circadian clock; bonus-of-excellence; Per2; addiction; depression; adaptation
Kowalska E Ripperger JA Hoegger DC Bruegger P Buch T Birchler T Mueller A Albrecht U Contald (2013), NONO couples the circadian clock to the cell cycle, in Proc Natl Acad Sci U S A
, 110(5), 1592-1599.
Ripperger JA Albrecht U (2012), REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology, in Cell Research
, 22(9), 1319-1321.
Carvas Joao, et al. (2012), Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis, in Front. Physiol.
, 3, 337.
Ripperger JA Albrecht U (2012), The circadian clock component PERIOD2: from molecular to cerebral functions, in Prog Brain Res.
, 199, 233-245.
Albrecht Urs (2012), Timing to perfection: The biology of central and peripheral circadian clocks, in Neuron
, 74(2), 246-260.
Jeyaraj Darwin, Scheer Frank A J L, Ripperger Jürgen A, Haldar Saptarsi M, Lu Yuan, Prosdocimo Domenick A, Eapen Sam J, Eapen Betty L, Cui Yingjie, Mahabeleshwar Ganapathi H, Lee Hyoung-Gon, Smith Mark A, Casadesus Gemma, Mintz Eric M, Sun Haipeng, Wang Yibin, Ramsey Kathryn M, Bass Joseph, Shea Steven A, Albrecht Urs, Jain Mukesh K (2012), Klf15 orchestrates circadian nitrogen homeostasis., in Cell metabolism
, 15(3), 311-23.
Jeyaraj Darwin, Haldar Saptarsi M, Wan Xiaoping, McCauley Mark D, Ripperger Jürgen A, Hu Kun, Lu Yuan, Eapen Betty L, Sharma Nikunj, Ficker Eckhard, Cutler Michael J, Gulick James, Sanbe Atsushi, Robbins Jeffrey, Demolombe Sophie, Kondratov Roman V, Shea Steven A, Albrecht Urs, Wehrens Xander H T, Rosenbaum David S, Jain Mukesh K (2012), Circadian rhythms govern cardiac repolarization and arrhythmogenesis., in Nature
, 483(7387), 96-9.
Schmutz I, Albrecht U, Ripperger J A (2012), The role of clock genes and rhythmicity in the liver., in Molecular and cellular endocrinology
, 349(1), 38-44.
Albrecht Urs (2012), Circadian rhythms and sleep--the metabolic connection., in Pflügers Archiv : European journal of physiology
, 463(1), 23-30.
Schmutz Isabelle, Wendt Sabrina, Schnell Anna, Kramer Achim, Mansuy Isabelle M, Albrecht Urs (2011), Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock., in PloS one
, 6(6), 21325-21325.
Albrecht Urs (2011), The circadian clock, reward, and memory., in Frontiers in molecular neuroscience
, 4, 41-41.
Janich P, Pascual G, Merlos-Suarez A, Batlle E, Ripperger J, Albrecht U, Cheng HYM, Obrietan K, Di Croce L, Benitah SA (2011), The circadian molecular clock creates epidermal stem cell heterogeneity, in NATURE
, 480(7376), 209-209.
Dong L, Bilbao A, Laucht M, Henriksson R, Yakovleva T, Ridinger M, Desrivieres S, Clarke TK, Lourdusamy A, Smolka MN, Cichon S, Blomeyer D, Treutlein J, Perreau-Lenz S, Witt S, Leonardi-Essmann F, Wodarz N, Zill P, Soyka M, Albrecht U, Rietschel M, Lathrop M, Bakalkin G, Spanagel R, Schumann G (2011), Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking, in AMERICAN JOURNAL OF PSYCHIATRY
, 168(10), 1090-1098.
Ripperger JA, Jud C, Albrecht U (2011), The daily rhythm of mice, in FEBS LETTERS
, 585(10), 1384-1392.
Daan Serge, Spoelstra Kamiel, Albrecht Urs, Schmutz Isabelle, Daan Moritz, Daan Berte, Rienks Froukje, Poletaeva Inga, Dell'Omo Giacomo, Vyssotski Alexei, Lipp Hans-Peter (2011), Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele., in Journal of biological rhythms
, 26(2), 118-29.
Anna Erzberger Gabriele Hampp Adrian Granada Urs Albrecht and Hanspeter Herzel., Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range, in J. Royal Soc. Interface
Life on earth uses the sun as a reference point to time biological processes over the 24 hours of a day. To optimize energy expenditure and uptake a mechanism developed internalizing the cyclic availability of light in the form of the circadian clock. Because the period length of one cycle is circadian (circa diem = about one day) and not exactly 24 hours, the clock needs to be adapted periodically to serve as a reliable predictor of solar time. In this proposal we are interested in adaptation mechanisms of the mammalian circadian clock to changing light and temperature conditions.