Projekt

Zurück zur Übersicht

High density admixture mapping for assessing the impact of interspecific recombination in ecologically important species

Titel Englisch High density admixture mapping for assessing the impact of interspecific recombination in ecologically important species
Gesuchsteller/in Lexer Christian
Nummer 134660
Förderungsinstrument ProDoc (Forschungsmodul, FM)
Forschungseinrichtung Unité d'Ecologie et Evolution Département de Biologie Université de Fribourg
Hochschule Universität Freiburg - FR
Hauptdisziplin Botanik
Beginn/Ende 01.12.2011 - 28.02.2015
Bewilligter Betrag 202'124.00
Alle Daten anzeigen

Alle Disziplinen (3)

Disziplin
Botanik
Genetik
Oekologie

Keywords (7)

Gene mapping; Adaptation; Reproductive isolation; Speciation; Genetic admixture; Next Generation Sequencing; Model forest tree

Lay Summary (Englisch)

Lead
Lay summary

Populations of mixed ancestry (exhibiting socalled “genetic admixture”) have been used successfully in medicine for mapping genes of relevance for human health (for example in African Americans). Admixture between divergent populations also holds great promise for genomic studies of key evolutionary processes in wild species of animals and plants, such as adaptation, reproductive isolation and speciation. Important laboratory and analytical tools are now in place to map functionally important genes in ecologically important species using natural crosses found in mixed-ancestry populations. Here, we propose to use these newly developed tools to address topics of great current interest in ecological & evolutionary genomics.

Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Name Institut

Publikationen

Publikation
Integrating the ‘genomic mosaic’ view of species into studies of biotic interactions
Lexer C Caseys C Stritt C Whitham TG (2013), Integrating the ‘genomic mosaic’ view of species into studies of biotic interactions, in Ecology Letters, 16(12), 1515-e7.
Effects of interspecific recombination on functional traits in trees revealed by metabolomics and genotyping-by-resequencing
Caseys C, Glauser G, Stölting KN, Christe C, Albrectsen BR, Lexer C (2012), Effects of interspecific recombination on functional traits in trees revealed by metabolomics and genotyping-by-resequencing, in Plant Ecology and Diversity, 457-471.

Zusammenarbeit

Gruppe / Person Land
Formen der Zusammenarbeit
Nicolas Bierne / CNRS Montpellier Frankreich (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Austausch von Mitarbeitern
Benedicte Abrectsen, Umea University Schweden (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Gaetan Glauser/University of Neuchatel Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
Alex Buerkle/University of Wyoming Vereinigte Staaten von Amerika (Nordamerika)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten

Wissenschaftliche Veranstaltungen

Aktiver Beitrag

Titel Art des Beitrags Titel des Artikels oder Beitrages Datum Ort Beteiligte Personen
Workshop: Genomics of the speciation continuum Vortrag im Rahmen einer Tagung History of admixture in Populus hybrid zones 04.09.2014 Fribourg, Schweiz Christe Camille;
Biology 2014 Vortrag im Rahmen einer Tagung History of admixture in Populus hybrid zones 13.02.2014 University of Geneva, Schweiz Christe Camille;
Final ProDoc meeting in Population Genomics Vortrag im Rahmen einer Tagung Patterns of ancestry and history of recombination in three Populus hybrid zones 23.01.2014 University of Lausanne, Schweiz Christe Camille;
47th PopGroup (Population Genetics Group) meeting Poster History of admixture in Populus hybrid zones 07.01.2014 University of Bath, Grossbritannien und Nordirland Christe Camille;
4th Biological Evolution Workshop Vortrag im Rahmen einer Tagung 4th Biological Evolution Workshop 04.11.2013 Porto Alegre, Brasilien Lexer Christian;
iEOS2013 (Inaugural International Environmental 'Omics Synthesis Conference) Poster iEOS2013 (Inaugural International Environmental 'Omics Synthesis Conference) 09.09.2013 Cardiff, Grossbritannien und Nordirland Christe Camille;
Plant Population Biology 2013 Vortrag im Rahmen einer Tagung Plant Population Biology 2013 09.05.2013 Tartu, Estland Lexer Christian;
SwissPlant Vortrag im Rahmen einer Tagung SwissPlant 30.01.2013 Meiringen, Schweiz Lexer Christian;
Evolution 2012 Vortrag im Rahmen einer Tagung Evolution 2012 06.07.2012 Ottawa, Canada, Kanada Lexer Christian; Christe Camille;
Adaptive Landscape Genetics Vortrag im Rahmen einer Tagung Adaptive Landscape Genetics 07.02.2012 Neuchatel, Switzerland, Schweiz Lexer Christian; Christe Camille;


Selber organisiert

Titel Datum Ort
Workshop: Genomics of the speciation continuum 04.09.2014 Fribourg, Schweiz
Rapid evolution during biological invasions 06.09.2012 Fribourg, Switzerland, Swasiland
Biology 2012 08.02.2012 Fribourg, Switzerland, Schweiz

Verbundene Projekte

Nummer Titel Start Förderungsinstrument
149306 Coupling genomics with experiments to study divergence-with-gene-flow in trees 01.03.2014 Projektförderung (Abt. I-III)
127059 Intraspecific consequences of a porous species boundary in European Populus 01.02.2010 Projektförderung (Abt. I-III)
126393 Population Genomics 01.02.2010 ProDoc (Ausbildungsmodul, AM)

Abstract

Genomic admixture has been used successfully in medicine for mapping genes of relevance for human health. Admixture between divergent populations also holds great promise for genomic studies of the mechanisms involved in adaptation, reproductive isolation and speciation in wild species of animals and plants. Important laboratory and analytical tools are now in place to map fitness-related genes in ecologically important species using natural crosses found in admixture or hybrid zones. Here, we propose to use these newly developed tools to address topics of great current interest in ecological & evolutionary genomics. To complement ongoing PhD projects in this program and to make full use of the existing knowledge base in my lab, a plant model system will be used: Populus alba and P. tremula, two hybridizing European tree species related to P. trichocarpa, the first completely sequenced forest tree. The proposed PhD project is divided into three basic steps.First, a very large number of mapped single nucleotide polymorphisms (SNP) generated by well established ultra high throughput sequencing technology will be used to explore genomic patterns of recombination in three replicate hybrid zones of P. alba and P. tremula in Europe, with special emphasis on relationships with known climatic changes in Earth’s recent history. Second, the same population genomic data will be used to map important ecological trait differences (leaf morphology and defence chemistry) to the genomes of hybrids and to study the genomic architecture of these traits. Third, newly discovered DNA polymorphisms that cross the species barrier unexpectedly well will be converted into simple, Sanger sequence based genetic markers to test whether these genetic variants spread in the recipient species’ genome due to positive selection, or rather due to neutral processes in the course of geographic range expansion.Building on > 6 years of evolutionary genetics research on these hybrid zones in my lab, the PhD student will have the chance to contribute significantly to the establishment of concepts and methods of high density admixture mapping in ecology and evolutionary biology. The close relationship with core objectives of this ‘ProDoc’ PhD program on population genomics will serve as a guarantee for extensive interactions with other research teams and students in this program.
-