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Airflow obstruction in non-smoking women: the role of air pollution and co-determinants in two longitudinal studies in Switzerland and Germany (D-A-CH/MFCL)

English title Airflow obstruction in non-smoking women: the role of air pollution and co-determinants in two longitudinal studies in Switzerland and Germany (D-A-CH/MFCL)
Applicant Künzli Nino
Number 133148
Funding scheme Project funding (special)
Research institution Schweizerisches Tropen- und Public Health-Institut
Institution of higher education University of Basel - BS
Main discipline Respiratory Diseases
Start/End 01.01.2011 - 31.12.2013
Approved amount 250'000.00
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All Disciplines (4)

Discipline
Respiratory Diseases
Public Health and Health Services
Methods of Epidemiology and Preventive Medicine
Medical Statistics

Keywords (13)

COPD; non-smoking; women; air pollution; reproductive factors; obesity; systemic inflammation; gender; susceptibility; lung function; airflow obstruction; large nested project; SAPALIDA Cohort on Healthy Aging

Lay Summary (English)

Lead
Lay summary
Airflow obstruction refers to an abnormal narrowing of the airways, resulting in reduced airflow from the lungs on exhalation. It is often associated with the diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, which clinically manifests later in life. The prevalence is increasing worldwide and this increase is particularly strong among women. Smoking - a well established cause of COPD - has been the focus of research and prevention for a long time. However, it has been recognized that a substantial proportion of COPD cases cannot be explained by smoking alone. The American Thoracic Society identified research of the causes of COPD in non-smokers and women as an important need. The role of ambient air pollution in the development of this severe disease has been poorly investigated. Moreover, gender-specific factors may be relevant for the susceptibility of women to COPD, and the role of reproductive factors, body weight, or sub-clinical systemic inflammation and interactions of these factors with ambient air pollutants have not been elucidated. Aim: The contribution of ambient air pollution on COPD development and COPD-related phenotypes in non-smoking women are the subject of this proposal. So far, the SALIA study (Germany) was the only study publishing a cross-sectional association between traffic related pollution and objectively defined COPD, while the SAPALDIA study (Switzerland) is the only longitudinal study providing first evidence that the decline of the FEV1/FVC ratio may be attenuated if air quality improves. With the given sample size, none of these population based studies is powerful alone to elucidate the relevance of air pollution in the development of COPD among non-smoking women and to investigate the interaction between pollution and individual susceptibility factors. This project proposes the complete pooling of all data from SAPALDIA and SALIA women, covering 20 years of follow-up. Impact: The proposed collaboration will be of high scientific and public health relevance and enhance promising research collaborations between Switzerland and Germany. The project will strengthen the scientific value of both the SAPALDIA and the SALIA study.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Ambient air pollution- a cause for COPD?
Schikowski Tamara, Mills Inga C., Anderson H. Ross, Cohen Aaron, Hansell Anna, Kauffmann Francine, Krämer Ursula, Marcon Alessandro, Perez Laura, Sunyer Jordi, Probst-Hensch Nicole, Künzli Nino (2014), Ambient air pollution- a cause for COPD?, in European Respiratory Journal, (43), 250-263.
Improved Air Quality and Attenuated Lung Function Decline: Modification by Obesity in the SAPALDIA Cohort
Schikowski Tamara, Schaffner Emmanuel, MeierFlurina, PhuleriaHarish C., VierkötterAndrea, Schindler Christian, Kriemler Susi, Zemp Elisabeth, Krämer Ursula, Bridevaux Pierre-Olivier, Rochat Thierry, Schwartz Joel, Künzli Nino, Probst-Hensch Nicole (2013), Improved Air Quality and Attenuated Lung Function Decline: Modification by Obesity in the SAPALDIA Cohort, in Environmental Health Perspective, (121), 1034-1039.
Association of ambient air pollution with the prevalence and incidence of COPD
Schikowski Tamara, AdamMartin, Marcon Alessandro, Cai Yutong, Vierkötter Andrea, CarsinAnne Elie, Jacquemin Benedicte, Al Kanani Zaina, Beelen Rob, Birk Matthias, Bridevaux Pierre-Olivier, Brunekeef Bert, Burney Peter, Cirach Marta, Cyrys Josef, de Hoogh Kees, de Marco Roberto, Tsai Ming-Yi, Zemp Elisabeth, Hansell Anna, Kauffmann Francine, Sunyer Jordi, Probst-Hensch Nicole, Krämer Ursula, Künzli Nino, Association of ambient air pollution with the prevalence and incidence of COPD, in European Respiratory Journal.

