eye movement disorders; vestibular disorders; humans; neuro-ophthalmology; neuro-otology; neurology; congenital nystagmus; infantile nystagmus syndrome; vestibulo-ocular reflex; vestibular evoked myogenic potentials; latency
Shaikh Aasef G, Marti Sarah, Tarnutzer Alexander A, Palla Antonella, Crawford Thomas O, Zee David S, Straumann Dominik (2013), Effects of 4-aminopyridine on nystagmus and vestibulo-ocular reflex in ataxia-telangiectasia., in
J Neurol, 2728-35.
Bockisch Christopher J, Khojasteh Elham, Straumann Dominik, Hegemann Stefan C A (2013), Eye position dependency of nystagmus during constant vestibular stimulation., in
Exp Brain Res, 175-82.
Ni Jianguang, Tatalovic Milos, Straumann Dominik, Olasagasti Itsaso (2013), Gaze direction affects linear self-motion heading discrimination in humans., in
Eur J Neurosci, 3248-60.
Bertolini Giovanni, Tarnutzer Alexander A, Olasagasti Itsaso, Khojasteh Elham, Weber Konrad P, Bockisch Christopher J, Straumann Dominik, Marti Sarah (2013), Gaze holding in healthy subjects., in
PLoS One, 61389-61389.
Tarnutzer Alexander A, Bertolini Giovanni, Bockisch Christopher J, Straumann Dominik, Marti Sarah (2013), Modulation of Internal Estimates of Gravity during and after Prolonged Roll-Tilts., in
PLoS One, 78079-78079.
Weber Konrad P, Straumann Dominik (2013), Neuro-ophthalmology update., in
J Neurol, epub.
Chen Chien-Cheng, Bockisch Christopher J, Bertolini Giovanni, Olasagasti Itsaso, Neuhauss Stephan Cf, Weber Konrad P, Straumann Dominik, Huang Melody Ying-Yu (2013), Velocity storage mechanism in zebrafish larvae., in
J Physiol, 111-120.
Poretti Andrea, Palla Antonella, Tarnutzer Alexander A, Petersen Jens A, Weber Konrad P, Straumann Dominik, Jung Hans H (2013), Vestibular impairment in patients with Charcot-Marie-Tooth disease., in
Neurology, 2099-105.
Straumann Dominik (2013), Vestibular Physiology: How to be a Clinician and Yet Think Physiologically, 15-30.
Tarnutzer A A, Bockisch C J, Straumann D. (2013), Visually guided adjustments of body posture in the roll plane., in
Exp Brain Res, 111-20.
Khojasteh Elham, Bockisch Christopher J, Straumann Dominik, Hegemann Stefan C A (2012), A mechanism for eye position effects on spontaneous nystagmus., in
Conf Proc IEEE Eng Med Biol Soc, 3572-5.
Khojasteh Elham, Bockisch Christopher J, Straumann Dominik, Hegemann Stefan C A (2012), A re-examination of the time constant of the oculomotor neural integrator in human., in
Conf Proc IEEE Eng Med Biol Soc, 4780-3.
Traber Ghislaine L., Chen Chien-Cheng C., Huang Ying-Yu Y., Spoor Marcella, Roos Jeanine, Frens Maarten A., Straumann Dominik, Grimm Christian (2012), Albino mice as an animal model for infantile nystagmus syndrome., in
Invest Ophthalmol Vis Sci, 53(9), 5737-47.
Traber Ghislaine L, Chen Chien-Cheng, Huang Ying-Yu, Spoor Marcella, Roos Jeanine, Frens Maarten A, Straumann Dominik, Grimm Christian (2012), Albino mice as an animal model for infantile nystagmus syndrome., in
Invest Ophthalmol Vis Sci , 5737-47.
Bockisch Christopher J, Khojasteh Elham, Straumann Dominik, Hegemann Stefan C A (2012), Development of eye position dependency of slow phase velocity during caloric stimulation., in
PLoS One, 51409-51409.
