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Single-trial EEG Analysis Methods for Understanding Individual Mechanisms of Learning and Plasticity

English title Single-trial EEG Analysis Methods for Understanding Individual Mechanisms of Learning and Plasticity
Applicant De Lucia Marzia
Number 122518
Funding scheme Interdisciplinary projects
Research institution Centre d'Imagerie BioMédicale (CIBM) CHUV
Institution of higher education University of Lausanne - LA
Main discipline Biomedical Engineering
Start/End 01.05.2009 - 31.10.2012
Approved amount 182'266.00
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All Disciplines (2)

Discipline
Biomedical Engineering
Physiology : other topics

Keywords (5)

Electroencephalography; single-trial; learning and plasticity; Event Related Potential; machine learning methods

Lay Summary (English)

Lead
Lay summary
Understanding how the human brain processes incoming sensory stimuli has greatly benefited from the development of high-resolution functional brain imaging techniques. Within the others, electromagnetic brain imaging techniques such as electroencephalography (EEG) represent a unique access on this temporal dynamic at the same speed as the brain processes these stimuli. Classical analysis and interpretation of electrical responses to external stimuli relies on the assumption that stimulus related activities, the so called event related potential, are stable in time (stationary) across several trials. Based on this assumption, the standard approach consists in analysing an average of brain responses to similar stimuli. However, the stationary hypothesis does not take into account many factors influencing the neural activity context, including effects of learning, plasticity and fatigue. These limitations have driven an increasing interest in developing new tools of EEG analysis at the level of single brain responses. These kinds of methods open the way to address a fundamental issue in cognitive neuroscience, which consists in discovering relations between behavioural output and brain activity measures during the course of an experiment. Our plan is to further develop a single-trial method that we recently proposed and to exploit this approach for uncovering mechanisms underlying learning and plasticity phenomena. Our novel proposition for tackling single-trial multichannel EEG analysis -based on topographic map analysis and with minimal use of a priori constraints- has shown promising results on auditory stimulation dataset. Establishing robust criteria of application in general experimental conditions represent the next step to be taken. The present project plan is expected to have an impact in several domains. In clinical research, this novel approach gives the possibility to statistically evaluate single subject data, an essential tool for analysing patients with specific deficits and impairments and that cannot be considered part of a group. In cognitive neuroscience, it provides a novel tool for understanding behaviour and brain activity interdependencies at both single subject and at group levels. In basic neurophysiology, it provides a new representation of event related potentials and promises to cast light on the mechanisms of its generation.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
A Tutorial Review of Electrical Neuroimaging From Group-Average to Single-Trial Event-Related Potentials
Tzovara A, Murray MM, Michel CM, De Lucia M (2012), A Tutorial Review of Electrical Neuroimaging From Group-Average to Single-Trial Event-Related Potentials, in DEVELOPMENTAL NEUROPSYCHOLOGY, 37(6), 518-544.
Decoding stimulus-related information from single-trial EEG responses based on voltage topographies
Tzovara A, Murray MM, Plomp G, Herzog MH, Michel CM, De Lucia M (2012), Decoding stimulus-related information from single-trial EEG responses based on voltage topographies, in PATTERN RECOGNITION, 45(6), 2109-2122.
The timing of exploratory decision-making revealed by single-trial topographic EEG analyses
Tzovara A, Murray MM, Bourdaud N, Chavarriaga R, Millan JD, De Lucia M (2012), The timing of exploratory decision-making revealed by single-trial topographic EEG analyses, in NEUROIMAGE, 60(4), 1959-1969.
Auditory perceptual decision-making based on semantic categorization of environmental sounds
De Lucia M, Tzovara A, Bernasconi F, Spierer L, Murray MM (2012), Auditory perceptual decision-making based on semantic categorization of environmental sounds, in NEUROIMAGE, 60(3), 1704-1715.
Decoding Sequence Learning from Single-Trial Intracranial EEG in Humans
De Lucia M, Constantinescu I, Sterpenich V, Pourtois G, Seeck M, Schwartz S (2011), Decoding Sequence Learning from Single-Trial Intracranial EEG in Humans, in PLOS ONE, 6(12), e28630.
Noise in Brain Activity Engenders Perception and Influences Discrimination Sensitivity
Bernasconi F, De Lucia M, Tzovara A, Manuel AL, Murray MM, Spierer L (2011), Noise in Brain Activity Engenders Perception and Influences Discrimination Sensitivity, in JOURNAL OF NEUROSCIENCE, 31(49), 17971-17981.
Dynamic Changes in Brain Functional Connectivity during Concurrent Dual-Task Performance
Cocchi L, Zalesky A, Toepel U, Whitford TJ, De-Lucia M, Murray MM, Carter O (2011), Dynamic Changes in Brain Functional Connectivity during Concurrent Dual-Task Performance, in PLOS ONE, 6(11), e28301.
Learning-induced plasticity in human audition: Objects, time, and space
Spierer L, De Lucia M, Bernasconi F, Grivel J, Bourquin NMP, Clarke S, Murray MM (2011), Learning-induced plasticity in human audition: Objects, time, and space, in HEARING RESEARCH, 271(1-2), 88-102.
Working memory load improves early stages of independent visual processing
Cocchi L, Toepel U, De Lucia M, Martuzzi R, Wood SJ, Carter O, Murray MM (2011), Working memory load improves early stages of independent visual processing, in NEUROPSYCHOLOGIA, 49(1), 92-102.
A Temporal Hierarchy for Conspecific Vocalization Discrimination in Humans
De Lucia M, Clarke S, Murray MM (2010), A Temporal Hierarchy for Conspecific Vocalization Discrimination in Humans, in JOURNAL OF NEUROSCIENCE, 30(33), 11210-11221.
Perceptual and Semantic Contributions to Repetition Priming of Environmental Sounds
De Lucia M, Cocchi L, Martuzzi R, Meuli RA, Clarke S, Murray MM (2010), Perceptual and Semantic Contributions to Repetition Priming of Environmental Sounds, in CEREBRAL CORTEX, 20(7), 1676-1684.
Comparing ICA-based and Single-Trial Topographic ERP Analyses
De Lucia M, Michel CM, Murray MM (2010), Comparing ICA-based and Single-Trial Topographic ERP Analyses, in BRAIN TOPOGRAPHY, 23(2), 119-127.
The role of actions in auditory object discrimination
De Lucia M, Camen C, Clarke S, Murray MM (2009), The role of actions in auditory object discrimination, in NEUROIMAGE, 48(2), 475-485.
Principles of Topographic Analyses of Electrical Neuroimaging.
Murray MM De Lucia M Brunet D Michel C.M. (2009), Principles of Topographic Analyses of Electrical Neuroimaging., in Handy TC (ed.), MIT Press, Cambridge, MA 02142-1315 USA, 21.
Progression of auditory discrimination based on neural decoding predicts awakening from coma.
Tzovara A. Rossetti A.O. Murray M.M. Spierer L. Grivel J. Oddo M. De Lucia M., Progression of auditory discrimination based on neural decoding predicts awakening from coma., in Brain.

