prematurity; brain development; learning disabilities; cortex; magnetic resonance imaging; neuro-electrophysiology; animal models; brain damage; neuroprotection; developmental neuroscience; prematurity ; perinatal brain damage ; long-term developmental disabilities; functional brain development; neurprotection
Natalucci G, Rousson V, Bucher HU, Bernet V, Hagmann C, Latal B (2013), Delayed cyclic activity development on early amplitude-integrated eeg in the preterm infant with brain lesions, in Neonatology
, 103(2), 134-140.
L'Abate P, Wiegert S, Struck J, Wellmann S, Cannizzaro V (2013), Determinants of plasma copeptin: A systematic investigation in a pediatric mechanical ventilation model, in Respiratory Physiology and Neurobiology
, 185(2), 222-227.
Natalucci G, Becker J, Becher K, Bickle GM, Landolt MA, Bucher HU (2013), Self-perceived health status and mental health outcomes in young adults born with less than 1000 g, in Acta Paediatrica, International Journal of Paediatrics
, 102(3), 294-299.
Schlapbach LJ, Adams M, Proietti E, Aebischer M, Grunt S, Borradori-Tolsa C, Bickle-Graz M, Bucher HU, Latal B, Natalucci G (2012), Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008, in BMC Pediatrics
, 12, 1.
Kostović I, Jovanov-Milošević N, Radoš M, Sedmak G, Benjak V, Kostović-Srzentić M, Vasung L, Čuljat M, Radoš M, Hüppi P, Judaš M (2012), Perinatal and early postnatal reorganization of the subplate and related cellular compartments in the human cerebral wall as revealed by histological and MRI approaches, in Brain Structure and Function
Burkhardt T, Schwabe S, Morgenthaler NG, Natalucci G, Zimmermann R, Wellmann S (2012), Copeptin: a marker for stress reaction in fetuses with intrauterine growth restriction, in AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
, 207(6), 497.
Gui L, Lisowski R, Faundez T, Huppi PS, Lazeyras F, Kocher M (2012), Morphology-driven automatic segmentation of MR images of the neonatal brain, in MEDICAL IMAGE ANALYSIS
, 16(8), 1565-1579.
Letzner J, Berger F, Schwabe S, Benzing J, Morgenthaler NG, Bucher HU, Buhrer C, Arlettaz R, Wellmann S (2012), Plasma C-Terminal Pro-Endothelin-1 and the Natriuretic Pro-Peptides NT-proBNP and MR-proANP in Very Preterm Infants with Patent Ductus Arteriosus, in NEONATOLOGY
, 101(2), 116-124.
Chip S (2012), Subfield-specific neurovascular remodeling in the entorhino-hippocampal-organotypic slice culture as a response to oxygen-glucose deprivation and excitotoxic cell death., in J Cereb Blood Flow Metab.
Natalucci Giancarlo, Iten Manuela, Hofmann Julia, Bucher Hans U., Arlettaz Romaine, Molinari Luciano, Latal Beatrice, Landolt Markus A. (2012), Health-Related Quality of Life and Behavior of Triplets at Adolescent Age, in JOURNAL OF PEDIATRICS
, 161(3), 495-495.
Admaty D, Benzing J, Burkhardt T, Lapaire O, Hegi L, Szinnai G, Morgenthaler NG, Bucher HU, Buhrer C, Wellmann S (2012), Plasma midregional proadrenomedullin in newborn infants: impact of prematurity and perinatal infection, in PEDIATRIC RESEARCH
, 72(1), 70-76.
van de Looij Yohan, Lodygensky Gregory A, Dean Justin, Lazeyras François, Hagberg Henrik, Kjellmer Ingemar, Mallard Carina, Hüppi Petra S, Sizonenko Stéphane V (2012), High-field diffusion tensor imaging characterization of cerebral white matter injury in LPS-exposed fetal sheep., in Pediatric research
, 72, 285-292.
Wellmann S, Bührer Christoph (2012), Who plays the strings in newborn analgesia at birth, vasopressin or oxytocin?, in Front Neurosci
, 6, 78.
Benzing J, Stabile O, Szinnai G, Morgenthaler NG, Schulzke SM, Buhrer C, Wellmann S (2012), Plasma Pro-Endothelin-1 and Respiratory Distress in Newborn Infants, in JOURNAL OF PEDIATRICS
, 160(3), 517-519.
Lodygensky GA, Marques JP, Maddage R, Perroud E, Sizonenko SV, Huppi PS, Gruetter R (2012), In vivo assessment of myelination by phase imaging at high magnetic field, in NEUROIMAGE
, 59(3), 1979-1987.
Zgraggen Eloisa, Boitard Michael, Roman Inge, Kanemitsu Michiko, Potter Gael, Salmon Patrick, Vutskits Laszlo, Dayer Alexandre G., Kiss Jozsef Z. (2012), Early Postnatal Migration and Development of Layer II Pyramidal Neurons in the Rodent Cingulate/Retrosplenial Cortex, in CEREBRAL CORTEX
, 22(1), 144-157.
