Projekt

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Population genomic survey of genes influencing fitness in a hybrid zone of fire ants

Titel Englisch Population genomic survey of genes influencing fitness in a hybrid zone of fire ants
Gesuchsteller/in Keller Laurent
Nummer 130313
Förderungsinstrument ProDoc (Forschungsmodul, FM)
Forschungseinrichtung Département d'Ecologie et d'Evolution Faculté de Biologie et de Médecine Université de Lausanne
Hochschule Universität Lausanne - LA
Hauptdisziplin Oekologie
Beginn/Ende 01.10.2010 - 31.03.2014
Bewilligter Betrag 216'118.00
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Keywords (3)

adaptation; ant; hybrid zone

Lay Summary (Englisch)

Lead
Lay summary
The aim of the project is to conduct detailed studies of gene and trait associations in a hybrid zone between two invasive fire ant species in the southern U.S.A., Solenopsis invicta and S. richteri. Admixture mapping takes advantage of the presence of highly admixed (introgressed) populations to survey nuclear genomes both for regions under selection in foreign genomic backgrounds and for regions influencing the development of species-specific phenotypic or ecological traits. The proposed studies will provide unprecedented power to address central issues pertaining to the genetic bases of species differences and speciation, the molecular basis of adaptation, and the origin of morphological and ecological novelty in this evolutionarily and economically significant group. The long-term goal is to integrate results from the proposed research with previous genetic, ecological, behavioral, and phylogenetic information to produce new insights into the evolutionary diversification and ecological success of fire ants.
Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Publikationen

Publikation
Molecular and social regulation of worker division of labour in fire ants
Manfredini Fabio, Lucas Christophe, Nicolas Michael, Keller Laurent, Shoemaker Dewayne, Grozinger Christina M. (2014), Molecular and social regulation of worker division of labour in fire ants, in MOLECULAR ECOLOGY, 23(3), 660-672.
A simple genetic basis for complex social behaviour mediates widespread gene expression differences
Nipitwattanaphon Mingkwan, Wang John, Dijkstra Michiel B., Keller Laurent (2013), A simple genetic basis for complex social behaviour mediates widespread gene expression differences, in Molecular Ecology, 22(14), 3797-3813.
Ant genomics sheds light on the molecular regulation of social organization
Libbrecht, Oxley, Kronauer, Keller (2013), Ant genomics sheds light on the molecular regulation of social organization, in Genome Biology, 212-212.
Duplication and concerted evolution in a master sex determiner under balancing selection
Privman Eyal, Wurm Yannick, Keller Laurent (2013), Duplication and concerted evolution in a master sex determiner under balancing selection, in PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 280(1758), 20122968.
Evolution at two levels in fire ants: The relationship between patterns of gene expression and protein sequence evolution
Hunt Brendan G., Ometto Lino, Keller Laurent, Goodisman Michael A D (2013), Evolution at two levels in fire ants: The relationship between patterns of gene expression and protein sequence evolution, in Molecular Biology and Evolution, 30(2), 263-271.
Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality
Simola Daniel F., Wissler Lothar, Donahue Greg, Waterhouse Robert M., Helmkampf Martin, Roux Julien, Nygaard Sanne, Glastad Karl M., Hagen Darren E., Viljakainen Lumi, Reese Justin T., Hunt Brendan G., Graur Dan, Elhaik Eran, Kriventseva Evgenia V., Wen Jiayu, Parker Brian J., Cash Elizabeth I., Privman Eyal, Childers Christopher P., Muñoz-Torres Mónica C., Boomsma Jacobus J., Bornberg-Bauer Erich G., Currie Cameron R., Elsik Christine G. (2013), Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality, in Genome Research, 23(8), 1235-1247.
Sociogenomics of Cooperation and Conflict during Colony Founding in the Fire Ant Solenopsis invicta
Manfredini Fabio, Riba-Grognuz Oksana, Wurm Yannick, Keller Laurent, Shoemaker DeWayne, Grozinger Christina M. (2013), Sociogenomics of Cooperation and Conflict during Colony Founding in the Fire Ant Solenopsis invicta, in PLOS GENETICS, 9(8), e1003633.
The molecular basis of social behavior: models, methods and advances.
LeBoeuf Adria C, Benton Richard, Keller Laurent (2013), The molecular basis of social behavior: models, methods and advances., in Current opinion in neurobiology, 23(1), 3-10.
Vitellogenin Underwent Subfunctionalization to Acquire Caste and Behavioral Specific Expression in the Harvester Ant Pogonomyrmex barbatus
Corona Miguel A., Libbrecht Romain, Wurm Yannick, Riba-Grognuz Oksana, Studer Romain A., Keller Laurent (2013), Vitellogenin Underwent Subfunctionalization to Acquire Caste and Behavioral Specific Expression in the Harvester Ant Pogonomyrmex barbatus, in PLoS Genetics, 9(8), e1003730.
Disruption of gene expression in hybrids of the fire ants Solenopsis invicta and Solenopsis richteri
Ometto L, Ross KG, Shoemaker D, Keller L (2012), Disruption of gene expression in hybrids of the fire ants Solenopsis invicta and Solenopsis richteri, in MOLECULAR ECOLOGY, 21(10), 2488-2501.
Evolution of Gene Expression in Fire Ants: The Effects of Developmental Stage, Caste, and Species
Ometto L, Shoemaker D, Ross KG, Keller L (2011), Evolution of Gene Expression in Fire Ants: The Effects of Developmental Stage, Caste, and Species, in MOLECULAR BIOLOGY AND EVOLUTION, 28(4), 1381-1392.
Relaxed selection is a precursor to the evolution of phenotypic plasticity
Hunt BG, Ometto L, Wurm Y, Shoemaker D, Yi SV, Keller L, Goodisman MAD (2011), Relaxed selection is a precursor to the evolution of phenotypic plasticity, in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(38), 15936-15941.
The genome of the fire ant Solenopsis invicta.
Y. Wurm, J. Wang, O. Riba-Grognuz, M. Corona, S. Nygaard, B.G. Hunt, K.K. Ingram, L. Falquet, M. Nipitwattanaphon, D. Gotzek, M.B. Dijkstra, J. Oettler, F. Comtesse, C.J. Shih, W.J. Wu, C.C. Yang, J. Thomas, E. Beaudoing, S. Pradervand, V. Flegel, E.D. Cook, R. Fabbretti, H. Stockinger, L. Long, W.G. Farmerie (2011), The genome of the fire ant Solenopsis invicta., in Proceedings of the National Academy of Sciences of the United States of America, 108(14), 5679-5684.
Visualization and quality assessment of de novo genome assemblies
O. Riba-Grognuz, L. Keller, L. Falquet, I. Xenarios, Y. Wurm, Visualization and quality assessment of de novo genome assemblies, in Bioinformatics.

