Zurück zur Übersicht

Beyond vascular anatomy: hemodynamics in cerebral aneurysms and endovascular treatment

Titel Englisch Beyond vascular anatomy: hemodynamics in cerebral aneurysms and endovascular treatment
Gesuchsteller/in Kollias Spyros S.
Nummer 120663
Förderungsinstrument Projektförderung (Abt. I-III)
Forschungseinrichtung Institut für Neuroradiologie Departement Medizinische Radiologie Universitätsspital Zürich
Hochschule Universität Zürich - ZH
Hauptdisziplin Biomedical Engineering
Beginn/Ende 01.05.2008 - 30.06.2010
Bewilligter Betrag 162'213.00
Alle Daten anzeigen

Alle Disziplinen (5)

Biomedical Engineering
Klinische Herz- und Kreislaufforschung
Herz- und Kreislaufforschung
Andere Gebiete der Ingenieurwissenschaften

Keywords (5)

aneurysm; phase-contrast magnetic resonance angiography; cerebral hemodynamics; endovascular treatment; numerical simulation

Lay Summary (Englisch)

Lay summary
Based on angiographic studies, between 3 and 6 % of humans harbor intracranial aneurysms. The yearly rupture rate of intracranial aneurysms is approximately 2 %. Due to the high mortality and morbidity associated with aneurysmal rupture, incidentally detected unruptured aneurysms are commonly treated either by endovascular coiling or surgical clipping during open craniotomy. Both of these treatment approaches are invasive procedures with recognized risks of morbidity and mortality. Understanding and predicting the hemodynamics of the unruptured aneurysms are of central importance in ensuring safe and efficient treatment by offering information relevant to therapeutic decision-making and patient management. Currently, morphological properties form the basis of pretreatment assessment of such vascular lesions, without reference to the associated hemodynamic abnormalities. This ignores the fact that the natural history of aneurysms as well as the course of their treatment are strongly influenced by hemodynamic factors. To be clinically useful, hemodynamic measurements must be combined with numerical simulations to describe the hemodynamic forces present in the specific diseased arterial segment of the individual patient, under flow conditions typical for that patient. The long-term goal of the proposed research is to integrate hemodynamic measures into the pre-interventional assessment of patients with intracranial aneurysms undergoing treatment. As Magnetic Resonance Angiography (MRA) techniques are widely available non-invasive methods for performing in vivo measurements of blood vessel geometry and blood velocity, this goal can be achieved by the following procedures: (a) An aneurysm patient is surveyed in the MR scanner where anatomical (3D-Time-of-Flight (3D-ToF)) as well as velocity images (Phase-contrast MRA (PC-MRA)) are acquired at specific locations around the aneurysm. (b) A numerical model is developed from this data and the velocity field is calculated over the entire vascular geometry. (c) By analyzing the velocity field results, different treatment options can be chosen and simulated to select the best treatment for the specific patient. These single events must first be validated and should then be implemented into one clinical tool. Transcending the specific research aims, this project will extend a program of ongoing, clinically oriented research by linking and inter-relating expertise in endovascular therapy and non-invasive vascular imaging within the Institute of Neuroradiology of the University Hospital Zurich, with ongoing basic and engineering research in the ETH.
Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende