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Development of Emotion and Cognition in Preterm Born Cohorts: Neurostructural and Neurofunctional Correlates from Birth to Early Adolescence

English title Development of Emotion and Cognition in Preterm Born Cohorts: Neurostructural and Neurofunctional Correlates from Birth to Early Adolescence
Applicant Hüppi Petra
Number 135817
Funding scheme Project funding (special)
Research institution Service de Développement et Croissance Département de Pédiatrie Hôpital des Enfants - HUG
Institution of higher education University of Geneva - GE
Main discipline Paediatrics
Start/End 01.10.2011 - 31.12.2015
Approved amount 468'000.00
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All Disciplines (2)

Discipline
Paediatrics
Psychology

Keywords (7)

Emotion; Imaging; Prematurity; Cognition ; Brain; Music; Prematurity

Lay Summary (English)

Lead
Development of Emotion and Cognition in Preterm Born Cohorts: Neurostructural and Neurofunctional Correlates from Birth to Early AdolescenceLay summary; research aim and project
Lay summary

Brain development takes place both intrauterine as well as postnatally and many factors influence structural and functional brain development. In that sense, poor intrauterine environment leading to growth restriction and premature birth are conditions shown to be associated with considerable effects on cognitive development. Evidently, emotional regulation is affected as well in infants born premature and with poor intrauterine growth. But to what extent the development of emotional processing and regulation affects the cognitive development and what underlying brain structures are responsible for emotion processing during development, are unknown.
The proposed project aims to demonstrate the development of emotion and cognition, structural associations, and their interaction in premature children, and children with poor intrauterine growth.
Measured will be the development of normal affective cognition and the underlying neural models in newborns, 3 years old infants and in 9-12 years old children as well as in a high risk population of preterm infants with and without growth restriction. Neurobehavioral functioning, neuropsychological assessment, structural brain and functional assessments (DTI and fMRI) will be applied.

