magnetic resonance imaging; Biochemical Imaging; Tissue Characterization; Development of Imaging Methods; Steady State Imaging Techniques
Crooijmans Hendrikus J A, Ruder Thomas D., Zech Wolf Dieter, Somaini Sandra, Scheffler Klaus, Thali Michael Josef, Bieri Oliver (2014), Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study, in Journal of Magnetic Resonance Imaging
, 40(4), 915-919.
Heule Rahel, Ganter Carl, Bieri Oliver (2014), Rapid estimation of cartilage T2 with reduced T1 sensitivity using double echo steady state imaging, in Magnetic Resonance in Medicine
, 71(3), 1137-1143.
Heule Rahel, Bär Peter, Mirkes Christian, Scheffler Klaus, Trattnig Siegfried, Bieri Oliver (2014), Triple-echo steady-state T2 relaxometry of the human brain at high to ultra-high fields., in NMR in biomedicine
, 27(9), 1037-45.
Crooijmans Hendrikus J A, Ruder Thomas D., Zech Wolf Dieter, Somaini Sandra, Scheffler Klaus, Thali Michael Josef, Bieri Oliver (2013), Feasibility of quantitative diffusion imaging of the heart in post-mortem MR, in Journal of Forensic Radiology and Imaging
, 1(3), 124-128.
Heule Rahel, Ganter Carl, Bieri Oliver (2013), Triple echo steady-state (TESS) relaxometry, in Magnetic Resonance in Medicine
, 71(1), 230-237.
Bieri Oliver, Ganter Carl, Scheffler Klaus (2012), On the fluid-tissue contrast behavior of high-resolution steady-state sequences, in Magnetic Resonance in Medicine
, 68(5), 1586-1592.
Bieri Oliver, Ganter Carl, Scheffler Klaus (2012), Quantitative in vivo diffusion imaging of cartilage using double echo steady-state free precession, in Magnetic Resonance in Medicine
, 68(3), 720-729.
In the early diagnosis or detection of subtle or diffuse pathological changes, as with osteoarthritis (OA), the most common musculoskeletal degenerative disease, or with epilepsy or other neurodegenerative disorders, such as schizophrenia Parkinson’s or Alzheimer’s disease, especially quantitative magnetic resonance (qMR) imaging has shown to be a valuable biomarker and a promising tool for a bias-free and reproducible measurement of changes in clinically relevant quantities. Furthermore, qMR is a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research across different sites. Clearly, more time and effort is needed to detect small biological changes in a quantitative rather than qualitative way, thereby limiting the practical applicability of qMR imaging in clinics. In this research proposal we focus on the development of new rapid qMR imaging techniques for two of the most sensitive tissue parameters to diseases, namely transverse relaxation (T2) and diffusion. More specifically, we intend to develop and explore new MR steady state imaging approaches for quantitative T2 and diffusion mapping in living tissue at 1.5T, 3T and 7T to overcome present limitations in either resolution or scan-time in state-of-the-art qMR SSFP-based methods.