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Preventing viral exacerbation of chronic obstructive pulmonary disease in upper respiratory tract infection - The PREVENT study

English title Preventing viral exacerbation of chronic obstructive pulmonary disease in upper respiratory tract infection - The PREVENT study
Applicant Stolz Daiana
Number 128412
Funding scheme SNSF Professorships
Research institution Abteilung für Pneumologie Medizinische Universitätsklinik A Universitätsspital Basel
Institution of higher education University of Basel - BS
Main discipline Internal Medicine
Start/End 01.02.2011 - 31.01.2015
Approved amount 1'336'214.00
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All Disciplines (2)

Discipline
Internal Medicine
Respiratory Diseases

Keywords (7)

COPD; exacerbation; viral infection; bacterial infection; inflammatory markers; airway remodelling; common cold

Lay Summary (English)

Lead
Lay summary
Aims: A) To explore the role of different viral infections in exacerbations of COPD and its influence on bacterial co-infection, local and systemic inflammation, airway remodelling and systemic repercussions in patients with COPD; B) To evaluate whether intensified combination therapy with inhaled corticosteroids and long-acting ?2-agonists at the onset of upper respiratory tract infection symptoms as compared to placebo decreases the incidence of exacerbation of COPD in patients receiving low maintenance dose inhaled corticosteroids/long-acting ?2-agonists, thus reducing disease associated morbidity.Significance: Exacerbations are associated with significant morbidity, mortality and health-care associated costs. Therefore, there is an urgent need to develop novel therapeutic strategies to optimize management of COPD and associated co-morbidities. At present, with the exception of influenza vaccination, there are no interventions available that specifically target viral induced infection in an attempt to reduce the prevalence and effects of exacerbations in COPD. By preventing exacerbations, the patient-driven management approach investigated in this trial might improve quality of life and reduce costs associated with COPD in spite of preserving patients' autonomy. The integrated and subsidiary projects related to the main study will provide a decisive improvement in the characterization of viral- and bacterial induced exacerbation, airway inflammation as well as remodelling mechanisms and their systemic repercussions in COPD. Scientific Frame & Methodology: Investigator-initiated and driven, double-blind randomized multinational trial. Patients with stable COPD will be included and randomized 1:1 either to intensified combination therapy with inhaled corticosteroid/ corticosteroid and long-acting ?2-agonists or to placebo. Randomization will be stratified by center. In addition, 8 integrated and subsidiary projects evaluating the domains of infection, inflammation, airway remodelling and systemic repercussions are associated with the main study. Setting: Teaching hospitals in several European countries including Switzerland, Italy, and The Netherlands. Patients: Age ? 40 years, smoking history ? 10 pack-years and moderate to very severe stable COPD (GOLD II-IV without exacerbation for ? 4 weeks), history of severe exacerbation in previous year. Excluded are patients with pulmonary conditions other than COPD as the main respiratory disease; rapid lethal disease, severe immunosuppression; known allergy or intolerance to the study medication; pregnancy.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Time-course of upper respiratory tract viral infection and COPD exacerbation
Stolz Daiana, Papakonstantinou Eleni, Grize Leticia, Schilter Daniel, Strobel Werner, Louis Renaud, Schindler Christian, Hirsch Hans H., Tamm Michael (2019), Time-course of upper respiratory tract viral infection and COPD exacerbation, in European Respiratory Journal, 1900407-1900407.
Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective.
Schuetz Philipp, Balk Robert, Briel Matthias, Kutz Alexander, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Mueller Beat, Lacey Michael J, Ohsfeldt Robert L, Scheibling Cara M, Schneider John E (2015), Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective., in Clinical chemistry and laboratory medicine : CCLM / FESCC, 53(4), 583-92.
Prognostic value of procalcitonin in respiratory tract infections across clinical settings.
Kutz Alexander, Briel Matthias, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Mueller Beat, Schuetz Philipp (2015), Prognostic value of procalcitonin in respiratory tract infections across clinical settings., in Critical care (London, England), 19(1), 74-74.
Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index.
Stolz Daiana, Kostikas Kostantinos, Blasi Francesco, Boersma Wim, Milenkovic Branislava, Lacoma Alicia, Louis Renaud, Aerts Joachim G, Welte Tobias, Torres Antoni, Rohde Gernot G U, Boeck Lucas, Rakic Janko, Scherr Andreas, Hertel Sabine, Giersdorf Sven, Tamm Michael (2014), Adrenomedullin refines mortality prediction by the BODE index in COPD: the "BODE-A" index., in The European respiratory journal, 43(2), 397-408.
Ampicillin/sulbactam in elderly patients with community-acquired pneumonia.
Majcher-Peszynska J, Loebermann M, Klammt S, Frimmel S, Mundkowski R G, Welte T, Reisinger E C, Drewelow B, CAPNETZ Study Group (2014), Ampicillin/sulbactam in elderly patients with community-acquired pneumonia., in Infection, 42(1), 79-87.
