Project

Back to overview

High resolution quantitative molecular imaging of small animals using a preclinical PET/CT system

English title High resolution quantitative molecular imaging of small animals using a preclinical PET/CT system
Applicant Zaidi Habib
Number 125246
Funding scheme Project funding (Div. I-III)
Research institution Service de Médecine Nucléaire Hôpitaux Universitaires de Genève
Institution of higher education University of Geneva - GE
Main discipline Biomedical Engineering
Start/End 01.04.2009 - 31.08.2011
Approved amount 275'502.00
Show all

All Disciplines (2)

Discipline
Biomedical Engineering
Experimental Cancer Research

Keywords (11)

Positron Emission Tomography (PET); Dual-modality (PET/CT) imaging; Small-animal imaging; Quantitative molecular imaging; Image reconstruction; CT-based corrections; Multimodality; molecular imaging; PET/CT; Quantification; small-animals

Lay Summary (English)

Lead
Lay summary
Multimodality molecular imaging has become an essential tool for the development of new tracers, to study the molecular pathways of disease, including factors such as gene expression, in living subjects, and to test new therapeutic approaches in animal models of human disease. Multimodality imaging also has important ramifications for quantification of molecular targets of disease states. Dual-modality PET/CT imaging provides x-ray CT data which can be normalized to obtain a subject-specific attenuation map that can be used to compensate the PET data for photon attenuation and Compton scatter. In addition, regions of interest defined anatomically on the CT image can be used to quantify the correlated radiotracer data in a way that allows more precise target and background definition, and that can use methods that correct the extracted quantitative data for partial-volume effects. However, there are several challenges that still face the use of preclinical PET/CT imaging, and that may represent inherent limitations in this technique; some of them will be addressed in this research proposal.Our laboratory foresees to develop innovative approaches for quantitative molecular imaging with the goals to:A.Further develop and validate our PET and x-ray CT Monte Carlo simulators to allow accurate modelling of both subsystems of the combined preclinical PET/CT scanner and generation of PET/CT data using computerized anthropomorphic dynamic 4-D models depicting the anatomy and physiological functions of rodents;B.Develop new, more accurate, fast and robust 4-D statistical image reconstruction algorithms and projection-based partial volume effect correction strategies to improve both the spatial resolution of reconstructed images and enhance the quantitative capability of the PET subsystem;C.Characterize the magnitude and spatial distribution of Compton scattered photons for the flat-panel x-ray microCT subsystem using both experimental and Monte Carlo-based techniques and develop new, more accurate, robust and fast scatter correction algorithms;D.Develop and validate a versatile strategy for CT-based attenuation and scatter corrections of PET data including accurate and robust algorithms that compensate for the presence of contrast media in contrast-enhanced CT images;E.Develop and assess the performance of Altas-guided automated analysis of PET data based on computerized anthropomorphic 4-D models using retrospective registration-guided methods for motion artefact reduction;F.Validate the developed quantitative imaging methodology using simulated and experimental phantom studies and preclinical data aiming at mapping specific molecular targets.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Scatter characterization and correction for simultaneous multiple small-animal PET imaging
Prasad R and Zaidi H (2014), Scatter characterization and correction for simultaneous multiple small-animal PET imaging, in Mol Imaging Biol, 16(2), 199-209.
A cone-shaped phantom for assessment of small animal PET scatter fraction and count rate performance
Prasad R and Zaidi H (2012), A cone-shaped phantom for assessment of small animal PET scatter fraction and count rate performance, in Mol Imaging Biol, 14(5), 561-571.
[11C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results.
