Project

Back to overview

Development of fast quantitative diffusion and transverse relaxation time magnetic resonance steady state imaging concepts for living tissues

English title Development of fast quantitative diffusion and transverse relaxation time magnetic resonance steady state imaging concepts for living tissues
Applicant Bieri Oliver
Number 132906
Funding scheme Project funding (Div. I-III)
Research institution Radiologische Physik Departement Radiologie Universitätsspital Basel
Institution of higher education University of Basel - BS
Main discipline Biophysics
Start/End 01.07.2011 - 31.12.2013
Approved amount 294'604.00
Show all

All Disciplines (2)

Discipline
Biophysics
Other disciplines of Physics

Keywords (5)

magnetic resonance imaging; Biochemical Imaging; Tissue Characterization; Development of Imaging Methods; Steady State Imaging Techniques

Lay Summary (English)

Lead
Lay summary
This research project aims at the development of new rapid quantitative magnetic resonance imaging techniques for the diagnosis or detection of subtle or diffuse pathological changes in living tissue to overcome present limitations in either resolution or scan-time in state-of-the-art methods.In the early diagnosis or detection of subtle or diffuse pathological changes, quantitative magnetic resonance imaging (qMRI) has shown to be a valuable biomarker and a promising tool towards a bias-free and reproducible measurement of changes in clinically relevant quantities. Furthermore, qMRI is a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research across different sites. More time and effort, however, is needed to detect small biological changes in a quantitative rather than qualitative way, thereby limiting the practical applicability of qMRI in clinics. As a result, the development of new and fast imaging techniques for qMRI to overcome present limitations is highly desirable. In this research project we focus on the development of new rapid qMRI techniques for two of the most sensitive tissue parameters to diseases, namely transverse relaxation (T2) and diffusion. More specifically, we intend to develop and explore new MR steady state imaging approaches for quantitative T2 and diffusion mapping in living tissue at various field strengths to overcome present limitations in either resolution or scan-time in state-of-the-art qMR SSFP-based methods. Rapid and quantitative measurement of physiological or functional parameters of living tissue is a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research across different sites. The quantitative assessment of MR parameters such as relaxation times or diffusion effects as potential biomarkers is a very time consuming process but allows for the detection of small biological changes in a quantitative rather than qualitative way. Especially for the early diagnosis of subtle or diffuse pathological changes, quantitative MR has indicated a possible huge impact and the development and evaluation of new and fast qMRI techniques is of high clinical interest.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study
Crooijmans Hendrikus J A, Ruder Thomas D., Zech Wolf Dieter, Somaini Sandra, Scheffler Klaus, Thali Michael Josef, Bieri Oliver (2014), Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study, in Journal of Magnetic Resonance Imaging, 40(4), 915-919.
Rapid estimation of cartilage T2 with reduced T1 sensitivity using double echo steady state imaging
Heule Rahel, Ganter Carl, Bieri Oliver (2014), Rapid estimation of cartilage T2 with reduced T1 sensitivity using double echo steady state imaging, in Magnetic Resonance in Medicine, 71(3), 1137-1143.
Triple-echo steady-state T2 relaxometry of the human brain at high to ultra-high fields.
Heule Rahel, Bär Peter, Mirkes Christian, Scheffler Klaus, Trattnig Siegfried, Bieri Oliver (2014), Triple-echo steady-state T2 relaxometry of the human brain at high to ultra-high fields., in NMR in biomedicine, 27(9), 1037-45.
Feasibility of quantitative diffusion imaging of the heart in post-mortem MR
Crooijmans Hendrikus J A, Ruder Thomas D., Zech Wolf Dieter, Somaini Sandra, Scheffler Klaus, Thali Michael Josef, Bieri Oliver (2013), Feasibility of quantitative diffusion imaging of the heart in post-mortem MR, in Journal of Forensic Radiology and Imaging, 1(3), 124-128.
Triple echo steady-state (TESS) relaxometry
Heule Rahel, Ganter Carl, Bieri Oliver (2013), Triple echo steady-state (TESS) relaxometry, in Magnetic Resonance in Medicine, 71(1), 230-237.
On the fluid-tissue contrast behavior of high-resolution steady-state sequences
Bieri Oliver, Ganter Carl, Scheffler Klaus (2012), On the fluid-tissue contrast behavior of high-resolution steady-state sequences, in Magnetic Resonance in Medicine, 68(5), 1586-1592.
Quantitative in vivo diffusion imaging of cartilage using double echo steady-state free precession
Bieri Oliver, Ganter Carl, Scheffler Klaus (2012), Quantitative in vivo diffusion imaging of cartilage using double echo steady-state free precession, in Magnetic Resonance in Medicine, 68(3), 720-729.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Proceedings of the RSNA Talk given at a conference Multiparametric MRI of Cartilage of the Ankle Joint after Autologous Matrix Induced Chondrogenesis (AMIC) using Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC), Quantitative Diffusion and T2 Relaxation Time Measurements. 25.11.2012 Chicago, United States of America Bieri Oliver;
Proceedings of the 29th annual scientific meeting of ESMRMB Talk given at a conference Post-mortem quantitative cardiac diffusion imaging with double echo steady-state free precession 04.10.2012 Lisbon, Portugal Crooijmans Hendrikus Joseph Alphons; Bieri Oliver;
Proceedings of the 29th annual scientific meeting of ESMRMB Poster T1-corrected Rapid T2 Estimation Using Double Echo Steady State (DESS) 04.10.2012 Lisbon, Portugal Bieri Oliver; Heule Rahel;
Swiss Congress of Radiology Talk given at a conference Identifying a myocardial infarct in forensic imaging by means of MTR-mapping 31.05.2012 Zürich, Switzerland Crooijmans Hendrikus Joseph Alphons; Bieri Oliver;
Proceedings of the 21st annual meeting & exhibition of ISMRM Talk given at a conference Triple Echo Steady State (TESS) Relaxometry 05.05.2012 Salt Lake City, United States of America Bieri Oliver; Heule Rahel;
Proceedings of the 21st annual meeting & exhibition of ISMRM Poster Mono-exponential T2-analysis of a two-pool system – Does echo-spacing matter? 05.05.2012 Salt Lake city, United States of America Crooijmans Hendrikus Joseph Alphons; Bieri Oliver;
Proceedings of the 20th annual meeting & exhibition of ISMRM Poster Quantitative cardiac diffusion imaging using double echo steady-state free precession 05.05.2012 Melbourne, Australia Bieri Oliver; Crooijmans Hendrikus Joseph Alphons;
Proceedings of the 28th annual scientific meeting of ESMRMB Talk given at a conference Cardiac MTR mapping in forensic medicine 06.10.2011 Leipzig, Germany Bieri Oliver; Crooijmans Hendrikus Joseph Alphons; Scheffler Klaus;
Proceedings of the 28th annual scientific meeting of ESMRMB Poster Diffusion mapping in the post mortem porcine and human heart after possible myocardial infarct 06.10.2011 Leipzig, Germany Scheffler Klaus; Crooijmans Hendrikus Joseph Alphons; Bieri Oliver;
Proceedings of the 28th annual scientific meeting of ESMRMB Poster Single pool assumption in SE and DESPOT2 T2 quantifications on multi-T2 probes 06.10.2011 Leipzig, Germany Crooijmans Hendrikus Joseph Alphons; Bieri Oliver; Scheffler Klaus;


