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Population Genomic Basis of Evolutionary Change in Drosophila Aging and Life History

Titel Englisch Population Genomic Basis of Evolutionary Change in Drosophila Aging and Life History
Gesuchsteller/in Flatt Thomas
Nummer 133641
Förderungsinstrument SNF-Förderungsprofessuren
Forschungseinrichtung Département d'Ecologie et d'Evolution Faculté de Biologie et de Médecine Université de Lausanne
Hochschule Universität Lausanne - LA
Hauptdisziplin Oekologie
Beginn/Ende 01.12.2012 - 30.11.2016
Bewilligter Betrag 1'640'746.00
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Alle Disziplinen (3)

Disziplin
Oekologie
Zoologie
Genetik

Keywords (13)

Evolution; Life History Traits; Life History Evolution; Lifespan; Population Genetics; Latitudinal Adaptation; Experimental Evolution; Artificial Selection; Evolutionary Ecology; Speed Mapping; Next Generation Sequencing; Genome-wide Association Mapping; Drosophila melanogaster

Lay Summary (Englisch)

Lead
Lay summary

So-called life history traits - such as developmental rate, age and size at maturity, number and size of offspring, rates of survival and lifespan - are the most important determinants of reproductive success ("Darwinian fitness"), and variation in such fitness traits drives ecological adaptations by natural selection. However, despite the fundamental importance of life history traits in evolutionary biology, their genetic and genomic basis is not yet well understood. Which genes are responsible for the remarkable diversity in life history traits we observe in natural populations? In this project we will use next generation sequencing technology to investigate the genetic underpinnings of life history evolution by identifying naturally occuring genetic variants that contribute to variation in adult lifespan and associated life history traits in natural and artificially selected populations of the fruit fly, Drosophila melanogaster. By sequencing the genome of flies that have evolved different sets of life history traits along a latitudinal climate gradient in the wild and that of flies selected for a delayed age at breeding and thus increased longevity in the laboratory, we aim to identify the genetic factors that shape the evolution of aging and life histories.

 

Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Publikationen

Publikation
. Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster.
Kapun Martin, Schmidt Chloe, Durmaz Esra, Schmidt Paul S., Flatt Thomas (2016), . Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster., in Journal of Evolutionary Biology , 29, 1059-1072.
Endocrine uncoupling of the trade-off between reproduction and somatic maintenance in eusocial insects
Rodrigues Marisa Almeida, Flatt Thomas (2016), Endocrine uncoupling of the trade-off between reproduction and somatic maintenance in eusocial insects, in Current Opinion in Insect Science , 16, 1-8.
Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster.
Kapun Martin, Fabian Daniel K., Goudet Jerome, Flatt Thomas (2016), Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster., in Molecular Biology and Evolution, 33, 1317-1336.
Genomics of clinal variation in Drosophila: disentangling the interactions of selection and demography
Flatt Thomas (2016), Genomics of clinal variation in Drosophila: disentangling the interactions of selection and demography, in Molecular Ecology, 25, 1023-10126.
Living long and well: prospects for a personalized approach to the medicine of ageing
Fuellen G., Schofield P.N., Flatt T., Schulz R.-J., Boege F., Kraft K., Rimbach G., Ibrahim S., Schmidt C., Köhling R., Simm A. (2016), Living long and well: prospects for a personalized approach to the medicine of ageing, in Gerontology, 62, 409-416.
Organ plasticity: Paying the costs of reproduction
Flatt T. (2015), Organ plasticity: Paying the costs of reproduction, in eLife, 4, e09556.
Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa.
Fabian D.K., Lack J.B., Mathur V., Schlötterer C., Schmidt P.S., Pool J.E., Flatt T. (2015), Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa., in Journal of Evolutionary Biology , 28, 826-840.
Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of D. melanogaster
Kapun Martin, van Schalwyk Hester, McAllister Bryant, Flatt Thomas, Schlötterer C. (2014), Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of D. melanogaster, in Molecular Ecology, 23, 1813-1827.
Plasticity of Lifespan – A Reaction Norm Perspective
Flatt T. (2014), Plasticity of Lifespan – A Reaction Norm Perspective, in Proceedings of the Nutrition Society , 73, 532-542.
Similarities and differences in altitudinal versus latitudinal variation for morphological traits in Drosophila melanogaster
Klepsatel Peter, Galikova Martina, Huber Christian D., Flatt Thomas (2014), Similarities and differences in altitudinal versus latitudinal variation for morphological traits in Drosophila melanogaster, in Evolution, 68, 1385-1398.
The Evolution of Aging (German original title; "Die Evolution der Alterung")
Flatt T. (2014), The Evolution of Aging (German original title; "Die Evolution der Alterung"), in Pipette - Swiss Laboratory Medicine, 2014((1) 2014), 6-7.
Ecdysone Triggered PGRP-LC Expression Controls Drosophila Innate Immunity
Rus Florentina, Flatt Thomas, Tong Mei, Aggarwal Kamna, Okuda Kendi, Kleino Anni, Yates Elisabeth, Tatar Marc, Silverman Neal (2013), Ecdysone Triggered PGRP-LC Expression Controls Drosophila Innate Immunity, in EMBO Journal, 32, 1626-1638.
Life-History Evolution and the Polyphenic Regulation of Somatic Maintenance and Survival
Flatt Thomas, Amdam Gro V., Kirkwood Thomas B. L., Omholt Stig O. (2013), Life-History Evolution and the Polyphenic Regulation of Somatic Maintenance and Survival, in Quarterly Review of Biology, 88, 185-218.
Neuronal Inputs and Outputs of Aging and Longevity
Alcedo Joy, Flatt Thomas, Pasyukova Elena (2013), Neuronal Inputs and Outputs of Aging and Longevity, in Frontiers in Genetics, 4(71), 1-14.
Neuronal Inputs and Outputs of Aging and Longevity.
Alcedo Joy (ed.) (2013), Neuronal Inputs and Outputs of Aging and Longevity., Frontiers Media SA, Lausanne, Switzerland.
Reproduction, Fat Metabolism, and Life Span: What Is the Connection?
Hansen Malene, Flatt Thomas, Aguilaniu Hugo (2013), Reproduction, Fat Metabolism, and Life Span: What Is the Connection?, in Cell Metabolism, 17, 10-19.
Reproductive and post-reproductive life history of wild-caught Drosophila melanogaster.
Klepsatel Peter, Galikova Martina, De Maio Nicola, Ricci Sara, Schlötterer Christian, Flatt Thomas (2013), Reproductive and post-reproductive life history of wild-caught Drosophila melanogaster., in Journal of Evolutionary Biology, 26, 1508-1520.
The Role of the Nervous System in Aging and Longevity
Alcedo Joy, Flatt Thomas, Pasyukova Elena (2013), The Role of the Nervous System in Aging and Longevity, in Frontiers in Genetics, 4(124), 1-2.
Variation in Thermal Performance and Reaction Norms Among Populations of Drosophila melanogaster.
Klepsatel Peter, Galikova Martina, De Maio Nicola, Huber Christian, Schlötterer C., Flatt T. (2013), Variation in Thermal Performance and Reaction Norms Among Populations of Drosophila melanogaster., in Evolution, 67, 3573-3587.
Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America
Fabian Daniel K., Kapun Martin, Nolte Viola, Kofler Robert, Schmidt Paul S., Schlötterer Christian, Flatt Thomas (2012), Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America, in Molecular Ecology, 21, 4748-4769.
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span.
Garschall Kathrin, Dellago Hanna, Galikova Martina, Schosserer Markus, Flatt Thomas, Grillari Johannes, Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span., in npj Aging and Mechanisms of Disease.

Zusammenarbeit

Gruppe / Person Land
Formen der Zusammenarbeit
Prof. Robert Arking, Wayne State University Vereinigte Staaten von Amerika (Nordamerika)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Dr. Josefa Gonzalez, Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra) Barcelona Spanien (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Prof. Ary Hoffmann, University of Melbourne Australien (Ozeanien)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Dr. Alistair McGregor, Oxford Brookes University, Oxford, UK Grossbritannien und Nordirland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Prof. Bas Zwaan, Laboratory of Genetics, Wageningen University Niederlande (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Austausch von Mitarbeitern
Dr. Nick Priest, Department of Biology and Biochemistry, University of Bath Grossbritannien und Nordirland (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
Dr. Elio Sucena, Instituto Gulbenkian, Oeiras, Portugal Portugal (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Austausch von Mitarbeitern
Prof. Paul Schmidt, University of Pennsylvania Vereinigte Staaten von Amerika (Nordamerika)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Austausch von Mitarbeitern
Prof. Bruno Lemaitre, EPFL Lausanne Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Dr. Alan Bergland, Stanford University Vereinigte Staaten von Amerika (Nordamerika)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
Prof. Christian Schlötterer, Vetmeduni Vienna Österreich (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten
- Publikation
- Forschungsinfrastrukturen
- Austausch von Mitarbeitern

