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Miniaturised ventricular assist device made of biometal muscle for paediatric applications

English title Miniaturised ventricular assist device made of biometal muscle for paediatric applications
Applicant Tozzi Piergiorgio
Number 121580
Funding scheme Project funding (Div. I-III)
Research institution Service de Chirurgie Cardio-Vasculaire Département de chirurgie - CHUV
Institution of higher education University of Lausanne - LA
Main discipline Biomedical Engineering
Start/End 01.10.2008 - 31.12.2010
Approved amount 166'667.00
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All Disciplines (2)

Biomedical Engineering
Cardiovascular Research

Keywords (5)

cardiac failure in pediatrics; ventricular assist devices; artificial muscles; paediatric cardiogenic shock; nitinol implantable device

Lay Summary (English)

Lay summary
LeadThere are very few mechanical means to treat severe cardiac failure in paediatric age. All the existing devices are bulky and badly their design suits for the body of a baby. The use of artificial muscle technology allows the construction of smaller devices having no contact with blood stream, that compress the heart from its surface. SummaryThe existing ventricular assist devices are either pneumatic or magnetically suspended pumps. They are bulky and require very invasive procedures to be implanted. Moreover, because there are huge synthetic surfaces exposed to blood they need full anticoagulation and patients suffer of hemorrhagic complications. The use of artificial muscle technology could solve both problems: smaller devices and no blood exposed surfaces. Heart compression is a physiologic way to mechanically support the heart function because there is the need for neither artificial valves nor anticoagulation therapy. Applicants believe it is possible to assist child’s heart using synthetic muscles placed around the heart that synchronously compress it. AimApplicants have developed a cardiac assist device that restores the capacity of the ventricle to generate work. The pump is a micro engine based on shape memory alloy technology, driven by a pacemaker equivalent microprocessor that is positioned far from the heart. When activated, the pump squeezes the ventricles partially replacing their transport function. Applicants design an animal model to assess in vivo performances of this micro engine.Potential significanceIf the results will confirm that this device provides hemodynamic performance comparable to that of normal heart of young patients, it would substantiate the theory that it is possible to restore the pump function of failing heart even in children using synthetic muscles. For the first time, it would be feasible to create a small size, low cost cardiac assist device driven by pacemaker like battery for bridge-to-transplant and bridge-to-recovery applications.
Direct link to Lay Summary Last update: 21.02.2013

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