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Adaptation mechanisms of the circadian clock to light and temperature

English title Adaptation mechanisms of the circadian clock to light and temperature
Applicant Albrecht Urs Emanuel
Number 131086
Funding scheme Project funding (Div. I-III)
Research institution Division de Biochimie Département de Biologie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Molecular Biology
Start/End 01.04.2010 - 31.03.2013
Approved amount 508'672.00
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All Disciplines (2)

Discipline
Molecular Biology
Biochemistry

Keywords (6)

circadian clock; bonus-of-excellence; Per2; addiction; depression; adaptation

Lay Summary (German)

Lead
Lay summary
Unsere innere Uhr synchronisiert sich zum Tagesablauf. Dies merken wir meist erst im Frühling und Herbst, bei der Zeitumstellung. Wir geraten für ein paar Tage aus dem Takt, können uns aber wieder an die neuen Tageszeiten gewöhnen. Die innere Uhr ist also anpassungsfähig. Dabei spielt das Licht eine wichtige Rolle. Durch das Auge gelangen Lichtsignale direkt in den SCN, den Dirigenten der inneren Uhr im Hypothalamus. Als Antwort wird das Uhrwerk vor- oder nachgestellt; unser Taktgeber ist nun wieder im Einklang mit dem Tag/Nacht-Rhythmus in der Natur. So erreichen wir eine kontinuierliche Anpassung an die Jahreszeiten - mit den langen Tagen im Sommer und den kürzeren im Winter.In diesem Projekt wollen wir herausfinden, wie diese Anpassung funktioniert und ob sich die innere Uhr auch and Temperaturänderungen anpasst. Wie sich die innere Uhr an veränderte Umweltbedingungen anpasst ist wichtig zu verstehen, da z.B bei sehr kurzen Tagen im Winter eine innere Unordnung entstehen kann die sich in Bedrücktheit oder Depressionen äussert. Ist unsere innere Uhr schlecht eingestellt, schlägt dies nicht nur aufs Gemüt - es kurbelt überdies den Appetit an. Deshalb erwarten wir, dass unsere Resultate dazu beitragen Krankheiten des modernen Lebens wie z. B. Folgen der Schichtarbeit und Formen von Sucht wie Essucht oder Trinksucht, besser zu verstehen. Dies könnte zu verbesserten Behandlungsformen als auch zu einer Verbesserung präventiver Massnahmen gegen diese Krankheiten führen.Um unsere Ziele zu erreichen verwenden wir biochemische und molekularbiologische Methoden. Dabei wollen wir mit Hilfe von Verhaltensstudien an Mäusen die molekularen Zusammenhängen zwischen Physiologie und genetischer Regulation der inneren Uhr herausfinden.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
NONO couples the circadian clock to the cell cycle
Kowalska E Ripperger JA Hoegger DC Bruegger P Buch T Birchler T Mueller A Albrecht U Contald (2013), NONO couples the circadian clock to the cell cycle, in Proc Natl Acad Sci U S A, 110(5), 1592-1599.
REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology
Ripperger JA Albrecht U (2012), REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology, in Cell Research, 22(9), 1319-1321.
Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis
Carvas Joao, et al. (2012), Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis, in Front. Physiol., 3, 337.
The circadian clock component PERIOD2: from molecular to cerebral functions
Ripperger JA Albrecht U (2012), The circadian clock component PERIOD2: from molecular to cerebral functions, in Prog Brain Res., 199, 233-245.
Timing to perfection: The biology of central and peripheral circadian clocks
Albrecht Urs (2012), Timing to perfection: The biology of central and peripheral circadian clocks, in Neuron, 74(2), 246-260.
Klf15 orchestrates circadian nitrogen homeostasis.
Jeyaraj Darwin, Scheer Frank A J L, Ripperger Jürgen A, Haldar Saptarsi M, Lu Yuan, Prosdocimo Domenick A, Eapen Sam J, Eapen Betty L, Cui Yingjie, Mahabeleshwar Ganapathi H, Lee Hyoung-Gon, Smith Mark A, Casadesus Gemma, Mintz Eric M, Sun Haipeng, Wang Yibin, Ramsey Kathryn M, Bass Joseph, Shea Steven A, Albrecht Urs, Jain Mukesh K (2012), Klf15 orchestrates circadian nitrogen homeostasis., in Cell metabolism, 15(3), 311-23.
Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Jeyaraj Darwin, Haldar Saptarsi M, Wan Xiaoping, McCauley Mark D, Ripperger Jürgen A, Hu Kun, Lu Yuan, Eapen Betty L, Sharma Nikunj, Ficker Eckhard, Cutler Michael J, Gulick James, Sanbe Atsushi, Robbins Jeffrey, Demolombe Sophie, Kondratov Roman V, Shea Steven A, Albrecht Urs, Wehrens Xander H T, Rosenbaum David S, Jain Mukesh K (2012), Circadian rhythms govern cardiac repolarization and arrhythmogenesis., in Nature, 483(7387), 96-9.
The role of clock genes and rhythmicity in the liver.
Schmutz I, Albrecht U, Ripperger J A (2012), The role of clock genes and rhythmicity in the liver., in Molecular and cellular endocrinology, 349(1), 38-44.
Circadian rhythms and sleep--the metabolic connection.
Albrecht Urs (2012), Circadian rhythms and sleep--the metabolic connection., in Pflügers Archiv : European journal of physiology, 463(1), 23-30.
Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
Schmutz Isabelle, Wendt Sabrina, Schnell Anna, Kramer Achim, Mansuy Isabelle M, Albrecht Urs (2011), Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock., in PloS one, 6(6), 21325-21325.
The circadian clock, reward, and memory.
Albrecht Urs (2011), The circadian clock, reward, and memory., in Frontiers in molecular neuroscience, 4, 41-41.
The circadian molecular clock creates epidermal stem cell heterogeneity
Janich P, Pascual G, Merlos-Suarez A, Batlle E, Ripperger J, Albrecht U, Cheng HYM, Obrietan K, Di Croce L, Benitah SA (2011), The circadian molecular clock creates epidermal stem cell heterogeneity, in NATURE, 480(7376), 209-209.
Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking
Dong L, Bilbao A, Laucht M, Henriksson R, Yakovleva T, Ridinger M, Desrivieres S, Clarke TK, Lourdusamy A, Smolka MN, Cichon S, Blomeyer D, Treutlein J, Perreau-Lenz S, Witt S, Leonardi-Essmann F, Wodarz N, Zill P, Soyka M, Albrecht U, Rietschel M, Lathrop M, Bakalkin G, Spanagel R, Schumann G (2011), Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking, in AMERICAN JOURNAL OF PSYCHIATRY, 168(10), 1090-1098.
The daily rhythm of mice
Ripperger JA, Jud C, Albrecht U (2011), The daily rhythm of mice, in FEBS LETTERS, 585(10), 1384-1392.
Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele.
Daan Serge, Spoelstra Kamiel, Albrecht Urs, Schmutz Isabelle, Daan Moritz, Daan Berte, Rienks Froukje, Poletaeva Inga, Dell'Omo Giacomo, Vyssotski Alexei, Lipp Hans-Peter (2011), Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele., in Journal of biological rhythms, 26(2), 118-29.
Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range
Anna Erzberger Gabriele Hampp Adrian Granada Urs Albrecht and Hanspeter Herzel., Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range, in J. Royal Soc. Interface.