Collaboration

Group / person Country
Types of collaboration
Departments of Neurosciences and Clinical Neurology University of Geneva (Sophie Schwartz) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Center for Neuroprosthetics (José del R. Millán & Ricardo Chavarriaga Lozano) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Intensive Care (Mauro Oddo), University Hospital Lausanne Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Neurology Unit, Department Clinical Neuroscience, University Hospital, Lausanne (Andrea Rossetti) Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Invited presentation at Neuroscience, Physiology & Pharmacology Department, University College London: "Auditory discrimination in post-anoxic comatose patients during and after therapeutic hypothermia" 19.11.2012 London, UK
Invited presentation at Departments of Neurosciences and Clinical Neurology, University of Geneva: "Auditory discrimination in post-anoxic comatose patients during and after therapeutic hypothermia" 13.11.2012 Geneva, Switzerland
The Sixth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Application, New York, USA. 01.05.2012 New York, USA.
Invited presentation at the The Nathan Kline Institute for Psychiatric Research, New York, USA: “Decoding auditory stimuli from single trial EEG in normal and clinical populations”. 30.04.2012 New York, USA
Invited presentation at the Fondazione Santa Lucia, Rome, Italy: “Decoding auditory stimuli from single trial EEG in normal and clinical populations”. 11.04.2012 Rome, Italy
Invited presentation at The Institute of Medical Psychology and Behavioral Neurobiology, Faculty of Medicine of the University of Tübingen: "Perceptual decision-making of environmental sounds based on single-trial EEG responses". 01.05.2011 University of Tübingen, Germany
Alpine Brain Imaging Meeting 09.01.2011 Champéry
Alpine Brain Imaging Meeting 10.01.2010 Champéry
7th International Symposium on Noninvasive Functional Source Imaging of the Brain and Heart 29.05.2009 Rome, Italy


