Project

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Flame synthesis of nanostructured materials for functional nanocomposites

Applicant Pratsinis Sotiris E.
Number 126694
Funding scheme Project funding (Div. I-III)
Research institution Institut für Verfahrenstechnik ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Mechanical Engineering
Start/End 01.01.2010 - 31.12.2012
Approved amount 196'194.00
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All Disciplines (2)

Discipline
Mechanical Engineering
Chemical Engineering

Keywords (3)

flame synthesis; nanoparticles; nanocomposites

Lay Summary (English)

Lead
Lay summary
There is growing interest in nanocomposites of sophisticated nanoparticles (multicomponent and even metal-ceramic) in polymers for their unique optical, electrical, magnetic and mechanical applications, to name a few. Nanocomposite properties are affected by the individual component properties as well as the dispersion of nanoparticles within the host matrix and the particle-polymer interface. As a result, understanding the relationship between nanocomposite properties and performance is essential in any of these applications.Here, nanoparticles with closely controlled characteristics (primary particle, aggregate and agglomerate sizes, phase and chemical composition and extent of agglomeration) will be used to make nanocomposites. The synthesis of such nanoparticles by scalable dry (aerosol) methods is a unique asset of our laboratory enabling a systematic investigation of the effect of filler characteristics on nanocomposite properties and performance. The focus is on synthesis agglomerates of primary and/or aggregate nanoparticles that can be easily dispersed in polymer matrices. Such nanoparticles will be made by flame spray pyrolysis (FSP) at high temperatures followed by rapid cooling to minimize, if not prevent, the formation of sinter necks between constituent primary nanoparticles of the product agglomerates following recent advances made in our laboratories regarding the interplay of coagulation and sintering during particle formation. The efficient incorporation of nanoparticles to the host matrix will be further investigated by systematically exploring the role of catalysts and surfactants along with that of mixing operation and devices (e.g. planetary mixers). Emphasis will be placed also on understanding the mixing of nanoparticles in polymers including their degree of agglomeration and its effect on nanocomposite properties (e.g. for mechanical: Young modulus and extent of elongation). A project target is the detailed investigation of the parameters which are essential to synthesis of sophisticated mixed-phase nanoparticles for process understanding and eventual scale-up capitalizing of our understanding of FSP synthesis of single component materials. The morphology of the produced nanoparticles will be characterized by an array of techniques such as x-ray diffraction, nitrogen adsorption, TEM imaging, spectroscopy analysis (Raman, FTIR, UV/vis) available in our and other ETH laboratories. The key goal of this project is to place nanocomposite synthesis on a firm scientific basis that may even contribute to development of novel applications (e.g. environmentally-friendly, non-leaching silver-containing anti-bacterial nanocomposites).
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Effect of Size, Composition and Morphology on Magnetic Performance: First Order Reversal Curves Evaluation of Iron Oxide Nanoparticles
Hirt A.M., Sotiriou G.A.: Kidambi P.R., Teleki A., (2014), Effect of Size, Composition and Morphology on Magnetic Performance: First Order Reversal Curves Evaluation of Iron Oxide Nanoparticles, in J. Appl. Phys., 115, 044314.
Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica-coated Au/Fe2O3 Nanoaggregates
Sotiriou G.A. Starsich F. Dasargyri A. Wurnig M.C. Krumeich F. Boss A. Leroux J-C. Pratsinis S.E. (2014), Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica-coated Au/Fe2O3 Nanoaggregates, in Adv. Funct. Mater. , 24, 2818-2827.
Biomedical Applications of Multifunctional Plasmonic Nanoparticles
Sotiriou G. A. (2013), Biomedical Applications of Multifunctional Plasmonic Nanoparticles, in Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 5, 19-30.
Flexible, Multifunctional, Magnetically Actuated Nanocomposite Films
Sotiriou G. A., Blattmann C. O., Pratsinis S. E. (2013), Flexible, Multifunctional, Magnetically Actuated Nanocomposite Films, in Advanced Functional Materials, 23(1), 34-41.
Safer Formulation Concept for Flame-Generated Engineered Nanomaterials
Gass S., Cohen J., Pyrgiotakis G., Sotiriou G.A., Pratsinis S.E., Demokritou P., (2013), Safer Formulation Concept for Flame-Generated Engineered Nanomaterials, in ACS Sustainable Chem. Eng. , 1, 843-857.