Buchegger Franz, Ratib Osman, Willi Jean-Pierre, Steiner Charles, Seimbille Yann, Zaidi Habib, Graf Véronique, Peter Robin, Jung Maximilien, [11C]acetate PET/CT visualizes skeletal muscle exercise participation, impaired function, and recovery after hip arthroplasty; first results., in Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 13(4), 793-9.
18F-fluorocholine PET-guided target volume delineation techniques for partial prostate re-irradiation in local recurrent prostate cancer.
Wang Hui, Vees Hansjörg, Miralbell Raymond, Wissmeyer Michael, Steiner Charles, Ratib Osman, Senthamizhchelvan Srinivasan, Zaidi Habib, 18F-fluorocholine PET-guided target volume delineation techniques for partial prostate re-irradiation in local recurrent prostate cancer., in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 93(2), 220-5.
A contextual based double watermarking of PET images by patient ID and ECG signal.
Nambakhsh Mohammad-Saleh, Ahmadian Alireza, Zaidi Habib, A contextual based double watermarking of PET images by patient ID and ECG signal., in Computer methods and programs in biomedicine.
A new method for experimental characterisation of scattered radiation in 64-slice CT scanner.
Akbarzadeh A, Ay Mr, Ghadiri H, Sarkar S, Zaidi H, A new method for experimental characterisation of scattered radiation in 64-slice CT scanner., in Biomedical imaging and intervention journal, 6(1).
A novel fuzzy C-means algorithm for unsupervised heterogeneous tumor quantification in PET.
Belhassen Saoussen, Zaidi Habib, A novel fuzzy C-means algorithm for unsupervised heterogeneous tumor quantification in PET., in Medical physics, 37(3), 1309-24.
A virtual sinogram method to reduce dental metallic implant artefacts in computed tomography-based attenuation correction for PET.
Abdoli Mehrsima, Ay Mohammad Reza, Ahmadian Alireza, Zaidi Habib, A virtual sinogram method to reduce dental metallic implant artefacts in computed tomography-based attenuation correction for PET., in Nuclear medicine communications, 31(1), 22-31.
Accurate Monte Carlo modeling and performance assessment of the X-PET subsystem of the FLEX triumph preclinical PET/CT scanner.
Zeraatkar N, Ay M R, Kamali-Asl A R, Zaidi H, Accurate Monte Carlo modeling and performance assessment of the X-PET subsystem of the FLEX triumph preclinical PET/CT scanner., in Medical physics, 38(3), 1217-25.
Advances in multimodality molecular imaging.
Zaidi Habib, Prasad Rameshwar, Advances in multimodality molecular imaging., in Journal of medical physics / Association of Medical Physicists of India, 34(3), 122-8.
An outlook on future design of hybrid PET/MRI systems.
Zaidi Habib, Guerra Alberto Del, An outlook on future design of hybrid PET/MRI systems., in Medical physics, 38(10).
Artificial Neural Network-Based System for PET Volume Segmentation.
Sharif Mhd Saeed, Abbod Maysam, Amira Abbes, Zaidi Habib, Artificial Neural Network-Based System for PET Volume Segmentation., in International journal of biomedical imaging, 2010.
Assessment of scatter for the micro-CT subsystem of the trimodality FLEX Triumph preclinical scanner.
Gutierrez Daniel, Zaidi Habib, Assessment of scatter for the micro-CT subsystem of the trimodality FLEX Triumph preclinical scanner., in Medical physics, 38(7), 4154-65.
Breathing adapted radiotherapy: a 4D gating software for lung cancer.
Peguret Nicolas, Vock Jacqueline, Vinh-Hung Vincent, Fenoglietto Pascal, Azria David, Zaidi Habib, Wissmeyer Michael, Ratib Osman, Miralbell Raymond, Breathing adapted radiotherapy: a 4D gating software for lung cancer., in Radiation oncology (London, England), 6.
Combined evaluation of myocardial perfusion and coronary morphology in the identification of subclinical CAD. Radiation exposure of 13N-ammonia PET/CT.
Vincenti G, Quercioli A, Zaïdi H, Nkoulou R, Dewarrat S, Rager O, Ambrosio G, Seimbille Y, Mach F, Ratib O, Schindler T H, Combined evaluation of myocardial perfusion and coronary morphology in the identification of subclinical CAD. Radiation exposure of 13N-ammonia PET/CT., in Nuklearmedizin. Nuclear medicine, 49(5), 173-82.
Comparative assessment of energy-mapping approaches in CT-based attenuation correction for PET.