Awards

Title Year
Gorterpreisträger. Die Deutsche Sektion zeichnet mit dem Gorter-Preis die beste Arbeit eines jungen Wissenschaftlers aus der Medizin oder einer Naturwissenschaft aus. Es können Diplom-, Doktorarbeiten sowie Originalarbeiten oder Gleichwertiges auf dem Gebiet der biomedizinischen Magnetresonanz eingereicht werden. 2015
ISMRM Magna Cum Laude Merit Award 2012

Associated projects

Number Title Start Funding scheme
118377 Development of new magnetic resonance acquisition concepts for magnetization transfer and oscillating steady state imaging 01.03.2008 Project funding (Div. I-III)

Abstract

In the early diagnosis or detection of subtle or diffuse pathological changes, as with osteoarthritis (OA), the most common musculoskeletal degenerative disease, or with epilepsy or other neurodegenerative disorders, such as schizophrenia Parkinson’s or Alzheimer’s disease, especially quantitative magnetic resonance (qMR) imaging has shown to be a valuable biomarker and a promising tool for a bias-free and reproducible measurement of changes in clinically relevant quantities. Furthermore, qMR is a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research across different sites. Clearly, more time and effort is needed to detect small biological changes in a quantitative rather than qualitative way, thereby limiting the practical applicability of qMR imaging in clinics. In this research proposal we focus on the development of new rapid qMR imaging techniques for two of the most sensitive tissue parameters to diseases, namely transverse relaxation (T2) and diffusion. More specifically, we intend to develop and explore new MR steady state imaging approaches for quantitative T2 and diffusion mapping in living tissue at 1.5T, 3T and 7T to overcome present limitations in either resolution or scan-time in state-of-the-art qMR SSFP-based methods.
-