Resource not found: 'e5ac094a-b6c5-4d1b-acb2-7763d2d4e0ae'

Resource not found: '2a7ac579-62da-4f94-83b5-5b0f1b4e406f'

Synaptic Mechanisms of Sensory Perception and Associative Learning

Resource not found: '5853ecf8-d88c-4616-85df-626cdf54e619' Synaptic Mechanisms of Sensory Perception and Associative Learning
Applicant Petersen Carl
Resource not found: '135b3af7-1b09-4b6a-8be1-755e1fff1aa3' 131089
Resource not found: 'e06e8ec8-6cda-4a10-b575-4fefe07abcdf' Project funding (Div. I-III)
Resource not found: 'd682b91c-fc5e-49a1-9e9c-83b0dda5e2a6' Brain Mind Inst., Faculty of Life Sciences SV-BMI-BMI-GE EPFL
Resource not found: 'bcdeb9eb-9212-4c14-9bbf-8fb3163c3c73' EPF Lausanne - EPFL
Resource not found: 'a21e0013-75a3-417f-aca2-51547398bba1' Neurophysiology and Brain Research
Resource not found: '93d4f2ee-a6aa-43d4-b606-c789b39e2fd8' 01.04.2010 - 31.03.2013
Resource not found: '32923d6e-9866-44c7-a2f1-dd0c228f517a' 537'000.00
Resource not found: 'b32db384-870a-464e-9bca-736634c1190f'

Keywords (6)

Awake mice; behaviour; neocortex somatosensory cortex; barrel cortex; perception; learning

Lay Summary (English)

Lead
Lay summary
The overall goal of this research project is to obtain a mechanistic and causal explanation for simple forms of sensory perception and associative learning at the level of individual neurons and their synaptic interactions. The quantitative understanding of the neurophysiological basis of mammalian behaviour poses a major challenge to neuroscientists. Our approach is to focus on the mouse whisker sensorimotor pathway, which provides a relatively simple system for studying active sensory perception. Each whisker on the snout is mapped onto a homologous anatomically-defined barrel column in the primary somatosensory cortex of the mouse. So for example, sensory processing of tactile information from the C2 whisker is primarily processed in the C2 barrel column. Mice actively gather sensory information with their whiskers, which they move back and forth at high speed while exploring their environment. Interactions between sensory and motor systems must therefore be important for interpretation of tactile information, but little is currently known about the synaptic mechanisms of such sensorimotor integration. In this research project we will apply electrophysiological, imaging and genetic approaches for investigating cortical function in awake behaving mice. Gaining an understanding of how animals can actively gather and utilize sensory information to drive goal-directed actions is likely to offer basic insights into the neurobiological mechanisms of how the brain governs behavior. Integration of sensory and motor signals must occur in all sensory systems and important general principles may therefore emerge from our studies. Equally through studying the mechanisms underlying reward-based learning, we will begin to uncover the changes that occur in the brain during simple associative learning paradigms, which are also likely to provide insight of general importance.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Name Resource not found: '84cc0509-a3de-4a74-af63-b053822e3e56'

Employees

Publications

Publication
Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex.
Avermann Michael, Tomm Christian, Mateo Celine, Gerstner Wulfram, Petersen Carl C H (2012), Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex., in Journal of neurophysiology, 107(11), 3116-34.
Thalamic control of cortical states.
Poulet James F A, Fernandez Laura M J, Crochet Sylvain, Petersen Carl C H (2012), Thalamic control of cortical states., in Nature neuroscience, 15(3), 370-2.
Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex.
Gentet Luc J, Kremer Yves, Taniguchi Hiroki, Huang Z Josh, Staiger Jochen F, Petersen Carl C H (2012), Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex., in Nature neuroscience, 15(4), 607-12.
In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition
Mateo C, Avermann M, Gentet LJ, Zhang F, Deisseroth K, Petersen CCH (2011), In Vivo Optogenetic Stimulation of Neocortical Excitatory Neurons Drives Brain-State-Dependent Inhibition, in CURRENT BIOLOGY, 21(19), 1593-1602.

Associated projects

Number Title Start Funding scheme
139219 Multi-user two-photon microscope facility for advanced neuron imaging in-vivo and in-vitro 01.07.2012 R'EQUIP
146252 Synaptic Mechanisms of Sensory Perception and Associative Learning 01.04.2013 Project funding (Div. I-III)
127289 Structure, Function and Plasticity of the Barrel Cortex 01.01.2010 Sinergia
130826 Barrel Cortex Function (BaCoFun FOR 1341) (D-A-CH/LAE) 01.01.2010 Project funding (Div. I-III)
116027 Synaptic mechanisms of sensory perception and associative learning 01.04.2007 Project funding (Div. I-III)
182010 Neural circuits for goal-directed sensorimotor transformation 01.04.2019 Project funding (Div. I-III)

Abstract

The overall goal of this research project is to obtain a mechanistic and causal explanation for simple forms of sensory perception and associative learning at the level of individual neurons and their synaptic interactions. The quantitative understanding of the neurophysiological basis of mammalian behaviour poses a major challenge to neuroscientists. Our approach is to focus on the mouse whisker sensorimotor pathway, which provides a relatively simple system for studying active sensory perception. Each whisker on the snout is mapped onto a homologous anatomically-defined barrel column in the primary somatosensory cortex of the mouse. So for example, sensory processing of tactile information from the C2 whisker is primarily processed in the C2 barrel column. Mice actively gather sensory information with their whiskers, which they move back and forth at high speed while exploring their environment. Interactions between sensory and motor systems must therefore be important for interpretation of the tactile information, but little is currently known about the synaptic mechanisms of such sensorimotor integration. Over the past years we have developed electrophysiological, imaging and genetic approaches for investigating cortical function in awake behaving mice, which we now apply to investigate the synaptic mechanisms of sensory perception and associative learning.
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