotional processing and regulation affects the cognitive development and what underlying brain structures are responsible for emotion processing during development are unknown.Application of affective neuroscience tasks in relationship with structural and functional brain assessment with advanced Magnetic Resonance Imaging from the newborn period up to 12 years of age offers the opportunity to characterize the development of the emotional and cognitive development and their structural association in children born preterm and with low birth weight.The proposed project aims to demonstrate the development of emotion and cognition and their interaction in high risk children. The goals of the project are: 1)to study the development of emotional processing in premature infants with and without fetal growth restriction from newborn age to age 12 years2)to investigate differences in emotional processing and cognition and their relationship to alterations in brain structure and function at birth in premature infants at the age of 3½ years in the cohort recruited in our prior project (32003B-113632)3)to study the effects of prematurity and growth restriction on the affective cognition at age 9-12 years and the early signs of mood disorders (cohort from (32003B-113632) 4)to study the structure-function relationship of affective cognition at the age of 9-12 years with fMRI and neuropsychological assessment in the cohorts studied in our prior project (32003B-113632)5)to define basic brain functional connectivity in the newborns and evaluate the effects of prematurity and growth restriction with resting state fMRI (RS-fMRI) and Diffusion Tensor Imaging (DTI), and to study the brain structural and functional effects of an emotion directed intervention (music) in the premature infants (new cohort)The proposal maintains that the last trimester of gestation, especially when compromised by IUGR and the early perinatal period in premature infants is a critical period for brain development and the development of Affective Cognition and builds on prior research data obtained through SNF projects (3200-056927&32003B-113632)The primary infant measures proposed will be brain functional (neurobehavioral functioning, neuropsychological assessment) and brain structural &functional assessments (DTI and fMRI). The project is expected to deliver comprehensive and substantive results to better understand the development of normal affective cognition and the underlying neural models in newborns, 3 years old infants and in 9-12 years old children as well as in a high risk population of preterm infants with and without growth restriction