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Role of wall stress in the pathogenesis of spontaneous dissection of the cervical carotid artery

English title Role of wall stress in the pathogenesis of spontaneous dissection of the cervical carotid artery
Applicant Baumgartner Ralf
Number 112685
Funding scheme Project funding (Div. I-III)
Research institution NeuroZentrum Zürich Klinik Hirslanden
Institution of higher education ETH Zurich - ETHZ
Main discipline Biomedical Engineering
Start/End 01.02.2007 - 31.12.2010
Approved amount 260'000.00
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All Disciplines (3)

Discipline
Biomedical Engineering
Electrical Engineering
Mechanical Engineering

Keywords (11)

ischemic stroke; internal carotid artery dissection; biomechanics; arterial wall; wall stress; nonlinear elasticity; Cervical arterydissection; Arterial wallmechanics; Numerical modelling; Carotid sinus; Magnetic resonance imaging

Lay Summary (English)

Lead
Lay summary
Spontaneous dissection of the cervical internal carotid artery (sICAD) is a major cause of stroke in young adults. The etiology of sICAD is an intimal tear of the cervical internal carotid artery (ICA) leading to intramural hemorrhage. The mechanism causing the intimal lesion is still unclear. The working hypothesis is that sICAD is due to an increased wall stress induced by minor traumas. The aim of the study is to compare the wall stress in the cervical ICA during static positions of the head in patients with sICAD and healthy volunteers. The optimized magnetic resonance imaging (MRI) protocols are summarized in [1]. These data serve as an input for finite element (FE) simulations, which are performed using sophisticated computational tools. The new MRI protocols were used for comparing patients with sICAD that occured at least 12 months ago and matched healthy controls. It will be investigated whether the site of peak wall stress in the non-dissected cervical ICA occurring during different static position of the head (1) is identical in patients with sICAD and control subjects and (2) corresponds to the location of the intimal tear identified at autopsy and endarterectomy studies, and (3) the change of wall stress occurring during simulated blood pressure increase will be compared between both groups. If the planned study could show that the present working hypothesis is true, an important step in the understanding of the mechanis of so-called "spontaneous" ICAD would have been done. Thus, strategies to avoid provocative situations might be developed to prevent the occurrence and recurrence of slCAD, and improve patient management in the acute phase.[1] Callaghan FM, Soellinger M, Baumgartner RW, Poulikakos D, Boesiger P, Kurtcuoglu V. The role of the carotid sinus in the reduction of arterial wall stresses due to head movements--potential implications for cervical artery dissection. J Biomechanics 42, 755-761, 2009
Direct link to Lay Summary Last update: 21.02.2013

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108476 Transcranial ultrasound enhanced trombolysis 01.09.2005 Project funding (Div. I-III)
120531 SmartShunt - The Hydrocephalus Project 01.09.2008 Interdisciplinary projects

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