Association of adrenal function and disease severity in community-acquired pneumonia.
Mueller Cornelia, Blum Claudine A, Trummler Michael, Stolz Daiana, Bingisser Roland, Mueller Christian, Tamm Michael, Mueller Beat, Schuetz Philipp, Christ-Crain Mirjam (2014), Association of adrenal function and disease severity in community-acquired pneumonia., in PloS one, 9(6), 99518-99518.
Detection of respiratory viruses using a multiplex real-time PCR assay in Germany, 2009/10.
Bierbaum Sibylle, Forster Johannes, Berner Reinhard, Rücker Gerta, Rohde Gernot, Neumann-Haefelin Dieter, Panning Marcus, CAPNETZ study group (2014), Detection of respiratory viruses using a multiplex real-time PCR assay in Germany, 2009/10., in Archives of virology, 159(4), 669-76.
Effect of a smoking ban on respiratory health in nonsmoking hospitality workers: a prospective cohort study.
Rajkumar Sarah, Stolz Daiana, Hammer Jürg, Moeller Alexander, Bauer Georg F, Huynh Cong Khanh, Röösli Martin (2014), Effect of a smoking ban on respiratory health in nonsmoking hospitality workers: a prospective cohort study., in Journal of occupational and environmental medicine / American College of Occupational and Environmen, 56(10), 86-91.
Galactomannan in bronchoalveolar lavage for diagnosing invasive fungal disease.
Affolter Kristina, Tamm Michael, Jahn Kathleen, Halter Jörg, Passweg Jakob, Hirsch Hans H, Stolz Daiana (2014), Galactomannan in bronchoalveolar lavage for diagnosing invasive fungal disease., in American journal of respiratory and critical care medicine, 190(3), 309-17.
Mortality risk prediction in COPD by a prognostic biomarker panel.
Stolz Daiana, Meyer Anja, Rakic Janko, Boeck Lucas, Scherr Andreas, Tamm Michael (2014), Mortality risk prediction in COPD by a prognostic biomarker panel., in The European respiratory journal, 44(6), 1557-70.
Predictors of success for smoking cessation at the workplace: a longitudinal study.
Stolz Daiana, Scherr Andreas, Seiffert Bruno, Kuster Martin, Meyer Anja, Fagerström Karl-Olov, Tamm Michael (2014), Predictors of success for smoking cessation at the workplace: a longitudinal study., in Respiration; international review of thoracic diseases, 87(1), 18-25.
Propofol sedation for flexible bronchoscopy: a randomised, noninferiority trial.
Grendelmeier Peter, Tamm Michael, Pflimlin Eric, Stolz Daiana (2014), Propofol sedation for flexible bronchoscopy: a randomised, noninferiority trial., in The European respiratory journal, 43(2), 591-601.
Propofol versus midazolam in medical thoracoscopy: a randomized, noninferiority trial.
Grendelmeier Peter, Tamm Michael, Jahn Kathleen, Pflimlin Eric, Stolz Daiana (2014), Propofol versus midazolam in medical thoracoscopy: a randomized, noninferiority trial., in Respiration; international review of thoracic diseases, 88(2), 126-36.
Atherogenesis in youth - Early consequence of adolescent smoking
Dratva Julia, Probst-Hensch Nicole M., Schmidt-Trücksäss Arno, Caviezel Seraina, De Groot Eric, Bettschart Robert W., Saleh Lanja, Gapoz Jean Michel, Rothe Thomas, Schindler Christian, Stolz Daiana Prestes, Turk Alexander J., Rochat Thierry S., Kuenzli Nino, Zemp Elisabeth (2013), Atherogenesis in youth - Early consequence of adolescent smoking, in Atherosclerosis, 230(2), 304-309.
Diagnosis and management of chronic obstructive pulmonary disease: the swiss guidelines. Official guidelines of the swiss respiratory society.
Russi E W, Karrer W, Brutsche M, Eich C, Fitting J W, Frey M, Geiser T, Kuhn M, Nicod L, Quadri F, Rochat T, Steurer-Stey C, Stolz D (2013), Diagnosis and management of chronic obstructive pulmonary disease: the swiss guidelines. Official guidelines of the swiss respiratory society., in Respiration; international review of thoracic diseases, 85(2), 160-74.
European COPD Audit: design, organisation of work and methodology.
López-Campos Jose Luis, Hartl Sylvia, Pozo-Rodriguez Francisco, Roberts C Michael, European COPD Audit team (2013), European COPD Audit: design, organisation of work and methodology., in The European respiratory journal, 41(2), 270-6.
European hospital adherence to GOLD recommendations for chronic obstructive pulmonary disease (COPD) exacerbation admissions.
Roberts C Michael, Lopez-Campos Jose Luis, Pozo-Rodriguez Francisco, Hartl Sylvia, European COPD Audit team (2013), European hospital adherence to GOLD recommendations for chronic obstructive pulmonary disease (COPD) exacerbation admissions., in Thorax, 68(12), 1169-71.
Outcomes in females hospitalised with community-acquired pneumonia are worse than in males.
Arnold Forest W, Wiemken Timothy L, Peyrani Paula, Mirsaeidi Mehdi, Ramirez Julio A, Community Acquired Pneumonia Organization (CAPO) Study Group (2013), Outcomes in females hospitalised with community-acquired pneumonia are worse than in males., in The European respiratory journal, 41(5), 1135-40.
Pancreatic stone protein predicts positive sputum bacteriology in exacerbations of COPD.
Scherr Andreas, Graf Rolf, Bain Martha, Christ-Crain Mirjam, Müller Beat, Tamm Michael, Stolz Daiana (2013), Pancreatic stone protein predicts positive sputum bacteriology in exacerbations of COPD., in Chest, 143(2), 379-87.
Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.
