motor cortex; optical imaging; mouse behavior; skill learning ; brain plasticity
Guo Zengcai V, Hires S Andrew, Li Nuo, O'Connor Daniel H, Komiyama Takaki, Ophir Eran, Huber Daniel, Bonardi Claudia, Morandell Karin, Gutnisky Diego, Peron Simon, Xu Ning-long, Cox James, Svoboda Karel (2014), Procedures for behavioral experiments in head-fixed mice., in PloS one
, 9(2), 88678-88678.
Andrásfalvy Bertalan, Galiñanes Gregorio, Huber Daniel, Barbic Mladen, Macklin John, Susumu K, Delhandty John, Huston Alen, Makara Judit, Menditz Igor (2014), Quantum dot-based multiphoton fluorescent pipettes for targeted neuronal electrophysiology, in Nature Methods
, 11, 1237-1241.
The motor cortex undergoes rapid functional reorganization during the acquisition of novel skills. The circuit mechanisms underlying theses changes are not well understood. The general aim of this project is to use optogentic tools and long term imaging with genetically encoded activity indicators to characterize the fine-scale organization of cortical motor circuits and to dissect the role of individual cell types and specific neuromodulators in motor learning. These experiments in rodents will not only help us to understand some of the basic neuronal mechanisms that govern our own actions, they can potentially pave the way to novel approaches for the treatment of motor impairments, frequently caused by cerebrovascular accidents.