Wissenschaftliche Veranstaltungen

Aktiver Beitrag

Titel Art des Beitrags Titel des Artikels oder Beitrages Datum Ort Beteiligte Personen
School of Biology, Centre for Biological Diversity, University of St. Andrews, St. Andrews, Fife, UK Einzelvortrag The Population Genomic Basis of Life History Adaptation 15.12.2016 St. Andrews, Grossbritannien und Nordirland Flatt Thomas;
Symposium on Genetics of Adaptation, National Centre for Biological Sciences (NCBS), Bangalore, India Vortrag im Rahmen einer Tagung Adaptive Evolution of Clinal Inversion Polymorphisms in Drosophila melanogaster 01.12.2016 Bangalore, Indien Kapun Martin; Flatt Thomas;
Department of Zoology, Stockholm University, Stockholm, Sweden Einzelvortrag Mechanisms of Life History Adaptation 28.10.2016 Stockhom, Schweden Flatt Thomas;
Center for Integrative Genomics (CIG), University of Lausanne, Switzerland Einzelvortrag Genomic Basis of Adaptation in Drosophila 24.10.2016 Lausanne, Schweiz Flatt Thomas;
Lead Speaker, The Rank Prize Funds Symposium on Nutrition and Ageing, Grasmere, UK (Cancelled due to scheduling conflict; replaced by my student Kathrin Garschall) Vortrag im Rahmen einer Tagung The evolution of longevity in Drosophila melanogaster 03.10.2016 Grasmere, UK , Grossbritannien und Nordirland Garschall Kathrin; Flatt Thomas;
German Society for Genetics (GfG) Summer Academy "Adaptation in nature – from ecology to genomes", Technical University Braunschweig, Braunschweig, Germany Vortrag im Rahmen einer Tagung Genomic Basis of Adaptation in Drosophila 27.09.2016 Braunschweig, Deutschland Flatt Thomas;
6th European Meeting of the International Union for the Study of Social Insects, Helsinki Vortrag im Rahmen einer Tagung The physiological basis of the fecundity-longevity trade-off in Drosophila as compared to eusocial insects 09.08.2016 Helsinki, Finnland Flatt Thomas;
Evolution 2016, Austin, TX, USA Vortrag im Rahmen einer Tagung A clinal polymorphism in insulin signaling has pleiotropic effects on Drosophila life history 20.06.2016 Austin, Vereinigte Staaten von Amerika Flatt Thomas; Durmaz Mukaddes Esra;
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK Einzelvortrag Genomics of Adaptation 16.06.2016 Oxford, Grossbritannien und Nordirland Flatt Thomas;
Swiss Drosophila Meeting, ETH Zurich Switzerland Poster Adaptive evolution of a clinal inversion polymorphism in Drosophila 10.06.2016 Zürich, Schweiz Kapun Martin; Flatt Thomas;
Department of Biology, University of Fribourg, Fribourg, Switzerland Einzelvortrag The Genomic Basis of Adaptation 03.05.2016 Fribourg, Schweiz Flatt Thomas;
Centre for Ecology and Conservation, Biosciences, College of Life and Environmental Sciences University of Exeter, Penryn Campus, UK Einzelvortrag The Genomic Basis of Adaptation 28.04.2016 Penryn, Cornwall, UK, Grossbritannien und Nordirland Flatt Thomas;
EAWAG, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland Einzelvortrag The Genomic Basis of Life History Adaptation in Drosophila 24.03.2016 Dübendorf, Schweiz Flatt Thomas;
Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland Einzelvortrag The Genomic Basis of Life History Clines 26.02.2016 Neuchatel, Schweiz Flatt Thomas;
Biology 16, Annual Swiss Conference on Ecology, Evolution, Systematics, Biogeography and Conservation, University of Lausanne Vortrag im Rahmen einer Tagung Adaptive Evolution of In(3R)P, a clinal Inversion Polymorphism in Drosophila 12.02.2016 Lausanne, Schweiz Flatt Thomas; Kapun Martin;
Biology 16, Annual Swiss Conference on Ecology, Evolution, Systematics, Biogeography and Conservation, University of Lausanne Vortrag im Rahmen einer Tagung Identifying the genetic basis of longevity after 30 years of artificial selection in Drosophila 11.02.2016 Lausanne, Schweiz Flatt Thomas; Garschall Kathrin;
Biology 16, Annual Swiss Conference on Ecology, Evolution, Systematics, Biogeography and Conservation, University of Lausanne Poster A Clinal Polymorphism in Insulin Signaling Has Major Effects on Drosophila Life History 10.02.2016 Lausanne, Schweiz Durmaz Mukaddes Esra; Flatt Thomas;