Bjasch Daniel, Bockisch Christopher J., Straumann Dominik, Tarnutzer Alexander A. (2012), Differential effects of visual feedback on subjective visual vertical accuracy and precision., in
PLoS One, 7(11), 49311-49311.
Tarnutzer Alexander A., Bockisch Christopher J., Olasagasti Itsaso, Straumann Dominik (2012), Egocentric and allocentric alignment tasks are affected by otolith input., in
J Neurophysiol, 107(11), 3095-106.
Tarnutzer Alexander A., Palla Antonella, Marti Sarah, Schuknecht Bernhard, Straumann Dominik (2012), Hypertrophy of the inferior olivary nucleus impacts perception of gravity., in
Front Neurol, 3, 79-79.
Tarnutzer Alexander A., Schuler Jeanine R., Bockisch Christopher J., Straumann Dominik (2012), Hysteresis of haptic vertical and straight ahead in healthy human subjects., in
BMC Neurosci, 13, 114-114.
Bertolini Giovanni, Ramat Stefano, Bockisch Christopher J., Marti Sarah, Straumann Dominik, Palla Antonella (2012), Is vestibular self-motion perception controlled by the velocity storage? Insights from patients with chronic degeneration of the vestibulo-cerebellum., in
PLoS One, 7(6), 36763-36763.
Straube A., Bronstein A., Straumann D. (2012), Nystagmus and oscillopsia., in
Eur J Neurol, 6-14.
Tarnutzer Alexander A., Straumann Dominik (2012), Progress in neuro-otology research in the last year., in
J Neurol, 259(11), 2506-9.
Huber-Reggi Sabina P., Chen Chien-Cheng C., Grimm Lea, Straumann Dominik, Neuhauss Stephan C. F., Huang Melody Ying-Yu (2012), Severity of Infantile Nystagmus Syndrome-Like Ocular Motor Phenotype Is Linked to the Extent of the Underlying Optic Nerve Projection Defect in Zebrafish belladonna Mutant., in
J Neurosci, 32(50), 18079-86.
Weber Konrad P., Rosengren Sally M., Michels Rike, Sturm Veit, Straumann Dominik, Landau Klara (2012), Single motor unit activity in human extraocular muscles during the vestibulo-ocular reflex., in
J Physiol, 590(Pt 13), 3091-101.
Winter Lotta, Kruger Tillmann H. C., Laurens Jean, Engler Harald, Schedlowski Manfred, Straumann Dominik, Wollmer M. Axel (2012), Vestibular Stimulation on a Motion-Simulator Impacts on Mood States, in
Frontiers in Psychology, 3, 499-499.
Tatalias M., Bockisch C. J., Bertolini G., Straumann D., Palla A. (2011), Antihysteresis of perceived longitudinal body axis during continuous quasi-static whole-body rotation in the earth-vertical roll plane., in
Exp Brain Res, 209(3), 443-454.
Shaikh Aasef G., Marti Sarah, Tarnutzer Alexander Andrea, Palla Antonella, Crawford Thomas O., Straumann Dominik, Carey John P., Nguyen Kimanh, Zee David S. (2011), Ataxia telangiectasia: a "disease model" to understand cerebellar control of vestibular reflexes., in
J Neurophysiol, 105(6), 3034-3041.
Huang Melody Ying-Yu, Chen Chieng-Cheng C., Huber-Reggi Sabina P., Neuhauss Stephan C. F., Straumann Dominik (2011), Comparison of infantile nystagmus syndrome in achiasmatic zebrafish and humans., in
Ann N Y Acad Sci, 1233, 285-91.
Olasagasti Itsaso, Bockisch Christopher J., Zee David S., Straumann Dominik (2011), Dynamic Cyclovergence during Vertical Translation in Humans., in
J Neurosci, 31(27), 9991-7.