Ay Mohammad R, Shirmohammad Maryam, Sarkar Saeed, Rahmim Arman, Zaidi Habib, Comparative assessment of energy-mapping approaches in CT-based attenuation correction for PET., in Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 13(1), 187-98.
Compton scattered imaging based on the V-line radon transform and its medical imaging applications.
Nguyen M K, Regniery R, Truong T T, Zaidi H, Compton scattered imaging based on the V-line radon transform and its medical imaging applications., in Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and, 2010, 4300-3.
Coronary calcium score scan-based attenuation correction in cardiovascular PET imaging.
Ghafarian Pardis, Aghamiri Seyed Mahmoud Reza, Ay Mohammad Reza, Fallahi Babak, Rahmim Arman, Schindler Thomas H, Ratib Osman, Zaidi Habib, Coronary calcium score scan-based attenuation correction in cardiovascular PET imaging., in Nuclear medicine communications, 31(9), 780-7.
CT-based attenuation correction on the FLEX Triumph™ preclinical PET/CT scanner
Prasad R Ay MR Ratib O Zaidi H, CT-based attenuation correction on the FLEX Triumph™ preclinical PET/CT scanner, in IEEE Trans Nucl Sci, 58(1), 66-75.
Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system.
Zaidi H, Ojha N, Morich M, Griesmer J, Hu Z, Maniawski P, Ratib O, Izquierdo-Garcia D, Fayad Z A, Shao L, Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system., in Physics in medicine and biology, 56(10), 3091-106.
Four-dimensional (4D) image reconstruction strategies in dynamic PET: beyond conventional independent frame reconstruction.
Rahmim Arman, Tang Jing, Zaidi Habib, Four-dimensional (4D) image reconstruction strategies in dynamic PET: beyond conventional independent frame reconstruction., in Medical physics, 36(8), 3654-70.
Impact of miscentering on patient dose and image noise in x-ray CT imaging: Phantom and clinical studies.
Habibzadeh M A, Ay M R, Asl A R Kamali, Ghadiri H, Zaidi H, Impact of miscentering on patient dose and image noise in x-ray CT imaging: Phantom and clinical studies., in Physica medica : PM : an international journal devoted to the applications of physics to medicine an.
Is metal artefact reduction mandatory in cardiac PET/CT imaging in the presence of pacemaker and implantable cardioverter defibrillator leads?
Ghafarian Pardis, Aghamiri S M R, Ay Mohammad R, Rahmim Arman, Schindler Thomas H, Ratib Osman, Zaidi Habib, Is metal artefact reduction mandatory in cardiac PET/CT imaging in the presence of pacemaker and implantable cardioverter defibrillator leads?, in European journal of nuclear medicine and molecular imaging, 38(2), 252-62.
Is metal artefact reduction mandatory in cardiac PET/CT imaging in the presence of pacemaker and implantable cardioverter defibrillator leads?
Ghafarian P Aghamiri SM Ay MR Rahmim A Schindler TH Ratib O Zaidi H., Is metal artefact reduction mandatory in cardiac PET/CT imaging in the presence of pacemaker and implantable cardioverter defibrillator leads?, in Eur J Nucl Med Mol Imaging, 38(2), 252-262.
Measurement of scattered radiation in a volumetric 64-slice CT scanner using three experimental techniques.
Akbarzadeh A, Ay M R, Ghadiri H, Sarkar S, Zaidi H, Measurement of scattered radiation in a volumetric 64-slice CT scanner using three experimental techniques., in Physics in medicine and biology, 55(8), 2269-80.
Molecular PET/CT imaging-guided radiation therapy treatment planning.
Zaidi Habib, Vees Hansjörg, Wissmeyer Michael, Molecular PET/CT imaging-guided radiation therapy treatment planning., in Academic radiology, 16(9), 1108-33.
Navigating beyond the 6th dimension: a challenge in the era of multi-parametric molecular imaging.
Zaidi Habib, Navigating beyond the 6th dimension: a challenge in the era of multi-parametric molecular imaging., in European journal of nuclear medicine and molecular imaging, 36(7), 1025-8.
NEMA NU-04-based performance characteristics of the LabPET-8™ small animal PET scanner.
Prasad Rameshwar, Ratib Osman, Zaidi Habib, NEMA NU-04-based performance characteristics of the LabPET-8™ small animal PET scanner., in Physics in medicine and biology, 56(20), 6649-64.
Novel detector design for reducing intercell x-ray cross-talk in the variable resolution x-ray CT scanner: a Monte Carlo study.
