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Risk factors, manifestitations and consequences of age-related frailty in the community-dwelling population: an analysis of 2004-2009 data from the Lc65+ cohorty study

English title Risk factors, manifestitations and consequences of age-related frailty in the community-dwelling population: an analysis of 2004-2009 data from the Lc65+ cohorty study
Applicant Santos-Eggimann Brigitte
Number 120795
Funding scheme Project funding (special)
Research institution Institut Universitaire de Médecine Sociale et Préventive - IUMSP CHUV et Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Medico-Social Problems of the Elderly
Start/End 01.11.2008 - 31.10.2011
Approved amount 195'782.00
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All Disciplines (7)

Discipline
Medico-Social Problems of the Elderly
Neurology, Psychiatry
Sociology
Psychology
Public Health and Health Services
Economics
Geriatrics

Keywords (8)

Frailty; Old Age; Epidemiology; cohort study; frail elderly; large nested project; SWITCO-65+; Swiss Venous Thromboembolism Cohort 65+

Lay Summary (English)

Lead
Lay summary
Background. Frailty is a recognized multidimensional geriatric syndrome characterized by an increased vulnerability to stressors that results from multi-organ damage. However, frailty is still a relatively new concept with various definitions. Because it may be a reversible precursor of functional dependence in the old age and predict adverse outcomes, including dependence, understanding this geriatric syndrome is a major challenge both in the clinical setting and from a public health perspective.Objectives. To analyze the sequence Determinants of frailty > Components of frailty > Consequences of frailty in the "Lausanne cohort Lc65+ for the study of age-related frailty" project. Various aspects of frailty (phenotype, perception, risk factors, natural history and outcomes) will be investigated in this cohort, with an emphasis on the youngest old and initial manifestations of frailty. Analyses of Lc65+ data will provide a longitudinal insight on frailty, with the ultimate perspective to help design preventive interventions. Methods. Prospective analyses of data collected between 2004 and 2009 in the Lc65+ project. The Lc65+ cohort is representative of the non-institutionalized Lausanne population aged 65-70 (first sample born between 1934 and 1938). Of 1'564 participants in an initial survey, 1'422 completed the baseline data collection in 2005, of which 1'416 could be classified into not-frail, pre-frail of frail according to the Fried index. Baseline data collected in 2004-2005 through questionnaires, examinations and performance tests cover a large range of medical and psychosocial dimensions. Follow-up information (subjective health, BADL, IADL, mobility, medical diagnoses and treatments, chronic health problems, health services utilization, as well as psychosocial factors and indicators of frailty such as falls, weight loss, etc.) is collected each year by mailed questionnaires and every third year by questionnaires, examinations and performance tests similar to baseline. For additional information, see Santos-Eggimann B, Karmaniola A, Seematter-Bagnoud L, et al. The Lausanne cohort Lc65+: a population-based prospective study of the manifestations, determinants and outcomes of frailty BMC Geriatrics 2008, 8:20, http://www.biomedcentral.com/1471-2318/8/20.Significance. With recent increases in longevity and demographic changes originating in the years following the second world war (baby-boom), industrialized countries will have to face the needs of large numbers of very old individuals in next decades. Understanding frailty is a necessity to prevent an epidemic of functional dependency in the second quarter of this century.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Handwriting and pre-frailty in the Lausanne cohort 65+ (Lc65+) study.
Camicioli Richard, Mizrahi Seymour, Spagnoli Jacques, Büla Christophe, Demonet Jean-François, Vingerhoets François, von Gunten Armin, Santos-Eggimann Brigitte (2015), Handwriting and pre-frailty in the Lausanne cohort 65+ (Lc65+) study., in Archives of gerontology and geriatrics, 61(1), 8-13.
Alcohol Use and Frailty in Community-Dwelling Older Persons Aged 65 to 70 Years.
Seematter-Bagnoud L, Spagnoli J, Büla C, Santos-Eggimann B (2014), Alcohol Use and Frailty in Community-Dwelling Older Persons Aged 65 to 70 Years., in The Journal of frailty & aging, 3(1), 9-14.