Plenary Speaker, "The Evolution of Mechanisms: A Workshop on the Integration of Life-History Evolution and Physiology", University of Debrecen, Debrecen, Hungary Vortrag im Rahmen einer Tagung The Mechanisms Underpinning Life History Evolution 29.01.2016 Debrecen, Ungarn Flatt Thomas;
Plenary Speaker, 12th Women’s Health Congress, University Hospital Basel, Basel, Switzerland Vortrag im Rahmen einer Tagung The Fountain of Youth: Aging and Immortality from the Perspective of Evolutionary Biology 14.01.2016 Basel, Schweiz Flatt Thomas;
Naturforschende Gesellschaft des Kantons Solothurn (Natural History Society of the Canton Solothurn), Natural History Museum, Solothurn, Switzerland Einzelvortrag De Brevitate Vitae – wie die Evolutionsbiologie die Alterung erklärt 11.01.2016 Solothurn, Schweiz Flatt Thomas;
Population Genetics Group Meeting 49, Edinburgh, United Kingdon (co-author) Vortrag im Rahmen einer Tagung Adaptive evolution of a clinal inversion polymorphism in Drosophila 16.12.2015 Edinburgh, Grossbritannien und Nordirland Flatt Thomas; Kapun Martin;
24th European Drosophila Research Conference, Heidelberg, Germany (co-author) Vortrag im Rahmen einer Tagung Identifying the loci of selection for longevity in Drosophila melanogaster 09.09.2015 Heidelberg, Deutschland Garschall Kathrin; Flatt Thomas;
24th European Drosophila Research Conference Vortrag im Rahmen einer Tagung Identifying the Loci of Selection in a 30-Year Long Selection Experiment for Longevity in Drosophila melanogaster 09.09.2015 Heidelberg, Deutschland Kapun Martin; Flatt Thomas; Garschall Kathrin;
Evo-Devo Workshop (organized by Daniela Nunes and Alistair McGregor) Vortrag im Rahmen einer Tagung The Adaptive Role of the Cosmopolitan Inversion In(3R)Payne in D. melanogaster 04.09.2015 Barrow upon Trent, Derbyshire, Grossbritannien und Nordirland Flatt Thomas; Kapun Martin;
15th Congress of the European Society for Evolutionary Biology (ESEB) Vortrag im Rahmen einer Tagung Correlated experimental evolution of life history and behaviour in Drosophila 10.08.2015 Lausanne, Schweiz Flatt Thomas;
15th Congress of the European Society for Evolutionary Biology (ESEB) Vortrag im Rahmen einer Tagung The Adaptive Role of the Cosmopolitan Inversion In(3R)Payne in D. melanogaster 10.08.2015 Lausanne, Schweiz Kapun Martin; Flatt Thomas;
12th International Symposium on Neurobiology and Neuroendocrinology of Aging Poster Overexpression of the DNA repair factor SNEVhPrp19/hPso4 extends cellular and organismal life span and increases resistance to genotoxic stress 27.07.2015 Bregenz, Österreich Garschall Kathrin; Flatt Thomas;
Invited Talk at Max Planck Institute for Demographic Research (MPIDR), “Meet the Expert Series” Seminar Series, MaxNetAging Doctoral School (MNARS) Einzelvortrag The Genomic Basis of the Evolution of Longevity 24.07.2015 Rostock, Deutschland Flatt Thomas;
Society for Molecular Biology and Evolution (SMBE) Vortrag im Rahmen einer Tagung Adaptive Evolution of a Clinal Inversion Polymorphism in Drosophila 12.07.2015 Vienna, Österreich Flatt Thomas; Kapun Martin;
Invited Talk at Institute for Evolution and Biodiversity, University of Münster Einzelvortrag The Genomic Basis of Life History Adaptation 08.06.2015 Münster , Deutschland Flatt Thomas;
Invited Talk at Instituto Gulbenkian de Ciencia Einzelvortrag The Genomic Basis of Clinal Adaptation in Drosophila 28.05.2015 Oeiras, Portugal Flatt Thomas;
Society for Molecular Biology & Evolution Satellite Meeting (SMBEBA) Poster Adaptive Evolution of a Clinal Inversion Polymorphism in Drosophila 26.05.2015 Hameau de l'Etoile, Frankreich Kapun Martin; Flatt Thomas;
Keynote Speaker, Inauguration Symposium for the new Groningen Centre for Evolutionary Sciences (GELIFES) and “Adaptive Life” research plan, University of Groningen Vortrag im Rahmen einer Tagung The Molecular (Genomic) Basis of Life History Adaptation 22.04.2015 Groningen, Niederlande Flatt Thomas;
3rd LIMNA (Lausanne Integrative Metabolism and Nutrition Alliance) Symposium Poster The effects of reproduction on the levels of fat and its mobilization in Drosophila melanogaster 17.03.2015 Lausanne, Schweiz Flatt Thomas; Carvalho Sara;
Talk at University of Freiburg, Institute of Biology, Assessment Meeting for DFG Research Unit FOR 2281 Vortrag im Rahmen einer Tagung The physiological and metabolic basis of the fecundity/longevity trade-off in Drosophila 10.03.2015 Freiburg, Deutschland Flatt Thomas;
