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Cooled ion trap photofragment spectrometer

English title Cooled ion trap photofragment spectrometer
Applicant Rizzo Thomas R.
Number 117416
Funding scheme R'EQUIP
Research institution Institut des sciences et ingénierie chimiques EPFL - SB - ISIC
Institution of higher education EPF Lausanne - EPFL
Main discipline Physical Chemistry
Start/End 01.07.2007 - 30.06.2008
Approved amount 180'000.00
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Keywords (8)

Molecular spectroscopy; Photochemistry; Laser chemistry; Mass spectrometry; biophysical chemistry; laser spectroscopy; biological molecules; peptides

Lay Summary (English)

Lay summary
The goal of this project is to build a new, state-of-the-art machine that will allow us to obtain structural information on biological molecules in the gas phase. As their structure is related to their function, the results of this project should ultimately provide insight into the latter.

From a more applied point of view, the techniques developed here should find applications in the analysis of biological molecules, since information on a molecule's mass, which is traditionally provided by classical mass spectrometry, can be complemented by information on secondary structure via laser spectroscopy.

Another important result of these experiments will be to provide rigorous tests of calculations of biological molecules -- something that is essential for improving our ability to predict their structure computationally. This has direct implications in the pharmaceutical industry.

Our method combines the techniques of mass spectrometry, namely electrospray ionization, quadrupole mass analysis and ion traps, together with laser spectroscopy of various types. Ultimately, we will obtain infrared spectra of biologically related molecules that carry information on their secondary structure.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Associated projects

Number Title Start Funding scheme
130579 New dimensions in the spectroscopy of gas-phase biomolecular ions 01.04.2010 Project funding (Div. I-III)
120065 Spectroscopic studies of secondary structure in cold, gas-phase, biological ions 01.04.2008 Project funding (Div. I-III)
112071 Photofragment spectroscopy: from triatomics to small peptides 01.04.2006 Project funding (Div. I-III)