auditory cognition; auditory cortex; neural plasticit; connectivity; recovery; neurorehabilitation; Audition; Human; Brain lesion; Functional imaging; Neurorehabilitation,; Neural networks; Cerebral cortex; Plasticity
Bourquin Nathalie M-P, Simonin Alexandre, Clarke Stephanie (2013), Repetition-induced plasticity of motor representations of action sounds., in Brain topography
, 26(1), 152-6.
Duffour-Nikolov Catherine, Tardif Eric, Maeder Philippe, Thiran Anne Bellmann, Bloch Jocelyne, Frischknecht Rolf, Clarke Stephanie (2012), Auditory spatial deficits following hemispheric lesions: dissociation of explicit and implicit processing., in Neuropsychological rehabilitation
, 22(5), 674-96.
Clarke P G H, Clarke S (2012), Nineteenth century research on cell death., in Experimental oncology
, 34(3), 139-45.
Urben Sébastien, Baumann Pierre, Barcellona Sandra, Hafil Muriel, Preuss Ulrich, Peter-Favre Claire, Clarke Stéphanie, Halfon Olivier, Holzer Laurent (2012), Cognitive efficacy of quetiapine in early-onset first-episode psychosis: a 12-week open label trial., in The Psychiatric quarterly
, 83(3), 311-24.
Bourquin Nathalie M-P, Spierer Lucas, Murray Micah M, Clarke Stephanie (2012), Neural plasticity associated with recently versus often heard objects., in NeuroImage
, 62(3), 1800-6.
Da Costa Sandra, van der Zwaag Wietske, Marques Jose P, Frackowiak Richard S J, Clarke Stephanie, Saenz Melissa (2011), Human primary auditory cortex follows the shape of Heschl's gyrus., in The Journal of neuroscience : the official journal of the Society for Neuroscience
, 31(40), 14067-75.
Bindschaedler Claire, Peter-Favre Claire, Maeder Philippe, Hirsbrunner Thérèse, Clarke Stephanie (2011), Growing up with bilateral hippocampal atrophy: from childhood to teenage., in Cortex; a journal devoted to the study of the nervous system and behavior
, 47(8), 931-44.
At Ayse, Spierer Lucas, Clarke Stephanie (2011), The role of the right parietal cortex in sound localization: a chronometric single pulse transcranial magnetic stimulation study., in Neuropsychologia
, 49(9), 2794-7.
Lindemann Astrigh, Antille Valérie, Clarke Stéphanie (2011), [Cognitive impairment in alcohol addiction]., in Revue médicale suisse
, 7(302), 1450-1450.
van der Zwaag Wietske, Gentile Giovanni, Gruetter Rolf, Spierer Lucas, Clarke Stephanie (2011), Where sound position influences sound object representations: a 7-T fMRI study., in NeuroImage
, 54(3), 1803-11.
Spierer Lucas, De Lucia Marzia, Bernasconi Fosco, Grivel Jeremy, Bourquin Nathalie M-P, Clarke Stephanie, Murray Micah M (2011), Learning-induced plasticity in human audition: objects, time, and space., in Hearing research
, 271(1-2), 88-102.
De Lucia Marzia, Clarke Stephanie, Murray Micah M (2010), A temporal hierarchy for conspecific vocalization discrimination in humans., in The Journal of neuroscience : the official journal of the Society for Neuroscience
, 30(33), 11210-21.
De Lucia Marzia, Cocchi Luca, Martuzzi Roberto, Meuli Reto A, Clarke Stephanie, Murray Micah M (2010), Perceptual and semantic contributions to repetition priming of environmental sounds., in Cerebral cortex (New York, N.Y. : 1991)
, 20(7), 1676-84.
Sacco Carolyn B, Tardif Eric, Genoud Christel, Probst Alphonse, Tolnay Markus, Janzer Robert-Charles, Verney Catherine, Kraftsik Rudolf, Clarke Stephanie (2009), GABA receptor subunits in human auditory cortex in normal and stroke cases., in Acta neurobiologiae experimentalis
, 69(4), 469-93.
De Lucia Marzia, Camen Christian, Clarke Stephanie, Murray Micah M (2009), The role of actions in auditory object discrimination., in NeuroImage
, 48(2), 475-85.
Spierer Lucas, Bellmann-Thiran Anne, Maeder Philippe, Murray Micah M, Clarke Stephanie (2009), Hemispheric competence for auditory spatial representation., in Brain : a journal of neurology
, 132(Pt 7), 1953-66.