Schuetz Philipp, Müller Beat, Christ-Crain Mirjam, Stolz Daiana, Tamm Michael, Bouadma Lila, Luyt Charles E, Wolff Michel, Chastre Jean, Tubach Florence, Kristoffersen Kristina B, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Wei Long, Bhatnagar Neera, Bucher Heiner C, Briel Matthias (2013), Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections., in Evidence-based child health : a Cochrane review journal, 8(4), 1297-371.
Serum bilirubin is associated with lung function in a Swiss general population sample.
Curjuric Ivan, Imboden Medea, Adam Martin, Bettschart Robert W, Gerbase Margaret W, Künzli Nino, Rochat Thierry, Rohrer Lucia, Rothe Thomas B, Schwartz Joel, Stolz Daiana, Tschopp Jean-Marie, von Eckardstein Arnold, Kronenberg Florian, Probst-Hensch Nicole M (2013), Serum bilirubin is associated with lung function in a Swiss general population sample., in The European respiratory journal, epub.
Systemic Biomarkers in the Evaluation and Management of COPD Patients: Are We Getting Closer to Clinical Application?
Kostikas Konstantinos, Bakakos Petros, Papiris Spyros, Stolz Daiana, Celli Bartolome R (2013), Systemic Biomarkers in the Evaluation and Management of COPD Patients: Are We Getting Closer to Clinical Application?, in Current drug targets, 14(2), 177-91.
Water pipe smoking and its association with cigarette and cannabis use in young adults in Switzerland.
Albisser Silvio, Schmidlin Jérome, Schindler Christian, Tamm Michael, Stolz Daiana (2013), Water pipe smoking and its association with cigarette and cannabis use in young adults in Switzerland., in Respiration; international review of thoracic diseases, 86(3), 210-5.
A combined cardiorenal assessment for the prediction of acute kidney injury in lower respiratory tract infections.
Breidthardt Tobias, Christ-Crain Mirjam, Stolz Daiana, Bingisser Roland, Drexler Beatrice, Klima Theresia, Balmelli Catharina, Schuetz Philipp, Haaf Philip, Schärer Michael, Tamm Michael, Müller Beat, Müller Christian (2012), A combined cardiorenal assessment for the prediction of acute kidney injury in lower respiratory tract infections., in The American journal of medicine, 125(2), 168-75.
A combined cardiorenal assessment for the prediction of acute kidney injury in lower respiratory tract infections.
Breidthardt Tobias, Christ-Crain Mirjam, Stolz Daiana, Bingisser Roland, Drexler Beatrice, Klima Theresia, Balmelli Catharina, Schuetz Philipp, Haaf Philip, Schärer Michael, Tamm Michael, Müller Beat, Müller Christian (2012), A combined cardiorenal assessment for the prediction of acute kidney injury in lower respiratory tract infections., in The American journal of medicine, 125(2), 168-75.
Acute effects of aerosolized iloprost in COPD related pulmonary hypertension - a randomized controlled crossover trial.
Boeck Lucas, Tamm Michael, Grendelmeier Peter, Stolz Daiana (2012), Acute effects of aerosolized iloprost in COPD related pulmonary hypertension - a randomized controlled crossover trial., in PloS one, 7(12), 52248-52248.
Acute respiratory health effects of urban air pollutants in adults with different patterns of underlying respiratory disease.
Mehta A J, Schindler C, Perez L, Probst-Hensch N, Schwartz J, Brändl O, Karrer W, Tschopp J M, Rochat T, Künzli N, SAPALDIA Team (2012), Acute respiratory health effects of urban air pollutants in adults with different patterns of underlying respiratory disease., in Swiss medical weekly, 142, 13681-13681.
Aquarism: an innocent leisure activity? Palytoxin-induced acute pneumonitis.
Bernasconi M, Berger D, Tamm M, Stolz D (2012), Aquarism: an innocent leisure activity? Palytoxin-induced acute pneumonitis., in Respiration; international review of thoracic diseases, 84(5), 436-9.
Aspergillus-PCR in bronchoalveolar lavage for detection of invasive pulmonary aspergillosis in immunocompromised patients.
Buess Michael, Cathomas Gieri, Halter Jörg, Junker Lilian, Grendelmeier Peter, Tamm Michael, Stolz Daiana (2012), Aspergillus-PCR in bronchoalveolar lavage for detection of invasive pulmonary aspergillosis in immunocompromised patients., in BMC infectious diseases, 12, 237-237.
Enhanced didactic methods of smoking cessation training for medical students--a randomized study.
Stolz Daiana, Langewitz Wolf, Meyer Anja, Pierer Karen, Tschudi Peter, S'ng Ching T, Strobel Werner, Perruchoud André P, Fagerström Karl, Tamm Michael (2012), Enhanced didactic methods of smoking cessation training for medical students--a randomized study., in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 14(2), 224-8.
Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults.
Mehta Amar J, Miedinger David, Keidel Dirk, Bettschart Robert, Bircher Andreas, Bridevaux Pierre-Olivier, Curjuric Ivan, Kromhout Hans, Rochat Thierry, Rothe Thomas, Russi Erich W, Schikowski Tamara, Schindler Christian, Schwartz Joel, Turk Alexander, Vermeulen Roel, Probst-Hensch Nicole, Künzli Nino, SAPALDIA Team (2012), Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults., in American journal of respiratory and critical care medicine, 185(12), 1292-300.
Presentation, etiology and outcome of pneumonia in younger nursing home residents.
Klapdor Benjamin, Ewig Santiago, Schaberg Tom, Rohde Gernot, Pletz Mathias W, Schütte Hartwig, Welte Tobias, CAPNETZ study group (2012), Presentation, etiology and outcome of pneumonia in younger nursing home residents., in The Journal of infection, 65(1), 32-8.
Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis.