Arabi Hosein, Asl Ali Reza Kamali, Ay Mohammad Reza, Zaidi Habib, Novel detector design for reducing intercell x-ray cross-talk in the variable resolution x-ray CT scanner: a Monte Carlo study., in Medical physics, 38(3), 1389-96.
On the v-line radon transform and its imaging applications.
Morvidone M, Nguyen M K, Truong T T, Zaidi H, On the v-line radon transform and its imaging applications., in International journal of biomedical imaging, 2010.
Performance evaluation of the FLEX triumph X-PET scanner using the national electrical manufacturers association NU-4 standards.
Prasad Rameshwar, Ratib Osman, Zaidi Habib, Performance evaluation of the FLEX triumph X-PET scanner using the national electrical manufacturers association NU-4 standards., in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(10), 1608-15.
PET-guided delineation of radiation therapy treatment volumes: a survey of image segmentation techniques.
Zaidi Habib, El Naqa Issam, PET-guided delineation of radiation therapy treatment volumes: a survey of image segmentation techniques., in European journal of nuclear medicine and molecular imaging, 37(11), 2165-87.
PET-guided prostate cancer radiotherapy: technological innovations for dose delivery optimisation.
Lucignani Giovanni, Zaidi Habib, PET-guided prostate cancer radiotherapy: technological innovations for dose delivery optimisation., in European journal of nuclear medicine and molecular imaging, 37(7), 1426-9.
Qualitative and Quantitative Assessment of Metal Artifacts Arising from Implantable Cardiac Pacing Devices in Oncological PET/CT Studies: A Phantom Study.
Ay Mohammad R, Mehranian Abolfazl, Abdoli Mehrsima, Ghafarian Pardis, Zaidi Habib, Qualitative and Quantitative Assessment of Metal Artifacts Arising from Implantable Cardiac Pacing Devices in Oncological PET/CT Studies: A Phantom Study., in Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.
Quantifying the effect of anode surface roughness on diagnostic x-ray spectra using Monte Carlo simulation.
Mehranian A, Ay M R, Alam N Riyahi, Zaidi H, Quantifying the effect of anode surface roughness on diagnostic x-ray spectra using Monte Carlo simulation., in Medical physics, 37(2), 742-52.
RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study.
Weber Damien C, Wang Hui, Cozzi Luca, Dipasquale Giovanna, Khan Haleem G, Ratib Osman, Rouzaud Michel, Vees Hansjoerg, Zaidi Habib, Miralbell Raymond, RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study., in Radiation oncology (London, England), 4.
Reduction of artefacts caused by hip implants in CT-based attenuation-corrected PET images using 2-D interpolation of a virtual sinogram on an irregular grid.
Abdoli Mehrsima, de Jong Johan R, Pruim Jan, Dierckx Rudi A J O, Zaidi Habib, Reduction of artefacts caused by hip implants in CT-based attenuation-corrected PET images using 2-D interpolation of a virtual sinogram on an irregular grid., in European journal of nuclear medicine and molecular imaging.
Reduction of dental filling metallic artifacts in CT-based attenuation correction of PET data using weighted virtual sinograms optimized by a genetic algorithm.
Abdoli Mehrsima, Ay Mohammad Reza, Ahmadian Alireza, Dierckx Rudi A J O, Zaidi Habib, Reduction of dental filling metallic artifacts in CT-based attenuation correction of PET data using weighted virtual sinograms optimized by a genetic algorithm., in Medical physics, 37(12), 6166-77.
Scattered radiation emission imaging: principles and applications.
Nguyen M K, Truong T T, Morvidone M, Zaidi H, Scattered radiation emission imaging: principles and applications., in International journal of biomedical imaging, 2011.
Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT.
Valenta Ines, Quercioli Alessandra, Vincenti Gabriella, Nkoulou René, Dewarrat Stephan, Rager Olivier, Zaidi Habib, Seimbille Yann, Mach Francois, Ratib Osman, Schindler Thomas H, Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT., in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 17(6), 1023-33.
The clinical role of fusion imaging using PET, CT, and MR imaging.
Zaidi Habib, Montandon Marie-Louise, Alavi Abass, The clinical role of fusion imaging using PET, CT, and MR imaging., in Magnetic resonance imaging clinics of North America, 18(1), 133-49.

