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Quantitative Analysis of Micro-heterogeneous Systems: Joined Forces of Complementary Micro Beam Techniques

English title Quantitative Analysis of Micro-heterogeneous Systems: Joined Forces of Complementary Micro Beam Techniques
Applicant Grolimund Daniel
Number 119779
Funding scheme Project funding (Div. I-III)
Research institution Paul Scherrer Institut
Institution of higher education Paul Scherrer Institute - PSI
Main discipline Inorganic Chemistry
Start/End 01.09.2009 - 31.08.2012
Approved amount 210'419.00
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Keywords (11)

quantitative analysis; trace concentrations; complex matrix; LA-ICP-MS; XAS; EXAFS; analytical microprobe; synchrotron radiation; X-ray fluorescence; microXRF; micro-heterogeneous systems

Lay Summary (English)

Lead
Lay summary
Micro-heterogeneity represents an inherent and highly relevant characteristic of most natural and engineered (geo-) materials. Typical examples of such micro-heterogeneous materials include rocks and sediments, ceramics and composites, or engineered barrier materials such as bentonite and cement. Macroscopic physical properties as well as the chemical reactivity of these materials are generally determined by the nature of their micro-domain configuration. Accordingly, to improve our knowledge about the behaviour of specific materials, an adequate understanding of the impact of the assembly structure is required. Obviously, developing new analytical techniques and strategies providing a combination of high spatial resolution with the potential to obtain spectroscopic and structural information would pave the pathway for promising future scientific findings. For most microprobe techniques a tremendous progress concerning improvement of spatial resolution could be established. However, much less advancement was achieved regarding quantitative capabilities. In the vast majority of chases, micro-analytical techniques still yield semi-quantitative results. In this project a novel, connective multi-technique approach towards advanced quantitative investigations of micro-heterogeneous systems will be established. The symbiotic exploitation of different micro-beam techniques, in combination with macroscopic analytical techniques is expected to lead to significant progress towards an improved understanding of fundamental process of relevance in the context of trace element quantification. The initiate is headed by two leading micro-analytical facilities: The hard X-ray microprobe facility (microXAS beamline) at the Swiss Light Source and the Laboratory of Inorganic Chemistry (Trace Element and Micro Analysis) at the Swiss Federal Institute of Technology, Zurich (ETHZ). The designated case studies will focus on the quantitative analysis of distribution pattern of reactive contaminants observed after contaminant plume migration through environmentally relevant heterogeneous systems. The main focus will be on argillaceous host rock materials of designated Swiss radioactive waste repositories. The present research initiative is expected to yield improved fundamental knowledge towards quantitative imaging of trace elements (and their chemical speciation). Further, the establishment of a collaborative network of analytical facilities will be beneficial to the broad scientific user community and will open up new or improved micro-analytical research opportunities.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Name Institute