Sander T., Sprenger A., Marti S., Naumann T., Straumann D., Helmchen C. (2011), Effect of 4-aminopyridine on gravity dependence and neural integrator function in patients with idiopathic downbeat nystagmus., in
J Neurol, 258(4), 618-22.
Laurens Jean, Valko Yulia, Straumann Dominik (2011), Experimental parameter estimation of a visuo-vestibular interaction model in humans., in
J Vestib Res, 21(5), 251-66.
Keller Chandra Sandra, Bockisch Christopher J., Dietz Volker, Hegemann Stefan C. A., Straumann Dominik, van Hedel Hubertus J. A. (2011), Gaze strategies for avoiding obstacles: Differences between young and elderly subjects., in
Gait Posture, 34(3), 340-6.
Cohen Bernard, Dai Mingjia, Ogorodnikov Dmitri, Laurens Jean, Raphan Theodore, Müller Philippe, Athanasios Alexiou, Edmaier Jürgen, Grossenbacher Thomas, Stadtmüller Klaus, Brugger Ueli, Hauser Gerald, Straumann Dominik (2011), Motion sickness on tilting trains., in
FASEB J, 25(11), 3765-3774.
Straumann Dominik, Bockisch Christopher J. (2011), Neurophysiology: vertigo in MRI machines., in
Curr Biol, 21(19), 806-7.
Straube A., Bronstein A., Straumann D. (2011), Nystagmus and oscillopsia., in
Eur J Neurol, 19(1), 6-14.
Valko Yulia, Hegemann Stefan C. A., Weber Konrad P., Straumann Dominik, Bockisch Christopher J. (2011), Relative diagnostic value of ocular vestibular evoked potentials and the subjective visual vertical during tilt and eccentric rotation., in
Clin Neurophysiol, 122(2), 398-404.
Bertolini G., Ramat S., Laurens J., Bockisch C. J., Marti S., Straumann D., Palla A. (2011), Velocity storage contribution to vestibular self-motion perception in healthy human subjects., in
J Neurophysiol, 105(1), 209-23.
Tarnutzer A., Schuknecht B., Straumann D. (2011), Verticality perception in patients with lesions along the graviceptive pathways, in
SANP, 162(2), 60-5.
Tarnutzer Alexander A., Shaikh Aasef G., Palla Antonella, Straumann Dominik, Marti Sarah (2011), Vestibulo-cerebellar disease impairs the central representation of self-orientation., in
Front Neurol, 2, 11-11.
The long-term goal of this research (since 1998) is to better understand diseases of the ocular motor system in humans and to assess potential treatments. The focus of interest is on the three-dimensional (horizontal, vertical, torsional) kinematical properties of ocular rotations. For the next grant period, our research will concentrate on: (A) The influence of visual, vestibular, and pharmacological stimuli on the dynamics and kinematics of infantile nystagmus syndrome (INS) in humans and of its behavioral model in zebrafish and (B) the electro-myo-oculographic (EMG) characterization of angular and linear vestibulo-ocular reflexes (VOR) in healthy human subjects and patients with vestibular disorders. A: We will examine how spontaneous nystagmus in achiasmatic zebrafish bel mutant and patients with INS can be reduced by varying the properties of visual input (e.g. frequency, contrast, luminance) and how it is influenced by vestibular stimulation (e.g. changing the direction of gravity) and drugs (e.g. gabapentin, memantine). Experimental findings will lead to the construction of detailed computer models of INS and therapeutic measures to reduce INS.B: We will characterize the short-latency VOR evoked by controlled, impulsive head angular and linear acceleration in multiple planes in healthy human subjects and in patients with unilateral peripheral-vestibular deficits. We will develop analytical methods to distinguish between semicircular canal and otolith driven ocular EMG responses based on latency. This analysis, in turn, will elucidate the mechanisms of interaction between the angular and linear VOR in the intact system and how this system compensates for unilateral semicircular canal or otolith deficits.