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Molecular PET/CT imaging-guided radiation therapy treatment planning

English title Molecular PET/CT imaging-guided radiation therapy treatment planning
Applicant Zaidi Habib
Number 116547
Funding scheme Project funding (Div. I-III)
Research institution Service de Médecine Nucléaire Hôpitaux Universitaires de Genève
Institution of higher education University of Geneva - GE
Main discipline Biomedical Engineering
Start/End 01.04.2007 - 30.06.2009
Approved amount 187'444.00
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All Disciplines (2)

Biomedical Engineering
Clinical Cancer Research

Keywords (6)

molecular imaging; PET/CT; quantification; image analysis; oncology; radiation therapy

Lay Summary (English)

Lay summary
Positron Emission Tomography (PET) provides qualitative as well as quantitative information about the volume distribution of biologically significant radiotracers after injection into the human body. Dual-modality imaging is an approach that combines imaging modalities in a way that provides diagnostic information that is not available from a single imaging modality alone. A significant success of PET/CT has been the improved image quality of FDG images for tumour localization. The recent enthusiasm in the use of PET/CT-guided radiation therapy treatment planning is stimulated by the commercial availability of advanced imaging technologies and treatment planning software. One of the main difficulties encountered by radiation therapists is the delineation of the treatment volume from noisy PET data.This project aims to develop strategies for improvement of tumour detectability in clinical oncology using dynamic PET acquisition protocols combined with multivariate image analysis and nonlinear similarity measures, and to implement the techniques and methodology required for accurate and reproducible dual-modality PET/CT-guided radiation therapy treatment planning incorporating automated image segmentation techniques for target volume delineation and robust partial volume correction techniques for accurate lesion quantification as well as protocols designed to reduce respiratory motion artefacts in PET images of the upper abdomen and lung cancer thus enabling correct localization and accurate quantitation of lesion size and radiation dose delivery to the target volume.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
125246 High resolution quantitative molecular imaging of small animals using a preclinical PET/CT system 01.04.2009 Project funding (Div. I-III)