Emotion, Memory, Amygdala, PTSD, Genetics, Bioinformatics, Humans, Animals, Emotional memory, health, disease, molecular, genetic, psychiatric disease
Ackermann S, Spalek K, Rasch B, Gschwind L, Coynel D, Fastenrath M, Papassotiropoulos A, de Quervain DJF (2012), Testosterone levels in healthy men are related to amygdala reactivity and memory performance, in PSYCHONEUROENDOCRINOLOGY
, 37(9), 1417-1424.
Wilker S, Pfeiffer A, Kolassa S, Elbert T, Lingenfelder B, Ovuga E, Papassotiropoulos A, de Quervain D, Kolassa I-T (2014), The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder., in Translational psychiatry
, 4, 403-403.
Luksys Gediminas, Ackermann Sandra, Coynel David, Fastenrath Matthias, Gschwind Leo, Heck Angela, Rasch Bjoern, Spalek Klara, Vogler Christian, Papassotiropoulos Andreas, de Quervain Dominique (2014), BAIAP2 is related to emotional modulation of human memory strength., in PloS one
, 9(1), 83707-83707.
Heck Angela, Vogler Christian, Gschwind Leo, Ackermann Sandra, Auschra Bianca, Spalek Klara, Rasch Björn, de Quervain Dominique, Papassotiropoulos Andreas (2011), Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory., in PloS one
, 6(12), 29337-29337.
Hadziselimovic Nils, Vukojevic Vanja, Peter Fabian, Milnik Annette, Fastenrath Matthias, Fenyves Bank Gabor, Hieber Petra, Demougin Philippe, Vogler Christian, de Quervain Dominique J-F, Papassotiropoulos Andreas, Stetak Attila (2014), Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex., in Cell
, 156(6), 1153-66.
Heck Angela, Fastenrath Matthias, Ackermann Sandra, Auschra Bianca, Bickel Horst, Coynel David, Gschwind Leo, Jessen Frank, Kaduszkiewicz Hanna, Maier Wolfgang, Milnik Annette, Pentzek Michael, Riedel-Heller Steffi G, Ripke Stephan, Spalek Klara, Sullivan Patrick, Vogler Christian, Wagner Michael, Weyerer Siegfried, Wolfsgruber Steffen, de Quervain Dominique J-F, Papassotiropoulos Andreas (2014), Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity., in Neuron
, 81(5), 1203-13.
Papassotiropoulos Andreas, Gerhards Christiane, Heck Angela, Ackermann Sandra, Aerni Amanda, Schicktanz Nathalie, Auschra Bianca, Demougin Philippe, Mumme Eva, Elbert Thomas, Ertl Verena, Gschwind Leo, Hanser Edveena, Huynh Kim-Dung, Jessen Frank, Kolassa Iris-Tatjana, Milnik Annette, Paganetti Paolo, Spalek Klara, Vogler Christian, Muhs Andreas, Pfeifer Andrea, de Quervain Dominique J-F (2013), Human genome-guided identification of memory-modulating drugs., in Proceedings of the National Academy of Sciences of the United States of America
, 110(46), 4369-74.
Wilker Sarah, Kolassa Stephan, Vogler Christian, Lingenfelder Birke, Elbert Thomas, Papassotiropoulos Andreas, de Quervain Dominique J-F, Kolassa Iris-Tatjana (2013), The role of memory-related gene WWC1 (KIBRA) in lifetime posttraumatic stress disorder: evidence from two independent samples from African conflict regions., in Biological psychiatry
, 74(9), 664-71.
Vukojevic V, Gschwind L, Vogler C, Demougin P, de Quervain DJF, Papassotiropoulos A, Stetak A (2012), A role for alpha-adducin (ADD-1) in nematode and human memory, in EMBO JOURNAL
, 31(6), 1453-1466.
de Quervain DJF, Kolassa IT, Ackermann S, Aerni A, Boesiger P, Demougin P, Elbert T, Ertl V, Gschwind L, Hadziselimovic N, Hanser E, Heck A, Hieber P, Huynh KD, Klarhofer M, Luechinger R, Rasch B, Scheffler K, Spalek K, Stippich C, Vogler C, Vukojevic V, Stetak A, Papassotiropoulos A (2012), PKC alpha is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors, in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
, 109(22), 8746-8751.
Milnik Annette, Heck Angela, Vogler Christian, Heinze Hans-Jochen, de Quervain Dominique J-F, Papassotiropoulos Andreas (2012), Association of KIBRA with episodic and working memory: A meta-analysis., in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication o
, 159B(8), 958-69.
Ackermann Sandra, Heck Angela, Rasch Björn, Papassotiropoulos Andreas, de Quervain Dominique J-F (accepted), The BclI polymorphism of the glucocorticoid receptor gene is associated with emotional memory performance in healthy individuals., in Psychoneuroendocrinology
Mata R, Hau R, Papassotiropoulos A, Hertwig R (accepted), DAT1 Polymorphism Is Associated with Risk Taking in the Balloon Analogue Risk Task (BART), in PLOS ONE
Heck A, Vogler C, Gschwind L, Ackermann S, Auschra B, Spalek K, Rasch B, de Quervain D, Papassotiropoulos A (accepted), Statistical Epistasis and Functional Brain Imaging Support a Role of Voltage-Gated Potassium Channels in Human Memory, in PLOS ONE
Emotionally arousing events are typically well remembered. This is a highly adaptive phenomenon, which helps us to remember both dangerous and favorable situations. Under certain conditions, however, this mechanism can also lead to intrusive and persistent traumatic and fearful memories of an aversive event, thereby contributing to the development and symptoms of anxiety disorders, such as phobia or posttraumatic stress disorder.
The aim of the present proposal is to better understand the molecular genetic basis of emotional memory in health and disease. Using a translational approach which links cognitive/emotional and molecular neuroscience to computational biology, we plan to identify genetic clusters and regulatory gene networks underlying emotional memory processes. We will employ emotional memory tasks that engage the amygdala both in animals and humans allowing for direct comparison across species and for translating to disease states with altered amygdala function.
Both targeted and genome-wide genetic analyses and imaging genetics studies will be performed in healthy and diseased human populations. Gene regulation will be studied at high resolution by transcriptomics in animals under different experimental conditions, at the level of defined neuronal subpopulations and circuits. Advanced bioinformatics methods will be used to generate testable hypotheses, identify the underlying genetic pathways and networks and define fundamental patterns of gene interactions.
By integrating cognitive/emotional and molecular neuroscience in animals and humans by computational approaches, this project will substantially and uniquely increase our knowledge about the molecular genetic physiology and pathophysiology of neuronal circuits and networks underlying emotional memory. Ultimately, this knowledge will be crucial for the development of diagnostic and new therapeutic approaches for diseases related to disturbed emotional memory.