Thermal Energy Dissipation by SiO2-coated Plasmonic-Superparamagnetic Nanoparticles in Alternating Magnetic Fields
Sotiriou G.A., Visbal-Onufrak M.A., Teleki A., Juan E.J., Hirt A.M., Pratsinis S.E., RinaldiC (2013), Thermal Energy Dissipation by SiO2-coated Plasmonic-Superparamagnetic Nanoparticles in Alternating Magnetic Fields, in Chem. Mater., 25, 4603-4612.
A Novel Platform for Pulmonary and Cardiovascular Toxicological Characterization of Inhaled Engineered Nanomaterials
Sotiriou G. A., Diaz E., Long M. S., Godleski J., Brain J., Pratsinis S. E., Demokritou P. (2012), A Novel Platform for Pulmonary and Cardiovascular Toxicological Characterization of Inhaled Engineered Nanomaterials, in Nanotoxicology, 6(6), 680-690.
Antioxidant and Antiradical SiO2 Nanoparticles Covalently Functionalized with Gallic Acid
Deligiannakis Y., Sotiriou G. A., Pratsinis S. E. (2012), Antioxidant and Antiradical SiO2 Nanoparticles Covalently Functionalized with Gallic Acid, in ACS Applied Materials & Interfaces, 4, 6609-6617.
Electrical Resistivity of Assembled Transparent Inorganic Oxide Nanoparticle Thin Layers: Influence of Silica, Insulating Impurities and Surfactant Layer Thickness
Bubenhofer S. B., Schumacher C. M., Koehler F. M., Luechinger N. A., Sotiriou G. A., Grass R. N., Stark W. J. (2012), Electrical Resistivity of Assembled Transparent Inorganic Oxide Nanoparticle Thin Layers: Influence of Silica, Insulating Impurities and Surfactant Layer Thickness, in ACS Applied Materials & Interfaces, 4(5), 2664-2671.
Evaluation of Environmental Filtration Control of Engineered Nanoparticles using the Harvard Versatile Engineered Nanomaterial Generation System (VENGES)
Tsai C. S. J., Echevarria-Vega M. E., Sotiriou G. A., Santeufemio C., Schmidt D., Demokritou P., Ellenbecker M. (2012), Evaluation of Environmental Filtration Control of Engineered Nanoparticles using the Harvard Versatile Engineered Nanomaterial Generation System (VENGES), in Journal of Nanoparticle Research, 14(5), 812.
Green, Silica-coated Monoclinic Y2O3:Tb3+ Nanophosphors: Flame Synthesis and Characterization
Sotiriou G. A., Schneider M., Pratsinis S. E. (2012), Green, Silica-coated Monoclinic Y2O3:Tb3+ Nanophosphors: Flame Synthesis and Characterization, in Journal of Physical Chemistry C, 116(7), 4493-4499.
Optically Stable Biocompatible Flame-Made SiO2-Coated Y2O3:Tb3+ Nanophosphors for Cell Imaging
Sotiriou G. A., Franco D., Poulikakos D., Ferrari A. (2012), Optically Stable Biocompatible Flame-Made SiO2-Coated Y2O3:Tb3+ Nanophosphors for Cell Imaging, in ACS Nano, 6(5), 3888-3897.
Quantifying the Origin of Released Ag+ ions from Nanosilver
Sotiriou G. A., Meyer A., Knijnenburg J. T. N., Panke S., Pratsinis S. E. (2012), Quantifying the Origin of Released Ag+ ions from Nanosilver, in Langmuir, 28(45), 15929-15929.
Color-Tunable Nanophosphors by Codoping Flame-Made Y2O3 with Tb and Eu
Sotiriou G. A., Schneider M., Pratsinis S. E. (2011), Color-Tunable Nanophosphors by Codoping Flame-Made Y2O3 with Tb and Eu, in Journal of Physical Chemistry C, 115(4), 1084-1089.
Electrochemical Crystallization of Plasmonic Nanostructures
Dahlin A. B., Sannomiya T., Zahn R., Sotiriou G. A., Voros J. (2011), Electrochemical Crystallization of Plasmonic Nanostructures, in Nano Letters, 11(3), 1337-1343.
Engineering Nanosilver as an Antibacterial, Biosensor and Bioimaging Material
Sotiriou G. A., Pratsinis S. E. (2011), Engineering Nanosilver as an Antibacterial, Biosensor and Bioimaging Material, in Current Opinion in Chemical Engineering, 1(1), 3-10.
Hybrid Silica-coated, Janus-like Plasmonic-Magnetic Nanoparticles
Sotiriou G. A., Hirt A. M., Lozach P. Y., Teleki A., Krumeich F., Pratsinis S. E. (2011), Hybrid Silica-coated, Janus-like Plasmonic-Magnetic Nanoparticles, in Chemistry of Materials, 23(7), 1985-1992.
Nanosilver on Nanostructured silica: Antibacterial Activity and Ag Surface Area
Sotiriou G. A., Teleki A., Camenzind A., Krumeich F., Meyer A., Panke S., Pratsinis S. E. (2011), Nanosilver on Nanostructured silica: Antibacterial Activity and Ag Surface Area, in Chemical Engineering Journal, 170(2-3), 547-557.
Antibacterial Activity of Nanosilver Ions and Particles
Sotiriou G. A., Pratsinis S. E. (2010), Antibacterial Activity of Nanosilver Ions and Particles, in Environmental Science & Technology, 44(14), 5649-5654.
Non-Toxic Dry-Coated Nanosilver for Plasmonic Biosensors
Sotiriou G. A., Sannomiya T., Teleki A., Krumeich F., Voros J., Pratsinis S. E. (2010), Non-Toxic Dry-Coated Nanosilver for Plasmonic Biosensors, in Advanced Functional Materials, 20(24), 4250-4257.
Toxicity of Silver Nanoparticles in Macrophages
Pratsinis A., Hervella P., Leroux J-C., Pratsinis S. E., Sotiriou G. A., Toxicity of Silver Nanoparticles in Macrophages, in Small.

