Twist1/2; PKB/Akt; epithelial-mesenchymal transition; metastasis; breast cancer; prostate cancer; glioblastoma multiforme; Protein Kinase (PKB/Akt); transcription factor
Xue Gongda Hemmings Brian (2016), Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling, in Physiological Reviews
Xue Gongda Hemmings Brian (2016), AKT-ions with a TWIST between EMT and MET, in Oncotarget
Xue Gongda Zippelius Alfred Wicki Andreas Mandalà Mario Tang Fengyuan Massi Daniela Hemmings (2015), Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy, in JNCI
Tang Fengyuan, Zhuang Lei, Xue Gongda, Hynx Debby, Wang Yuhua, Cron Peter, Hundsrucker Christian, Hergovich Alexander, Frank Stephan, Hemmings Brian, Schmitz Debora (2014), hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiform, in Cancer Research
Wang Y, Moncayo G, Morin P, Xue G, Grzmil M, Lino M M, Clément-Schatlo V, Frank S, Merlo A, Hemmings B A (2013), Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme, in Oncogene
, 32(7), 872-882.
Xue Gongda, Hemmings A. Brian (2013), PKB/Akt-dependent regulation of cell motility, in J Natl Cancer Inst.
, 105(6), 393-404.
Xue Gongda, Restuccia David F, Lan Qiang, Hynx Debby, Dirnhofer Stephan, Hess Daniel, Rüegg Curzio, Hemmings Brian A (2012), Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes., in Cancer Discovery
, 2(3), 248-259.
Xue Gongda, Hemmings Brian A (2012), Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease., in Biochemical Society transactions
, 40(1), 90-3.
The basic aim of this proposal is to target the PKB signalling pathway in epithelial-mesenchymal transition (EMT) and metastasis.A growing body of the data indicates that PKB signalling pathway plays vital roles in invasive tumor progression. However, the mechanism of the regulation is unclear. In addition to cancer cell line-based studies, we will mainly use animal models of three invasive cancers (breast, prostate and skin cancers) to investigate the PKB singalling-dependent regulation of EMT and metastasis through Twist1 phosphorylation in order to look for more specific therapeutic targets for clinical treatments.