Project

Back to overview

Integration of advanced biomarkers to deep brain stimulation in epilepsy

English title Integration of advanced biomarkers to deep brain stimulation in epilepsy
Applicant Boex Colette
Number 133080
Funding scheme Project funding (Div. I-III)
Research institution Unité d'EEG et d'exploration de l'épilepsie Service de Neurologie Hôpitaux Universitaires de Genève
Institution of higher education University of Geneva - GE
Main discipline Neurophysiology and Brain Research
Start/End 01.10.2010 - 30.09.2013
Approved amount 288'000.00
Show all

All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Biomedical Engineering

Keywords (7)

Epilepsy; DBS; spike; Microelectrode; ripple; deep brain stimulation; temporal lobe

Lay Summary (English)

Lead
Lay summary
This project will develop measurements of advanced biomarkers of epilepsy devoted to optimize deep brain stimulation (DBS). These biomarkers will be exploited to distinguish the irritative zone from the epileptogenic zone in order to optimize the localization of the stimulation electrodes. These biomarkers will be used to evaluate the effects of the stimulation of the irritative zone, not only for the standard parameters, but also for completely innovative parameters in the field of DBS. At the same time, they will be evaluated and possibly exploited to tailor ablative surgeries in epilepsy.We make the hypothesis that similarly to interictal epileptic discharge rates (IEDRs), multi-unit activity (MUA) can be used as biomarkers of epileptogenesis. MUA are studied from micro-electrode recordings. MUA will be used to identify the neuronal substrates at the source of epileptic discharges and to evaluate their changes when DBS is applied.These measurements will be conducted at the time of invasive presurgical evaluation, during implantation of chronic DBS electrodes, and also intra-operatively during ablative surgeries. Scalp EEG, intracranial EEG, and microelectrode recordings will be conducted. They will be analyzed with advanced methods of digital signal processing. They will be compared between each others, correlated with interictal events, seizures and DBS parameters.Beyond the optimization of DBS, this research project will provide biomarkers that could be used to trigger electric stimulation, in the perspective to develop closed-loop systems (which stimulate only at the time a seizure might occur). This research will contribute, to understand the fundamental mechanisms of action of DBS. These developments will be exploited to monitor intraoperavitely ablative surgeries in order to correlate the surgical process to the epileptogenicity, and to develop super selective ablative surgery. The results are of potential relevance in a number of brain diseases, i.e. beyond epilepsy, and possibly also for rehabilitation.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Basic instinct undressed: early spatiotemporal processing for primary sexual characteristics.
Legrand Lore (2013), Basic instinct undressed: early spatiotemporal processing for primary sexual characteristics., in PLoS One, 8(7), 11.
Effects of amygdala-hippocampal stimulation on interictal epileptic discharges
Tyrand Rémi, Seeck Margitta, Spinelli Laurent, Pralong Etienne, Vullièmoz Serge, Rossetti Andrea, Folettti Giovanni, Allali Gilles, Lantz Goran, Pollo Claudio, Boex Colette (2012), Effects of amygdala-hippocampal stimulation on interictal epileptic discharges, in Epilepsy Research, 99(1-2), 87-93.
Chronic deep brain stimulation in mesial temporal lobe epilepsy.
Boëx Colette, Seeck Margitta, Vulliémoz Serge, Rossetti Andrea O, Staedler Claudio, Spinelli Laurent, Pegna Alan J, Pralong Etienne, Villemure Jean-Guy, Foletti Giovanni, Pollo Claudio (2011), Chronic deep brain stimulation in mesial temporal lobe epilepsy., in Seizure : the journal of the British Epilepsy Association, 20(6), 485-90.
Possible new avenues in epilepsy treatment: The stimulation techniques - Deep brain stimulation, vagal nerve stimulation, transcranial magnetic stimulation
Boëx C, Brodbeck V, Vulliémoz S, Spinelli L, Rossetti AO, Foletti GF, Pollo C, Seeck M (2011), Possible new avenues in epilepsy treatment: The stimulation techniques - Deep brain stimulation, vagal nerve stimulation, transcranial magnetic stimulation, in Schweizer Archiv fur Neurologie und Psychiatrie, 162(2), 51-56.
Continuous intraoperative monitoring of temporal lobe epilepsy surgery
Tyrand Rémi, Continuous intraoperative monitoring of temporal lobe epilepsy surgery, in Stereotactic and Functional Neurosurgery.
Effects of amygdala-hippocampal stimulation on synchronization.
Tyrand Rémi, Pollo Claudio, Seeck Margitta, Boëx Colette, Effects of amygdala-hippocampal stimulation on synchronization., in Epilepsy Research.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Swiss society for neuroscience Poster Microelectrode recordings in the framework of neuromodulation in epilepsy 02.02.2013 Genève, Switzerland Boex Colette; Tyrand Rémi;
What does human intracerebral recording tell us about emotions Poster Microelectrode recordings in the framework of neuromodulation in epilepsy 19.09.2012 Genève, Switzerland Pollo Claudio; Boex Colette; Tyrand Rémi;
International society of intraoperative neuropyhsiology Talk given at a conference Intraoperative monitoring of epileptic discharges as a predictor of epilepsy surgery outcome (Free paper) 17.09.2012 Barcelona, Spain, Spain Tyrand Rémi; Pollo Claudio; Boex Colette;
Réunion Suisse de la Société de Neurophysiologie Talk given at a conference Microelectrode in the framework of neuromodulation 03.05.2012 Lugano, Switzerland Tyrand Rémi; Boex Colette; Pollo Claudio;


