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The role of arginase II in atherogenesis, obesity and obesity-associated vascular dysfunctions

English title The role of arginase II in atherogenesis, obesity and obesity-associated vascular dysfunctions
Applicant Yang Zhihong
Number 120435
Funding scheme Project funding (Div. I-III)
Research institution Département de Médecine Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Cardiovascular Research
Start/End 01.04.2008 - 31.03.2011
Approved amount 279'000.00
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Keywords (5)

atherosclerosis; endothelial function; obesity; diabetes; insulin resistance

Lay Summary (English)

Lay summary
Our recent study provided in vitro evidence that increased arginase activity is involved in atherosclerotic endothelial dysfunction in ApoE-/- mouse model. Studies from literatures also showed that significantly higher arginase activity in the blood vessels of mice contributes to endothelial dysfunction in diabetes mellitus. The current research proposal is to elucidate and validate the causal role of increased arginase II isoenzyme activity in the pathogenesis of atherosclerosis and vascular dysfunctions associated with diabetes mellitus in animal models. The final results of this project will not only elucidate a novel mechanism of endothelial dysfunction in atherosclerosis and other risk factors, but also provide first in vivo evidence that targeting vascular arginase II could be a novel strategy for treatment of atherosclerosis and metabolic stress-associated vasculopathy. It may also explain the controversial results on atherogenesis published recently by several studies with L-arginine supplementation therapy.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
105917 Endothelial dysfunction in metabolic syndrome (insulin resistance syndrome): Role of Rho/Rho-kinase pathway and protective effect of HDL/ApoA-1 01.10.2004 Project funding (Div. I-III)
141070 S6K1, arginase-II, and vascular endothelial aging 01.04.2012 Project funding (Div. I-III)
133864 Fluorescence-Mediated Tomography (FMT) to study cellular and molecular events in physiology and pathology: application to cancer, cardiovascular and circadian biology 01.02.2011 R'EQUIP