Direct link to Lay Summary Last update: 17.11.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Brain network characterization of high-risk preterm-born school-age children
Fischi-Gomez Elda (2016), Brain network characterization of high-risk preterm-born school-age children, in Neuroimage Clin, 6(11), 195-209.
Evaluation of automatic neonatal brain segmentation algorithms: the NeoBrainS12 challenge.
Išgum Ivana, Benders Manon J N L, Avants Brian, Cardoso M Jorge, Counsell Serena J, Gomez Elda Fischi, Gui Laura, Hűppi Petra S, Kersbergen Karina J, Makropoulos Antonios, Melbourne Andrew, Moeskops Pim, Mol Christian P, Kuklisova-Murgasova Maria, Rueckert Daniel, Schnabel Julia A, Srhoj-Egekher Vedran, Wu Jue, Wang Siying, de Vries Linda S, Viergever Max A (2015), Evaluation of automatic neonatal brain segmentation algorithms: the NeoBrainS12 challenge., in Medical image analysis, 20(1), 135-51.
Response inhibition difficulties in preterm children aged 9-12 years: Relations with emotion and behavior.
Réveillon Morgane, Borradori Tolsa Cristina, Monnier Maryline, Hüppi Petra S, Barisnikov Koviljka (2015), Response inhibition difficulties in preterm children aged 9-12 years: Relations with emotion and behavior., in Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 1-23.
[Detection of executive function disorders with a standard neurodevelopmental follow-up of premature children].
Monnier M, Jaunin L, Bickle Graz M, Borradori Tolsa C, Hüppi P, Sancho Rossignol A, Barisnikov K, Forcada Guex M (2014), [Detection of executive function disorders with a standard neurodevelopmental follow-up of premature children]., in Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 21(9), 944-52.
[Executive functions in preterm-born children].
Borradori Tolsa C, Barisnikov K, Lejeune F, Hüppi P (2014), [Executive functions in preterm-born children]., in Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie, 21(9), 1035-40.
Emotional and effortful control abilities in 42-month-old very preterm and full-term children.
Witt Arnaud, Theurel Anne, Tolsa Cristina Borradori, Lejeune Fleur, Fernandes Lisa, de Jonge Laurence van Hanswijck, Monnier Maryline, Bickle Graz Myriam, Barisnikov Koviljka, Gentaz Edouard, Hüppi Petra S (2014), Emotional and effortful control abilities in 42-month-old very preterm and full-term children., in Early human development, 90(10), 565-9.
Structural Brain Connectivity in School-Age Preterm Infants Provides Evidence for Impaired Networks Relevant for Higher Order Cognitive Skills and Social Cognition.
Fischi-Gómez Elda, Vasung Lana, Meskaldji Djalel-Eddine, Lazeyras Fançois, Borradori-Tolsa Cristina, Hagmann Patric, Barisnikov Koviljka, Thiran Jean-Philippe, Hüppi Petra S (2014), Structural Brain Connectivity in School-Age Preterm Infants Provides Evidence for Impaired Networks Relevant for Higher Order Cognitive Skills and Social Cognition., in Cerebral cortex (New York, N.Y. : 1991), In press(In press), In press-In press.
Emotional reactivity at 12 months in very preterm infants born at <29 weeks of gestation
Langerock, van Hanswijck de Jonge Laurence, Bickle Graz Myriam, Hüppi Pétra Susan, Borradori Tolsa Cristina, Barisnikov Koviljka (2013), Emotional reactivity at 12 months in very preterm infants born at <29 weeks of gestation, in Infant Behavior and Development, 36(3), 289-297.
Functional neuroimaging study of performances on a Go/No-go task in 6- to 7-year-old preterm children: Impact of intrauterine growth restriction
Réveillon, Urben Sébastien, Barisnikov Koviljka, Borradori Tolsa Cristina, Hüppi Pétra Susan, Lazeyras François Oois (2013), Functional neuroimaging study of performances on a Go/No-go task in 6- to 7-year-old preterm children: Impact of intrauterine growth restriction, in NeuroImage: Clinical, 3, 429-437.
Functional neuroimaging study of performances on a Go/No-go task in 6- to 7-year-old preterm children: Impact of intrauterine growth restriction.
Réveillon Morgane, Urben Sébastien, Barisnikov Koviljka, Borradori Tolsa Cristina, Hüppi Petra S, Lazeyras François (2013), Functional neuroimaging study of performances on a Go/No-go task in 6- to 7-year-old preterm children: Impact of intrauterine growth restriction., in NeuroImage. Clinical, 3, 429-37.
Développement des prématurés: Prédicteurs et prévention
Barisnikov K. Lejeune F. (2012), Développement des prématurés: Prédicteurs et prévention, in Psychoscope, 30(5), 12-15.
Development of executive functions in children born prematurely: cognitive, neuronal and behavioural aspects
Barisnikov K Van Hanswijck de Jonge L Reveillon M Urben S Lazeyras F Borradori Tolsa C Hüpp, Development of executive functions in children born prematurely: cognitive, neuronal and behavioural aspects, in K. Barishnikov and Y. Zinchenko (ed.), Lomonosov Moscow State University: Publ.House, Moscow, 229-253.
Emotion regulation and attention abilities in preterm born children at 12 months.
Borradori Tolsa C. Xavier T. Langerock N. bachmann A. Hüppi P. & Barisnikov K., Emotion regulation and attention abilities in preterm born children at 12 months., in K. Barisnikov and Y. Zinchenko (ed.), Lomonosov Moscow State University: Publ. House, Moscow, 283-300.

