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Infection & Immunity Training

English title Infection & Immunity Training
Applicant Soldati-Favre Dominique
Number 127182
Funding scheme ProDoc
Research institution Dépt Microbiologie et Médecine Moléculaire Faculté de Médecine Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Medical Microbiology
Start/End 01.09.2009 - 31.08.2014
Approved amount 244'002.00
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All Disciplines (2)

Discipline
Medical Microbiology
Immunology, Immunopathology

Keywords (11)

innate immunity; adaptative immunity; virology; bacteriology; parasitology; infectious diseases; vaccinology; drug therapies; pathogenesis; virulence; training

Lay Summary (English)

Lead
Lay summary
Infectious diseases are representing a huge human health concern and causing devastating social and economic costs across the globe. A concerted action between research in Immunology and in Microbial Pathogenesis is a priority towards finding innovative biomedical interventions appropriate solutions.
To sustain competitiveness of the research performed in Switzerland in the future, there is a need to integrate collaborative initiatives between institutions on broad-based training program that emphasizes the path from fundamental research to translation into disease control strategies.
To address this need, the Infection & Immunity PhD training program between the Universities of Geneva and Lausanne will train a cohort of early stage researchers to PhD level by means of collaborative research projects in Immunology and Pathogenic Microbiology.
The Universities of Geneva and Lausanne are hosting internationally competitive group leaders in the field of infectious diseases and Immunology who are joining their efforts and expertise to propose a new broad and high quality training environment. This program will build upon research module projects that will be jointly coordinated and supervised by two or three principal investigators from separate partner institutions affording a multidisciplinary element to the training. Through this and additional broad-based, intensive training provided by experts from both the Immunology community and Microbiology at large, it is intended to represent an instrumental contribution to the formation of the new generation of highly skilled young MD and PhD students. The objective is to assure a cross-disciplinary training with sufficient breadth to ensure that it is applicable across and beyond the field of infectious diseases. The activities will include the access to specialized workshops. Students of the program will participate in numerous networking activities around the common themes of their projects and will develop their independent skill as organizers of seminars and PhD retreats. They will be well acquainted with each other and with the International community of scientists in this field.
The coordinators are responsible for a coherent coordination of training and research activities of the program. Selected supervisors with proven records of excellence in research and training are directly involved in the research component and together with tutors will participate in the educational aspect of the training to ensure that the PhD students will be supplemented by a comprehensive range of specific training activities focusing on the basic, clinical and translational research in the field of infection & Immunity.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
Crosstalk between neutrophils and dendritic cells: A context-dependent process
Schuster Steffen, Hurrell Benjamin, Tacchini-Cottier Fabienne M. (2013), Crosstalk between neutrophils and dendritic cells: A context-dependent process, in Journal of Leukocyte Biology, 94(4), 671-675.
Detecting, visualizing and quantitating the generation of reactive oxygen species in an amoeba model system
Zhang Xuezhi, Soldati Thierry (2013), Detecting, visualizing and quantitating the generation of reactive oxygen species in an amoeba model system, in Journal of Visualized Experiments, (81), 1-10.
Discovery of catalases in members of the Chlamydiales order
Rusconi Brigida, Greub Gilbert (2013), Discovery of catalases in members of the Chlamydiales order, in Journal of Bacteriology, 195(16), 3543-3551.
Evolution of the Ferric Reductase Domain (FRD) Superfamily: Modularity, Functional Diversification, and Signature Motifs
Zhang Xuezhi, Krause Karl-Heinz, Xenarios Ioannis, Soldati Thierry, Boeckmann Brigitte (2013), Evolution of the Ferric Reductase Domain (FRD) Superfamily: Modularity, Functional Diversification, and Signature Motifs, in PLOS ONE, 8(3), 1-15.
Notch signaling regulates follicular helper T cell differentiation
Auderset Floriane, Schuster Steffen, Fasnacht Nicolas, Coutaz Manuel, Charmoy Mélanie, Koch Ute, Favre Stéphanie, Wilson Anne, Trottein François, Alexander James, Luther Sanjiv Andreas, MacDonald H. Robson, Radtke Freddy, Tacchini-Cottier Fabienne M. (2013), Notch signaling regulates follicular helper T cell differentiation, in Journal of Immunology, 191(5), 2344-2350.
Role of toll-like receptor 9 signaling in experimental leishmania braziliensis infection
Weinkopff Tiffany, Mariotto Anita, Simon Gregoire, Torre Yazmin Hauyon La, Auderset Floriane, Schuster Steffen, Zangger Haroun, Fasel Nicolas J., Barral Aldina Maria Prado, Tacchini-Cottier Fabienne M. (2013), Role of toll-like receptor 9 signaling in experimental leishmania braziliensis infection, in Infection and Immunity, 81(5), 1575-1584.
Novel murine dendritic cell lines: A powerful auxiliary tool for dendritic cell research
Fuertes Marraco Silvia A., Grosjean Frédéric, Duval Anaïs, Rosa Muriel, Lavanchy Christine, Ashok Devika, Haller Sergio, Otten Luc Alain, Steiner Quynh Giao, Descombes Patrick, Luber Christian A., Meissner Felix, Mann Matthias, Széles Lajos, Reith Walter, Acha-Orbea Hans J. (2012), Novel murine dendritic cell lines: A powerful auxiliary tool for dendritic cell research, in Frontiers in Immunology, 3(NOV), 1-25.
Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major.
Auderset Floriane, Schuster Steffen, Coutaz Manuel, Koch Ute, Desgranges Florian, Merck Estelle, MacDonald H. Robson, Radtke Freddy, Tacchini-Cottier Fabienne M. (2012), Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major., in PLoS pathogens, 8(3), 1002560-1002560.
Chlamydiales and the innate immune response: Friend or foe?
Rusconi Brigida, Greub Gilbert (2011), Chlamydiales and the innate immune response: Friend or foe?, in FEMS Immunology and Medical Microbiology, 61(3), 231-244.

