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The evolutionary significance of whole genome duplication in teleost fishes

Titel Englisch The evolutionary significance of whole genome duplication in teleost fishes
Gesuchsteller/in Robinson-Rechavi Marc
Nummer 116798
Förderungsinstrument Projektförderung (Abt. I-III)
Forschungseinrichtung Département d'Ecologie et d'Evolution Faculté de Biologie et de Médecine Université de Lausanne
Hochschule Universität Lausanne - LA
Hauptdisziplin Genetik
Beginn/Ende 01.12.2007 - 30.11.2010
Bewilligter Betrag 276'021.00
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Keywords (5)

bioinformatics; development; evolution; fishes; genomics

Lay Summary (Englisch)

Lay summary
Many groups of species have had their genome shaped by a complete duplication in their evolutionary past, tens of millions of years ago. We feel, intuitively, that an event as dramatic as genome duplication should impact the organism in a visible manner, but details have been elusive. Do the copies share an ancestral function, or does one keep it while the other evolves a new function? Are these functional changes mostly at the level of the protein structure, or do they affect more where and when the gene is expressed? Are the consequences of genome duplication visible in the evolution of new morphological adaptations, or of more species?To answer such questions, we focus on teleost fishes, which constitute about half of all vertebrate species. The genome duplication which occurred at the origin of this group, about 200 to 300 million years ago, is conclusively demonstrated, and abundant data is available for fishes. In this project, we will use bioinformatics to study on the one hand the evolution of all proteins from fish genomes, after whole genome duplication. And on the other hand, to investigate more specifically the evolution of genes involved in embryonic development. This should help us link genome duplication to features of animal diversity. The relation between these two fields has remained a fascinating but open question for two decades.
Direktlink auf Lay Summary Letzte Aktualisierung: 21.02.2013

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Verbundene Projekte

Nummer Titel Start Förderungsinstrument
133011 Bioinformatic study of molecular evolution in the context of animal development and anatomy 01.10.2011 Projektförderung (Abt. I-III)