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Regulatory functions of the tasting gut

English title Regulatory functions of the tasting gut
Applicant Beglinger Christoph
Number 132960
Funding scheme Project funding (Div. I-III)
Research institution Abt. für Gastroenterologie und Hepatologie Universitätsspital Basel
Institution of higher education University of Basel - BS
Main discipline Pathophysiology
Start/End 01.10.2010 - 30.09.2013
Approved amount 375'000.00
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All Disciplines (2)

Discipline
Pathophysiology
Physiology : other topics

Keywords (3)

Satiety peptides; brain-gut axis; taste receptors

Lay Summary (German)

Lead
Lay summary
Molekulare Antennen des Geschmacks im DarmUnser Geschmackssinn unterscheidet fünf Gruppen von Substanzen: süsse, saure, salzige, bittere und solche für das fleischige Aroma umami. Grundlage dieser Empfindungen sind molekulare Erkenntnisprozesse beim Kontakt von Nahrung mit den Geschmacksknospen in Zunge und Gaumen. Vor ein paar Jahren fanden verschiedene Arbeitsgruppen heraus, dass die gleichen molekularen Antennen oder eben Geschmacksrezeptoren auch im Gastrointestinaltrakt von Tier und Mensch nachgewiesen werden können. Sie sind an Zellmembranen von spezialisierten Zellen der Schleimhaut des Magens und Darms angesiedelt und werden durch Bestandteile der Nahrung angeregt (z.B. wird der Rezeptor für süss durch Zucker stimuliert). Nach Stimulierung kommunizieren die Geschmacksrezeptoren mit spezifischen Eiweissen, den sogenannten G-Proteinen. Damit können spezielle organische Moleküle wie Glukose als Reizauslöser wirken.Die physiologische Bedeutung der Geschmacksrezeptoren im Darm ist aber bisher weitgehend ungeklärt. Völlig offen bleibt, ob gewisse Krankheiten wie Diabetes oder Adipositas mit einer veränderten Geschmackswahrnehmung im Darm assoziiert sind.Ziel dieses Projektes ist deshalb die Ergründung der Geschmacksmoleküle im Magendarmtrakt, insbesondere was nach der Erkennung des Nahrungsbestandteils durch Geschmacksmoleküle passiert. Welche Signale werden stimuliert? Wie werden die Signale weitergeleitet? Findet schon in der Geschmacksknospe eine Interpretation statt oder erst im Gehirn? Mit der Erforschung des Geschmackssinns im Magendarmtrakt wollen wir mithelfen, die physiolgische Bedeutung dieser Rezeptoren im Magendarmtrakt des Menschen zu klären. Ein tieferes Verständnis für gewisse Stoffwechselstörungen (Diabetes, Adipositas) ist nur ein erster Schritt, um diese Probleme besser zu kontrollieren und Krankheiten zu behandeln.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
DIGESTIVE PHYSIOLOGY OF THE PIG SYMPOSIUM: Secretion of gastrointestinal hormones and eating control
Steinert R. E., Feinle-Bisset C., Geary N., Beglinger C. (2013), DIGESTIVE PHYSIOLOGY OF THE PIG SYMPOSIUM: Secretion of gastrointestinal hormones and eating control, in JOURNAL OF ANIMAL SCIENCE, 91(5), 1963-1973.
Effects of Chenodeoxycholic Acid on the Secretion of Gut Peptides and Fibroblast Growth Factors in Healthy Humans
Meyer-Gerspach A. C., Steinert R. E., Keller S., Malarski A., Schulte F. H., Beglinger C. (2013), Effects of Chenodeoxycholic Acid on the Secretion of Gut Peptides and Fibroblast Growth Factors in Healthy Humans, in JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 98(8), 3351-3358.
Hormonal and Metabolic Implications of Weight Loss after Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Randomized, Prospective Trial.
Peterli Ralph, Steinert Robert. E., Woelnerhanssen Bettina, Peters Thomas, Christoffel-Courtin Caroline, von Flüe Markus, Beglinger Christoph (2012), Hormonal and Metabolic Implications of Weight Loss after Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Randomized, Prospective Trial., in Obes Surg, 22(5), 740-748.
The role of the stomach in the control of appetite and the secretion of satiation peptides
Steinert Robert E., Meyer-Gerspach Anne Christin, Beglinger Christoph (2012), The role of the stomach in the control of appetite and the secretion of satiation peptides, in Am J Physiol Endocrinol Metab, 302(6), E666-E673.
Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides.
Steinert Robert E, Frey Florian, Töpfer Antonia, Drewe Jürgen, Beglinger Christoph (2011), Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides., in The British journal of nutrition, 105(9), 1320-8.
Effects of postbariatric surgery weight loss on adipokines and metabolic parameters: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy--a prospective randomized trial.
Woelnerhanssen Bettina, Peterli Ralph, Steinert Robert E, Peters Thomas, Borbély Yves, Beglinger Christoph (2011), Effects of postbariatric surgery weight loss on adipokines and metabolic parameters: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy--a prospective randomized trial., in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Su, 7(5), 561-8.
Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides.
Steinert Robert E, Beglinger Christoph (2011), Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides., in Physiology & behavior, 105(1), 62-70.
The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).
Steinert R E, Gerspach A C, Gutmann H, Asarian L, Drewe J, Beglinger C (2011), The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)., in Clinical nutrition (Edinburgh, Scotland), 30(4), 524-32.
The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.
Gerspach A C, Steinert R E, Schönenberger L, Graber-Maier A, Beglinger C (2011), The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans., in American journal of physiology. Endocrinology and metabolism, 301(2), E317-E325.
Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial.
Steinert Robert E, Peterli Ralph, Keller Sylvia, Meyer-Gerspach Anne C, Drewe Jürgen, Peters Thomas, Beglinger Christoph, Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial., in Obesity (Silver Spring, Md.), (Epub ahead).
Neural effects of green tea extract on dorsolateral prefrontal cortex
Borgwardt Stephan, Hammann Felix, Scheffler Klaus, Kreuter Matthias, Drewe Juergen, Beglinger Christoph, Neural effects of green tea extract on dorsolateral prefrontal cortex, in Eur J Clin Nutr .