Physical activity in daily life is associated with lower adiposity values than doing weekly sports in Lc65+ cohort at baseline.
Danon-Hersch Nadia, Santos-Eggimann Brigitte (2013), Physical activity in daily life is associated with lower adiposity values than doing weekly sports in Lc65+ cohort at baseline., in BMC public health, 13, 1175-1175.
Prefrailty and chronic morbidity in the youngest old: an insight from the lausanne cohort lc65+.
Danon-Hersch Nadia, Rodondi Nicolas, Spagnoli Jacques, Santos-Eggimann Brigitte (2012), Prefrailty and chronic morbidity in the youngest old: an insight from the lausanne cohort lc65+., in Journal of the American Geriatrics Society, 60(9), 1687-94.
Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis.
Birnie Kate, Cooper Rachel, Martin Richard M, Kuh Diana, Sayer Avan Aihie, Alvarado Beatriz E, Bayer Antony, Christensen Kaare, Cho Sung-il, Cooper Cyrus, Corley Janie, Craig Leone, Deary Ian J, Demakakos Panayotes, Ebrahim Shah, Gallacher John, Gow Alan J, Gunnell David, Haas Steven, Hemmingsson Tomas, Inskip Hazel, Jang Soong-nang, Noronha Kenya, Osler Merete, Palloni Alberto (2011), Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis., in PloS one, 6(1), 15564-15564.
Self-perception of aging and vulnerability to adverse outcomes at the age of 65-70 years.
Moser Charlotte, Spagnoli Jacques, Santos-Eggimann Brigitte (2011), Self-perception of aging and vulnerability to adverse outcomes at the age of 65-70 years., in The journals of gerontology. Series B, Psychological sciences and social sciences, 66(6), 675-80.
Adverse life events among community-dwelling persons aged 65-70 years: gender differences in occurrence and perceived psychological consequences.
Seematter-Bagnoud Laurence, Karmaniola Athanassia, Santos-Eggimann Brigitte (2010), Adverse life events among community-dwelling persons aged 65-70 years: gender differences in occurrence and perceived psychological consequences., in Social psychiatry and psychiatric epidemiology, 45(1), 9-16.
Vulnerability in high-functioning persons aged 65 to 70 years: the importance of the fear factor.
Seematter-Bagnoud Laurence, Santos-Eggimann Brigitte, Rochat Stéphane, Martin Estelle, Karmaniola Athanassia, Aminian Kamiar, Piot-Ziegler Chantal, Büla Christophe J (2010), Vulnerability in high-functioning persons aged 65 to 70 years: the importance of the fear factor., in Aging clinical and experimental research, 22(3), 212-8.
What is the relationship between fear of falling and gait in well-functioning older persons aged 65 to 70 years?
Rochat Stephane, Büla Christophe J, Martin Estelle, Seematter-Bagnoud Laurence, Karmaniola Athanassia, Aminian Kamiar, Piot-Ziegler Chantal, Santos-Eggimann Brigitte (2010), What is the relationship between fear of falling and gait in well-functioning older persons aged 65 to 70 years?, in Archives of physical medicine and rehabilitation, 91(6), 879-84.
Life-course socioeconomic environment and health risk behaviours. A multilevel small-area analysis of young-old persons in an urban neighbourhood in Lausanne, Switzerland.
Cornaz Sarah, Taffé Patrick, Santos-Eggimann Brigitte (2009), Life-course socioeconomic environment and health risk behaviours. A multilevel small-area analysis of young-old persons in an urban neighbourhood in Lausanne, Switzerland., in Health & place, 15(1), 273-83.
The Lausanne cohort Lc65+: a population-based prospective study of the manifestations, determinants and outcomes of frailty.
Santos-Eggimann Brigitte, Karmaniola Athanassia, Seematter-Bagnoud Laurence, Spagnoli Jacques, Büla Christophe, Cornuz Jacques, Rodondi Nicolas, Vollenweider Peter, Waeber Gérard, Pécoud Alain (2008), The Lausanne cohort Lc65+: a population-based prospective study of the manifestations, determinants and outcomes of frailty., in BMC geriatrics, 8, 20-20.
Association between adiposity and disability in the Lc65+ cohort.
Danon-Hersch Nadia, Association between adiposity and disability in the Lc65+ cohort., in Journal of nutrition health and aging.
The association between different levels of alcohol use and gait under single and dual task in community-dwelling older persons aged 65 to 70 years.
Seematter-Bagnoud Laurence, The association between different levels of alcohol use and gait under single and dual task in community-dwelling older persons aged 65 to 70 years., in Current Gerontol Geriatr Research.