Scientific events



Self-organised

Title Date Place
Summer Course in Immunology 12.09.2014 Lausanne, Switzerland
Forum of the Graduate Schools 06.06.2014 Geneva, Switzerland
Annual Retreat 24.04.2014 Villars sur Ollon, Switzerland
Infection & Immunuty 15.10.2013 Lausanne, Switzerland

Awards

Title Year
financement de l ecole doctorale infection , immunite et cancer de la subvention CUS pour les programmes doctoraux. 2013

Associated projects

Number Title Start Funding scheme
129700 Role of dendritic cell subsets in Leishmania infection 01.05.2010 ProDoc
135701 Junctional adhesion molecules, versatile players in inflammatory immune reactions 01.04.2011 Project funding (Div. I-III)

Abstract

Summary of the doctoral programme Infectious diseases are representing a huge human health concern and causing devastating social and economic costs across the globe. Several European institutions at the forefront of basic research in Immunology and in Microbial Patho-genesis have made of these two intimately linked topics a priority in their PhD schools. To sustain competitiveness of the research performed in Switzerland in the future, there is a need to integrate collabora-tive initiatives between institutions on broad-based training programme that emphasizes the path from fundamental research to translation into disease control strategies.To address this need, it is proposed here to establish an Infection & Immunity PhD training programme between the Universities of Geneva and Lausanne, which will train a cohort of early stage researchers to PhD level by means of collaborative research projects in Immunology and Pathogenic Microbiology. The Universities of Geneva and Lausanne are hosting internationally competitive group leaders in the field of infectious diseases and Immunology who are joining their efforts and expertise to propose a new broad and high quality training environement. This programme will build upon research module projects that will be jointly coordinated and supervised by two or three principal investigators from separate partner institutions affording a multidisciplinary element to the training. Through this and additional broad-based, intensive training provided by experts from both the Immunology community and Microbiology at large, it is intended to represent an instrumental contribution to the formation of the new generation of highly skilled young MD and PhD students.The objective is to assure a cross-disciplinary training with sufficient breadth to ensure that it is applicable across and beyond the field of infectious diseases. The activities will include the access to the Medicine-Biologie PhD programme and to specialized workshops. Students of the programme will participate in numerous networking activities around the common themes of their projects and will develop their independent skill as organizers of seminars and PhD retreats. They will be well acquainted with each other and with the International community of scientists in this field.The coordinators will be collectively responsible for a coherent coordination of training and research activities of the programme. Twelve selected supervisors with proven records of excellence in research and training will be directly involved in the research component of the training. Additionally, and together with the 3 coordinators and an open list of tutors, they will participate in the educational aspect of the training to ensure that the PhD students will be supple-mented by a comprehensive range of specific training activities focusing on the basic, clinical and translational research in the field of infection & Immunity. Students joining the programme should be engaged in collaborative research pro-jects between supervisors or between supervisors and tutors or coordinators.Short and long term main objectives of the Infection & Immunity Training programme:- Select and train 15 to 25 young researchers to PhD levelProvide to the graduate students a theoretical and practical training in modern microbiology and immunology in the hope that such a comprehensive training will provide essential research-related as well as more generic and complemen-tary transferable skills. The training will prioritise key elements of the pipeline between basic research findings and their application to disease control.- Foster career developmentProduce a new generation of competent, young research scientists equipped with basic research skills as well as an appreciation of the principles underpinning the application of basic biological knowledge to disease control. Open new prospects for a career in their chosen area and suiting them to be future leaders in research institutions, industry or clini-cal settings.-Enhance visibility and harmonize the fragmented Swiss research on Immunity and infection Promote selectively the collaborative interdisciplinary projects between academic institutions to stimulate concerted action between basic and clinical research. Capitalize on the recruitment of the most talented young researchers in the fields of human health to assure the highest level of excellence for the research performed in our Universities.The long-term objective to create a larger is to create a visible pole of excellence in infection &Immunity including other Swiss Universities and other Research Institutes.
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