Schuetz Philipp, Briel Matthias, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Mueller Beat (2012), Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 55(5), 651-62.
Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis.
Schuetz Philipp, Briel Matthias, Christ-Crain Mirjam, Stolz Daiana, Bouadma Lila, Wolff Michel, Luyt Charles-Edouard, Chastre Jean, Tubach Florence, Kristoffersen Kristina B, Wei Long, Burkhardt Olaf, Welte Tobias, Schroeder Stefan, Nobre Vandack, Tamm Michael, Bhatnagar Neera, Bucher Heiner C, Mueller Beat (2012), Procalcitonin to guide initiation and duration of antibiotic treatment in acute respiratory infections: an individual patient data meta-analysis., in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 55(5), 651-62.
Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study.
Lepper Philipp M, Ott Sebastian, Nüesch Eveline, von Eynatten Maximilian, Schumann Christian, Pletz Mathias W, Mealing Nicole M, Welte Tobias, Bauer Torsten T, Suttorp Norbert, Jüni Peter, Bals Robert, Rohde Gernot, German Community Acquired Pneumonia Competence Network (2012), Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study., in BMJ (Clinical research ed.), 344, 3397-3397.
Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge.
Koutsokera Angela, Stolz Daiana, Loukides Stelios, Kostikas Konstantinos (2012), Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge., in Chest, 141(2), 396-405.
Association of daily physical activity volume and intensity with COPD severity.
Jehn Melissa, Schmidt-Trucksäss Arno, Meyer Anja, Schindler Christian, Tamm Michael, Stolz Daiana (2011), Association of daily physical activity volume and intensity with COPD severity., in Respiratory medicine, 105(12), 1846-52.
Endobronchial ultrasound in hilar and conventional TBNA-negative/inconclusive mediastinal lymphadenopathy.
Chhajed Prashant N, Odermatt Rahel, von Garnier Christophe, Chaudhari Parag, Leuppi Joerg D, Stolz Daiana, Tamm Michael (2011), Endobronchial ultrasound in hilar and conventional TBNA-negative/inconclusive mediastinal lymphadenopathy., in Journal of cancer research and therapeutics, 7(2), 148-51.
Feasibility and safety of propofol sedation in flexible bronchoscopy.
Grendelmeier Peter, Kurer Gabriel, Pflimlin Eric, Tamm Michael, Stolz Daiana (2011), Feasibility and safety of propofol sedation in flexible bronchoscopy., in Swiss medical weekly, 141, 13248-13248.
International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance.
Rudolf Daniel, Michaylov Nikolay, van der Linden Mark, Hoy Ludwig, Klugman Keith P, Welte Tobias, Pletz Mathias W, CAPNETZ Study Group (2011), International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance., in Antimicrobial agents and chemotherapy, 55(10), 4915-7.
Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP.
Boeck L, Eggimann P, Smyrnios N, Pargger H, Thakkar N, Siegemund M, Marsch S, Rakic J, Tamm M, Stolz D (2011), Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP., in The European respiratory journal : official journal of the European Society for Clinical Respiratory, 37(3), 595-603.
Midregional proatrial natriuretic peptide predicts survival in exacerbations of COPD.
Bernasconi Maurizio, Tamm Michael, Bingisser Roland, Miedinger David, Leuppi Jörg, Müller Beat, Christ-Crain Mirjam, Stolz Daiana (2011), Midregional proatrial natriuretic peptide predicts survival in exacerbations of COPD., in Chest, 140(1), 91-9.
Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia.
Boeck Lucas, Graf Rolf, Eggimann Philippe, Pargger Hans, Raptis Dimitri A, Smyrnios Nicholas, Thakkar Nehal, Siegemund Martin, Rakic Janko, Tamm Michael, Stolz Daiana (2011), Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia., in Chest, 140(4), 925-32.
Propofol versus propofol plus hydrocodone for flexible bronchoscopy: a randomised study.
Schlatter L, Pflimlin E, Fehrke B, Meyer A, Tamm M, Stolz D (2011), Propofol versus propofol plus hydrocodone for flexible bronchoscopy: a randomised study., in The European respiratory journal : official journal of the European Society for Clinical Respiratory, 38(3), 529-37.
The Role of Biomarkers in COPD Exacerbation
Stolz D, Bernasconi M, Tamm M (2011), The Role of Biomarkers in COPD Exacerbation, in Clin Pulm Med, 18(3), 101-108.
The use of copeptin, the stable peptide of the vasopressin precursor, in the differential diagnosis of sodium imbalance in patients with acute diseases.
Nigro Nicole, Müller Beat, Morgenthaler Nils G, Fluri Felix, Schütz Philipp, Neidert Stefanie, Stolz Daiana, Bingisser Roland, Tamm Michael, Christ-Crain Mirjam, Katan Mira (2011), The use of copeptin, the stable peptide of the vasopressin precursor, in the differential diagnosis of sodium imbalance in patients with acute diseases., in Swiss medical weekly, 141, 13270-13270.
Un update on COPD exacerbations
Scherr A, Blasi F, Stolz D (2011), Un update on COPD exacerbations , in Minerva Pneumologica, 50(2), 129-146.
What Is the Value of Midregional Proatrial Natriuretic Peptide in COPD Research or Clinical Practice? Response
Bernasconi M, Stolz D (2011), What Is the Value of Midregional Proatrial Natriuretic Peptide in COPD Research or Clinical Practice? Response, in CHEST, 140(2), 555-556.
Adenovirus-specific immunoglobulin G maturation as a surrogate marker in acute exacerbations of COPD
Boeck Lucas, Gencay Messut, Roth Michael, Hirsch Hans, Christ-Crain Mirjam, Muller Beat, Tamm Michael, Stolz Daiana, Adenovirus-specific immunoglobulin G maturation as a surrogate marker in acute exacerbations of COPD, in Chest.