Collaboration

Group / person Country
Types of collaboration
Roche AG Basel Switzerland (Europe)
- Industry/business/other use-inspired collaboration
Klinikum Grosshardern München Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
ETH Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
United European Gastroenterology Week 2013 Talk given at a conference 14.10.2013 Berlin, Germany Beglinger Christoph; Meyer-Gerspach Anne Christin;
21st Annual Meeting SSIB Talk given at a conference 30.07.2013 New Orleans, United States of America Wölnerhanssen Bettina; Meyer-Gerspach Anne Christin; Beglinger Christoph;
United EUropean Gastroenterology Week 2012 Talk given at a conference 20.10.2012 Amsterdam, Netherlands Gamboni Gerdien; Drewe Jürgen; Meyer-Gerspach Anne Christin; Beglinger Christoph;
20th Annual Meeting SSIB Talk given at a conference 15.07.2012 Zürich, Switzerland Meyer-Gerspach Anne Christin; Beglinger Christoph;
Symposium on Olfaction and Taste, ISOT XVI Talk given at a conference 23.05.2012 Stockholm, Sweden Wölnerhanssen Bettina; Meyer-Gerspach Anne Christin; Beglinger Christoph;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
United Europen Gastroenterology Week 2012 22.10.2012 Amsterdam, Netherlands Beglinger Christoph;
PYY Meeting 01.07.2012 Montreal, Canada Beglinger Christoph;


Awards

Title Year
Travel Grant for Oral Presentation UEGW 2013, Berlin, A.C. Meyer-Gerspach 2013
Travel Grant for Oral Presentation, SSIB New Orleans 2013
Travel Grant for Oral Presentation UEGW 2012, Amsterdam, A.C. Gerspach 2012

Associated projects

Number Title Start Funding scheme
118330 The role of gastrointestinal satiety peptides in appetite control 01.10.2007 Project funding (Div. I-III)
118330 The role of gastrointestinal satiety peptides in appetite control 01.10.2007 Project funding (Div. I-III)
120020 Laparoscopic sleeve-gastrectomy (LSG) or laparoscopic proximal Roux-Y-gastric bypass (LRYGB) in the treatment of morbid obesity 01.06.2008 Project funding (Div. I-III)

Abstract

The main objective is to better understand the mechanism of appetite regulation and hunger/satiety. This knowledge will contribute to reducing the risk of the development of chronic disease (overweight, obesity, diabetes mellitus). More knowledge of the brain-gut function and dysfunction related to the food intake, the neuroendocrine pathways that regulates the digestive processes and the mechanism of hunger/satiety is needed. This will lead to identify dietary components/food structure that can help to control food intake and to develop food prototype that control satiety.
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