Interactions within and between specialised cortical networks: postlesional plasticity and the underlying connectivity1. Summary1.1 BackroundSeveral lines of evidence from human and non-human primate studies support a dual-pathway model of audition, with partially segregated cortical networks for sound recognition and sound localisation. Haemodynamic and electrophysiological studies in normal human subjects have shown that these two networks overlap partially, suggesting that parts of the auditory cortex are involved in processing of either auditory feature alone or the two in combination. Our project will concentrate on how these pathways participate in two particular tasks, the representation of sound objects and auditory spatial plasticity. The representation of visual objects has been shown to comprise multiple levels, as demonstrated with repetition priming paradigms in combination with fMRI or EEG. A similar organisation may exist for sound object representations.The auditory spatial system is highly plastic, but only a few studies have addressed the issue of learning-related plasticity of auditory spatial representations in man. In animal models perceptual learning has been shown to pass through a stage of fast and a subsequent stage of slow improvement, associated with changes of neural connectivity. The complex connections of the human brain can be in part visualised by structural and functional MRI techniques, and the connectivity patterns deduced in the two cases match. Functional connectivity, as revealed by coherent spontaneous fluctuations of the BOLD signal, can be altered by a relatively short intervening motor or cognitive task.1.2 Working hypothesisi) The recognition of sound objects relies critically on the interaction between perceptual, semantic and space- or action-related representations. A transient disruption or focal lesion within one or several of these representations impairs recognition; recovery following focal lesions depends on the reconstitution of an alternative network.ii) Plastic changes in auditory spatial representations due to discrimination training in normal subjects involve several mechanisms, including activity modulations within the corresponding networks, changes of network configuration or more widespread changes in functional connectivity. Transient disruption of the activity within the involved network at specific temporo-spatial points impairs discrimination performance and, when applied during learning, its improvement.iii) Following unilateral hemispheric lesions, recovery and the ability to improve performance through training depend on the extent to which specific neural networks re-establish functional connectivity within and between the damaged and intact hemispheres.1.3 Specific aimsi)Determine the temporo-spatial patterns of neural activity associated with different levels of sound object analysis and particularly with perceptual, semantic and space-related representations. Assess the effect of transient disruptions of action-related sound representations on sound recognition.ii)Assess the effects of focal hemispheric lesions on object specific representations and the reorganisation of these representations associated with recovery.iii)Determine how short (half-day) and long auditory spatial discrimination training (5 consecutive days) changes cortical spatial representations and cortical connectivity in normal subjects and in patients with a first focal hemispheric lesions.iv)Assess the effect of transient disruption at specific temporo-spatial points of the auditory spatial discrimination network on discrimination performance and learning.v)Establish longitudinal data of long-term post-stroke functional and structural plasticity in a well defined patient population and compare how postlesional changes in structural and functional connectivity correlate with recovery or effects of specific rehabilitation measures.1.4 Experimental design and methodsProject A. The temporo-spatial patterns of i) perceptual, ii) semantic, and iii) spatially dependent/independent sound object representations will be investigated with priming effect paradigms in normal subjects and in patients with a first focal hemispheric lesion. Using EEG we will investigate, apart from reaction times, the temporo-spatial patterns of neural activity, making use of the fine temporal resolution of the EEG. Using fMRI we will investigate the finer aspects of the anatomical organisation of the involved network, in particular in the supratemporal region, where our new registration method will allow us to analyse activations within the primary and non-primary auditory areas. In a second part, the interactions between sound and action representations will be investigated in normal subjects with single-pulse TMS.Project B. Normal subjects and patients with a first focal hemispheric lesion will undergo a short or a long auditory spatial discrimination training combined with an EEG or structural and functional connectivity study. In a second part, auditory spatial discrimination training will be combined in normal subjects with single-pulse TMS to determine which are the critical events for learning and plastic changes to occur.Project C. Structural and functional connectivity as well as network analysis will be carried out in normal subjects and patients with a first focal hemispheric lesion before and after auditory spatial training, to assess plastic changes associated with learning. In addition, we will establish and analyse longitudinal data of long-term post-stroke functional and structural plasticity in a well defined patient population.1.5 Expected value of the proposed projectThe primary importance of the project is conceptual, in that it will help to answer several fundamental questions. By addressing these issues in non-verbal auditory domain, we will be able to draw comparisons with data from animal models and yet to extrapolate to human functions such as language. Thus, this research is likely to give new understanding of the recovery of cognitive functions and their rehabilitation in brain-damaged patients.