childhood brain tumour; epidemiology; mobile phone; case-control study; mobile phone; brain tumour; epidemiology; non-ionizing radiation; radiofrequency electromagnetic fields
Vienneau Danielle, Infanger Denis, Feychting Maria, Schüz Joachim, Schmidt Lisbeth Samsø, Poulsen Aslak Harbo, Tettamanti Giorgio, Klæboe Lars, Kuehni Claudia E, Tynes Tore, Von der Weid Nicolas, Lannering Birgitta, Röösli Martin (2016), A multinational case-control study on childhood brain tumours, anthropogenic factors, birth characteristics and prenatal exposures: A validation of interview data., in Cancer epidemiology
, 40, 52-9.
Adel Fahmideh Maral, Lavebratt Catharina, Schüz Joachim, Röösli Martin, Tynes Tore, Grotzer Michael A, Johansen Christoffer, Kuehni Claudia E, Lannering Birgitta, Prochazka Michaela, Schmidt Lisbeth S, Feychting Maria (2016), Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility., in Oncotarget
Tettamanti Giorgio, Shu Xiaochen, Adel Fahmideh Maral, Schüz Joachim, Röösli Martin, Tynes Tore, Grotzer Michael, Johansen Christoffer, Klaeboe Lars, Kuehni Claudia E, Lannering Birgitta, Schmidt Lisbeth S, Vienneau Danielle, Feychting Maria (2016), Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case-Control Study., in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer
, 26(1), 110-115.
Shu X, Prochazka M, Lannering B, Schüz J, Röösli M, Tynes T, Kuehni C E, Andersen T V, Infanger D, Schmidt L S, Poulsen A H, Klaeboe L, Eggen T, Feychting M (2014), Atopic conditions and brain tumor risk in children and adolescents--an international case-control study (CEFALO)., in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
, 25(4), 902-8.
Fahmideh Maral Adel, Lavebratt Catharina, Schüz Joachim, Röösli Martin, Röösli Martin, Tynes Tore, Tynes Tore, A.Grotzer Michael, Johansen Christoffer, Johansen Christoffer, E.Kuehni Claudia, Lannering Birgitta, Prochazka Michaela, S.Schmidt Lisbeth, Feychting Maria (2014), CCDC26, CDKN 2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility, in Carcinogenesis
, 36(8), 876-882.
Röösli M., Feychting M., Schüz J. (2014), Use of Mobile Phones and Brain Cancer Risk in Children?, in Hayat M.A. (ed.), Springer, ebook, 293-300.
Andersen T V, Schmidt L S, Poulsen A H, Feychting M, Röösli M, Tynes T, Aydin D, Prochazka M, Lannering B, Klæboe L, Eggen T, Kuehni C E, Schmiegelow K, Schüz J (2013), Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International Case-Control Study (CEFALO)., in British journal of cancer
, 108(11), 2346-53.
Christensen Jeppe Schultz, Mortensen Laust Hvas, Röösli Martin, Feychting Maria, Tynes Tore, Andersen Tina Veje, Schmidt Lisbeth Samsø, Poulsen Aslak Harbo, Aydin Denis, Kuehni Claudia E, Prochazka Michaela, Lannering Birgitta, Klaeboe Lars, Eggen Tone, Schüz Joachim (2012), Brain tumors in children and adolescents and exposure to animals and farm life: a multicenter case-control study (CEFALO)., in Cancer causes & control : CCC
, 23(9), 1463-73.
Aydin Denis, Feychting Maria, Schüz Joachim, Röösli Martin (2012), Childhood brain tumours and use of mobile phones: comparison of a case–control study with incidence data, in Environmental Health
, 11, 35.
Aydin D, Feychting M, Schuz J, Roosli M (2012), Re: Mobile Phone Use and Brain Tumors in Children and Adolescents Response
, NN, NN.
Aydin D, Feychting M, Schuz J, Roosli M (2012), Re: Mobile Phone Use and Brain Tumors in Children and Adolescents: A Multicenter Case-Control Study Response
, NN, NN.