56th Annual Drosophila Research Conference Poster Genomic evidence for non-neutral evolution of In(3R)Payne, a major clinal chromosomal inversion in Drosophila melanogaster. 04.03.2015 Chicago, Vereinigte Staaten von Amerika Flatt Thomas; Kapun Martin;
56th Annual Drosophila Research Conference, Poster Juvenile Hormone regulates body proportion in Drosophila. 04.03.2015 Chicago, Vereinigte Staaten von Amerika Flatt Thomas;
Invited Talk at Institute of Integrative Biology, University of Liverpool Einzelvortrag Population Genomic Basis of Life History Adaptation in Drosophila 24.02.2015 Liverpool, Grossbritannien und Nordirland Flatt Thomas;
Invited Talk at Faculty of Biology, Ludwig Maximilians University Munich Einzelvortrag The Genomic Basis of Life History Adaptation in Drosophila 16.02.2015 Munich, Deutschland Flatt Thomas;
Popgen Alumni Symposium Vienna, Institute of Population Genetics, Vetmeduni Vienna Vortrag im Rahmen einer Tagung The Adaptive Role of Chromosomal Inversions in D. melanogaster 05.11.2014 Vienna, Austria, Österreich Kapun Martin;
Invited talk at Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland Einzelvortrag Understanding the Genomic Basis of Adaptation in Drosophila 29.09.2014 Neuchatel, Switzerland, Schweiz Flatt Thomas;
Stockholm University, Department of Zoology Einzelvortrag Understanding the Genomic Basis of Adaptation in Drosophila 26.09.2014 Stockholm, Schweden Flatt Thomas;
Symposium Speaker, Annual Meeting of the German Zoological Society (Deutsche Zoologische Gesellschaft, DZG), Evolutionary Biology Section, University of Göttingen, Göttingen, Germany Vortrag im Rahmen einer Tagung Genomic Basis of a 30 Year-long Selection Experiment for Longevity in Drosophila 12.09.2014 Göttingen, Germany, Deutschland Flatt Thomas;
2nd Eco-Evo-Devo Postgraduate Summer School (organized by Alistair McGregor and Casper Breuker), Oxford Brookes University, Oxford, UK Vortrag im Rahmen einer Tagung Understanding the Genomic Basis of Adaptation in Drosophila 05.08.2014 Oxford, UK, Grossbritannien und Nordirland Flatt Thomas;
Hauptstadtkongress Medizin und Gesundheit, Deutsches Ärzteforum, “Am Puls der Zeit: Regeneration und Verlangsamung des Alterungsprozesses in der Welt von Übermorgen”, Citycube, Berlin, Germany Vortrag im Rahmen einer Tagung Endlich in Reichweite: Interventionen zur Verlängerung der Healthspan, individuell und machbar 27.06.2014 Berlin, Germany, Deutschland Flatt Thomas;
Evolution 2014, Raleigh Convention Center, Raleigh, NC, USA Vortrag im Rahmen einer Tagung Genomic response to 30-years of selection for increased lifespan reveals increased immunity as correlated trait (talk given by Daniel Fabian) 21.06.2014 Raleigh, North Carolina, Vereinigte Staaten von Amerika Flatt Thomas;
Invited talk at Mini Symposium in Evolutionary Biology, Institute of Ecology and Evolution, University of Bern, Switzerland Vortrag im Rahmen einer Tagung Understanding the Genomic Basis of Adaptation in Drosophila 12.06.2014 Bern, Switzerland, Schweiz Flatt Thomas;
Annual Retreat of the PhD Students of the Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal Vortrag im Rahmen einer Tagung How Does Aging Evolve? Genomic Analysis of a 30 year-long Selection Experiment for Longevity in Drosophila 24.05.2014 Hotel São Domingos, Mertola, Portugal, Portugal Flatt Thomas;
Eukaryotic –“omics”: exploring and testing with next-generation sequencing, CUSO Doctoral Program in Ecology and Evolution, University of Geneva Vortrag im Rahmen einer Tagung Testing The Life History Effects of SNP Polymorphisms As Identified by a NGS Analysis of a Latitudinal Cline in Drosophila 25.04.2014 Geneva, Switzerland, Schweiz Durmaz Mukaddes Esra; Flatt Thomas;
Invited talk at Wageningen Evolution and Ecology Seminars (WEES), Wageningen University, Wageningen, Netherlands Einzelvortrag Genomic Analysis of an Artificial Selection Experiment in Drosophila Uncovers a Link Between Longevity and Immunity 15.04.2014 Wageningen, Netherlands, Niederlande Flatt Thomas;
Participant in Panel Roundtable Discussion about the Swiss National Science Foundation (SNF) Professorship Program, at the Life Sciences Switzerland (LS2) 2014 Annual Meeting (4-5 February 2014), University of Lausanne. Vortrag im Rahmen einer Tagung Panel Roundtable Discussion about the Swiss National Science Foundation (SNF) Professorship Program 05.02.2014 Lausanne, Switzerland, Schweiz Flatt Thomas;
Invited talk at the Department of Genetics, University of Georgia, Athens, GA, USA Einzelvortrag Population Genomic Basis of Life History Evolution 06.01.2014 Athens, Georgia, USA, Vereinigte Staaten von Amerika Flatt Thomas;
Seminar at University of Neuchâtel, Institute of Biology, Mini-Seminar Series on Evolutionary Ecophysiology Einzelvortrag Life History Evolution and the Genotype-Phenotype Map 18.11.2013 Neuchatel, Schweiz Flatt Thomas;
Seminar at Institute of Ecology and Evolution, Population Genetics Seminar, University of Bern Einzelvortrag Population Genomics of Drosophila Life History 11.11.2013 Bern, Schweiz Flatt Thomas;
Symposium on "Genomics of Experimental Evolution", 14th Congress of the European Society for Evolutionary Biology (ESEB) Vortrag im Rahmen einer Tagung Genomic Patterns of Experimental Evolution of Drosophila Lifespan 21.08.2013 Lissabon, Portugal Flatt Thomas;
"Genomics of Experimental Evolution", 14th Congress of the European Society for Evolutionary Biology (ESEB) Vortrag im Rahmen einer Tagung The impact of chromosomal inversions on genetic variation in natural and laboratory populations of D. melanogaster 21.08.2013 Lissabon, Portugal Kapun Martin; Flatt Thomas;
“The Evolution of Proximate Mechanisms for Behavioural and Life History Decisions”, Summer Course of the Doctoral Program in Ecology and Evolution, Conférence Universitaire de Suisse Occidentale (CUSO) Vortrag im Rahmen einer Tagung Life History Evolution and the Genotype-Phenotype Map 12.08.2013 Arolla, Schweiz Flatt Thomas;
Insect Hormone Workshop (19th International Ecdysone Workshop) Vortrag im Rahmen einer Tagung The Contribution of Endocrine Genes to Latitudinal Population Differentiation in Drosophila melanogaster 25.07.2013 Minneapolis, Vereinigte Staaten von Amerika Flatt Thomas;
FBM (Faculty of Biology and Medicine) Research Day at University of Lausanne: “Strong winds for discoveries”, invited by the FBM Research Commission, Lausanne, Switzerland Vortrag im Rahmen einer Tagung The Evolution and Mechanisms of Life History Traits 28.06.2013 Lausanne, Schweiz Flatt Thomas;
Nutrition and Healthy Ageing", Nutrition Society Summer Meeting 2013 Vortrag im Rahmen einer Tagung Plasticity of Aging In Model Systems 16.06.2013 Newcastle, Grossbritannien und Nordirland Flatt Thomas;
Swiss Drosophila Meeting 2013, ETH Zürich, Zürich, Switzerland Vortrag im Rahmen einer Tagung Genetics and Physiology of Life History Traits and Trade-Offs in Drosophila melanogaster 07.06.2013 Zürich, Schweiz Flatt Thomas;
Royal Society Workshop on Nutrition and Ageing, Kavli Royal Society International Centre Vortrag im Rahmen einer Tagung Survival Costs of Reproduction in Drosophila 30.05.2013 Buckinghamshire, UK, Grossbritannien und Nordirland Flatt Thomas;
Colloquium (part 2) "Bridging the Gap Between Genomics and Evolutionary Biology", Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biology, University of Oslo, held at the Norwegian Academy of Science and Letters Vortrag im Rahmen einer Tagung Population Genomic Basis of Clinal Variation in Drosophila Life History 06.05.2013 Oslo, Norwegen Flatt Thomas;
Seminar at Ecole Normale Supérieure de Lyon, Department of Biology, Lyon, France Einzelvortrag Genomic Basis of Drosophila Life History Variation Along a Latitudinal Cline 15.04.2013 Lyon, Frankreich Flatt Thomas;
Ecdysone Workshop, 54th Annual Drosophila Research Conference Vortrag im Rahmen einer Tagung The Contribution of Endocrine Genes to Latitudinal Population Differentiation in Drosophila melanogaster 03.04.2013 Washington, DC, Vereinigte Staaten von Amerika Flatt Thomas;
54th Annual Drosophila Research Conference Poster Genomic Basis of Latitudinal Differentiation Among North American Populations of Drosophila melanogaster 03.04.2013 Washington, DC, Vereinigte Staaten von Amerika Kapun Martin; Flatt Thomas;


