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Connexins in the cardiovascular system

English title Connexins in the cardiovascular system
Applicant Kléber André
Number 117331
Funding scheme Scientific Conferences
Research institution Institut für Physiologie Medizinische Fakultät Universität Bern
Institution of higher education University of Berne - BE
Main discipline Cardiovascular Research
Start/End 01.10.2007 - 31.03.2008
Approved amount 5'000.00
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Keywords (4)

cardiovascular science; connexins; cell-to-cell couplings; cardiovascular diseases

Lay Summary (English)

Lay summary
The International Symposium on „ Connexins in the Cardiovascular System“ was taking place from June 7 - June 9, 2007 at the University of Bern Switzerland. The presentations summarized the research of the last 5 years performed in specific fields of cardiovascular science. Session I presented new data on the relationship between connexin channels, mechanical junctions and scaffolding proteins, the role of heteromeric and heterotypic gap junction channels, and the mechanisms regulating permeability and voltage-gating of gap junction channels. Session II presented the newest results on the effect of genetic deletion of specific connexion proteins, the role of connexins in cardiac development, and in linking cells of different types in different cardio-vascular compartments. Session III focused on the role of connexins in cardio-vascular disease, such as hypertension, myocardial ischemia, myocardial failure and atrial fibrillation. Moreover, newest data were presented on genetic diseases involving reduced connexin expression, such as arrhythmogenic right ventricular cardiomyopathy. Session IV discussed possibilities to influence cell-to-cell coupling by gap junctions through therapeutic interventions (drugs, interfering RNA’s, stem cells). 7 of the 21 speakers came form the USA, 7 from Europe, 7 from Switzerland. The symposium was attended by 100 participants mainly from Europe. The large majority of the attendants were Doctoral Students and Postdoctoral fellows from the Swiss Cardiovascular Research and Training Network who could profit from this Symposium to discuss their recent experimental and theoretical work with the International experts.
Direct link to Lay Summary Last update: 21.02.2013

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