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Imaging of clinical evoked potentials

English title Imaging of clinical evoked potentials
Applicant Michel Christoph
Number 111783
Funding scheme Project funding (Div. I-III)
Research institution Département des neurosciences fondamentales Faculté de Médecine Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Neurophysiology and Brain Research
Start/End 01.06.2006 - 31.03.2010
Approved amount 430'000.00
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Keywords (6)

clinical neurophysiology; electric neuroimaging; evoked potentials; functional brain mapping; multiple sclerosis; stroke

Lay Summary (English)

Lead
Lay summary
The purpose of this project is to introduce and evaluate high-resolution evoked potential (EP) imaging in clinical practice. This technique differs from the conventional clinical evoked potentials in two principal aspects:
1. The evoked potentials are recorded simultaneously from multiple scalp electrodes instead of a few electrodes only. In our case we will record the signals from 256 electrodes. New technical achievements allow to apply this high number of electrodes very rapidly and with high comfort for the person. 2. The data is analyzed using modern imaging methods instead of the analysis of latency and amplitude of single EP waveforms.
Thus most important in this project is the processing of the data, while the acquisition follows the standard clinical protocols, just recorded with more electrodes.
During the last decade we have developed high resolution EEG imaging methods for the analysis of spontaneous EEG and evoked potentials. Up to now we applied these methods in two principal domains: cognitive neuroscience and presurgical epilepsy evaluation. We repeatedly showed the utility of these methods to precisely localize brain functions in time and in space. With the present project we aim to extent the application to the clinical sensory evoked potentials. We predict an enhanced sensitivity and specificity of clinical evoked potentials when recorded and analyzed with this technique. We also expect to gain more insights into the brain locations and time features of the neuronal generators of the middle- and late-latency EP components. We propose to record high resolution somatosensory EPs (SSEP), visual EPs (VEP), and simple cognitive auditory event-related potentials (ERP).
We will record these evoked potentials from a large population of healthy subjects in different age ranges in order to determine normative values of these new parameters. We will then apply the technique to patients with various kinds of neurological diseases at different progressive levels.The focus will be on patients with multiple sclerosis (MS), patients that suffer from brain lesions (particularly stroke), and patients that are candidates for functional brain surgery, particularly due to epilepsy.
The four principal objectives of the study are the following:
1. Evaluation of the diagnostic value of the method, particularly early diagnosis of MS.
2. Evaluation of the prognostic value of the method concerning functional recovery.
3. Advance our understanding of the generators of the different EP components.
4. Advance our understanding of repair and plasticity mechanisms after lesion.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
132952 The Idling Brain: The Temporal Structure of Resting State Networks Revealed by Electrical Neuroimaging 01.11.2010 Project funding (Div. I-III)
121334 Establishing a pluridisciplinary brain and behavior laboratory at the University of Geneva 01.10.2008 R'EQUIP
100745 Direct non invasive Human Brain Machine Interfaces 01.04.2003 Project funding (Div. I-III)

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