Collaboration

Group / person Country
Types of collaboration
Prof. Sven Panke, Bioprocess Laboratory, ETH Zürich Switzerland (Europe)
- Publication
Prof. Dimos Poulikakos, Laboratory of Thermodynamics in Emerging Technologies, ETH Zurich Switzerland (Europe)
- Publication
Prof. Ann M. Hirt, Earth and Planetary Magnetism Group, ETH Zurich Switzerland (Europe)
- Publication
Prof. Janos Voros, Laboratory of Biosensors and Bioelectronics, ETH Zurich Switzerland (Europe)
- Publication
Prof. Leroux/ETH Zürich Switzerland (Europe)
- Publication
Prof. Wendelin Stark, Functional Materials Lab, ETH Zurich Switzerland (Europe)
- Publication
Prof. Philip Demokritou, Lab for Environmental Health Nanoscience, Harvard University United States of America (North America)
- Publication
Dr. Pierre-Yves Lozach, Helenius group, ETH Zurich Switzerland (Europe)
- Publication
Prof. Rinaldi, Univ Florida United States of America (North America)
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
MRS Fall Meeting & Exhibit 2012 Talk given at a conference Silica coated multifunctional plasmonic nanoparticles for theranostics 25.11.2012 Boston, USA, United States of America Sotiriou Georgios A.; Pratsinis Sotiris E.;
Sustainable Nanotechnology Organization Conference 2012 Talk given at a conference Multifunctional plasmonic nanoparticles for biomedical applications 04.11.2012 Washington DC, USA, United States of America Pratsinis Sotiris E.; Sotiriou Georgios A.;
AIChE Annual Meeting 2012 Poster Plasmonic biosensors with composite nanosilver structures 28.10.2012 Pittsburgh, USA, United States of America Pratsinis Sotiris E.; Sotiriou Georgios A.;
AIChE Annual Meeting 2012 Talk given at a conference Size-dependent cytotoxicity of nanosilver: Effect of released Ag+ ions & Flexible multifunctional superparamagnetic nanocomposite films 28.10.2012 Pittsburgh, USA, United States of America Sotiriou Georgios A.; Pratsinis Sotiris E.;
EAC 2012 Talk given at a conference Plasmonic biosensors with composite nanosilver structures 02.09.2012 Granada, Spain, Spain Sotiriou Georgios A.; Pratsinis Sotiris E.;
EAC 2012 Poster Flexible superparamagnetic-plasmonic nanocomposite films with flame-made fillers 02.09.2012 Granada, Spain , Spain Sotiriou Georgios A.; Pratsinis Sotiris E.;
DSM Science & Technology Awards 2012 Talk given at a conference Understanding the toxicity of nanosilver for synthesis of biocompatible plasmonic-superparamagnetic nanocomposites 18.06.2012 Interlaken, Switzerland, Switzerland Sotiriou Georgios A.;
E-MRS Spring Meeting 2012 Poster Plasmonic biosensors with composite nanosilver structures 14.05.2012 Strasbourg, France, France Pratsinis Sotiris E.; Sotiriou Georgios A.;
E-MRS Spring Meeting 2012 Talk given at a conference Multilayer superparamagnetic polymer nanocomposites 14.05.2012 Strasbourg, France, France Pratsinis Sotiris E.; Sotiriou Georgios A.;
PolyColl Meeting 2012 Talk given at a conference Hybrid, silica-coated, Janus-like plasmonic-magnetic nanoparticles 20.04.2012 Fribourg, Switzerland, Switzerland Sotiriou Georgios A.;
MRS Fall Meeting & Exhibit 2011 Talk given at a conference Quantifying the origin of nanosilver’s antibacterial activity & Biocompatible hybrid plasmonic-magnetic nanoparticles for bioimaging 28.11.2011 Boston, USA, United States of America Pratsinis Sotiris E.; Sotiriou Georgios A.;