Aydin Denis, Feychting Maria, Schüz Joachim, Andersen Tina Veje, Poulsen Aslak Harbo, Prochazka Michaela, Klaeboe Lars, Kuehni Claudia E, Tynes Tore, Röösli Martin (2011), Impact of random and systematic recall errors and selection bias in case--control studies on mobile phone use and brain tumors in adolescents (CEFALO study)., in Bioelectromagnetics
, 32(5), 396-407.
Aydin Denis, Feychting Maria, Schüz Joachim, Tynes Tore, Andersen Tina Veje, Schmidt Lisbeth Samsø, Poulsen Aslak Harbo, Johansen Christoffer, Prochazka Michaela, Lannering Birgitta, Klæboe Lars, Eggen Tone, Jenni Daniela, Grotzer Michael, Von der Weid Nicolas, Kuehni Claudia E, Röösli Martin (2011), Mobile phone use and brain tumors in children and adolescents: a multicenter case-control study., in Journal of the National Cancer Institute
, 103(16), 1264-76.
Aydin D, Feychting M, Schüz J, Veje Andersen T, Harbo Poulsen A, Prochazka M, Klæboe L, Kuehni CE, Tynes T, Röösli M (2011), Predictors and overestimation of recalled mobile phone use among children and adolescents, in Progress in Biophysics and Molecular Biology
, 107(3), 356-361.
Background: It has been hypothesized, that children could be more vulnerable to radio frequency electromagnetic field exposures from mobile telephones than adults, but no epidemiological studies of the relationship have been performed so far. The lack of knowledge causes conflicting recommendations from decision-makers, leading to anxiety and insecurity in the population. WHO and The National Academies (USA) has put a case-control study on childhood brain tumours as high priority on their research agenda on radio frequency electromagnetic fields. In 2006, CEFALO, a multinational case-control study of the association between the use of mobile telephones and the risk of brain tumours among children aged 7-19 years has been set up in Denmark, Norway, Sweden, United Kingdom and Switzerland. The PhD project is embedded in this multi-centre study.Methods: Cases are identified through a combination of data from the cancer registries and information from the wards treating the patients. All incident cases of brain tumour between May 2004 and May 2008 are identified, irrespective of vital status at the date of recruitment. In total, the study is expected to include 500 cases of brain tumours in the participating countries, thereof 100 originating from Switzerland. For each case, two control persons will be randomly selected from the general population, matched on age, sex and geographic regions. Information on the extent of exposure to radio frequency fields from mobile phones and on other known and suspected risk factors for childhood brain tumours is obtained by means of personal interviews conducted by an interviewer trained for this purpose. The interviews take place either at the hospital or at the study participant’s home. Objective information on the frequency and duration of mobile phone use will be obtained from mobile phone operators and from the information stored in the telephone that is in current use. In Switzerland all three mobile phone operators (Swisscom, Orange, Sunrise) agreed to provide data on mobile phone use from consenting study participants. Phone traffic records will be available 6 months back in time. Billing records and duration of subscription can be delivered for the whole period since GSM is used. Gene-environment interactions play a role in the expression of the noxious potency of an exogenous environmental agent (e.g. non-ionizing radiation) and thus may modify the individual cancer risk. For that reason we will investigate genetic polymorphisms of DNA repair genes as well as polymorphisms in genes which are involved in the metabolism of toxins. We will collect DNA in the form of saliva in cases and controls. Ethical approval has been obtained in all countries.PhD project: The field work will end in December 2008. Switzerland is in charge to investigate the association between mobile phone use and brain tumour in the whole dataset. The PhD student will be involved in the data cleaning and data management. Subsequently the PhD student will perform the data analyses with the following aims:Using data from the Swiss study arm: •To calculate incidence of brain tumours in Switzerland for children and adolescents aged 7-19 years (2004-2008). •To describe patient flows and referral practices for young brain tumour patients in the Swiss health systemUsing data from all collaborating European centres: •To evaluate the correlation between self reported use of mobile phones and operator data.•To analyse the association between use of mobile phones and risk for brain tumours in children and adolescents.•To participate in the analysis of gene-environment interactions relating to the risk of brain tumours and mobile phonesThe data will be analyzed using established statistical methods for case-control studies, primarily via logistic regression models adjusted for potential confounding factors. Schedule: The PhD will start in October 2008 and last 3 years.