Selber organisiert

Titel Datum Ort
Co-Organizer with Tobias Uller (Lund) and Bernhard Voelkl (Oxford), Workshop on Evolving Plasticity in Natural and Artificial Systems, Center for Interdisciplinary Research (ZiF - Zentrum für interdisziplinäre Forschung), Bielefeld, Germany, 5-7 September 05.09.2016 Bielefeld, Deutschland
Co-Organizer with Paul Schmidt (Philadelphia), Symposium How to Identify and Test the Loci and Alleles Underlying Adaptation?, 15th Congress of the European Society for Evolutionary Biology (ESEB), Lausanne, Switzerland, 10-14 August 2015. 10.08.2015 Lausanne, Schweiz
Member of Organizing Committee (main organizers: Kirst King-Jones and Kim Furbo Rewitz), 2015 (2nd) International Insect Hormone Workshop (formerly: (20th) International Ecdysone Workshop), Kolymbari, Crete, Greece. 12.07.2015 Kolymbari, Crete, Greece, Griechenland
Co-Organizer with Lukas Keller and Marta Manser of "Steve Fest", a symposium in honor of Stephen C. Stearns’ major contributions to evolutionary biology, University of Basel, Alte Universität (Rheinsprung), Basel, Switzerland, April 2015. 26.04.2015 Basel, Schweiz
Co-Organizer with Fisun Hamaratoglu of Swiss Drosophila Meeting, IDHEAP, University of Lausanne, April 2015. 24.04.2015 Lausanne, Schweiz
Co-Organizer with Josefa Gonzalez (Barcelona) and Martin Kapun (Lausanne) of the 2nd Workshop of the European Drosophila Population Genomics Consortium (DrosEu), Institut de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona, February 2015. 16.02.2015 Barcelona, Spanien
Co-Organizer with Josefa Gonzalez (Barcelona) and Martin Kapun (Lausanne) of the 1st Workshop of the European Drosophila Population Genomics Consortium (DrosEu), Institut de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona, April 2014 14.04.2014 Barcelona, Spain, Spanien
Satellite Workshop Creating an European Drosophila Population Genomics Network, European Drosophila Research Conference (EDRC), Barcelona, Spain 16.10.2013 Barcelona, Spanien
Mechanisms of Trade-Offs, 14th Congress of the European Society for Evolutionary Biology (ESEB), Lisbon, Portugal 23.08.2013 Lissabon, Portugal
Workshop "Creating a European Drosophila Population Genomics Network", XIV Congress of the European Society of Evolutionary Biology 19.08.2013 Lissabon, Portugal