Associated projects

Number Title Start Funding scheme
149804 Intraoperative neuromodulation and neuromonitoring of the temporal lobe 01.10.2013 Project funding (Div. I-III)
118385 Optimisation of deep brain stimulation in epilepsy 01.10.2007 Project funding (Div. I-III)

Abstract

BackgroundThis research project is the continuation of the ongoing project entitled "Optimization of Deep Brain Stimulation in Epilepsy”. It has been shown that the success of deep brain stimulation (DBS) is dependant not only of the stimulation parameters that have to be studied, but it is dependent of the precise localization of the irritative zone to where the stimulation electrodes must be placed.GoalsThis project will develop measurements of advanced biomarkers of epilepsy devoted to optimize DBS. These biomarkers will be exploited to distinguish the irritative zone from the epileptogenic zone in order to optimize the localization of the stimulation electrodes. These biomarkers will be used to evaluate the effects of the stimulation of the irritative zone, not only for the standard parameters, but also for completely innovative parameters in the field of DBS, i.e. very high frequency and stochastic frequency of stimulation. At the same time, they will be evaluated and possibly exploited to tailor resection surgeries in epilepsy.Working hypothesesWe make the hypothesis that similarly to interictal epileptic discharge rates (IEDRs), fast ripples and multi-unit activity (MUA) can be used as biomarkers of epileptogenesis. Similarly to IED rates, fast ripples can be detected from intracranial EEG recorded with particular technical precautions and from microelectrodes. MUA are studied from micro-electrode recordings. We make the hypothesis that fast ripples and MUA can be used to identify the neuronal substrates at the source of epileptic discharges and to evaluate their changes when DBS is applied.MethodsThese measurements will be conducted at the time of invasive presurgical evaluation, during implantation of chronic DBS electrodes, and also intra-operatively during resection surgeries. Scalp EEG, intracranial EEG, and microelectrode recordings will be conducted. They will be analyzed with advanced methods of digital signal processing. They will be compared between each others, correlated with interictal events, seizures and DBS parameters.Expected outcomeBeyond the optimization of DBS, this research project will provide biomarkers that could be used to trigger electric stimulation, in the perspective to develop closed-loop systems (which stimulate only at the time a seizure might occur). This research will contribute, to understand the fundamental mechanisms of action of DBS. These developments will be exploited to monitor intraoperavitely resection surgeries in order to correlate the surgical process to the epileptogenicity, and to develop super selective resection surgery. This project will provide the scientific community a wealth of data from the human brain during several states, i.e. wakefulness and sleep, cognitively active or resting. The results are of potential relevance of a number of brain diseases, i.e. beyond epilepsy, and possibly also for rehabilitation.
-