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Peptide Dendrimers as Synthetic Artificial Proteins for Catalysis and Binding

English title Peptide Dendrimers as Synthetic Artificial Proteins for Catalysis and Binding
Applicant Reymond Jean-Louis
Number 116555
Funding scheme Project funding (Div. I-III)
Research institution Departement für Chemie, Biochemie und Pharmazie Universität Bern
Institution of higher education University of Berne - BE
Main discipline Organic Chemistry
Start/End 01.04.2007 - 31.03.2009
Approved amount 397'635.00
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Keywords (18)

peptides; enzyme models; dendrimers; combinatorial libraries; fluorescence assays; artificial proteins; glycopeptides; esterases; vitamin B12; drug delivery; pseudomonas aeruginosa; antibacterials; biofilms; combinatorial chemistry; catalysis; combinatoiral libraries; anticancer agent; vitamin-B12

Lay Summary (English)

Lead
Lay summary
De novo protein design is one of the most difficult and fascinating problems in chemistry. Our approach to this question is based on peptide dendrimers as synthetic artificial proteins. A combinatorial synthesis protocol allows us to prepare and test over 60'000 different peptide dendrimers in a single experiment, which has opened the door to peptide dendrimers with selective binding affinities to small molecules such as vitamin B12, and to proteins such as lectins using glycosylated dendrimers. The present research project is dedicated to the development of peptide dendrimers with diverse functions considering fundmental aspects of structural design as well as their biomedical applications. Ongoing projects concern molelcular dynamics studies of catalytic peptide dendrimers, the study of peptide dendrimers containing secondary structure elements, a study of vitamin B12-binding peptide dendrimers, an investigation of the proteolytic stability and immunogenicity of peptide dendrimers, and the development of glycopeptide dendrimers for drug delivery and as antimicrobial agents.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
121304 Purchase of a High-Performance Mass Spectrometer 01.09.2008 R'EQUIP
125020 Peptide and Glycopeptide Dendrimers as Artificial Proteins 01.04.2009 Project funding (Div. I-III)
159941 A Chemical Space Approach to Bioactive Peptides 01.04.2015 Project funding (Div. I-III)
140349 Exploring Peptide Topologies in Search for New Drugs 01.04.2012 Project funding (Div. I-III)
107690 Enzyme Studies Using Molecular and Supramolecular Diversity a) Peptide Dendrimers; b) Selectivity Fingerprints 01.04.2005 Project funding (Div. I-III)

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