Adrenomedullin optimizes mortality prediction in COPD patients
Brusse-Keizer M, Zuur-Telgen M, Van der Palen J, Vandervalk P, Kersthens H, Boersma W, Blasi F, Konstantino K, Milenkovic B, Tamm M, Stolz D, Adrenomedullin optimizes mortality prediction in COPD patients, in Respiratory Medicine.
Associations of Daily Walking Activity with Biomarkers Related to Cardiac Distress in Patients with Chronic Obstructive Pulmonary Disease.
Jehn Melissa, Schindler Christian, Meyer Anja, Tamm Michael, Koehler Friedrich, Witt Christian, Schmidt-Trucksäss Arno, Stolz Daiana, Associations of Daily Walking Activity with Biomarkers Related to Cardiac Distress in Patients with Chronic Obstructive Pulmonary Disease., in Respiration; international review of thoracic diseases.
Cardiovascular comorbidities in hospitalized COPD patients: a determinant of future risk
Papaioannou A, Bartziokas K, Loukides S, Tsikrika S, Karakontaki F, Haniotou A, Papiris S, Stolz D, Kostikas K, Cardiovascular comorbidities in hospitalized COPD patients: a determinant of future risk, in European Respiratory Journal.
Daily walking intensity as a predictor of quality of life in patients with COPD
Jehn M, Schindler C, Meyer A, Tamm M, Schmidt-Trucksäss A, Stolz D, Daily walking intensity as a predictor of quality of life in patients with COPD, in Medicine & Science in Sports & Exercise.
Direct Comparison of Three Natriuretic Peptides for prediction of short- and long-term mortality in community acquired pneumonia.
Nowak Albina, Breidthardt Tobias, Christ-Crain Mirjam, Bingisser Roland, Meune Christophe, Tanglay Yunus, Heinisch Corinna, Reiter Miriam, Drexler Beatrice, Arenja Nisha, Twerenbold Raphael, Stolz Daiana, Tamm Michael, Müller Beat, Müller Christian, Direct Comparison of Three Natriuretic Peptides for prediction of short- and long-term mortality in community acquired pneumonia., in Chest.
Exertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin
Stolz Daiana, Boersma Wim, Blasi Francesco, Louis Renaud, Milenkovic Branislava, Kostikas Kostikas, Aerts Joachim, Rohde Gernot, Prat Christina, Boeck Lucas, Rakic Janko, Scherr Andreas, Torres Antoni, Welte Tobias, Hertel Sabine, Giersdorf Sven, Exertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin, in Chest.
Is there a differential impact of parity on blood pressure by age?
Dratva Julia, Schneider Cornelia, Schindler Christian, Stolz Daiana, Gerbase Margaret, Pons Marco, Bettschart Robert, Gaspoz Jean-Michel, Künzli Nino, Zemp Elisabeth, Probst-Hensch Nicole, Is there a differential impact of parity on blood pressure by age?, in Journal of hypertension, 32(11).
Lung resection in hematologic patients with pulmoary invasive fungal disease.
Nebiker Christian, Lardinois Didier, Junker Lilian, Gambazzi Franco, Matt Peter, Habicht James, Halter Joerg, Heim Dominik, Stern Martin, Buser Andreas, Passweg Jakob, Stolz Daiana, Flückiger Ursula, Weisser Maya, Battegay Manuel, Bubendorf Lukas, Gratwohl Alois, Tamm Michael, Lung resection in hematologic patients with pulmoary invasive fungal disease., in Chest.
Predictors of success for smoking cessation at the workplace - a longitudinal study
Stolz Daiana, Scherr Andreas, Seiffert Bruno, Kuster Martin, Meyer Anja, Fagerström Karl, Tamm Michael, Predictors of success for smoking cessation at the workplace - a longitudinal study, in Respiration.
Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
Schuetz P, Müller M, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolff M, Chastre J, Tubach F, Kristoffersen KB, Burkhardt O, Welte T, Schroeder S, Nobre V, Wei L, Bhatnagar N, Bucher HC, Briel M, Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections, in Cochrane Database Syst Rev., 12(9).
Respiratory Research Predictors of marked weight gain in a population of health care workers following smoking cessation
Scherr A, Seifert B, Kuster M, Meyer A, Fagerstroem K, Tamm M, Stolz D, Respiratory Research Predictors of marked weight gain in a population of health care workers following smoking cessation, in Respiration.
Spirometer Replacement and Serial Lung Function Measurements in Population Studies: Results From the SAPALDIA Study.
Bridevaux Pierre-Olivier, Dupuis-Lozeron Elise, Schindler Christian, Keidel Dirk, Gerbase Margaret W, Probst-Hensch Nicole M, Bettschart Robert, Burdet Luc, Pons Marco, Rothe Thomas, Turk Alexander, Stolz Daiana, Tschopp Jean-Marie, Kuenzli Nino, Rochat Thierry, Spirometer Replacement and Serial Lung Function Measurements in Population Studies: Results From the SAPALDIA Study., in American journal of epidemiology.
The Sequential Organ Failure Assessment score and copeptin for predicting survival in ventilator-associated pneumonia.
Boeck Lucas, Eggimann Philippe, Smyrnios Nicholas, Pargger Hans, Thakkar Nehal, Siegemund Martin, Morgenthaler Nils G, Rakic Janko, Tamm Michael, Stolz Daiana, The Sequential Organ Failure Assessment score and copeptin for predicting survival in ventilator-associated pneumonia., in Journal of critical care.
Variability of hospital resources for acute care of COPD patients: the European COPD Audit.
López-Campos Jose Luis, Hartl Sylvia, Pozo-Rodriguez Francisco, Roberts C Michael, European COPD Audit team, Variability of hospital resources for acute care of COPD patients: the European COPD Audit., in The European respiratory journal, 43(3), 754-62.