Collaboration

Group / person Country
Types of collaboration
Charité Berlin Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Universität Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Sleepmeeting Adelboden 07.03.2013 Adelboden
EASL monothematic conference 21.02.2013 Luxembourg
LS2 Annual Meeting 31.01.2013 Zürich
27th Conference of the international Society for Chronobiology 03.10.2012 Dehli, Indien
26th Conference of European Comparative Endocrinologists 21.08.2012 Zürich
XIIIth International Course on Chronopharmacology 30.07.2012 Mannheim, Deutschland
9. Fachschaftstreffen Naturwissenschaften der Konrad-Adenauer-Stiftung 06.07.2012 Wesseling, Deutschland
Annual Meeting of the Society for Light Treatment and Biological Rhythms 24.06.2012 Genf
XII Congress of the European Biological Rhythms Society 20.08.2011 Oxford, United Kingdom
41st Annual Conference of the International Society of Psychoneuroendocrinology 04.08.2011 Berlin, Germany
Conference of the European Society for Paediatric Endocrinology 27.05.2011 Berlin, Germany
Science School of the European Society for Paediatric Endocrinology 25.05.2011 Berlin, Germany
3rd World Congress of Chronobiology 05.05.2011 Puebla, Mexico
XI Latin American Symposium of Chronobiology 04.05.2011 Cholula, Mexico
Neurex Meeting 07.04.2011 Basel


Self-organised

Title Date Place
1st Swiss Chronobiology Meeting 06.09.2012 Fribourg
BENEFRI workshop in Neuroscience 18.01.2012 Fribourg, Switzerland

Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Association pour la formation continue dans les professions du laboratoire Western Switzerland 14.01.2013
Talks/events/exhibitions Cafés scientifiques Western Switzerland 07.02.2013
Talks/events/exhibitions 16. Berner Schlafsymposium German-speaking Switzerland 25.10.2012
Media relations: radio, television Arret Cardiac Radio Western Switzerland 02.03.2012
Media relations: radio, television Der Tagesrhythmusforscher Fernsehen German-speaking Switzerland 21.03.2012
Media relations: radio, television Herztod zu Randzeiten Radio German-speaking Switzerland 13.03.2012
New media (web, blogs, podcasts, news feeds etc.) Innere Uhr im Einsatz gegen Hautkrebs Uni Fribourg News Website Western Switzerland 15.11.2011

Awards

Title Year
USGEB Poster Award 2012

Associated projects

Number Title Start Funding scheme
115984 Adaptation mechanisms of the circadian clock to light and temperature 01.04.2007 Project funding (Div. I-III)
133864 Fluorescence-Mediated Tomography (FMT) to study cellular and molecular events in physiology and pathology: application to cancer, cardiovascular and circadian biology 01.02.2011 R'EQUIP
146265 Clock synchronization: From brain to periphery or periphery to brain? 01.04.2013 Project funding (Div. I-III)

Abstract

Life on earth uses the sun as a reference point to time biological processes over the 24 hours of a day. To optimize energy expenditure and uptake a mechanism developed internalizing the cyclic availability of light in the form of the circadian clock. Because the period length of one cycle is circadian (circa diem = about one day) and not exactly 24 hours, the clock needs to be adapted periodically to serve as a reliable predictor of solar time. In this proposal we are interested in adaptation mechanisms of the mammalian circadian clock to changing light and temperature conditions.
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