Verbundene Projekte

Nummer Titel Start Förderungsinstrument
126393 Population Genomics 01.02.2010 ProDoc (Ausbildungsmodul, AM)
133121 The determinants of social organisation in ants 01.10.2010 Projektförderung (Abt. I-III)
156732 Genetic basis of alternative social organizations in fire ants 01.01.2015 Projektförderung (Abt. I-III)

Abstract

The proposed project will employ the new method of admixture mapping to conduct detailed studies of gene and trait associations in a hybrid zone between two invasive fire ant species in the southern U.S.A., Solenopsis invicta and S. richteri. Admixture mapping takes advantage of the presence of highly admixed (introgressed) populations to survey nuclear genomes both for regions under selection in foreign genomic backgrounds and for regions influencing the development of species-specific phenotypic or ecological traits. Loci with variants that are relatively under- or over-represented in a foreign background mark genes subject to selection in hybrids; negatively selected loci may contribute to the process of speciation or to the maintenance of species differences, whereas positively selected loci may underlie important general adaptations. When such excess ancestry is shown to be associated with variation at known traits, the genetic architecture underlying such variation is revealed, thus informing the genetic basis of phenotypic novelties involved in anagenesis and speciation. Thus, admixture mapping is a useful tool for revealing gene numbers, locations, and effect sizes for a diversity of evolutionarily important traits involved in speciation and adaptation.The five specific objectives of the proposed work are to: 1) Collect and characterize samples for admixture mapping from two localities in the large S. invicta / S. richteri hybrid zone in the U.S.A.; 2) Develop several hundred microsatellite and SNP markers with large allele frequency differentials between the parental species; 3) Conduct admixture mapping on hybrids to identify loci under negative or positive selection; 4) Conduct admixture mapping on hybrids to identify loci affecting morphological traits that distinguish the two species; and 5) Construct a genetic map from hybrid males to reveal linkage relationships of the markers. The availability of relevant genetic resources for fire ants, combined with extensive background knowledge of their biology and history of hybridization, will provide unprecedented power to address central issues pertaining to the genetic bases of species differences and speciation, the molecular basis of adaptation, and the origin of morphological and ecological novelty in this evolutionarily and economically significant group. The long-term goal is to integrate results from the proposed research with previous genetic, ecological, behavioral, and phylogenetic information to produce new insights into the evolutionary diversification and ecological success of fire ants.
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