Collaboration

Group / person Country
Types of collaboration
University Hospital Thessaloniki Greece (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Clinic for Pulmonary Diseases Belgrade Serbien (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Kantonsspital Liestal Switzerland (Europe)
- Research Infrastructure
Universitätsspital Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Medizinische Universität Wien Austria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Spital Alkmar Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Medizinische Hochschule Hannover Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Hospital Badalona Spain (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Spital Breda Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Hospital Clinic Barcelona Spain (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
University Hospital Milano Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
University Hospital Maastricht Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Spital Tiefenau Switzerland (Europe)
- Research Infrastructure
University Hospital Liege Belgium (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Brasilian Annual Respiratory Congress 2014 Talk given at a conference Role of biomarkers in CAP 06.10.2014 Gramado, Brazil Stolz Daiana;
Brasilian Annual Respiratory Congress 2014 Talk given at a conference Exacerbation of COPD: are there reliable biomarkers? 06.10.2014 Gramado, Brazil Stolz Daiana;
Brasilian Annual Respiratory Congress 2014 Talk given at a conference Consolidation unresponsive to antibotics: how to manage? 06.10.2014 Gramado, Brazil Stolz Daiana;
Brasilian Annual Respiratory Congress 2014 Talk given at a conference Do biomarkers help in the management of mechanical ventilation? 06.10.2014 Gramado, Brazil Stolz Daiana;
European Respiratory Society Annual Conference 2014 Talk given at a conference Circulating copeptin is associated with mortality irrespectively of exacerbation rate in stable COPD 06.09.2014 München, Germany Stolz Daiana;
European Respiratory Society Annual Conference 2014 Talk given at a conference COPD on anti-GERD therapy remains at higher risk for severe exacerbation 06.09.2014 München, Germany Stolz Daiana;
Further Education for Heads of Swiss Pneumology Departments in Switzerland Talk given at a conference Helpfullness of steroids in COPD? Can less be more? 22.08.2014 Sils Maria, Switzerland Stolz Daiana;
MedArt Talk given at a conference COPD 24.06.2014 Basel, Switzerland Stolz Daiana;
Zystische Fibrose und andere Lungenerkrankungen, ACT Basis Kurs Talk given at a conference Andere Lungenerkrankungen 27.03.2014 Basel, Switzerland Stolz Daiana;
CHEST World Conference Talk given at a conference Biomarkers for the diagnosis of LRTI 22.03.2014 Madrid, Spain Stolz Daiana;
Un respiro profundo Talk given at a conference The role of proadrenomedullin in respiratory infections 03.03.2014 Milano, Italy Stolz Daiana;
Lunch Meeting Med. Clinic Karolinska University Hospital Individual talk Proadrenomedullin in COPD 28.11.2013 Stockholm, Sweden Stolz Daiana;
Neue COPD Therapien Talk given at a conference Neue COPD Therapien in der pneumologischen Praxis 21.11.2013 Basel, Switzerland Stolz Daiana;
Standards in the Bodyplethysmographie Talk given at a conference Interpretation der Resultate und Schwergradeinteilung 24.10.2013 Barmelweid, Switzerland Stolz Daiana;
European Respiratory Society Annual Conference 2013 Talk given at a conference The bronchitis phenotype is associated with frequent exacerbations in COPD irrespective of chronic bacterial airway infection 09.09.2013 Barcelona, Spain Stolz Daiana;
European Respiratory Society Annual Conference 2013 Talk given at a conference Adernomedullin independently predicts exertional hypoxemia in COPD 09.09.2013 Barcelona, Italy Stolz Daiana;
MedArt Basel 2013 Talk given at a conference Rundherd 23.05.2013 Basel, Switzerland Stolz Daiana;
Schweizer Gesellschaft für Innere Medizin 2013 Talk given at a conference Spirometrie in der Praxis 23.05.2013 Basel, Switzerland, Switzerland Stolz Daiana;
COPD Update Talk given at a conference COPD-Update for GPs 23.03.2013 Allschwil, Switzerland Stolz Daiana;
International Symposium on Intensive Care and Emergency Medicine Talk given at a conference Risk stratification in COPD: Beyond lung function 01.03.2013 Brussels, Belgium Stolz Daiana;
International Symposium on Intensive Care and Emergency Medicine Talk given at a conference Do wee need biomarkers - revisited 01.03.2013 Brussels, Belgium Stolz Daiana;
Pneumo Tag Basel 2013 Talk given at a conference LRTI: Biomarkers 24.01.2013 Basel, Switzerland Stolz Daiana;
European Respiratory Society Annual Conference 2012 Talk given at a conference Pro-adrenomedullin improves the prognostic property of the BODE index 01.09.2012 Vienna, Austria, Austria Stolz Daiana;
European Respiratory Society Annual Conference 2012 Talk given at a conference Combined assessment according to the new GOLD guidelines and its relation to outcome in COPD 01.09.2012 Vienna, Austria Stolz Daiana;
8th international Workshop Respiratory Intensive care unit: up date in respiratory critical medicine Talk given at a conference Does pro-atrial natriuretic peptide have a role in patients admitted to the RICU? 29.02.2012 Florence, Italien, Italy Stolz Daiana;
European Respiratory Society Annual Conference 2011 Talk given at a conference Long term predictors for smoking cessation in a long-term population study at the workplace 24.09.2011 Amsterdam, Netherlands Stolz Daiana;
European Respiratory Society Annual Conference 2011 Talk given at a conference Relation of health-related quality of life, frequent exacerbation phenotype adn circulating systemic biomarkers in stble COPD 24.09.2011 Amsterdam, Netherlands Stolz Daiana;
European Respiratory Society Annual Conference 2011 Talk given at a conference Association of the severe, freqeunt exacerbation phenotype with exercise capacity, sputum bacterioloy and copeptincirculating levels in COPD 24.09.2011 Amsterdam, Holland, Netherlands Stolz Daiana; Meyer Anja; Scherr Andreas;
Schweizer Gesellschaft für Innere Medizin 2011 Talk given at a conference Spirometrie in der Praxis 11.05.2011 Lausanne, Switzerland, Switzerland Stolz Daiana;


