natural product; paramagnetic protein NMR; enantioselective metal catalyst; artificial enzyme; metallopolymer; enantio-selective metal catalyst; metallo-polymer
Schumacher Andreas, Schrems Marcus G, Pfaltz Andreas (2011), Enantioselective synthesis of cis-1,2-disubstituted cyclopentanes and cyclohexanes by Suzuki-Miyaura cross-coupling and iridium-catalyzed asymmetric hydrogenation., in Chemistry (Weinheim an der Bergstrasse, Germany)
, 17(48), 13502-9.
Constable Edwin C, Harris Kate, Housecroft Catherine E, Neuburger Markus, Zampese Jennifer A (2011), Environmental control of solution speciation in cobalt(II) 2,2':6',2''-terpyridine complexes: anion and solvent dependence., in Dalton transactions (Cambridge, England : 2003)
, 40(43), 11441-50.
Jessen HJ, Schumacher A, Schmid F, Pfaltz A, Gademann K (2011), Catalytic Enantioselective Total Synthesis of (+)-Torrubiellone C, in ORGANIC LETTERS
, 13(16), 4368-4370.
Monnard Fabien W, Heinisch Tillmann, Nogueira Elisa S, Schirmer Tilman, Ward Thomas R (2011), Human carbonic anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor., in Chemical communications (Cambridge, England)
, 47(29), 8238-40.
Jana Chandan Kumar, Hoecker Johannes, Woods Tom M, Jessen Henning J, Neuburger Markus, Gademann Karl (2011), Synthesis of Withanolide A, Biological Evaluation of Its Neuritogenic Properties, and Studies on Secretase Inhibition., in Angewandte Chemie (International ed. in English)
, 50, 8407-8411.
Jessen Henning Jacob, Schumacher Andreas, Shaw Travis, Pfaltz Andreas, Gademann Karl (2011), A unified approach for the stereoselective total synthesis of pyridone alkaloids and their neuritogenic activity., in Angewandte Chemie (International ed. in English)
, 50(18), 4222-6.
Franzke Axel, Pfaltz Andreas (2011), Zwitterionic iridium complexes with P,N-ligands as catalysts for the asymmetric hydrogenation of alkenes., in Chemistry (Weinheim an der Bergstrasse, Germany)
, 17(15), 4131-4144.
Constable Edwin C, Harris Kate, Housecroft Catherine E, Neuburger Markus (2011), When is a metallopolymer not a metallopolymer? When it is a metallomacrocycle., in Dalton transactions (Cambridge, England : 2003)
, 40(7), 1524-34.
Ward Thomas R (2011), Artificial metalloenzymes based on the biotin-avidin technology: enantioselective catalysis and beyond., in Accounts of chemical research
, 44(1), 47-57.
The requested funding will be used for the replacement and upgrading of our dedicated research NMR instrumentation at the department of chemistry (500 and 600 MHz spectrometers). All of the five applicants use NMR as a key technique and critically rely on sufficient experiment time on state of the art technology spectrometers. Detailed information on the mechanistic and structural investigations that are carried out in the fields of natural product research, paramagnetic protein NMR, artificial enzymes, asymmetric organometal catalysis, metallopolymers, and supramolecular chemistry are provided, to unambiguously demonstrate the necessity and the potential achievements that can be expected from the desired upgrade.