Kommunikation mit der Öffentlichkeit

Kommunikation Titel Medien Ort Jahr
Referate/Veranstaltungen/Ausstellungen De Brevitate Vitae – wie die Evolutionsbiologie die Alterung erklärt, Naturmuseum Solothurn, NFGS Deutschschweiz 2016
Medienarbeit: Printmedien, Online-Medien Who wants to live forever? Horizons (Swiss magazine for scientific research, published by SNSF) Italienische Schweiz International Westschweiz Romanische Schweiz Deutschschweiz 2015
Medienarbeit: Radio, Fernsehen “The Fountain of Youth out of a Petri Plate? News from Molecular Aging Research” (In German) Austrian Radio OE1 (ORF) International 2014
Referate/Veranstaltungen/Ausstellungen Festvortrag über Evolution der Alterung,6. Solothurner Verbindungstag, Aula, Kantonsschule Solothurn Deutschschweiz 2013

Auszeichnungen

Titel Jahr
Associate Editor, Ecology and Evolution 2016
Associate Editor, Evolution 2016
Member of Scientific Advisory Board, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen 2016
Member of Steering Committee, DFG Research Unit Sociality and the reversal of the fecundity-longevity trade-off 2016
Reviewing Board Member, Peer Community in Evolutionary Biology 2016
Section Editor, BMC Zoology (Editor-in-Chief of life history section) 2016
Renewed Invitation to serve as an Expert/Reviewer on the National Scientific Advisory Council of the American Federation of Aging Research (AFAR) (2014-2015) 2014
Renewed invitation by the Editor-in-Chief Prof. M. Ritchie to serve another 2-4 year term as a Deciding Editor for the Journal of Evolutionary Biology 2013

Verbundene Projekte

Nummer Titel Start Förderungsinstrument
165836 The Genomic Basis of Life History Adaptation 01.12.2016 SNF-Förderungsprofessuren
165836 The Genomic Basis of Life History Adaptation 01.12.2016 SNF-Förderungsprofessuren

Abstract

Life history traits are the major determinants of Darwinian fitness, but despite their importance for our understanding of ecological adaptations driven by natural selection, we know almost nothing about their underlying genetic basis. Which genes and alleles are responsible for the remarkable diversity in life history traits we observe in natural populations? While recent advances in molecular and developmental genetics have uncovered several mechanisms that might underlie such variation, it remains largely unknown whether these pathways actually contribute to evolutionary changes in natural populations. For example, molecular genetics has uncovered a major role of the insulin signaling pathway in regulating growth, body size, reproduction, and lifespan in several model organisms, however, whether standing variation in this pathway also significantly contributes to the evolution of life history differentiation at the population level is not known. Here we will investigate the mechanisms underlying life history evolution by identifying the loci and allelic variants that contribute to variation in lifespan and associated life history traits in natural and artificially selected "experimental evolution" populations of the fruit fly, Drosophila melanogaster. To identify the genes and pathways that contribute to the evolution of lifespan and other life history traits we will use genome-wide association mapping by next generation sequencing (NGS). By comparing the results from our artificial selection lines with those from our survey of natural populations we will be able to determine whether natural populations have evolved life history differentiation via the same molecular mechanisms as the selection lines. Although we will employ an unbiased, genome-wide approach, we will be particularly interested in determining whether natural variation in insulin signaling contributes to life history adaptations. Candidate genes and polymorphisms identified in our genome-wide population screens will subsequently be tested and confirmed by using functional genetic tools such as transgenic RNAi and zinc-finger nuclease mediated gene targeting. By combining evolutionary genomics, molecular population genetics, experimental evolution, and functional genetics this project will yield fundamental and novel insights into the genetic factors that shape the evolution of aging and life histories.
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