Collaboration

Group / person Country
Types of collaboration
Anita Truttman MD PD is one of the staff neonatologists Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Mirjam Bickle Graz MD -Manon Cevey Macherel MD Child Development Unit, Division of Neonatology, CHUV Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
- Exchange of personnel
Didier Grandjean - UNIGE - Neuroscience of Emotion and Affective Dynamics Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
-Yaniv Assaf, Tel Aviv University, Tel Aviv, Israel&CONNECT Consortium EU Framework 7 project Israel (Asia)
- in-depth/constructive exchanges on approaches, methods or results
-Jessica Dubois, Neurospin, CEA, Saclay, Paris, France France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Andreas Vollenweider - Musician Switzerland (Europe)
- Industry/business/other use-inspired collaboration
David Sander, PhD is Professor in Psychology Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Simon Warfield, Surgical Planning Laboratory, Brigham and Women's Hospital, Harvard Medical School, United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
Cesar Caballero PhD CIBM University of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Jean Philippe Thiran CIBM Image analysis core EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Reto Meuli, Professor in Radiology CIBM Lausanne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Sylviane Hanquinet, MD Associated Professor in Radiology University of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
ISMRM 2015 Talk given at a conference Brain network modular fingerprint of premature born children 30.05.2015 Toronto, Canada Hüppi Petra; Lazeyras François; Fischi Elda;
ISMRM 2014 Poster Functional connectivity differences in full-term and preterm at term equivalent age newborns 17.12.2013 Milan, Italy Hüppi Petra; Lordier Lara; Lazeyras François;
PAS/ASPR 2014 Poster BRAIN CONNECTIONS ASSOCIATED WITH SOCIO-COGNITIVE SKILLS IN PRETERM AND LOW BIRTH WEIGHT SCHOOL AGE 17.12.2013 Vancouver, Canada Lazeyras François; Barisnikov Koviljka; Borradori Tolsa Cristina; Hüppi Petra;
ISMRM 2014 Poster LONGITUDINAL ANALYSIS OF BRAIN NETWORK REORGANIZATION IN PRETERM IUGR CHILDREN AT 1,6,9 17.12.2013 Milan, Italy Fischi Elda; Hüppi Petra;
ESPR Poster Emotion, attention and effortful control at 24 month-old in very preterm and full-term children 10.10.2013 Porto, Portugal Hüppi Petra; Borradori Tolsa Cristina; Barisnikov Koviljka;
ESPR Poster REGIONAL CHANGES OF CORTICAL THICKNESS IN CHILDREN BORN PREMATURELY AND CHILDREN BORN WITH INTRAUTERINE GROWTH RESTRICTION AT SCHOOL AGE 10.10.2013 Porto, Portugal Borradori Tolsa Cristina; Hüppi Petra; Lazeyras François;
ECDP 2013 Poster Impact of prematurity on executive control in children: evidence from stop-signal and flanker tasks 03.09.2013 Lausanne, Switzerland Borradori Tolsa Cristina; Hüppi Petra; Réveillon Morgane; Barisnikov Koviljka;
SSP Poster Emotional, attentional and inhibition abilities in very preterm and full-term children at 24 months of age 21.06.2013 Geneva, Switzerland Barisnikov Koviljka; Hüppi Petra; Borradori Tolsa Cristina;
SPUM meeting Poster Development of Executive Functions in children born prematurely in relation to neurostructural brain development 21.02.2013 Zürich, Switzerland Borradori Tolsa Cristina;
Congrès de la société suisse de Pédiatrie Poster Cortical thickness in preterm infants 20.01.2013 Geneve, Switzerland Hüppi Petra; Lazeyras François; Borradori Tolsa Cristina;
Alpine Brain Imaging Meeting Poster Impact of prematurity on executive control in children: evidence from an fMRI study with a flanker task 06.01.2013 Champéry, Switzerland Borradori Tolsa Cristina; Réveillon Morgane; Barisnikov Koviljka; Lazeyras François; Hüppi Petra; Sander David;
EAPS 2012 Poster NEW SEGMENTATION METHOD SHOWS EFFECTS OF PREMATURITY ON CEREBRAL TISSUE VOLUMES AT TERM 05.09.2012 Istanbul, Turkey Lazeyras François; Borradori Tolsa Cristina; Hüppi Petra;
Cognitive and affective neurosciences conference Poster Impact of intrauterine growth restriction (IUGR) on a Go/No-go task’s performances at 6 years of age: an fMRI study 09.05.2012 Marseille, France Borradori Tolsa Cristina; Hüppi Petra; Réveillon Morgane; Barisnikov Koviljka; Lazeyras François;
ISMRM 2012 Poster Graph theory to analyse developmental plasticity in connectivity of preterm children 08.05.2012 Melbourne, Australia Lazeyras François; Hüppi Petra;


