Project

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Investigation of language control and semantic processing mechanisms in the bilingual brain using fMRI, rTMS, electro-corticography and ERP

English title Investigation of language control and semantic processing mechanisms in the bilingual brain using fMRI, rTMS, electro-corticography and ERP
Applicant Annoni Jean-Marie
Number 118362
Funding scheme Project funding (Div. I-III)
Research institution Laboratoire d'Évaluation Préchirurgicale des Epilepsies Hôpital Universitaire Cantonal de Genève
Institution of higher education University of Geneva - GE
Main discipline Ethology
Start/End 01.10.2007 - 30.09.2011
Approved amount 342'459.00
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All Disciplines (2)

Discipline
Ethology
Neurophysiology and Brain Research

Keywords (7)

bilinguals; semantic processing; language selection; fMRI; ERP mapping; rTMS; electro-corticography

Lay Summary (English)

Lead
Lay summary
In bilinguals expressive language set, the question remains as to which regions are specifically involved in language control/selection and which areas are activated by the different tasks’ sets. Particularly, it’s still debated whether the cognitive mechanism that allows the selection of one language among others relies on a language-specific neural module or general executive regions that also allows switching between various competing behavioural responses. In continuation with our previous studies, and based on the results obtained, our aim in the present project is to shed light on some of the intriguing questions concerning language control/selection mechanisms in the bilingual brain and to specify the role of different brain regions that participate in such processes in bilinguals. Actually, we found in our last experiments that almost all brain regions hypothesised to be involved in language selection were activated during the selection of L1 items and some were even more extensively engaged during the selection of L2 items. In addition we found that the activation of the DLPFC was related to task but not to language selection. The first objective will thus be to specify the role of such regions in language selection vs non-linguistic task selection paradigms. Also, related to our previous ERP results obtained with the semantic categorization experiment, the second major aim of this project will be to investigate the time course of semantic processing in bilinguals and characterise the early steps of information processing that could be modulated by the proficiency level in L2, and to shed light on their nature and neural basis.To address the first question, this project will combine different paradigms (including language switching and task switching) and neurophysiological techniques. First, two different groups (2x15) of subjects with varying proficiency in L2 will be tested with fMRI paradigms. Varying the level of proficiency in L2 will allow determining the neural activations that can be modulated by language but not by task selection. Second, another group of 10 bilingual subjects will be investigated in similar but adapted paradigms to be tested with repetitive transcranial magnetic stimulation (rTMS) in order to verify which cortical areas can interfere with the ongoing task and language selection processes. Finally, a group of neurosurgery bilingual patients will also be tested with adapted paradigms under intra-operative electro-cortical stimulations of left hemisphere language and executive areas.To achieve the second goal, the same two groups of bilingual subjects with different levels of proficiency in L2 will be tested in an ERP mapping study using a bilingual semantic categorisation task. The analysis of the electrophysiological responses during different conditions and languages will allow determining the different steps of information processing that could be modulated by L2 mastery. The combination of spatio-temporal analysis of ERP map series with source localisation analysis will allow to identify when and where neural responses involved in L1 and L2 word recognition processes occur.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Mutism and Amnesia following High-Voltage Electrical Injury: Psychogenic Symptomatology Triggered by Organic Dysfunction?
Mishra N. K., Russmann H., Granziera C., Maeder P., Annoni J. M. (2011), Mutism and Amnesia following High-Voltage Electrical Injury: Psychogenic Symptomatology Triggered by Organic Dysfunction?, in Eur Neurol, 66(4), 229-234.
Language and syntactic impairment following stroke in late bilingual aphasics
