Projekt

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Emotional Memory in Health and Disease

Titel Englisch Emotional Memory in Health and Disease
Gesuchsteller/in De Quervain Dominique
Nummer 130080
Förderungsinstrument Sinergia
Forschungseinrichtung Kognitive Neurowissenschaften Universität Basel
Hochschule Universität Basel - BS
Hauptdisziplin Neurophysiologie und Hirnforschung
Beginn/Ende 01.10.2010 - 30.04.2014
Bewilligter Betrag 2'200'000.00
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Keywords (14)

Emotion, Memory, Amygdala, PTSD, Genetics, Bioinformatics, Humans, Animals, Emotional memory, health, disease, molecular, genetic, psychiatric disease

Lay Summary (Englisch)

Lead
Lay summary
Emotionally arousing events are typically well remembered. This is a highly adaptive phenomenon, which helps us to remember both dangerous and favorable situations. Under certain conditions, however, this mechanism can also lead to intrusive and persistent traumatic and fearful memories of an aversive event, thereby contributing to the development and symptoms of anxiety disorders, such as phobia or posttraumatic stress disorder. The aim of the present proposal is to better understand the molecular genetic basis of emotional memory in health and disease. Using a translational approach which links cognitive/emotional and molecular neuroscience to computational biology, we plan to identify genetic clusters and regulatory gene networks underlying emotional memory processes. We will employ emotional memory tasks that engage the amygdala both in animals and humans allowing for direct comparison across species and for translating to disease states with altered amygdala function. Both targeted and genome-wide genetic analyses and imaging genetics studies will be performed in healthy and diseased human populations. Gene regulation will be studied at high resolution by transcriptomics in animals under different experimental conditions, at the level of defined neuronal subpopulations and circuits. Advanced bioinformatics methods will be used to generate testable hypotheses, identify the underlying genetic pathways and networks and define fundamental patterns of gene interactions. This project is aimed to increase our knowledge about the molecular genetic physiology and pathophysiology of neuronal circuits and networks underlying emotional memory. Ultimately, this knowledge will be crucial for the development of diagnostic and new therapeutic approaches for diseases related to disturbed emotional memory.
Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Publikationen

Publikation
Testosterone levels in healthy men are related to amygdala reactivity and memory performance
Ackermann S, Spalek K, Rasch B, Gschwind L, Coynel D, Fastenrath M, Papassotiropoulos A, de Quervain DJF (2012), Testosterone levels in healthy men are related to amygdala reactivity and memory performance, in PSYCHONEUROENDOCRINOLOGY, 37(9), 1417-1424.
The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder.
Wilker S, Pfeiffer A, Kolassa S, Elbert T, Lingenfelder B, Ovuga E, Papassotiropoulos A, de Quervain D, Kolassa I-T (2014), The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder., in Translational psychiatry, 4, 403-403.
BAIAP2 is related to emotional modulation of human memory strength.
Luksys Gediminas, Ackermann Sandra, Coynel David, Fastenrath Matthias, Gschwind Leo, Heck Angela, Rasch Bjoern, Spalek Klara, Vogler Christian, Papassotiropoulos Andreas, de Quervain Dominique (2014), BAIAP2 is related to emotional modulation of human memory strength., in PloS one, 9(1), 83707-83707.
Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory.
Heck Angela, Vogler Christian, Gschwind Leo, Ackermann Sandra, Auschra Bianca, Spalek Klara, Rasch Björn, de Quervain Dominique, Papassotiropoulos Andreas (2011), Statistical epistasis and functional brain imaging support a role of voltage-gated potassium channels in human memory., in PloS one, 6(12), 29337-29337.
Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex.
Hadziselimovic Nils, Vukojevic Vanja, Peter Fabian, Milnik Annette, Fastenrath Matthias, Fenyves Bank Gabor, Hieber Petra, Demougin Philippe, Vogler Christian, de Quervain Dominique J-F, Papassotiropoulos Andreas, Stetak Attila (2014), Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex., in Cell, 156(6), 1153-66.
Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity.
Heck Angela, Fastenrath Matthias, Ackermann Sandra, Auschra Bianca, Bickel Horst, Coynel David, Gschwind Leo, Jessen Frank, Kaduszkiewicz Hanna, Maier Wolfgang, Milnik Annette, Pentzek Michael, Riedel-Heller Steffi G, Ripke Stephan, Spalek Klara, Sullivan Patrick, Vogler Christian, Wagner Michael, Weyerer Siegfried, Wolfsgruber Steffen, de Quervain Dominique J-F, Papassotiropoulos Andreas (2014), Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity., in Neuron, 81(5), 1203-13.
Human genome-guided identification of memory-modulating drugs.
Papassotiropoulos Andreas, Gerhards Christiane, Heck Angela, Ackermann Sandra, Aerni Amanda, Schicktanz Nathalie, Auschra Bianca, Demougin Philippe, Mumme Eva, Elbert Thomas, Ertl Verena, Gschwind Leo, Hanser Edveena, Huynh Kim-Dung, Jessen Frank, Kolassa Iris-Tatjana, Milnik Annette, Paganetti Paolo, Spalek Klara, Vogler Christian, Muhs Andreas, Pfeifer Andrea, de Quervain Dominique J-F (2013), Human genome-guided identification of memory-modulating drugs., in Proceedings of the National Academy of Sciences of the United States of America, 110(46), 4369-74.
The role of memory-related gene WWC1 (KIBRA) in lifetime posttraumatic stress disorder: evidence from two independent samples from African conflict regions.
Wilker Sarah, Kolassa Stephan, Vogler Christian, Lingenfelder Birke, Elbert Thomas, Papassotiropoulos Andreas, de Quervain Dominique J-F, Kolassa Iris-Tatjana (2013), The role of memory-related gene WWC1 (KIBRA) in lifetime posttraumatic stress disorder: evidence from two independent samples from African conflict regions., in Biological psychiatry, 74(9), 664-71.
A role for alpha-adducin (ADD-1) in nematode and human memory
Vukojevic V, Gschwind L, Vogler C, Demougin P, de Quervain DJF, Papassotiropoulos A, Stetak A (2012), A role for alpha-adducin (ADD-1) in nematode and human memory, in EMBO JOURNAL, 31(6), 1453-1466.
PKC alpha is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors
de Quervain DJF, Kolassa IT, Ackermann S, Aerni A, Boesiger P, Demougin P, Elbert T, Ertl V, Gschwind L, Hadziselimovic N, Hanser E, Heck A, Hieber P, Huynh KD, Klarhofer M, Luechinger R, Rasch B, Scheffler K, Spalek K, Stippich C, Vogler C, Vukojevic V, Stetak A, Papassotiropoulos A (2012), PKC alpha is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors, in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(22), 8746-8751.
Association of KIBRA with episodic and working memory: A meta-analysis.
Milnik Annette, Heck Angela, Vogler Christian, Heinze Hans-Jochen, de Quervain Dominique J-F, Papassotiropoulos Andreas (2012), Association of KIBRA with episodic and working memory: A meta-analysis., in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication o, 159B(8), 958-69.
The BclI polymorphism of the glucocorticoid receptor gene is associated with emotional memory performance in healthy individuals.
Ackermann Sandra, Heck Angela, Rasch Björn, Papassotiropoulos Andreas, de Quervain Dominique J-F (accepted), The BclI polymorphism of the glucocorticoid receptor gene is associated with emotional memory performance in healthy individuals., in Psychoneuroendocrinology.
DAT1 Polymorphism Is Associated with Risk Taking in the Balloon Analogue Risk Task (BART)
Mata R, Hau R, Papassotiropoulos A, Hertwig R (accepted), DAT1 Polymorphism Is Associated with Risk Taking in the Balloon Analogue Risk Task (BART), in PLOS ONE, 7(6).
Statistical Epistasis and Functional Brain Imaging Support a Role of Voltage-Gated Potassium Channels in Human Memory
Heck A, Vogler C, Gschwind L, Ackermann S, Auschra B, Spalek K, Rasch B, de Quervain D, Papassotiropoulos A (accepted), Statistical Epistasis and Functional Brain Imaging Support a Role of Voltage-Gated Potassium Channels in Human Memory, in PLOS ONE, 6(12).