Self-organised

Title Date Place
Update Asthma/COPD 20.11.2014 Basel, Switzerland
ERS COPD Audit Switzerland Data Meeting 06.11.2014 Basel, Switzerland
25 years human lung cell culture 18.03.2014 Basel, Switzerland
SAPALDIA Meeting 2013 06.03.2013 Basel, Switzerland, Switzerland
SAPALDIA Meeting 2012 06.11.2012 Bern, Switzerland, Switzerland
PREVENT investigator meeting 17.02.2012 Basel, Switzerland, Switzerland

Communication with the public

Communication Title Media Place Year
Media relations: radio, television Asthma – Umstrittene Operation für schwere Fälle Puls, SRF 1 German-speaking Switzerland 2015
Media relations: print media, online media Lungenzentrum BAZ, BZ German-speaking Switzerland 2014
Talks/events/exhibitions Spirometrietag German-speaking Switzerland 2014
Talks/events/exhibitions Sind die guten Vorsätze schon vergessen?Rauchstopp: Warum, Wann, Wie? German-speaking Switzerland 2012

Awards

Title Year
Swiss Addiction Research Award 2015 2015
Lung Liga Grant for Respiratory Research 2014
Preis der Schweizerischen Gesellschaft für allgemeine Innere Medizin 2012
Best COPD abstract Award, European Respiratory Society 2011

Patents

Title Date Number Inventor Owner
ProADM in combination with the BODE Index for prognosis prediction in COPD 01.04.2013 1111

Associated projects

Number Title Start Funding scheme
157530 The vicious-cycle of acute exacerbation in chronic obstructive pulmonary disease: orchestration of infection, systemic inflammatory response and airway remodelling 01.02.2015 SNSF Professorships
177506 SAPALDIA 5 - Cohort on Healthy Aging 01.04.2018 Cohort Studies Large