Tschirren M., Laganaro M., Michel P., Martory M. D., Di Pietro M., Abutalebi J., Annoni J. M. (2011), Language and syntactic impairment following stroke in late bilingual aphasics, in Brain Lang, 119(3), 238-242.
[Return to work after brain lesions: cognitive and behavioral factors]
Annoni J. M., Colombo F. (2011), [Return to work after brain lesions: cognitive and behavioral factors], in Rev Med Suisse, 7(293), 944-947.
Theory of mind tasks and executive functions: a systematic review of group studies in neurology
Aboulafia-Brakha T., Christe B., Martory M. D., Annoni J. M. (2011), Theory of mind tasks and executive functions: a systematic review of group studies in neurology, in J Neuropsychol, 5(Pt 1), 39-55.
Assessment of impulsivity after moderate to severe traumatic brain injury
Rochat L., Beni C., Billieux J., Azouvi P., Annoni J. M., Van der Linden M. (2010), Assessment of impulsivity after moderate to severe traumatic brain injury, in Neuropsychol Rehabil, 20(5), 778-797.
On the origin of the N400 effects: an ERP waveform and source localization analysis in three matching tasks
Khateb A., Pegna A. J., Landis T., Mouthon M. S., Annoni J. M. (2010), On the origin of the N400 effects: an ERP waveform and source localization analysis in three matching tasks, in Brain Topogr, 23(3), 311-320.
Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients.
Brioschi A, Gramigna S, Werth E, Staub F, Ruffieux C, Bassetti C, Schluep M, Annoni JM. (2009), Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients., in Eur Neurol., 62(4), 243-249.
Seeing the phantom: a functional magnetic resonance imaging study of a supernumerary phantom limb
Khateb A., Simon S. R., Dieguez S., Lazeyras F., Momjian-Mayor I., Blanke O., Landis T., Pegna A. J., Annoni J. M. (2009), Seeing the phantom: a functional magnetic resonance imaging study of a supernumerary phantom limb, in Ann Neurol, 65(6), 698-705.
Temporal dynamics of awareness for facial identity revealed with ERP
Genetti M, Khateb A, Heinzer S, Michel CM, Pegna AJ. (2009), Temporal dynamics of awareness for facial identity revealed with ERP, in Brain Cogn. , 69(2), 296-305.
Electrophysiological evidence for early non-conscious processing of fearful facial expressions
Pegna AJ, Landis T, Khateb A (2008), Electrophysiological evidence for early non-conscious processing of fearful facial expressions, in Int J Psychophysiol., 70(2), 127-136.
Frequency, characterisation and therapies of fatigue after stroke
Annoni JM, Staub F, Bogousslavsky J, Brioschi A (2008), Frequency, characterisation and therapies of fatigue after stroke, in Neurol Sci., Suppl 2, S244-S246.
A multidimensional approach to impulsivity changes in mild Alzheimer's disease and control participants: Cognitive correlates
Rochat L., Billieux J., Juillerat Van der Linden A. C., Annoni J. M., Zekry D., Gold G., Van der Linden M., A multidimensional approach to impulsivity changes in mild Alzheimer's disease and control participants: Cognitive correlates, in Cortex.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Lemanic Neuroscience annual meeting 23.09.2011 Les Diablerets
Lemanic Neuroscience annual meeting 29.10.2010 Genève
Human Brain Mapping meeting (HBM) 06.06.2010 Barcelone
Swiss Society of Neuroscience (SSN) 12.03.2010 Lausanne
Alpine Brain Imaging Meeting (ABIM) 09.01.2010 Champéry
Lemanic Neuroscience annual meeting 13.11.2009 Fribourg
Swiss Society of Neuroscience (SSN) 14.03.2009 Fribourg


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Comment naissent les idées? Western Switzerland 17.03.2010
Talks/events/exhibitions La nuit de la Science Western Switzerland 10.07.2010
Media relations: radio, television Le cerveau des bilingues RSR Western Switzerland 29.01.2010
Talks/events/exhibitions Notre cerveau bilingue Western Switzerland 18.03.2010

Associated projects

Number Title Start Funding scheme
156937 Role of executive functions on language: an experimental and clinical approach with application to mother language and second language 01.01.2015 Project funding (Div. I-III)
138497 Differences in reading strategies across languages in bilinguals: eye movements, ERP analysis and clinical implications 01.01.2012 Project funding (Div. I-III)
138497 Differences in reading strategies across languages in bilinguals: eye movements, ERP analysis and clinical implications 01.01.2012 Project funding (Div. I-III)
102271 The bilingual brain: role of the proficiency processing and language selection 01.10.2003 Project funding (Div. I-III)

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