Wissenschaftliche Veranstaltungen

Aktiver Beitrag

Titel Art des Beitrags Titel des Artikels oder Beitrages Datum Ort Beteiligte Personen
APS Presidential Symposium Vortrag im Rahmen einer Tagung Stress, Genes, and Memory: From Basic Mechanisms to Clinical Implications 23.05.2014 San Francisco, Vereinigte Staaten von Amerika De Quervain Dominique


Selber organisiert

Titel Datum Ort
Symposium: Stress, Emotions & Memory 28.03.2014 Basel, Schweiz
Frontiers in Stress and Cognition: From Molecules to Behavior 23.09.2012 Ascona, Schweiz

Auszeichnungen

Titel Jahr
Die Stiftung Prof. Dr. Max Cloëtta zeichnet in diesem Jahr zwei an der Universität Basel tätige Neurowissenschaftler aus: Prof. Andreas Papassotiropoulos und Prof. Dominique de Quervain erhalten den mit 50‘000 Franken dotierten Preis für ihre herausragenden Forschung zu den neurobiologischen und molekularen Mechanismen des menschlichen Gedächtnisses. 2012

Verbundene Projekte

Nummer Titel Start Förderungsinstrument
149722 Dis-inhibitory amygdala circuits in fear conditioning and extinction 01.10.2013 Projektförderung (Abt. I-III)
133137 Controlling fear: function and plasticity of inhibitory circuits in the amygdala 01.10.2010 Projektförderung (Abt. I-III)

Abstract

Emotionally arousing events are typically well remembered. This is a highly adaptive phenomenon, which helps us to remember both dangerous and favorable situations. Under certain conditions, however, this mechanism can also lead to intrusive and persistent traumatic and fearful memories of an aversive event, thereby contributing to the development and symptoms of anxiety disorders, such as phobia or posttraumatic stress disorder. The aim of the present proposal is to better understand the molecular genetic basis of emotional memory in health and disease. Using a translational approach which links cognitive/emotional and molecular neuroscience to computational biology, we plan to identify genetic clusters and regulatory gene networks underlying emotional memory processes. We will employ emotional memory tasks that engage the amygdala both in animals and humans allowing for direct comparison across species and for translating to disease states with altered amygdala function. Both targeted and genome-wide genetic analyses and imaging genetics studies will be performed in healthy and diseased human populations. Gene regulation will be studied at high resolution by transcriptomics in animals under different experimental conditions, at the level of defined neuronal subpopulations and circuits. Advanced bioinformatics methods will be used to generate testable hypotheses, identify the underlying genetic pathways and networks and define fundamental patterns of gene interactions. By integrating cognitive/emotional and molecular neuroscience in animals and humans by computational approaches, this project will substantially and uniquely increase our knowledge about the molecular genetic physiology and pathophysiology of neuronal circuits and networks underlying emotional memory. Ultimately, this knowledge will be crucial for the development of diagnostic and new therapeutic approaches for diseases related to disturbed emotional memory.