Collaboration

Group / person Country
Types of collaboration
Institut de Recherche et de Documentation en Economie de la Santé France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
University of Bristol, Department of Social Medicine Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
2011 Alliance for Healthy Aging Symposium on Frailty and Healthspan. Second Annual Mayo Clinic Robert and Arlene Kogod Center on Aging Conference Talk given at a conference Frailty phenotype's assessment in the community: the SHARE and Lc65+ studies 20.10.2011 Groningen, Netherlands, Netherlands Santos-Eggimann Brigitte;
Réunion scientifique 2011 de la Swiss Public Health Society Talk given at a conference Frailty, chronic diseases and disability in the youngest-old: an insight from the Lausanne cohort Lc65+ 25.08.2011 Bâle, Switzerland Danon-Hersch Nadia; Santos-Eggimann Brigitte;
VIIth European Congress of International Association of Gerontology and Geriatrics Talk given at a conference Can vulnerability to adverse outcomes be detected based on self-reports? 15.04.2011 Bologne, Italie, Italy Santos-Eggimann Brigitte;
Séminaire de recherche "Fragilité des personnes âgées", IRDES-Institut de Recherche et de Documentation en Economie de la Santé Talk given at a conference SHARE et Lc65+: deux sources de données pour étudier la fragilité d'un point de vue de santé publique 10.03.2011 Paris, France Santos-Eggimann Brigitte;
Colloque de formation continue du Département Universitaire de Médecine et Santé communautaires, Centre Hospitalier Universitaire Vaudois Individual talk Importance des études de cohorte 29.10.2010 Lausanne, Switzerland Santos-Eggimann Brigitte;
Séminaires du Centre Interfacultaire de Gérontologie, Université de Genève Individual talk Cohorte lausannoise Lc65+: pourquoi étudier la fragilité dans la population des jeunes âgés ? 27.04.2010 Genève, Switzerland Santos-Eggimann Brigitte;
Colloques de recherche Pavie, Universités de Genève et de Lausanne Individual talk Événements de vie stressants et survenue de symptômes dépressifs: résultats de l'étude Lc65+ 14.04.2010 Genève, Switzerland Santos-Eggimann Brigitte;
Colloque du Département de Médecine Interne, Centre Hospitalier Universitaire Vaudois Individual talk Étude Lc65+, instrument de recherche sur le développement d'une fragilité chez les personnes âgées 10.12.2009 Lausanne, Switzerland Santos-Eggimann Brigitte;
Colloques médicaux du Département de Réhabilitation et Gériatrie des Hôpitaux Universitaires de Genève Individual talk Prévalence de la fragilité 29.10.2009 Genève, Switzerland Santos-Eggimann Brigitte;
9ème Colloque de neuropsychologie: La fragilité entre soma et cognition. Individual talk Épidémiologie de la fragilité 24.09.2009 Mottex (VD), Switzerland Santos-Eggimann Brigitte;
XXIth World Congress of Gerontology and Geriatrics Talk given at a conference Does a frailty phenotype predict health services utilization in the community-dwelling young-old? 05.07.2009 Paris, France, France Santos-Eggimann Brigitte; Rodondi Nicolas;
61st Annual Meeting of the Gerontological Society of America (GSA) Talk given at a conference Does falls efficacy predict gait performance in high functionning older people ? 21.11.2008 National Harbor, Washington DC, USA, United States of America Santos-Eggimann Brigitte; Seematter-Bagnoud Laurence; Bula Christophe;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Symposium « Un autre regard sur le vieillissement ». Conférence Régionale de Santé du Languedoc-Roussillon, Commission Régionale du Vieillissement Talk 26.11.2009 Montpellier, France, France Santos-Eggimann Brigitte;
Symposium « Vieillir maintenant, vieillir demain », Groupement des médecins travaillant en EMS de la Société Vaudoise de Médecine Talk 05.11.2009 Signal de Bougy (VD), Switzerland Santos-Eggimann Brigitte;


Communication with the public

Communication Title Media Place Year
Print (books, brochures, leaflets) Lettre de la Cohorte N°8 Western Switzerland 2011
Print (books, brochures, leaflets) Lettre de la Cohorte N°7 Western Switzerland 2010
Print (books, brochures, leaflets) Lettre de la Cohorte N°6 Western Switzerland 2009
Print (books, brochures, leaflets) "Vieillissement et fragilité - comprendre pour prévenir", in: Au fil du temps, Gollion: Infolio éd. Western Switzerland 2008
Print (books, brochures, leaflets) Lettre de la Cohorte N°5 Western Switzerland 2008
Other activities Site internet International German-speaking Switzerland Western Switzerland Rhaeto-Romanic Switzerland Italian-speaking Switzerland 2008

Awards

Title Year
Prix de la Fondation Leenaards (recherche sur la qualité de vie des personnes âgées) 2011
Swiss Public Health Award 2011 for best research abstract 2011

Associated projects

Number Title Start Funding scheme
134042 Nutrition and health in a cohort representative of the general community-dwelling population of Lausanne aged 65 and over 01.10.2011 Marie Heim-Voegtlin grants

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