Evolution; Life History Traits; Life History Evolution; Lifespan; Population Genetics; Latitudinal Adaptation; Experimental Evolution; Artificial Selection; Evolutionary Ecology; Speed Mapping; Next Generation Sequencing; Genome-wide Association Mapping; Drosophila melanogaster
Kapun Martin, Schmidt Chloe, Durmaz Esra, Schmidt Paul S., Flatt Thomas (2016), . Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster., in Journal of Evolutionary Biology
, 29, 1059-1072.
Rodrigues Marisa Almeida, Flatt Thomas (2016), Endocrine uncoupling of the trade-off between reproduction and somatic maintenance in eusocial insects, in Current Opinion in Insect Science
, 16, 1-8.
Kapun Martin, Fabian Daniel K., Goudet Jerome, Flatt Thomas (2016), Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster., in Molecular Biology and Evolution
, 33, 1317-1336.
Flatt Thomas (2016), Genomics of clinal variation in Drosophila: disentangling the interactions of selection and demography, in Molecular Ecology
, 25, 1023-10126.
Fuellen G., Schofield P.N., Flatt T., Schulz R.-J., Boege F., Kraft K., Rimbach G., Ibrahim S., Schmidt C., Köhling R., Simm A. (2016), Living long and well: prospects for a personalized approach to the medicine of ageing, in Gerontology
, 62, 409-416.
Flatt T. (2015), Organ plasticity: Paying the costs of reproduction, in eLife
, 4, e09556.
Fabian D.K., Lack J.B., Mathur V., Schlötterer C., Schmidt P.S., Pool J.E., Flatt T. (2015), Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa., in Journal of Evolutionary Biology
, 28, 826-840.
Kapun Martin, van Schalwyk Hester, McAllister Bryant, Flatt Thomas, Schlötterer C. (2014), Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of D. melanogaster, in Molecular Ecology
, 23, 1813-1827.
Flatt T. (2014), Plasticity of Lifespan – A Reaction Norm Perspective, in Proceedings of the Nutrition Society
, 73, 532-542.
Klepsatel Peter, Galikova Martina, Huber Christian D., Flatt Thomas (2014), Similarities and differences in altitudinal versus latitudinal variation for morphological traits in Drosophila melanogaster, in Evolution
, 68, 1385-1398.
Flatt T. (2014), The Evolution of Aging (German original title; "Die Evolution der Alterung"), in Pipette - Swiss Laboratory Medicine
, 2014((1) 2014), 6-7.
Rus Florentina, Flatt Thomas, Tong Mei, Aggarwal Kamna, Okuda Kendi, Kleino Anni, Yates Elisabeth, Tatar Marc, Silverman Neal (2013), Ecdysone Triggered PGRP-LC Expression Controls Drosophila Innate Immunity, in EMBO Journal
, 32, 1626-1638.
Flatt Thomas, Amdam Gro V., Kirkwood Thomas B. L., Omholt Stig O. (2013), Life-History Evolution and the Polyphenic Regulation of Somatic Maintenance and Survival, in Quarterly Review of Biology
, 88, 185-218.
Alcedo Joy, Flatt Thomas, Pasyukova Elena (2013), Neuronal Inputs and Outputs of Aging and Longevity, in Frontiers in Genetics
, 4(71), 1-14.
Alcedo Joy (ed.) (2013), Neuronal Inputs and Outputs of Aging and Longevity.
, Frontiers Media SA, Lausanne, Switzerland.
Hansen Malene, Flatt Thomas, Aguilaniu Hugo (2013), Reproduction, Fat Metabolism, and Life Span: What Is the Connection?, in Cell Metabolism
, 17, 10-19.
Klepsatel Peter, Galikova Martina, De Maio Nicola, Ricci Sara, Schlötterer Christian, Flatt Thomas (2013), Reproductive and post-reproductive life history of wild-caught Drosophila melanogaster., in Journal of Evolutionary Biology
, 26, 1508-1520.
Alcedo Joy, Flatt Thomas, Pasyukova Elena (2013), The Role of the Nervous System in Aging and Longevity, in Frontiers in Genetics
, 4(124), 1-2.
Klepsatel Peter, Galikova Martina, De Maio Nicola, Huber Christian, Schlötterer C., Flatt T. (2013), Variation in Thermal Performance and Reaction Norms Among Populations of Drosophila melanogaster., in Evolution
, 67, 3573-3587.
Fabian Daniel K., Kapun Martin, Nolte Viola, Kofler Robert, Schmidt Paul S., Schlötterer Christian, Flatt Thomas (2012), Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America, in Molecular Ecology
, 21, 4748-4769.
Garschall Kathrin, Dellago Hanna, Galikova Martina, Schosserer Markus, Flatt Thomas, Grillari Johannes, Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span., in npj Aging and Mechanisms of Disease
Life history traits are the major determinants of Darwinian fitness, but despite their importance for our understanding of ecological adaptations driven by natural selection, we know almost nothing about their underlying genetic basis. Which genes and alleles are responsible for the remarkable diversity in life history traits we observe in natural populations? While recent advances in molecular and developmental genetics have uncovered several mechanisms that might underlie such variation, it remains largely unknown whether these pathways actually contribute to evolutionary changes in natural populations. For example, molecular genetics has uncovered a major role of the insulin signaling pathway in regulating growth, body size, reproduction, and lifespan in several model organisms, however, whether standing variation in this pathway also significantly contributes to the evolution of life history differentiation at the population level is not known. Here we will investigate the mechanisms underlying life history evolution by identifying the loci and allelic variants that contribute to variation in lifespan and associated life history traits in natural and artificially selected "experimental evolution" populations of the fruit fly, Drosophila melanogaster. To identify the genes and pathways that contribute to the evolution of lifespan and other life history traits we will use genome-wide association mapping by next generation sequencing (NGS). By comparing the results from our artificial selection lines with those from our survey of natural populations we will be able to determine whether natural populations have evolved life history differentiation via the same molecular mechanisms as the selection lines. Although we will employ an unbiased, genome-wide approach, we will be particularly interested in determining whether natural variation in insulin signaling contributes to life history adaptations. Candidate genes and polymorphisms identified in our genome-wide population screens will subsequently be tested and confirmed by using functional genetic tools such as transgenic RNAi and zinc-finger nuclease mediated gene targeting. By combining evolutionary genomics, molecular population genetics, experimental evolution, and functional genetics this project will yield fundamental and novel insights into the genetic factors that shape the evolution of aging and life histories.