Awards

Title Year
2010 Kuwait Prize in Applied Sciences for Contributions to Biomedical Technology (Arab Nobel prize) 2011
Paul Phelps Continuing Education Grant to attend the 2011 IEEE Medical Imaging Conference 2011

Associated projects

Number Title Start Funding scheme
116547 Molecular PET/CT imaging-guided radiation therapy treatment planning 01.04.2007 Project funding (Div. I-III)
135576 Development of quantitative procedures for dual-modality PET/MR imaging 01.09.2011 Project funding (Div. I-III)

Abstract

Positron emission tomography (PET) images generated by the preclinical dual-modality PET/CT system (Gamma Medica-Ideas) installed in our department ? funded by the “Centre d’Imagerie Biomédicale” (CIBM), a consortium of 5 academic institutions in the lemanic arch ? suffer from low spatial resolution characteristics and are not quantitative owing to the lack of sophisticated image correction and reconstruction techniques on software supplied by the scanner manufacturer. We request funding to develop strategies for improvement of spatial resolution and accurate quantification of molecular imaging PET data generated by our preclinical PET/CT system using CT-based reconstruction procedures combined with sophisticated image reconstruction algorithms, and to implement the techniques and methodology required for robust and accurate analysis of PET data incorporating fully automated Altas-guided techniques based on computerized anthropomorphic 4-D models depicting the anatomy and physiological functions of rodents combined with optimized protocols designed to reduce respiratory motion artefacts in PET images of the upper abdomen and thorax thus enabling correct localization and accurate quantitation of molecular targets for cancer research experiments performed on rodents. This research involves medical physicists, physicians, radiologists, radiochemists and scientists working at the Department of Radiology and Medical Informatics of Geneva University Hospital (HUG), the Department of Radiology of Lausanne (CHUV), and image processing and analysis researchers from the Swiss Federal Institute of Technology (EPFL).Multimodality molecular imaging has become an essential tool for the development of new tracers, to study the molecular pathways of disease, including factors such as gene expression, in living subjects, and to test new therapeutic approaches in animal models of human disease. Multimodality imaging also has important ramifications for quantification of molecular targets of disease states, which is the major focus of this proposal. For example, dual-modality PET/CT imaging provides x-ray CT data which can be normalized to obtain a patient-specific map of attenuation coefficients that can be used to compensate the correlated radiotracer data for photon attenuation or for Compton scatter. In addition, regions of interest defined anatomically on the CT image can be used to quantify the correlated radiotracer data in a way that allows more precise target and background definition, and that can use model-based methods that correct the extracted quantitative data for partial-volume effects and other physical perturbations. However, there are several challenges that still face the use of preclinical PET/CT imaging, and that may represent inherent limitations in this technique and remain hot topics undoubtedly still requiring further research and development efforts, some of them will be addressed in this research proposal.The division of nuclear medicine, together with national and international partners, foresees to develop innovative approaches for quantitative molecular imaging of small-animals using a preclinical PET/CT system. We submit this funding request to boost our research in this area with the goals to:A.Further develop and validate our PET Monte Carlo simulator and MCNP4C-based x-ray CT simulators to allow accurate modelling of both subsystems of the combined preclinical PET/CT scanner and generation of PET/CT data using computerized anthropomorphic dynamic 4-D models depicting the anatomy and physiological functions of rodents;B.Develop new, more accurate, fast and robust statistical image reconstruction algorithms and projection-based partial volume effect correction strategies for 3-D PET to improve both the spatial resolution of reconstructed images and enhance the quantitative capability of the PET subsystem;C.Characterize the magnitude and spatial distribution of Compton scattered photons for the flat-panel x-ray microCT subsystem using both experimental and Monte Carlo-based techniques and develop new, more accurate, robust and fast scatter correction algorithms;D.Develop and validate a versatile strategy for CT-based attenuation and scatter corrections of PET data including accurate and robust algorithms that compensate for the presence of contrast media in contrast-enhanced CT images;E.Develop and assess the performance of Altas-guided automated analysis of PET data based on computerized anthropomorphic 4-D models depicting the anatomy and physiological functions of rodents combined with retrospective registration-guided methods for motion artefact reduction thus enabling correct localization and accurate quantitation of molecular targets;F.Validate the developed quantitative imaging methodology using simulated and experimental phantom studies and preclinical data aiming at mapping specific molecular targets.
-