Project

Back to overview

Gene-gene interactions for hypertension candidate genes in a Swiss population-based sample (PROSPER)

English title Gene-gene interactions for hypertension candidate genes in a Swiss population-based sample (PROSPER)
Applicant Bochud Murielle
Number 111361
Funding scheme Ambizione
Research institution Institut Universitaire de Médecine Sociale et Préventive - IUMSP CHUV et Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Genetics
Start/End 01.07.2006 - 31.12.2008
Approved amount 358'028.00
Show all

All Disciplines (2)

Discipline
Genetics
Methods of Epidemiology and Preventive Medicine

Keywords (6)

genetic epidemiology; hypertension; blood pressure; cardiovascular disease; genetics; methology

Lay Summary (English)

Lead
Lay summary
Human genome discoveries have broad potential application for improving health and preventing disease. Genetic epidemiology aims at understanding the genetic determinants of common diseases in human populations. Genetic epidemiology will play an important role in the continuum from gene discovery to the development and applications of genetic tests. Because of the complexity and the rapidly evolving methods in genetic epidemiology, the need for well-trained health professionals in this field is rapidly growing. Hypertension (high blood pressure) affects about 1 billion people worldwide. Hypertension is a risk factor for stroke, heart and renal diseases and death. Hypertension aggregates in families, which suggests that genes influence the risk of hypertension and hence the level of blood pressure. So far, it has been difficult to identify genes involved in blood pressure control or hypertension. One potential reason is that many genes have a small effect on blood pressure and interact with each other: this is called gene-gene interactions. Although many hypertension genes have been identified, much remains to be done in order to clarify their impact at the population level, their interactions with other genes and with environmental factors. The proposed research program targets 6 main objectives: (1) to analyze gene-gene interactions for blood pressure/hypertension in a large population-based sample in the Lausanne area (CoLaus study), (2) to provide expertise in genetic epidemiology in Lausanne for the planning and the data analysis of genetic epidemiology projects in collaboration with local partners, (3) to participate to the development of genetic epidemiology in Switzerland in a flexible manner, according to opportunities, available resources and needs, (4) to develop new methods to identify genes involved in blood pressure control and related complex traits in collaboration with national and international partners, (5) to ensure a personal and professional development via training, sojourns in centers of excellence and international collaborative projects, (6) to conduct other genetic epidemiologic work on diseases related to hypertension (cardiovascular disease, renal diseases, metabolic syndrome). The outcomes of this research program will be extremely relevant and valuable to the development of genetic epidemiology in Switzerland and to improve knowledge on the genetic determinants of blood pressure/hypertension and related cardiovascular disorders in a Swiss population-based sample.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

-