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Role of microRNAs in tumourigenesis and chemoresistance in lung cancer and glioma

English title Role of microRNAs in tumourigenesis and chemoresistance in lung cancer and glioma
Applicant Vassella Erik
Number 118039
Funding scheme Project funding (Div. I-III)
Research institution Institut für Pathologie Medizinische Fakultät Universität Bern
Institution of higher education University of Berne - BE
Main discipline Experimental Cancer Research
Start/End 01.01.2008 - 31.07.2011
Approved amount 197'000.00
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Keywords (8)

non-small cell lung carcinoma; microRNA; chemosensitivity; apoptosis; proliferation; Glioma; differentiation; gene expression

Lay Summary (English)

Lead
Lay summary
MicroRNAs are short regulatory sequences that constitute a new layer of gene expression at the post-transcriptional level. They are involved in a wide variety of biological processes , including cell fate specification, proliferation, cell death and play key roles in tumor biology as they function as tumour suppressors or oncogenes. The proposed work will be subdivided into three parts. We aim to investigate the role microRNAs in cell cycle regulation and apoptosis of lung cancer cells and analyse if microRNAs can be used as a chemosensitizing agent in lung cancer. In addition, mechanisms of altered microRNA expression in lung cancer will be investigated. Some glioma tumours exhibit characteristic deletions that constitute important predictive markers for chemotherapy and prognostic markers for survival. In a third part, we will analyse microRNAs that are located in these regions for their role in chemoresistance, proliferation and differentiation of low grade gliomas. The experiments described in the research proposal may provide important information about the role of microRNAs in conferring resistance to chemotherapy in tumours.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

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Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
European microRNA meeting 01.11.2010 Cambridge


Associated projects

Number Title Start Funding scheme
138129 Analysis of microRNAs implicated in the regulation of NF-kB and MGMT pathways for their role in conferring apoptosis and chemoresistance of glioma tumours 01.04.2012 Project funding (Div. I-III)

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