Project

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Protective Factors in Asthma and Allergy: the role of farm milk - a potential tool for prevention

English title Protective Factors in Asthma and Allergy: the role of farm milk - a potential tool for prevention
Applicant Braun-Fahrländer Charlotte
Number 123115
Funding scheme ProDoc
Research institution Institut für Sozial- und Präventivmedizin Universität Basel Swiss TPH
Institution of higher education University of Basel - BS
Main discipline Methods of Epidemiology and Preventive Medicine
Start/End 01.02.2009 - 31.01.2012
Approved amount 165'136.90
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All Disciplines (2)

Discipline
Methods of Epidemiology and Preventive Medicine
Public Health and Health Services

Keywords (6)

children; allergic diseases; dairy products; immune response; prevention; epidemiology

Lay Summary (English)

Lead
Lay summary
Asthma and allergies are a major public health problem and strategies for primary prevention are warranted. The project investigates the protective effect of farm milk consumption on the occurrence of the disease, thus contributing to the development of allergy protective strategies.Asthma and allergies have developed into a major health concern in Europe. Primary prevention strategies must be based on a sound understanding of the various determinants of asthma and allergies. The onset of these diseases is due to a combination of environmental and genetic factors. Much research has been devoted to identify environmental risk factors such as smoking, air pollution and allergen exposure. More recently it has been suggested that a lack of exposure to microbes early in life might be responsible for the development of allergic diseases. Studies in farming areas, an environment rich in microbial exposure, have consistently shown that children living on a farm suffer significantly less often from allergic diseases. Limited information is available on the specific factors conferring protection in farming environments, but exposure to stable dust and consumption of farm milk have repeatedly been associated with a reduced risk for allergic diseases. Dietary intervention would be an attractive means for primary prevention. However, current knowledge about the components of farm milk conferring protection from developing asthma and allergy is very limited. To determine what underlies the epidemiologically observed protective effect of farm milk consumption on the development of asthma and allergy and to prospectively assess the association between the timing of farm milk consumption and immune development.The research project is embedded in two ongoing European collaborative projects, GABRIEL ( www.gabriel-fp6.org )and PASTURE/EFRAIM. The proposed research project will deepen the insight into the quantity and timing of consumption of protective farm milk and the relevant components responsible for the protective effect. It will thus contribute to the development of allergy preventive strategies.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Development of atopic dermatitis according to age of onset and association with early-life exposures.
Roduit C, Frei R, Loss G, Buchele G, Weber J, Depner M, Loeliger S, Dalphin M, Roponen M, Hyvarinen A, Riedler J, Dalphin C, Pekkanen J, von Mutius E, Braun-Fahrländer C, Lauener R (2012), Development of atopic dermatitis according to age of onset and association with early-life exposures., in J Allergy Clin Immunol , 130, 130-136.
Health-related quality of life does not explain the protective effect of farming on allergies.
Stöcklin L, Loss G, von Mutius E, Genuneit J, Horak E, Braun-Fahrländer C (2012), Health-related quality of life does not explain the protective effect of farming on allergies., in Pediatr Allergy Immunol, 23, 519-521.
Prenatal and early-life exposures alter expression of innate immunity genes: the PASTURE cohort study
Loss G, Bitter S, Wohlgensinger J, Frei R, Roduit C, Genuneit J, Pekkanen J, Roponen M, Hirvonen M, Dalphin C, Dalphin M, Riedler J, von Mutius E, Weber J, Kabesch M, Michel S, Braun-Fahrländer C, Lauener R (2012), Prenatal and early-life exposures alter expression of innate immunity genes: the PASTURE cohort study, in Journal of Allergy and Clinical Immunology, 130(2), 523-530.
Short communication: appropriate and alternative methods to determine viable bacterial counts in cow milk samples
Loss G, Apprich S, Kneifen W, von Mutius E, Genuneit J, Braun-Fahrländer C (2012), Short communication: appropriate and alternative methods to determine viable bacterial counts in cow milk samples, in J Dairy Sci , 95, 2916-2918.
The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study
Loss Georg, Apprich S, Waser M, Kneifel W, Genuneit J, Büchele G, Weber J, Sozanska B, Danielewicz H, Horak E, van Neerven RJ, Heederik D, Lorenzen PC, von Mutius E, Braun-Fahrländer C (2011), The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study, in J Allergy Clin Immunol., 128(4), 766-773.

Collaboration

Group / person Country
Types of collaboration
Dr. von Haunersches Kinderspital, LMU Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
BOKU Austria (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Awards

Title Year
Nestlé Wissenschaftspreis 2015
SSPH+ best publication Award, 2012 2012

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