Collaboration

Group / person Country
Types of collaboration
IUF Düsseldorf Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
CREAL Spain (Europe)
- in-depth/constructive exchanges on approaches, methods or results
IRAS Utrecht Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Inserm France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Imperial College London, UK Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
International Seminar on Air Pollution and Respiratory Diseases – RESPIRA Individual talk 19.10.2013 Milano, Italy Künzli Nino;
European Respiratory Society Annual Congress Individual talk 10.09.2013 Barcelona, Spain Künzli Nino;
European Respiratory Society Annual Congress Poster 01.09.2012 Vienna, Austria Krämer Ursula; Probst-Hensch Nicole; Schikowski Tamara; Vierkötter Andrea; Rochat Thierry; Künzli Nino; Zemp Stutz Elisabeth;
6th Conference of the Union Europe Region - COPD in Europe: current situation and open questions. Individual talk 06.07.2012 London, Great Britain and Northern Ireland Künzli Nino;
2nd Indo-Swiss Symposium Individual talk 27.01.2012 Thiruvananthapuram, India Probst-Hensch Nicole;
2nd Indo-Swiss Symposium: Cohorts and Biobanks with Special Reference to Chronic Non-Communicable Diseases Individual talk 27.01.2012 Thiruvananthapuram, India Probst-Hensch Nicole; Künzli Nino;
European Respiratory Society Annual Congress Talk given at a conference 24.09.2011 Amsterdam, Netherlands Probst-Hensch Nicole;
Annual Conference of the International Society for Environmental Epidemiology Poster 13.09.2011 Barcelona, Spain Vierkötter Andrea; Künzli Nino; Schikowski Tamara; Krämer Ursula; Probst-Hensch Nicole;
American Thoracic Society Annual Meeting Poster 13.05.2011 Denver, United States of America Zemp Stutz Elisabeth; Krämer Ursula; Vierkötter Andrea; Künzli Nino; Schikowski Tamara; Probst-Hensch Nicole; Rochat Thierry;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
16th ETH Nanoconference 26.06.2012 Zurich, Switzerland Künzli Nino;


Associated projects

Number Title Start Funding scheme
177506 SAPALDIA 5 - Cohort on Healthy Aging 01.04.2018 Cohort Studies Large
148470 SAPALDIA Cohort on Healthy Aging 01.04.2014 Cohort Studies Large
134276 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) 01.04.2011 Cohort Studies Large
108796 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) 01.04.2006 Cohort Studies Large

Abstract

1. SummaryChronic obstructive pulmonary disease (COPD) is a heterogeneous disease, which clinically manifests later in life. The prevalence is increasing worldwide and this increase is particularly strong among women. Smoking - a well established cause of COPD - has been the focus of research and prevention for a long time. However, it has been recognized that a substantial proportion of COPD cases cannot be explained by smoking alone. The American Thoracic Society identified research of the causes of COPD in non-smokers and women as an important need. The role of ambient air pollution in the development of this severe disease has been poorly investigated. Moreover, gender-specific factors may be relevant for the susceptibility of women to COPD, and the role of reproductive factors, body weight, or sub-clinical systemic inflammation and interactions of these factors with ambient air pollutants have not been elucidated. The contribution of ambient air pollution on COPD development and COPD-related phenotypes in non-smoking women are the subject of this proposal. So far, the SALIA study (Germany) was the only study publishing a cross-sectional association between traffic related pollution and objectively defined COPD, while the SAPALDIA study (Switzerland) is the only longitudinal study providing first evidence that the decline of the FEV1/FVC ratio may be attenuated if air quality improves. With the given sample size, none of these population based studies is powerful alone to elucidate the relevance of air pollution in the development of COPD among non-smoking women and to investigate the interaction between pollution and individual susceptibility factors. This project proposes the complete pooling of all data from SAPALDIA and SALIA women, covering 20 years of follow-up. This unique resource of ~3’200 non-smoking women will promote knowledge in this field. Both studies have state-of-the-art expertise to assign long-term exposure to ambient air pollution from traffic and other sources to each subjects’ residence, and extensive information on life-style, socio-economic, and biologic factors as well as co-morbidities will be available from all participants to conduct multivariate analyses, and to investigate susceptibility factors.The proposed collaboration will be of high scientific and public health relevance and enhance promising research collaborations between Switzerland and Germany. The project will strengthen the scientific value of both the SAPALDIA and the SALIA study.
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