AIChE Annual Meeting 2011 Talk given at a conference Quantifying the origin of nanosilver’s antibacterial activity & Hybrid, silica-coated, Janus-like, plasmonic-magnetic nanoparticles for cell imaging & treatment & Plasmonic biosensors with biocompatible nanosilver & A novel technique for in vivo toxicolo 16.10.2011 Minneapolis, USA, United States of America Sotiriou Georgios A.; Pratsinis Sotiris E.;
American Association for Aerosol Research 2011 Poster Quantifying the origin of nanosilver antibacterial activity 03.10.2011 Orlando, Florida, USA, United States of America Pratsinis Sotiris E.; Sotiriou Georgios A.;
American Association for Aerosol Research 2011 Talk given at a conference Hybrid, Janus-like, silica-coated plasmonic-magnetic nanoparticles for cell imaging & treatment & Flame-synthesis of SiO2-coated color tunable nanophosphors 03.10.2011 Orlando, USA, United States of America Sotiriou Georgios A.; Pratsinis Sotiris E.;
EAC 2011 Talk given at a conference Hybrid, Janus-like, silica-coated plasmonic-magnetic nanoparticles & Antibacterial activity by nanosilver ions and particles 04.09.2011 Manchester, UK, Great Britain and Northern Ireland Sotiriou Georgios A.; Pratsinis Sotiris E.;
MRS Fall Meeting & Exhibit 2010 Talk given at a conference Antibacterial activity by nanosilver ions and particles & Hybrid silica-coated plasmonic/magnetic biomarkers 29.11.2010 Boston, USA, United States of America Sotiriou Georgios A.; Pratsinis Sotiris E.;
AIChE Annual Meeting 2010 Talk given at a conference Hybrid magnetic/plasmonic nanoparticles for biomarkers & Antibacterial activity of nanosilver ions and particles 07.11.2010 Salt Lake City, USA, United States of America Pratsinis Sotiris E.; Sotiriou Georgios A.;
American Association for Aerosol Research 2010 Poster Non-toxic nanosilver for plasmonic biosensors 25.10.2010 Portland, OR, USA, United States of America Sotiriou Georgios A.; Pratsinis Sotiris E.;
Wold Congress on Particle Technology 2010 Talk given at a conference Silica-coated Ag nanoparticles by flame spray pyrolysis 29.04.2010 Nürnberg, Germany Pratsinis Sotiris E.; Sotiriou Georgios A.;
World Congress on Particle Technology 2010 Poster Universal correlation and mechanism for the antibacterial activity of silver nanoparticles 26.04.2010 Nurnberg, Germany, Germany Pratsinis Sotiris E.; Sotiriou Georgios A.;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media 24.03.2014 | News By: Angelika Jacobs Nanoparticles have a great deal of potential in medicine: ETH News International 2014
Media relations: print media, online media Gold Nanoparticles and Near-infrared Light Kill Cancer Cells With Heat IEEE Spectrum International 2014
Media relations: print media, online media http://spectrum.ieee.org/nanoclast/biomedical/devices/gold-nanoparticles-and-nearinfrared-light-kill in-Pharma Technologist.com International 2014
Media relations: print media, online media Antioxidant with a long shelf life ETH Life International 2013
New media (web, blogs, podcasts, news feeds etc.) Nanosilver for therapy and diagnostics ETH life Rhaeto-Romanic Switzerland Italian-speaking Switzerland German-speaking Switzerland Western Switzerland 2011