Self-organised

Title Date Place
EADcare 22.11.2013 Lyon, France

Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions DU PRÉMATURÉ À L’ÉCOLIER : Western Switzerland 2015
Media relations: radio, television le bébé funambule TV FRANCE 5 (crescendo Film) International 2013

Awards

Title Year
Prix Cloetta 2011 2011

Associated projects

Number Title Start Funding scheme
113632 Development of Executive Functions in children born prematurely in relation to neurostructural brain development 01.04.2007 Project funding (Div. I-III)
163084 Building the path to resilience in preterm infants: a neuroimaging investigation of the impact of multisensory and neurocognitive interventions 01.02.2016 Project funding (special)
124101 From cortex to classroom: enhancing brain development for premature infants 01.10.2009 SPUM
113632 Development of Executive Functions in children born prematurely in relation to neurostructural brain development 01.04.2007 Project funding (Div. I-III)
182832 Building the path to resilience after preterm birth: cortical development and network based interventions in longitudinal cohorts 01.02.2019 Project funding (Div. I-III)

Abstract

Brain development takes place both intrauterine as well as postnatally and many factors influence structural and functional brain development. Poor intrauterine environment leading to growth restriction and premature birth are conditions shown to be associated with considerable effects on cognitive development. Cognition is characterized by executive processes that develop during childhood and characterize both intellectual as well as behavioural development, but behaviour is defined not only by cognitive capacities but also by emotional processing and regulation. The development of affective cognition is fundamental to human behaviour. Cognitive tasks such as decision making are taking place in an emotional context, but conversely cognitive capacities modulate emotional responses. Therefore one can argue that the emotional development (feelings) is as important than the cognitive development (logical thought) in understanding the development of human behaviour. As outlined in the results from our prior project emotional regulation is indeed affected in infants born premature and with poor intrauterine growth, but to what extent the development of emotional processing and regulation affects the cognitive development and what underlying brain structures are responsible for emotion processing during development are unknown.Application of affective neuroscience tasks in relationship with structural and functional brain assessment with advanced Magnetic Resonance Imaging from the newborn period up to 12 years of age offers the opportunity to characterize the development of the emotional and cognitive development and their structural association in children born preterm and with low birth weight.The proposed project aims to demonstrate the development of emotion and cognition and their interaction in high risk children. The goals of the project are: 1)to study the development of emotional processing in premature infants with and without fetal growth restriction from newborn age to age 12 years2)to investigate differences in emotional processing and cognition and their relationship to alterations in brain structure and function at birth in premature infants at the age of 3½ years in the cohort recruited in our prior project (32003B-113632)3)to study the effects of prematurity and growth restriction on the affective cognition at age 9-12 years and the early signs of mood disorders (cohort from (32003B-113632) 4)to study the structure-function relationship of affective cognition at the age of 9-12 years with fMRI and neuropsychological assessment in the cohorts studied in our prior project (32003B-113632)5)to define basic brain functional connectivity in the newborns and evaluate the effects of prematurity and growth restriction with resting state fMRI (RS-fMRI) and Diffusion Tensor Imaging (DTI), and to study the brain structural and functional effects of an emotion directed intervention (music) in the premature infants (new cohort)The proposal maintains that the last trimester of gestation, especially when compromised by IUGR and the early perinatal period in premature infants is a critical period for brain development and the development of Affective Cognition and builds on prior research data obtained through SNF projects (3200-056927&32003B-113632)The primary infant measures proposed will be brain functional (neurobehavioral functioning, neuropsychological assessment) and brain structural &functional assessments (DTI and fMRI). The project is expected to deliver comprehensive and substantive results to better understand the development of normal affective cognition and the underlying neural models in newborns, 3 years old infants and in 9-12 years old children as well as in a high risk population of preterm infants with and without growth restriction
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