Publications

Publication
High-Speed, High-Resolution, Multielemental LA-ICP-TOFMS Imaging: Part II. Critical Evaluation of Quantitative Three-Dimensional Imaging of Major, Minor, and Trace Elements in Geological Samples
Burger Marcel, Gundlach-Graham Alexander, Allner Steffen, Schwarz Gunnar, Wang Hao A. O., Gyr Luzia, Burgener Simon, Hattendorf Bodo, Grolimund Daniel, Günther Detlef (2015), High-Speed, High-Resolution, Multielemental LA-ICP-TOFMS Imaging: Part II. Critical Evaluation of Quantitative Three-Dimensional Imaging of Major, Minor, and Trace Elements in Geological Samples, in Analytical Chemistry, 87(16), 8259-8267.
High-Speed, High-Resolution, Multielemental Laser Ablation-Inductively Coupled Plasma-Time-of-Flight Mass Spectrometry Imaging: Part I. Instrumentation and Two-Dimensional Imaging of Geological Samples
Gundlach-Graham Alexander, Burger Marcel, Allner Steffen, Schwarz Gunnar, Wang Hao A. O., Gyr Luzia, Grolimund Daniel, Hattendorf Bodo, Günther Detlef (2015), High-Speed, High-Resolution, Multielemental Laser Ablation-Inductively Coupled Plasma-Time-of-Flight Mass Spectrometry Imaging: Part I. Instrumentation and Two-Dimensional Imaging of Geological Samples, in Analytical Chemistry, 87(16), 8250-8258.
Anisotropic diffusion at the field scale in a 4-year multi-tracer diffusion and retention experiment – I: Insights from the experimental data
Gimmi Thomas, Leupin Olivier X., Eikenberg Jost, Glaus Martin A., Van Loon Luc R., Waber H. Niklaus, Wersin Paul, Wang Hao A.O., Grolimund Daniel, Borca Camelia N., Dewonck Sarah, Wittebroodt Charles (2014), Anisotropic diffusion at the field scale in a 4-year multi-tracer diffusion and retention experiment – I: Insights from the experimental data, in Geochimica et Cosmochimica Acta, 125, 373-393.
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
Giesen Charlotte, Wang Hao A O, Schapiro Denis, Zivanovic Nevena, Jacobs Andrea, Hattendorf Bodo, Schüffler Peter J, Grolimund Daniel, Buhmann Joachim M, Brandt Simone, Varga Zsuzsanna, Wild Peter J, Günther Detlef, Bodenmiller Bernd (2014), Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry, in Nature Methods, 11(4), 417-422.
Fast Chemical Imaging at High Spatial Resolution by Laser Ablation Inductively Coupled Plasma Mass Spectrometry
Wang Hao A. O., Grolimund Daniel, Giesen Charlotte, Borca Camelia N., Shaw-Stewart James R. H., Bodenmiller Bernd, Günther Detlef (2013), Fast Chemical Imaging at High Spatial Resolution by Laser Ablation Inductively Coupled Plasma Mass Spectrometry, in Analytical Chemistry, 85(21), 10107-10116.
High Spatial Resolution Quantitative Imaging by Cross-calibration Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Synchrotron Micro-X-ray Fluorescence Technique
Wang HAO, Grolimund D, Van Loon LR, Barmettler K, Borca CN, Aeschlimann B, Gunther D (2012), High Spatial Resolution Quantitative Imaging by Cross-calibration Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Synchrotron Micro-X-ray Fluorescence Technique, in CHIMIA, 66(4), 223-228.
Combined neutron and synchrotron X-ray microprobe analysis: attempt to disclose 3600 years-old secrets of a unique bronze age metal artifact
Grolimund D, Berger D, Schreyer SB, Borca CN, Hartmann S, Muller F, Hovind J, Hunger K, Lehmann EH, Vontobel P, Wang HAO (2011), Combined neutron and synchrotron X-ray microprobe analysis: attempt to disclose 3600 years-old secrets of a unique bronze age metal artifact, in JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 26(5), 1012-1023.
Quantitative Chemical Imaging of Element Diffusion into Heterogeneous Media Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry, Synchrotron Micro-X-ray Fluorescence, and Extended X-ray Absorption Fine Structure Spectroscopy
Wang HAO, Grolimund D, Van Loon LR, Barmettler K, Borca CN, Aeschimann B, Gunther D (2011), Quantitative Chemical Imaging of Element Diffusion into Heterogeneous Media Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry, Synchrotron Micro-X-ray Fluorescence, and Extended X-ray Absorption Fine Structure Spectroscopy, in ANALYTICAL CHEMISTRY, 83(16), 6259-6266.