Awards

Title Year
Assistant Professor at Karolinska Institutet in Stockholm 2016
Elsevier Top Cited Paper Award for 2011 and 2012, AIChE 2014, Atlanta, USA (2014). 2014
ETH Medal for Outstanding PhD Thesis, ETH Zurich 2013
Hilti Award for Innovative Research, ETH Zurich, Switzerland (2013). 2013
TechConnect Innovation Award, Washington D.C., USA (2013). 2013
Best PhD Thesis Award, Division of Polymers and Colloids, Swiss Chemical Society 2012
Best Poster Award, International Fine Particle Research Institute (IFPRI) 2012 Meeting 2012
Honorable Mention at the DSM Science & Technology Awards (South) 2012 2012
Reg Davies Award for Best Poster, International Fine Particle Research Institute (IFPRI) Annual Meeting, Ludwigsburg, Germany (2012). 2012
1st place at the AIChE Bionanotechnology Graduate Student Award 2011

Patents

Title Date Number Inventor Owner
Hybrid nanoantioxidant materials 17.10.2012 WO 2014060080 A1
Method for generation of nano- particle composite films and films made using such a method 21.06.2011 WO2012175175 A1

Associated projects

Number Title Start Funding scheme
144961 System for space-resolved surface analysis of nanomaterials 01.12.2012 R'EQUIP
146176 Flame-made multifunctional nanoparticles for biomedics 01.04.2013 Project funding (Div. I-III)
163243 Multifunctional nanoparticles for targeted theranostics 01.01.2016 Project funding (Div. I-III)
114095 Dry synthesis of softly-agglomerated, metal/ceramic nanoparticles for functional nanocomposites 01.10.2006 Project funding (Div. I-III)

Abstract

There is growing interest in nanocomposites of sophisticated nanoparticles (multicomponent and even metal-ceramic) in polymers for their unique optical, electrical, magnetic and mechanical applications, to name a few. Nanocomposite properties are affected by the individual component properties as well as the dispersion of nanoparticles within the host matrix and the particle-polymer interface. As a result, understanding the relationship between nanocomposite properties and performance is essential in any of these applications.Here, nanoparticles with closely controlled characteristics (primary particle, aggregate and agglomerate sizes, phase and chemical composition and extent of agglomeration) will be used to make nanocomposites. The synthesis of such nanoparticles by scalable dry (aerosol) methods is a unique asset of our laboratory enabling a systematic investigation of the effect of filler (nanoparticle) characteristics on nanocomposite properties and performance. The focus is on synthesis agglomerates of primary and/or aggregate nanoparticles that can be easily dispersed in polymer matrices. Such nanoparticles will be made by flame spray pyrolysis (FSP) at high temperatures followed by rapid cooling to minimize, if not prevent, the formation of sinter necks between constituent primary nanoparticles of the product agglomerates following recent advances made in our laboratories regarding the interplay of coagulation and sintering during particle formation. With FSP, liquid precursors are spray combusted resulting in a broad range of multicomponent ceramic/metal nanoparticles using single or multi-nozzle configurations. Furthermore the potential of in-situ functionalization of such flame-made particles will be explored capitalizing on our recent achievement of in-situ coating of such particles with nanothin inorganic films by swirling vapor jets downstream of core nanoparticle formation. This will facilitate the interfacing of such particles into matrices before or after polymerization of the nanocomposites. The efficient incorporation of nanoparticles to the host matrix will be further investigated by systematically exploring the role of catalysts and surfactants along with that of mixing operation and devices (e.g. planetary mixers). Emphasis will be placed also on understanding the mixing of nanoparticles in polymers including their degree of agglomeration and its effect on nanocomposite properties (e.g. for mechanical: Young modulus and extent of elongation at break-up). A project target is the detailed investigation of the parameters which are essential to synthesis of sophisticated mixed-phase nanoparticles for process understanding and eventual scale-up capitalizing of our understanding of FSP synthesis of single component materials. The morphology of the produced nanoparticles will be characterized by an array of techniques such as x-ray diffraction, nitrogen adsorption, TEM imaging, spectroscopy analysis (Raman, FTIR, UV/vis) available in our and other ETH laboratories. The key goal of this project is to place nanocomposite synthesis on a firm scientific basis that may even contribute to development of novel applications (e.g. environmentally-friendly, non-leaching silver-containing anti-bacterial nanocomposites).Last but not least, this project will assist the education of two doctoral students in engineering specializing in nanoparticle processing and will allow Bachelor and Master students to gain knowledge in analytical methods. Research results will be presented in international conferences and will be submitted for publication in refereed journals.
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