Communication with the public

Communication Title Media Place Year
Media relations: radio, television "Faites chanter vos neurones !" "Impatience" (radio program) Western Switzerland 12.11.2012
Media relations: radio, television Reaktion auf Töne erlaubt Prognose Sf1 - Puls German-speaking Switzerland 10.12.2012
Media relations: radio, television Telegiornal de "La Télé" La Télé Western Switzerland 12.11.2012
Media relations: radio, television Une étude permet de donner le pronostic vital d'un patient comateux ayant subi une crise cardiaque RTS Western Switzerland 02.12.2012

Abstract

Classical analysis and interpretation of electrical responses to external and internal stimuli relies on the assumption that evoked activities are stationary (i.e. stable in time) across several trials. However, several factors can influence the neural activity context where the stimulus arrives and therefore alter the brain response, including effects of learning, plasticity and fatigue. Even when these systemic factors are negligible, the evoked components in the electrical responses to external stimuli can occur at different latencies across trials and with some amplitude variability. All these circumstances have driven an increasing interest in developing new tools of EEG analysis at the level of single trials. These kinds of methods open the way to address a fundamental issue in cognitive neuroscience, which consists in discovering relations between behavioural output (i.e. reaction time, response accuracy) and brain activity measures during the course of an experiment. Indeed, as consequence of plasticity and adaptation, the behavioural output can change in a consistent manner from trial to trial. A typical example of this phenomenon can be observed when two stimuli are presented twice during an experiment, either in their exact physical replica or when they share semantic content. It has been shown across modalities and in human and animal studies that the response to the second stimulus is facilitated, a phenomenon known as priming.Our plan is to further develop a single-trial method that we recently proposed and to exploit this approach for uncovering mechanisms underlying priming. Our novel proposition for tackling single-trial multichannel EEG analysis -based on topographic map analysis and with minimal use of a priori constraints- has shown promising results on auditory stimulation dataset. Establishing robust criteria of application in general experimental conditions represent the next step to be taken.Specifically we propose:-Validating two criteria for choosing the optimal number of maps in the topographic analysis using already collected datasets-Testing model robustness when adding artefacts or noisy trials-Optimizing the model as a function of the number of electrodes in the montage So far, we have demonstrated how the model can be used to assess time periods when specific maps are significantly present and to statistically evaluate differences between experimental conditions. However, several more challenging directions are open to further investigation. Specifically in the context of priming, we plan to follow two research lines: -Assessing interdependencies between map appearance and behavioural responses-Monitoring effects of overall changes in the pattern of electrical responses during the progression of the experiment.This study will be conducted on a set of data currently under collection. The experiment is based on the same set of stimuli of our recent fMRI study on perceptual and semantic priming and therefore directly comparable.The present project plan is expected to have an impact in several domains.In clinical research, this novel approach gives the possibility to statistically evaluate single subject data, an essential tool for analysing patients with specific deficits and impairments and that cannot be considered part of a group. In cognitive neuroscience, it provides a novel tool for understanding behaviour and brain activity interdependencies at both single subject and at group levels. In basic neurophysiology, it provides a new representation of event related potentials and promises to cast light on the mechanisms of its generation.
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