small angle x-ray scattering; self-assembly; biomaterials; nanoparticles; microfluidics; soft matter
Hermes Jens Peter, Sander Fabian, Fluch Ulrike, Peterle Torsten, Thompson Damien, Urbani Raphael, Pfohl Thomas, Mayor Marcel (2012), Monofunctionalized Gold Nanoparticles Stabilized by a Single Dendrimer Form Dumbbell Structures upon Homocoupling, in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
, 134(36), 14674-14677.
Hermes Jens Peter, Sander Fabian, Peterle Torsten, Urbani Raphael, Pfohl Thomas, Thompson Damien, Mayor Marcel (2011), Gold Nanoparticles Stabilized by Thioether Dendrimers, in CHEMISTRY-A EUROPEAN JOURNAL
, 17(48), 13473-13481.
Braun Joerg, Bruns Nico, Pfohl Thomas, Meier Wolfgang (2011), Phase Behavior of Vesicle-Forming Block Copolymers in Aqueous Solutions, in MACROMOLECULAR CHEMISTRY AND PHYSICS
, 212(12), 1245-1254.
Kinahan Michelle E., Filippidi Emmanouela, Koester Sarah, Hu Xiao, Evans Heather M., Pfohl Thomas, Kaplan David L., Wong Joyce (2011), Tunable Silk: Using Microfluidics to Fabricate Silk Fibers with Controllable Properties, in BIOMACROMOLECULES
, 12(5), 1504-1511.
Hermes Jens P., Sander Fabian, Peterle Torsten, Cioffi Carla, Ringler Philippe, Pfohl Thomas, Mayor Marcel (2011), Direct Control of the Spatial Arrangement of Gold Nanoparticles in Organic-Inorganic Hybrid Superstructures, in SMALL
, 7(7), 920-929.
The hierarchical self-organization of biomolecules in cells and tissues is one of the most fascinating phenomena in life science. Therefore, great efforts are devoted to understand the dynamics of the self-organization processes as well as to mimic these biological systems. Microfluidic techniques provide an opportunity to study the complexity of the hierarchical structural assembly and to generate models, which reproduce biological processes in vitro. The marriage of scanning small angle X-ray scattering and state of the art microfluidic technologies enables time dependent studies of self-assembly, bundling, and network formation of DNA, DNA/(artificial) protein complexes, proteins of the cytoskeleton and extracellular matrix on a molecular as well as on a mesoscopic scale. The X-ray instrument “Nanostar” from Bruker, for which we request funding, will facilitate us to develop this microfluidic-based platform for unique experiments on these soft materials within the Chemistry Department, University of Basel. This powerful new tool shall be also used to shed light on the dynamics of the hierarchical self-assembly of hybrid protein networks, functionalized nanoparticles in supramolecular hybridstructures, structure and dynamics of block copolymer micelles and vesicles, and studies on nano- and microscale functional materials.