Brodie Tess, Brenna Elena, Sallusto Federica (2013), OMIP-018: chemokine receptor expression on human T helper cells., in Cytometry. Part A : the journal of the International Society for Analytical Cytology
, 83(6), 530-2.
Baumjohann Dirk, Preite Silvia, Reboldi Andrea, Ronchi Francesca, Ansel K Mark, Lanzavecchia Antonio, Sallusto Federica (2013), Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype., in Immunity
, 38(3), 596-605.
Lindestam Arlehamn Cecilia S, Gerasimova Anna, Mele Federico, Henderson Ryan, Swann Justine, Greenbaum Jason A, Kim Yohan, Sidney John, James Eddie A, Taplitz Randy, McKinney Denise M, Kwok William W, Grey Howard, Sallusto Federica, Peters Bjoern, Sette Alessandro (2013), Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset., in PLoS pathogens
, 9(1), 1003130-1003130.
Sallusto Federica, Zielinski Christina E, Lanzavecchia Antonio (2012), Human Th17 subsets., in European journal of immunology
, 42(9), 2215-20.
Sallusto Federica, Impellizzieri Daniela, Basso Camilla, Laroni Alice, Uccelli Antonio, Lanzavecchia Antonio, Engelhardt Britta (2012), T-cell trafficking in the central nervous system., in Immunological reviews
, 248(1), 216-27.
Zielinski Christina E, Mele Federico, Aschenbrenner Dominik, Jarrossay David, Ronchi Francesca, Gattorno Marco, Monticelli Silvia, Lanzavecchia Antonio, Sallusto Federica (2012), Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β., in Nature
, 484(7395), 514-8.
Chevalier N, Jarrossay D, Ho E, Avery DT, Ma CS, Yu D, Sallusto F, Tangye SG, Mackay CR (2011), CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses, in Journal of Immunology
, 186(10), 5556-5568.
Zielinski Christina E, Corti Davide, Mele Federico, Pinto Dora, Lanzavecchia Antonio, Sallusto Federica (2011), Dissecting the human immunologic memory for pathogens., in Immunological reviews
, 240(1), 40-51.
The present proposal stems from my long-standing interest in T cell differentiation and immunological memory and deals with three major questions. The first question relates to the heterogeneity of effector and memory T cells with particular regard to the recently described Th17 and Th22 subsets. We will analyze flexibility and stability of human memory Th17 and Th22 cells and attempt to further dissect the heterogeneity of effector and memory T cells using surface markers and functional assays. We will also further investigate the requirement for Th17 and Th22 cell differentiation in humans and the role these cells play in autoimmune diseases such as multiple sclerosis and psoriasis. The second question relates to the repertoire of effector and memory T cell subsets and the dynamics of human immune response. Using a recently developed analytical method to study the antigenic specificity of human T cells, we will perform a systematic analysis of frequency, distribution, and fine specificity of antigen specific T cells in naïve, effector and memory T cell subsets, in particular in the Th17 and the recently described Th22 subsets. This analysis will be performed in healthy individuals, in vaccinated donors and in patients with multiple sclerosis. The third question relates to the mechanisms that control traffic of differentiated effector and memory T cells. Here we will address the role of chemokine receptors and other homing receptors in regulating migration both of naïve, effector and memory T cells at the induction phase in antigen-stimulated lymph nodes and at the effector phase in peripheral tissues. These experiments will be conducted in the mouse system taking advantage of gene-targeted animals and models of inflammatory diseases.