Schlapbach LJ, Aebischer M, Adams M, Natalucci G, Bonhoeffer J, Latzin P, Nelle M, Bucher HU, Latal B, Zeilinger G, Capone A, Glanzmann R, Weber P, Steinlin M, Grunt S, Bär W, Keller E, Killer Ch, Tolsa J-F, Bickle-Graz M, Pfister RE, Huppi PS, Borradori-Tolsa C, Berger TM, Schmitt-Mechelke T (2011), Impact of sepsis on neurodevelopmental outcome in a swiss national cohort of extremely premature infants, in Pediatrics
, 128(2), e348-e357.
Natalucci G, Seitz J, von Siebenthal K, Bucher HU, Molinari L, Jenni OG, Latal B (2011), The role of birthweight discordance in the intellectual and motor outcome for triplets at early school age, in Developmental Medicine and Child Neurology
, 53(9), 822-828.
Dean Justin M, van de Looij Yohan, Sizonenko Stephane V, Lodygensky Gregory A, Lazeyras Francois, Bolouri Hayde, Kjellmer Ingemar, Huppi Petra S, Hagberg Henrik, Mallard Carina (2011), Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep., in Annals of neurology
, 70(5), 846-56.
Chip S, Zelmer A, Ogunshola OO, Felderhoff-Mueser U, Nitsch C, Buhrer C, Wellmann S (2011), The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection, in NEUROBIOLOGY OF DISEASE
, 43(2), 388-396.
Benzing J, Wellmann S, Achini F, Letzner J, Burkhardt T, Beinder E, Morgenthaler NG, Haagen U, Bucher HU, Buhrer C, Lapaire O, Szinnai G (2011), Plasma Copeptin in Preterm Infants: A Highly Sensitive Marker of Fetal and Neonatal Stress, in JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
, 96(6), 982-985.
Quairiaux Charles, Megevand Pierre, Kiss Jozsef Z., Michel Christoph M. (2011), Functional Development of Large-Scale Sensorimotor Cortical Networks in the Brain, in JOURNAL OF NEUROSCIENCE
, 31(26), 9574-9584.
van de Looij Y, Chatagner A, Huppi PS, Gruetter R, Sizonenko SV (2011), Longitudinal MR Assessment of Hypoxic Ischemic Injury in the Immature Rat Brain, in MAGNETIC RESONANCE IN MEDICINE
, 65(2), 305-312.
Wellmann S, Benzing J, Cippa G, Admaty D, Creutzfeldt R, Mieth RA, Beinder E, Lapaire O, Morgenthaler NG, Haagen U, Szinnai G, Buhrer C, Bucher HU (2010), High Copeptin Concentrations in Umbilical Cord Blood after Vaginal Delivery and Birth Acidosis, in JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
, 95(11), 5091-5096.
Lodygensky GA, Vasung L, Sizonenko SV, Huppi PS (2010), Neuroimaging of cortical development and brain connectivity in human newborns and animal models, in JOURNAL OF ANATOMY
, 217(4), 418-428.
Bernet Vera, Latal Beatrice, Natalucci Giancarlo, Doell Carsten, Ziegler Anna, Wohlrab Gabriele (2010), Effect of Sedation and Analgesia on Postoperative Amplitude-Integrated EEG in Newborn Cardiac Patients, in PEDIATRIC RESEARCH
, 67(6), 650-655.
Chatagner A (2010), Érythropoïétine et neuroprotection, in Archives de Pédiatrie
, 17, 78-84.
Natalucci G, Leuchter RH, Ulrich Bucher H, Latal B, Koller B, Hüppi PS, Hagmann C, Functional brain maturation assessed during early life correlates with anatomical brain maturation at term equivalent age in preterm infants, in Pediatr Res
Currently the rate for prematurity is the highest it has been in over 20 years. Long-term survival for premature infants has become an almost expected outcome over the past two decades due to improved neonatal care, but unfortunately often associated with perinatal brain damage and long-term developmental disabilities,such as cerebral palsy, mental retardation and a wide spectrum of learning disabilities. A critical feature of neonatal brain damage is that, in addition to the acute damage, neuronal circuits pursue developmental processes with a significant cell loss. This could lead to disruption of normal developmental processes and even more dramatic deterioration of brain functions. The key issue is to understand how, where and when these changes take place and to understand the cellular and molecular mechanisms of these processes. This will be important for developing new strategies to improve tissue repair and the subsequent development of preserved cortical circuits. The Cortex to Classroom programme is a specific targeted programme including research projects dedicated to young clinician scientists,and designed to (1) understand the effects of prematurity on long-term structural and functional brain development, (2) identify early markers of perinatal brain damage and its underlying mechanism and (3) target endogenous and exogenous molecules for potential neuroprotective and neuroregenerative intervention (e.g. Erythropoietin). One important objective of the project will be to use and to develop animal models of functional recovery which will represent a point of convergence between clinicians and basic scientists and simultaneously allow for addressing issues of medical relevance and testing molecular hypotheses, with a study design which uses methodology, such as magnetic resonance imaging and neuro-electrophysiology, that allows translation from animal to human and vice-versa. The current research is aimed at finding new strategies to help reduce the enormous individual, familial, and societal burden that perinatal brain damage in premature infants represents. It is this consortiums goal to contribute to an improvement of this situation for future generations.