Abstract

General background: Most exacerbations of COPD are triggered by either bacterial or viral infection or a combination of both. A growing body of evidence implicates viral respiratory tract infection as the predominant risk factor associated with exacerbations of COPD. The synergism of corticosteroid and long-acting ß2-agonists in suppressing viral-induced inflammation on airway epithelial cells has been demonstrated in vitro. However, high maintenance dose inhaled steroids is associated with serious adverse effects, particularly pneumonia, in patients with COPD. In asthma, a flexible regimen of inhaled corticosteroid and corticosteroid and long-acting ß2-agonists “on-demand” in patients on low maintenance dose steroid/LABA significantly reduces steroid exposure while leading to a decrease in exacerbation rate as compared to a fix regimen of high maintenance dose steroid/ corticosteroid and long-acting ß2-agonists. The efficacy of intensified combination therapy with inhaled corticosteroid/LABA at the onset of upper respiratory tract infection symptoms in COPD is unknown.Aims: A) To explore the role of different viral infections in exacerbations of COPD and its influence on bacterial co-infection, local and systemic inflammation, airway remodelling and systemic repercussions in patients with COPD; B) To evaluate whether intensified combination therapy with inhaled corticosteroids and long-acting ß2-agonists at the onset of upper respiratory tract infection symptoms as compared to placebo decreases the incidence of exacerbation of COPD in patients receiving low maintenance dose inhaled corticosteroids/long-acting ß2-agonists, thus reducing disease associated morbidity.Design: Investigator-initiated and driven, double-blind randomized multinational trial. Patients with stable COPD will be included and randomized 1:1 either to intensified combination therapy with inhaled corticosteroid/ corticosteroid and long-acting ß2-agonists or to placebo. Randomization will be stratified by center. In addition, 8 integrated and subsidiary projects evaluating the domains of infection, inflammation, airway remodelling and systemic repercussions are associated with the main study. Setting: Five teaching hospitals in Switzerland, Italy, The Netherlands and Greece Patients: Age = 40 years, smoking history = 10 pack-years and moderate to very severe stable COPD (GOLD II-IV without exacerbation for = 4 weeks), history of severe exacerbation in previous year. Excluded are patients with pulmonary conditions other than COPD as the main respiratory disease; rapid lethal disease, severe immunosuppression; known allergy or intolerance to the study medication; pregnancy.Endpoints: Primary: Number (%) of patients developing exacerbation within 21 days of URTI onset in the group receiving intensified combination therapy with inhaled steroids/LABA and placebo. Secondary: Viral PCR positivity during URTI, exacerbations and stable periods; positive sputum bacteriology and positive PCR for atypical pathogens during exacerbation and stable periods; symptoms scores and MMRC dyspnea scale; therapy-related side-effects; duration and cumulative dose of steroids and antibiotics; hospital admission for any cause. Endpoints will be assessed 7 days after upper respiratory tract symptoms onset, after 21 days, in case of exacerbation, and in the stable period of the disease (at 6, 12, and 18 months). In a second step, endpoints will be assessed in subgroups of patients according to the COPD severity.Intervention: Additionally to the low maintenance dose steroid/LABA therapy (Budesonide 200µg/Formoterol 6µg bid), patients will be randomized to the combination corticosteroid/long-acting ß2-agonists (“steroid/LABA group”) or to placebo ("placebo group"). Patients in the steroid/LABA group will receive Budenoside 400µg/Formoterol 12µg bid in case of upper respiratory tract infection symptoms for 7 days. Patients randomized to the placebo group will receive inhaled placebo for 7 days. Low maintenance dose steroid/LABA therapy will be left unchanged in both groups.Study hypothesis: Use of intensified combination therapy with corticosteroid and long-acting ß2-agonists at upper respiratory tract infection symptoms onset will lead to a 25% relative risk reduction in exacerbation rate from 43% in the placebo group to 28% in the corticosteroid group.Analyses: These will be done based on an intention-to-treat and a per-protocol principle. A sample size of 382 patients (191 per group) will be needed to achieve a statistical power of 80% to detect an absolute decrease in exacerbation rate of 15% from an estimated rate of 43% in placebo-treated patients to 28% in corticosteroid and long-acting ß2-agonists treated. Interim monitoring: Regular review of serious adverse events, quality and integrity of the study by an independent data safety and monitoring board is intended.Integrated Projects: I) Diagnosis of acute viral infection in exacerbation using a prototype avidity ELISA; II) Characterization of bacterial infection by single- and multi-locus sequence typing in the stable state and exacerbation of COPD; II) Airway remodelling mediated by VEGF-isoforms and vaso-intestinal peptide; IV) Systemic inflammatory and cardiovascular markers at exacerbation and stable period to identify responders to therapy. Subsidiary Projects: V) Predicting Outcome using systemic Markers In Severe Exacerbations of COPD (PROMISE-COPD Cohort Study); VI) On demand prostacyclin inhalation in obstructive pulmonary disease and pulmonary hypertension (OPTION study); VI) Systemic effects of exercise-induced, hypoxic stress in severe COPD; VIII) Water pipe consumption among young adults in Switzerland and its consequences to the development of bronchial hyperresponsiveness. Significance: COPD has become a leading cause of death worldwide. However, gaps in understanding the mechanisms involved in the development of the disease are still considerable. Exacerbations are associated with significant morbidity, mortality and health-care associated costs. Therefore, there is an urgent need to develop novel therapeutic strategies to optimize management of COPD and associated co-morbidities. At present, with the exception of influenza vaccination, there are no interventions available that specifically target viral induced infection in an attempt to reduce the prevalence and effects of exacerbations in COPD. By preventing exacerbations, the patient-driven management approach investigated in this trial might improve quality of life and reduce costs associated with COPD in spite of preserving patients’ autonomy. The integrated and subsidiary projects related to the main study will provide a decisive improvement in the characterization of viral- and bacterial induced exacerbation, airway inflammation as well as remodelling mechanisms and their systemic repercussions in COPD.
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