Neurogenesis; mirgration; dendritic development; sensory; perception; sensory coding; adult neurogenesis; neuronal maturation; sensory processing; olfaction
Gschwend Olivier, Beroud Jonathan, Carleton Alan (2012), Encoding odorant identity by spiking packets of rate-invariant neurons in awake mice., in PloS one
, 7(1), 30155-30155.
Vincis Roberto, Gschwend Olivier, Bhaukaurally Khaleel, Beroud Jonathan, Carleton Alan (2012), Dense representation of natural odorants in the mouse olfactory bulb., in Nature neuroscience
, 15(4), 537-9.
Bathellier Brice, Gschwend Olivier, Carleton Alan (2010), Temporal Coding in Olfaction, 329-351.
Carleton Alan, Accolla Riccardo, Simon Sidney A (2010), Coding in the mammalian gustatory system., in Trends in neurosciences
, 33(7), 326-34.
While most neurons in the central nervous system are born during the embryonic and early postnatal periods, it is now well accepted that few regions of the brain keep producing new neurons throughout life, even during aging. Adult neurogenesis may represent a new form of brain plasticity. It is therefore of great interest to understand how the entire neurogenetic process (birth, differentiation and death of a neuron) may be regulated both by internal and external factors since these information could also be used for future therapeutically treatments using adult neural stem cells. In this project, we propose to use a combination of time lapse 2-photon microscopy and computer vision algorithms to study the neuronal maturation process in living brain tissue. We propose to study the impact of genetic and epigenetic factors on neuronal maturation on the olfactory system. We further intend to study the impact of neurogenesis and the mechanisms controlling neuronal maturation on sensory processing using in vivo neuronal ensemble recordings during odor perception. Our project will not only provide new data about neuronal maturation but also on sensory processing.