Collaboration

Group / person Country
Types of collaboration
Universitaet Zuerich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
20th International Mass Spectrometry Conference, Geneva, Switzerland Talk given at a conference Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry 24.08.2014 Geneva, Switzerland, Switzerland Wang Hao;
2014 Winter Conference on Plasma Spectrochemistry, Amelia Island, Florida, USA Talk given at a conference Development of LA-ICP Imaging Mass Spectrometry at a Sub-Cellular Spatial Resolution 06.01.2014 Amelia Island, Florida, USA, United States of America Wang Hao;
CHAnalysis 2013, Beatenberg, Switzerland Talk given at a conference Chemical Imaging goes 4D 29.11.2013 Beatenberg, Switzerland, Switzerland Wang Hao; Grolimund Daniel;
CHAnalysis 2013, Beatenberg, Switzerland Talk given at a conference Multiplexed Chemical Imaging using Laser Ablation ICPMS at Sub-cellular Spatial Resolution 29.11.2013 Beatenberg, Switzerland, Switzerland Wang Hao; Grolimund Daniel;
8th Swiss Aerosol Group (SAG) meeting, Bern, Switzerland Talk given at a conference Laser-generated aerosol transportation and high spatial resolution biological tissue imaging 18.11.2013 Bern, Switzerland, Switzerland Wang Hao;
Swiss Chemical Society, 2013 Fall Meeting, Lausanne, Switzerland Poster Multiplexing Imaging Laser Ablation Mass Cytometry at Sub-cellular Spatial Resolution 06.09.2013 Lausanne, Switzerland, Switzerland Wang Hao;
Swiss Chemical Society, 2012 Fall Meeting, Zurich, Switzerland Poster A Novel Laser Ablation Cell for Chemical micro-Imaging by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICPMS) 12.09.2012 Zurich, Switzerland Wang Hao;
SLS Symposium 2012 Talk given at a conference High Spatial Resolution Quantitative Chemical Imaging by Complementary Techniques 03.07.2012 Villigen PSI, Switzerland Wang Hao; Grolimund Daniel;
11th European Workshop on Laser Ablation, Gijón, Spain Talk given at a conference High Spatial Resolution Fast Chemical Imaging by LA-ICPMS 19.06.2012 Gijón, Spain, Spain Wang Hao;
11th European Workshop on Laser Ablation Talk given at a conference High Spatial Resolution Fast Chemical Imaging by LA-ICPMS 11.06.2012 Gijon, Spain, Spain Wang Hao;
Migration 2011 Talk given at a conference Multi-dimensional Quantitative Microscopic Studies with High Spatial Resolution of Contaminant Diffusion into Opalinus clay rock 19.09.2011 Bejing, China, China Wang Hao; Grolimund Daniel;
Migration 2011 Talk given at a conference Imaging Chemistry (and Physics) in Space and Time: Towards a 3D Live View on Contaminant Transport in Heterogeneous Porous Media 19.09.2011 Bejing, China, China Wang Hao; Grolimund Daniel;
Joint Users’ Meeting at PSI 2011 Talk given at a conference High Spatial Resolution Quantitative Chemical Imaging by Complementary Techniques 12.09.2011 Villigen PSI, Switzerland Wang Hao; Grolimund Daniel;
NEA Clay Club 2011 Talk given at a conference Cs Migration in Opalinus Clay Rock: Results from X-Ray Tomography and Neutron Radiography 09.09.2011 Karlsruhe, Germany, Germany Grolimund Daniel;
Fall Meeting of the Swiss Chemical Society 2011 Talk given at a conference Quantitative Microscopic Studies with High Spatial Resolution of Contaminant Diffusion into Opalinus Clay Rock 05.09.2011 Lausanne, Switzerland Wang Hao;
ANAKON 2011 Talk given at a conference Imaging Chemistry in Space and Time 14.03.2011 Zuerich, Switzerland Grolimund Daniel;
Synchrotron Radiation in Art and Archaeometry SR2A 2010 Poster Combined neutron and synchrotron X-Ray microscope analysis: attempt to disclose 3600 years-old secrets of a unique bronze age metal artifact 09.11.2010 Amsterdam, Netherlands Grolimund Daniel;
TransPORE 2010 Talk given at a conference Evolution of Reactive Transport Plumes: Decipher physico-chemical micro-complexity using chemical micro-Imaging and micro-Tomography 16.08.2010 Villigen PSI, Switzerland Grolimund Daniel;
10th European Workshop on Laser-Ablation Talk given at a conference Quantitative imaging of elemental diffusion into heterogeneous media using LA-ICP-MS and synchrotron micro-XRF 29.06.2010 Kiel, Germany, Germany Wang Hao;


Self-organised

Title Date Place
Chemical Imaging School: Scanning and tomographic micro-XRPD imaging using the XRDUA package 14.11.2011 Villigen PSI, Switzerland
Advancing Quantitative Chemical Imaging 16.09.2011 Paul Scherrer Insitute, Villigen, Switzerland, Switzerland

Awards

Title Year
ETH Silver Medal for Outstanding Doctoral Thesis (highest distinction), 2014 2014
The Swiss Chemical Society- DSM Prize for Best Poster Presentation (2013) 2013
Metrohm Prize for Best Oral Presentation in Analytical Chemistry Division 2011

Patents

Title Date Number Inventor Owner
Method of multiplexed imaging of tissue sample by mass cytometry with sub-cellular resolution, by subjecting cells of labeled tissue sample to laser ablation with subcellular resolution at multiple known locations to form multiple plumes 27.02.2015 WO2015128490-A1
Ablation cell for laser ablation of sample material has sample chamber is configured to receive a sample in state which enables laser beam to enter sample chamber through lateral window and lateral opening and to impinge on sample surface 24.03.2014 WO2014147260-A1

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