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Comparative modular analysis of gene expression in vertebrate development

Titel Englisch Comparative modular analysis of gene expression in vertebrate development
Gesuchsteller/in Robinson-Rechavi Marc
Nummer 120624
Förderungsinstrument ProDoc (Forschungsmodul, FM)
Forschungseinrichtung Département d'Ecologie et d'Evolution Faculté de Biologie et de Médecine Université de Lausanne
Hochschule Universität Lausanne - LA
Hauptdisziplin Genetik
Beginn/Ende 01.10.2008 - 30.09.2011
Bewilligter Betrag 159'908.00
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Alle Disziplinen (2)

Disziplin
Genetik
Zoologie

Keywords (5)

bioinformatics; computational biology; evolution; microarrays; ontologies

Lay Summary (Englisch)

Lead
Lay summary
Understanding how the evolution of animal form is encoded in changes in the genome is a major challenge of modern biology. One of the issues confronting this intersection of genomics and evolutionary developmental biology is the complexity of the data and of the phenomena involved. Whenever we face such a large number of individual elements that have heterogeneous properties, grouping elements with similar properties together can help to obtain a better understanding of the entire ensemble. For example, individual genes can be categorized according to their properties to obtain a global picture of their organization in the genome. An advantage of studying modules is the reduction in variance relatively to individual measures, which is especially useful for noisy functional genomics data (e.g. gene expression). In terms of evolutionary biology, modules may be found at three levels: the "characters" of taxonomy, discrete parts which evolve semi-independently (e.g. the tetrapode forelimb); gene regulatory networks, which (to some extent) underlie these morphological modules; and sets of genes which act in a correlated manner, which reflect (again to some extent) the regulatory modules. Thus, we expect that the modularity at the morphological level is related to the modular organization of gene expression. In this project, we propose to conduct modular analyses of gene expression in the embryonic development of different animal species. The comparison of conserved or specific modules of gene expression will then provide us with information on the manner in which changes in genome regulation underlie the evolution of animal morphology. Importantly, this is a collaboration between the Robinson-Rechavi lab, specialized in the bioinformatics of genome and development evolution, and the Bergmann lab, specialized in the computational analysis of large and complex biological datasets. We expect that our collaboration will shed light on the fundamental modular nature of the regulation of development in animals, and its evolution. Our study will also result in methodological advances that will be useful to other applications, from biomedicine to the comparative study of plants.
Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

Verantw. Gesuchsteller/in und weitere Gesuchstellende

Mitarbeitende

Name Institut

Publikationen

Publikation
The hourglass and the early conservation models--co-existing patterns of developmental constraints in vertebrates
Piasecka Barbara, Lichocki Pawel, Moretti Sébastien, Bergmann Sven, Robinson-Rechavi Marc (2013), The hourglass and the early conservation models--co-existing patterns of developmental constraints in vertebrates, in PLOS Genetics, 9, e1003476.
Comparative modular analysis of gene expression in vertebrate organs
Piasecka Barbara, Kutalik Zoltan, Roux Julien, Bergmann Sven, Robinson-Rechavi Marc (2012), Comparative modular analysis of gene expression in vertebrate organs, in BMC Genomics, 13, 124.
Correcting for the bias due to expression specificity improves the estimation of constrained evolution of expression between mouse and human
Piasecka Barbara, Robinson-Rechavi Marc, Bergmann Sven (2012), Correcting for the bias due to expression specificity improves the estimation of constrained evolution of expression between mouse and human, in Bioinformatics, 14, 1865-1872.

Zusammenarbeit

Gruppe / Person Land
Formen der Zusammenarbeit
EPFL Schweiz (Europa)
- vertiefter/weiterführender Austausch von Ansätzen, Methoden oder Resultaten

Wissenschaftliche Veranstaltungen

Aktiver Beitrag

Titel Art des Beitrags Titel des Artikels oder Beitrages Datum Ort Beteiligte Personen
SMBE Vortrag im Rahmen einer Tagung Conservation of tissue-specific gene expression in vertebrates 04.07.2010 Lyon, Frankreich Robinson-Rechavi Marc; Piasecka Barbara;


Verbundene Projekte

Nummer Titel Start Förderungsinstrument
133011 Bioinformatic study of molecular evolution in the context of animal development and anatomy 01.10.2011 Projektförderung (Abt. I-III)
153341 Bioinformatics search for adaptive evolution in vertebrate development 01.10.2014 Projektförderung (Abt. I-III)

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